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Topic: Proteomics

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In the News (Mon 22 Apr 19)

  genome.gov | Proteomics Planning Workshop
The general goal of proteomics is to monitor the properties of the entire complement of proteins from a given cell or organism, and to determine how these properties change in response to various physiological states, such as signaling ligands, cell cycle, and disease.
Focused proteomics projects may represent a useful way to do limited studies on the way to full proteomics, although they can be informative explorations of specific problems in their own right.
Proteomics aids in the discovery of protein function; it helps in understanding specific biological processes such as apoptosis and the cell cycle, and it helps in developing new tools for diagnosis and therapy.
www.genome.gov /10004801   (1358 words)

  Proteomics Summary
Proteomics attempts to characterize proteins, compare variations in their expression levels in normal and disease states, study their interactions with other proteins, and identify their functional roles.
Proteomics is a discipline of microbiology and molecular biology that has arisen from the gene sequencing efforts that culminated in the sequencing of the human genome in the last years of the twentieth century.
Proteomics research often involves the comparison of the proteins produced by a bacterium (example, Escherichia coli) grown at different temperatures, or in the presence of different food sources, or a population grown in the lab versus a population recovered from an infection.
www.bookrags.com /Proteomics   (4227 words)

 Home - Clinical Proteomic Technologies Initiative for Cancer
The Clinical Proteomic Technologies Initiative for Cancer is a five-year, $104 million effort to build the foundation of technologies, data, reagents and reference materials, analysis systems, and infrastructure needed to systematically advance protein biology for the diagnosis, treatment and prevention of cancer.
Clinical Proteomic Technology Assessment for Cancer is a multidisciplinary network of teams conducting rigorous technology assessment; developing standard protocols and clinical reference sets; and evaluating methods to ensure data reproducibility.
The Mouse Proteomic Technologies Initiative is a multidisciplinary and collaborative team effort to use animal models to develop and standardize technologies that help improve the accurate measurement of proteins and peptides relevant to cancer.
proteomics.cancer.gov   (224 words)

 Proteomics and Cancer: Fact Sheet - National Cancer Institute
Proteomics is the study of the proteins in a cell, tissue or organism.
Another proteomic approach is to determine whether the changes in specific phosphoproteins (proteins with phosphate groups attached) believed to be important in cellular signaling events and cancer progression in prostate cancer patients can serve as a biomarker of early disease (10).
Proteomics data are being collected at a faster pace than the ability of the researchers to validate, interpret, and integrate them with other known data.
www.cancer.gov /cancertopics/factsheet/proteomicsqa/print?page=&keyword=   (3917 words)

 Utz: Santiago Groups - Proteomics Center - Stanford University School of Medicine
This is in contrast to solid-phase detection systems of microarrays, a leading candidate in combinatorial proteomics research, where the small spot sizes dictated by the needs for high sample density result in evaporation of solvents within seconds.
A number of emerging technologies are under development for proteomics applications, including arrays of proteins bound to planar surfaces such as microtiter plates or glass microscope slides; bead-based methods in which individual antigens are bound to distinct particles; and combinations of two dimensional electrophoretic separation followed by mass spectroscopic analysis of individual molecules.
This technique will be broadly useful for many proteomics applications, will yield results that will help elucidate the pathogenic mechanisms contributing to blood diseases, and can be performed easily by any laboratory with access to a standard CE DNA sequencing apparatus.
proteomics.stanford.edu /utz   (1102 words)

 PROTEOMICS: Proteomics in Genomeland -- Fields 291 (5507): 1221 -- Science   (Site not responding. Last check: 2007-11-02)
Proteomics includes not only the identification and quantification of proteins, but also the determination of their localization, modifications, interactions, activities, and, ultimately, their function.
Proteomics, like its precursor genomics, thus represents the emergence of a new way of doing research that is not dependent on the testing of specific models of cellular behavior.
Given the current genomic and proteomic commotion, we should keep in mind that a protein found to be "in the spliceosome complex," "interacting with actin," "co-evolving with a prion protein," or "up-regulated in leukemia" has not been functionally characterized in the traditional sense to which biologists are accustomed.
www.sciencemag.org /cgi/content/full/291/5507/1221   (3004 words)

 Chu: Tibshirani Groups - Proteomics Center - Stanford University School of Medicine
Proteomics data presents new problems of size and complexity that do not occur in genomics data from DNA microarrays.
Develop and apply methods to utilize megasets of proteomic, genomic, and clinical data for prognostication and monitoring response to therapy.
Megasets of proteomic and genomic data will be analyzed to identify profiles with utility for prognostication, guiding therapy, and monitoring response to therapy.
proteomics.stanford.edu /chu   (444 words)

