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Topic: Proteolytic cleavage

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	CLC bio: Proteolytic cleavage
		Proteolytic cleavage is basically the process of breaking the peptide bonds between amino acids in proteins.
		Another example of proteolytic processing of proteins is secretory proteins or proteins targeted to organelles, which have their signal peptide removed by specific signal peptidases before release to the extracellular environment or specific organelle.
		Proteolytic cleavage of proteins has shown its importance in laboratory experiments where it is often useful to work with specific peptide fragments instead of entire proteins.
	www.clcbio.com /index.php?id=42 (414 words)

	Proteolytic Cleavage of Recombinant Type 2A von Willebrand Factor Mutants R834W and R834Q: Inhibition by Doxycycline ...
		The response of the proteolytic susceptibility to guanidine HCl was investigated by treating the vWF with guanidine HCl at the designated concentration before it was incubated with the proteinase (Fig 4B).
		SP-2 reversed the inhibition of vWF cleavage caused by VP-1.
		Proteolytic cleavage was associated with a decrease of vWF ristocetin cofactor activity.
	www.bloodjournal.org /cgi/content/full/89/6/1954 (6709 words)

	Proteolytic Cleavage and Activation of Pro-Macrophage-stimulating Protein by Resident Peritoneal Macrophage Membrane ...
		Proteolytic Cleavage and Activation of Pro-Macrophage-stimulating Protein by Resident Peritoneal Macrophage Membrane Proteases
		Cleavage of pro-MSP by incubation with mouse peritoneal macrophages.
		nonspecific cleavage is inhibited by STI and AEBSF.
	www.jci.org /cgi/content/full/97/3/720 (5233 words)

	Ty1 Proteolytic Cleavage Sites Are Required for Transposition: All Sites Are Not Created Equal -- Merkulov et al. 75 ...
		Evidence for a semiordered pathway of proteolytic cleavage in Ty1.
		Cleavage sites of retrotransposons are not as well studied as their viral counterparts.
		Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain.
	jvi.asm.org /cgi/content/full/75/2/638 (4463 words)

	Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic ...
		Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations -- Song et al.
		Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
		Proteolytic Release of the NICD Is Impaired by PS1 Mutations.
	www.pnas.org /cgi/content/full/96/12/6959 (4376 words)

	Proteolytic Cleavage of the p65-RelA Subunit of NF-{kappa}B during Poliovirus Infection -- Neznanov et al. 280 (25): ...
		Proteolytic Cleavage of the p65-RelA Subunit of NF-{kappa}B during Poliovirus Infection -- Neznanov et al.
		Western blotting analysis is shown of the cytoplasmic proteins from poliovirus-infected HeLa cells with antibodies specific for the C terminus of p65-RelA and with anti-p50 antibodies.
		Cleavage of the p65-RelA protein coincided with the appearance of protease 3C-specific cleavage of poliovirus polyprotein.
	www.jbc.org /cgi/content/full/280/25/24153 (3804 words)

	Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function -- Herzig et al. 16 (18): ...
		Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function -- Herzig et al.
		Cleavage by separase occurs C-terminal from the conserved arginine residue.
		THR cleavage is inhibited in cells arrested by the mitotic spindle checkpoint and in pim mutants.
	www.genesdev.org /cgi/content/full/16/18/2443 (6854 words)

	AEGiS-05IAC: Proteolytic cleavage of the 66-Kd form of the HIV-1 reverse transcriptase.
		Proteolytic cleavage of the 66-Kd form of the HIV-1 reverse transcriptase.
		Proteolytic cleavage sites on HIV-1 RT were mapped using a battery of monoclonal antibodies that recognize known positions in HIV-1 RT.
		However, this poses the question of whether the specificity of cleavage resides in the protease or in the structure of the properly folded 66-Kd form of the RT.
	www.aegis.com /conferences/iac/1989/C666.html (315 words)

	Eukaryotic Translation Initiation Factor 4G Is Targeted for Proteolytic Cleavage by Caspase 3 during Inhibition of ...
		extent of its cleavage correlated with the onset and extent of
		Cleavage of eIF4G during PV infection has been clearly shown to be the major cause of shutoff of cellular translation (13,
		In vitro cleavage of eIF4G by caspase 3.
	mcb.asm.org /cgi/content/full/18/12/7565 (8284 words)

	Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis -- Chen et al. 272 (36): 22966 -- Journal of Biological ...
		Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis -- Chen et al.
		Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis
		Cleavage of mdm2 by the VM10 apoptotic cytosol.
	www.jbc.org /cgi/content/full/272/36/22966 (6526 words)

	The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in ...
		Located close to the crown of the V3 type-specific neutralization loop of the human immunodeficiency virus type 1 (HIV-1) (IIIB) SU glycoprotein gp120, are several potential sites that should be susceptible to proteolytic cleavage by enzymes of trypsinlike or chymotrypsinlike specificity, or by aspartic proteinases.
		Cleavage of HIV-1 gp120 by thrombin is enhanced by sCD4 binding, but is prevented by transient exposure of gp120 to nonionic detergent.
		We suggest that cleavage of the V3 loop by a cell surface or endosomal proteinase occurs during the HIV-cell fusion reaction, and that neutralizing antibodies directed against the V3 loop might act by inhibition of this reaction.
	www.aegis.com /aidsline/1991/jul/M9170282.html (567 words)