These proteomics companies range from companies that manufacture tools for other scientists' use to companies that use proteomics as a platform for their own drug discovery efforts.
At MDS Proteomics, based in Toronto, the company's scientists include biologists, biochemists, analytical chemists, synthetic and theoretical chemists, mechanical and software engineers, and bioinformaticians, according to Paul McCracken, director for planning and analysis.
Proteomics is such a broad field that people agree there's no one way in.
pubs.acs.org /cen/employment/8018/8018employment.html   (2284 words)

 Pharmaceutical proteomics Glossary
The concept of the proteome is fundamentally different to that of the genome: while the genome is virtually static and can be well defined for an organism, the proteome continually changes in response to external and internal events.
Proteomics is a rapidly evolving field that is rife with commercial opportunities as the technology achieves ever higher throughput at lower cost and greater sensitivity.
The most useful definition of proteomics is likely to be the broadest: proteomics represents the effort to establish the identities, quantities, structures and biochemical and cellular functions of all proteins in an organism, organ, or organelle, and how these properties vary in space, time and physiological state.
www.genomicglossaries.com /content/proteomics.asp   (7068 words)

 GSAS Harvard Biotechnology Club
Proteomics promises to discover unanticipated targets for drug design by determining the function of thousands of unidentified proteins expected to be found in the human genome.
Proteomics will also provide experimental data to improve computer-modeling programs that predict protein structure from DNA sequence; it will help us learn to interpret the information contained in the genome.
Proteomics efforts are currently hampered by the fact that the field’s main techniques, including 2D PAGE and X-ray crystallography, require highly skilled operators.
www.thebiotechclub.org /industry/emerging/proteomics.php   (2765 words)

 Proteomics: Research for the 21st Century - National Cancer Institute
Proteomics - the study of the proteins inside cells - has made its way into cancer trials.
A clinical trial already under way is testing the ability of proteomic technology to reliably detect relapse of ovarian cancer before clinical symptoms appear.
Another effort to use proteomics in the clinical setting involves a trial to monitor tumor cells' protein response to the cancer drug imatinib mesylate, commonly known as Gleevec.
newscenter.cancer.gov /newscenter/benchmarks-vol2-issue2/page2   (839 words)

 Genencor: Proteomics   (Site not responding. Last check: 2007-11-02)
Differential proteomics is used to compare the proteosomes of various strains.
Proteomics has emerged as a discipline that complements genomic research, which studies the characteristics, function, and nature of protein-protein, protein-RNA and protein-DNA interactions.
Differential proteomics is the qualitative and quantitative comparison of proteomes under different conditions to further unravel biological processes.
www.genencor.com /wt/gcor/gene_proteomics   (208 words)

 Pioneers of Proteomics - Clinical Proteomic Technologies Initiative for Cancer
The Pioneers of Proteomics video series presents leaders in the field of proteomics discussing recent developments in the field, the inherent challenges in studying proteins and significant opportunities afforded by this rapidly evolving field.
Fenselau discusses the application of proteomics to the study of drug resistance and the requirements for continued advancement in proteomics.
In addition to proteomics, Dr. Yates' research interests include the development of integrated methods for tandem mass spectrometry analysis of protein mixtures and bioinformatics using mass spectrometry data.
proteomics.cancer.gov /proteomics_basics/pioneers.asp   (586 words)

 UCHSC Proteomics and Mass Spectrometry Core Facility
The goal of the Proteomics Facility is to provide investigators with the capabilities to identify, characterize and quantify the proteins present in tissues, cells and biological fluids.
The facility is a collaborative research resource that balances applied proteomics research with the development of new and improved methods for protein identification and quantification.
The Proteomics Facility is housed within the Mass Spectrometry Research Center on the ground floor of RC-1 South at the Fitzsimons campus.
biomol.uchsc.edu /researchFacilities/MSCore/index.html   (501 words)

 Proteome Sciences, leader in applied proteomics | Technologies
Proteome Sciences has developed ProteoSHOP®, a toolkit of both gel-based and gel-free proteomics technologies to address differential protein expression in disease and the impact of therapeutic interventions.
Proteome Sciences has implemented procedures, including the subtraction of very high abundant proteins from body fluids, thereby enabling the detection and analysis of lower abundant components of the proteome, resulting in a much greater likelihood of relevance and utility for diagnostic and therapeutic applications.
Proteome Sciences has developed and implemented a stable isotope labelling approach termed DiPPA – differential phosphopeptide arrays – used for the selective monitoring of changes in protein phosphorylation.
www.proteomics.com /pages/technologies/0/index.html   (336 words)

 Proteomics and Genomics - the application of separation science to systems biology
Proteomics research is booming and genomics/proteomics are the words of the moment.
Proteomics essentially began in the 1970s with the discovery of 2D gels, allowing the separation of hundreds of proteins at once, but it really expanded from the mid-1990s when emerging mass spectrometry technologies permitted these proteins to be analyzed and identified in reasonable time scales.
In the early stages, proteomics methods can be used for the early detection of cancer, using a group of biomarkers as well as single compounds.
www.separationsnow.com /coi/cda/detail.cda?id=1673&type=Feature&chId=6&page=1   (767 words)

 CHI's Protein to Profits - Proteomics Europe
Although proteomics does remain hypothesis-driven, advances in technologies such as chips, arrays, and informatics mean this burgeoning enterprise has the potential application to turn "omics" from red into green.
Proteomics, the study of the proteins present in cells, tissues, or biofluids, is now moving to an industrial scale.
While proteomics is defined as a comprehensive study of proteins expressed by an organism, it is often limited to expression profiling and sequence analysis.
www.healthtech.com /2002/pre/index.htm   (2288 words)

 [No title]
The intent is for long-term participants to have an opportunity to learn about proteomics from the perspectives of many different fields--mathematics, statistics, biology and medicine--and to meet a diverse group of people and have an opportunity to form new collaborations.
The human proteome -- the collection of all proteins generated by the human genome -- is estimated to contain 10 million to 20 million proteins -- about 2-3 orders of magnitude higher than the number of human genes.
Proteomics is of importance to basic science, for elucidating the fundamental mechanisms of biology.
www.ipam.ucla.edu /programs/prot2004   (1214 words)

 AMA (Genetics) Proteomics
Proteomics studies the structure and function of proteins, the principal constituents of the protoplasm of all cells.
Proteomic technologies will play an important role in drug discovery, diagnostics and molecular medicine because is the link between genes, proteins and disease.
The sequencing of the human genome has increased interest in proteomics because while DNA sequence information provides a static snapshot of the various ways in which the cell might use its proteins, the life of the cell is a dynamic process.
www.ama-assn.org /ama/pub/category/3668.html   (675 words)

 in-cites - Journals - PROTEOMICS
Proteomics is a relatively new field which was developed to create a link between genomic information and biological function through global studies of protein expression.
Recently we have instigated a new category of scientific contribution, the viewpoint articles, which are intended to stimulate discussion and debate on areas of general concern and controversy in the field of proteomics, and will generally reflect the personal opinions of the author(s).
PROTEOMICS is the premier international source for information on all aspects of applications and technologies in proteomics.
www.in-cites.com /journals/PROTEOMICS.html   (839 words)

 World Wide Words: Proteomics
Proteomics is the study of the way proteins work inside cells, and how they interact with each other.
proteomics came about because ways were invented to study proteins in the complicated and messy real-life situation inside living cells.
The new Center for Genomics and Proteomics will team chemists, biologists, engineers, and computer scientists to mine genome data from a variety of organisms for clues to the genetics of behavior, evolution, and the origins of disease.
www.worldwidewords.org /turnsofphrase/tp-pro3.htm   (296 words)

PROTEOMICS is the premier international source for information on all aspects of applications and technologies in proteomics.
Its mission is to integrate the various areas of this rapidly developing field which will have a major impact in all areas of the life sciences and industry.
Topics include whole proteome analysis of any organism, expression profiling, disease studies, pharmaceutical, agricultural and biotechnological applications, and analysis of cellular systems, organelles and protein complexes.
www.wiley-vch.de /publish/en/journals/alphabeticIndex/2120   (123 words)

 HUPO Proteomics Standards Initiative
The HUPO Proteomics Standards Initiative (PSI) defines community standards for data representation in proteomics to facilitate data comparision, exchange and verification.
The PSI Proteomics Informatics standards group is a recent addition to the working groups of the Proteomics Standards Initiative.
Please look at the Proteomics Informatics Homepage for more details the activities of the group, including how to get involved.
psidev.sourceforge.net   (839 words)

A new publicly available data set entitled "COFRADIC N-terminal proteome of unstimulated human blood platelets, identified and unidentified spectra" is now available from PRIDE in support of Martens L. et al (2005), "The human platelet proteome mapped by peptide-centric proteomics: a functional protein profile.", Proteomics (12):3193-204.
A new publicly available data set entitled "Proteomic mapping of brain plasma membrane proteins" is now available from PRIDE in support of Nielsen PA et al.
A new publicly available data set entitled "Characterization of the Mouse Brain Proteome Using Global Proteomic Analysis Complemented with Cysteinyl-Peptide Enrichment" is now available from PRIDE in support of Wang, H. et al.
www.ebi.ac.uk /pride   (2221 words)

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