	Proteolytic Cleavage of the FlhB Homologue YscU of Yersinia pseudotuberculosis Is Essential for Bacterial Survival but ...
		Proteolytic Cleavage of the FlhB Homologue YscU of Yersinia pseudotuberculosis Is Essential for Bacterial Survival but Not for Type III Secretion -- Lavander et al.
		The cleavage pattern of full-length YscU was analyzed in the yscU-null mutant strain YPIII(pIB75) with pLS21 or pML13 expressing a wild-type or a Flag-tagged form of YscU, respectively.
		For analysis of the cleavage of the cytoplasmic domain (amino acids 211 to 354) of the protein, the wild-type strain YPIII(pIB102) with pML11 or pML12 was utilized, expressing a nontagged and a Flag-tagged variant of this domain of YscU, respectively.
	jb.asm.org /cgi/content/full/184/16/4500 (6811 words)

	Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I -- Jauhiainen et al. 40 (4): 654 ...
		Cleavage of apoprotein A-I (apoA-I) upon incubation of high density lipoprotein (HDL) in the presence of phospholipid transfer protein.
		Cleavage of radiolabeled apoA-I was assayed by incubating [
		PLTP activity and apoA-I cleavage were determined as described in panel A. The data in panels A and B represent average values from three independent experiments.
	www.jlr.org /cgi/content/full/40/4/654 (6628 words)

	Proteolytic Cleavage of ICAM-1 by Human Neutrophil Elastase -- Champagne et al. 161 (11): 6398 -- The Journal of ...
		to be shed from the surface of leukocytes by proteolytic cleavage,
		Proteolytic activity of purified human MMP-9 was confirmed by fluorescent activated substrate conversion, as previously described (15).
		Decrease of fluorescence associated with the microspheres is indicative of proteolytic removal of the FITC-gelatin from the microspheres.
	www.jimmunol.org /cgi/content/full/161/11/6398 (6134 words)

	Evidence for proteolytic cleavage of the baculovirus occlusion-derived virion envelope protein P74 -- Slack and ...
		Evidence for proteolytic cleavage of the baculovirus occlusion-derived virion envelope protein P74
		This was interpreted as the 28 kDa GFP being proteolytically
		Immunoblot evidence for proteolytic cleavage of P74 by BBMV proteases.
	vir.sgmjournals.org /cgi/content/full/86/6/1637 (2949 words)

	Phosphorylation and Proteolytic Cleavage of Gag Proteins in Budded Simian Immunodeficiency Virus -- Rue et al. 79 (4): ...
		Phosphorylation and Proteolytic Cleavage of Gag Proteins in Budded Simian Immunodeficiency Virus -- Rue et al.
		Phosphorylation and Proteolytic Cleavage of Gag Proteins in Budded Simian Immunodeficiency Virus
		relative to the phosphorylation of the cleavage intermediates
	jvi.asm.org /cgi/content/full/79/4/2484 (5862 words)

	Proteolytic cleavage of phospholipase C-{gamma}1 during apoptosis in Molt-4 cells -- BAE et al. 14 (9): 1083 -- The ...
		Proteolytic cleavage of phospholipase C-{gamma}1 during apoptosis in Molt-4 cells -- BAE et al.
		Proteolytic cleavage of phospholipase C- 1 during apoptosis in Molt-4 cells
		inhibits its cleavage by caspase CPP32 in vitro.
	www.fasebj.org /cgi/content/full/14/9/1083 (4715 words)

	Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins -- ...
		Inspection of the proposed region of cleavage (45 to 65 amino
		support the proteolytic cleavage and will thus not be cleaved.
		Cupit, L.D., Schmidt, V.A., and Bahou, W.F. Proteolytically activated receptor-3.
	www.proteinscience.org /cgi/content/full/11/3/698 (4035 words)

	Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cdelta Is Essential for Oxidative Stress-Mediated ...
		Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cdelta Is Essential for Oxidative Stress-Mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl -- Anantharam et al.
		MMT-induced proteolytic cleavage of PKC was also isoform-specific, because exposure of PC12 cells to 200 or 500 µ
		Biochemical consequences of caspase-3 activation are proteolytic cleavage of cellular targets associated with apoptosis.
	www.jneurosci.org /cgi/content/full/22/5/1738 (6462 words)

	Reactome: A third proteolytic cleavage releases NICD
		It may contain functionality which is unstable, experimental and does not work properly (yet).
		The third proteolytic cleavage releases the Notch IntraCellu...
		Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
	reactome.org:8000 /cgi-bin/eventbrowser?DB=test_reactome_14&ID=157212 (69 words)

	DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites -- ...
		Proteolytic cleavage of DREG by the proprotein convertase family of enzymes
		Abe, J., Fukuzawa, T. and Hirose, S. (2002) Cleavage of Ig-Hepta at a ‘SEA’ module and at a conserved G protein-coupled receptor proteolytic site.
		(2002) Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor.
	www.genestocellsonline.org /cgi/content/full/9/6/549 (4765 words)

	Carboxy-Terminal Proteolytic Processing at a Consensus Furin Cleavage Site Is a Prerequisite Event for Quail ZPC ...
		a mutated consensus furin cleavage sequence with a noncleavable
		Western blot analysis with anti-ZPC antiserum of the culture medium (A) and cell lysates (B) from granulosa layers cultured with 0 (lane 1) or 30 µM RVKR (lane 2) for 6 h, or from CHO-K1 cells introduced with qZPC (lanes 3 and 4), qZPC-RFAA (lane 5), or vector alone (lane 6).
		Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
	www.biolreprod.org /cgi/content/full/68/5/1613 (4538 words)

	Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis -- ...
		Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis -- Kaufmann et al.
		Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis
		In the present study, the proteolytic cleavage of
	cancerres.aacrjournals.org /cgi/content/abstract/53/17/3976 (2786 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #6790677 - Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=6790677 (167 words)

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