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Topic: Prothrombin time

Related Topics

International normalized ratio

Coagulation

Mixing test

Partial thromboplastin time

Coagulation factors

APTT

Disseminated intravascular coagulation

Reference range

Bleeding time

Thrombin

Warfarin

Cerebrovascular accident

Thrombotic thrombocytopenic purpura

Antiphospholipid syndrome

Paroxysmal nocturnal hemoglobinuria

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	Prothrombin Time - [Medical Test]
		Prothrombin, or factor II, is one of several clotting factors produced by the liver.
		Prothrombin time is an important coagulation test because it measures the presence and activity of five different blood clotting factors (factors I, II, V, VII, and X).
		An abnormal prothrombin time is often caused by liver disease or injury or by treatment with the medication warfarin (Coumadin), which is used to prevent the formation of blood clots.
	www.peacehealth.org /kbase/topic/medtest/hw203083/descrip.htm (258 words)

	Prothrombin Time Information on Healthline
		The normal prothrombin time is 11-15 seconds, although there is some variation depending on the source of the thromboplastin used in the test.
		The prothrombin time of patients receiving warfarin therapy will also be prolonged—usually in the range of one and one half to two times the normal PT time.
		A PT time that exceeds approximately two and a half times the control value (usually 30 seconds or longer) is grounds for concern, as abnormal bleeding may occur.
	www.healthline.com /galecontent/prothrombin-time (656 words)

	Prothrombin Time (PT) - Health Centers
		This is a test that measures the clotting time of plasma (the liquid portion of the blood).
		Because of the link between vitamin K and prothrombin, people who take warfarin need to have consistent levels of vitamin K in their diet, as instructed by their doctor.
		It measures the clotting ability of factors I (fibrinogen), II (prothrombin), V, VII, and X. When any of these factors is deficient, the PT is prolonged.
	www.wftv.com /encyclopedia/6864717/detail.html (903 words)

	Home Prothrombin Time Monitor for Anticoagulation Management
		Monitoring of the prothrombin time is recommended to ensure that the dose levels are within the therapeutic range.
		Prothrombin time is measured by a method known as the International Normalized Ratio (INR).
		The INR reflects the ratio of the individual's prothrombin time to the normal time.
	www.bcbst.com /MPManual/Home_Prothrombin_Time_Monitoring.htm (724 words)

	Fat emulsion effects on prothrombin time in warfarin anticoagulated patients: an in vitro study -- Cotto et al. 14 (2): ...
		The effect of lipid emulsions on prothrombin time in blood from anticoagulated patients was determined.
		The prothrombin time was measured on the plasma from these samples and compared to the prothrombin time of the plasma samples without lipid.
		The mean decrease in prothrombin times were: 0.29 sec at 50 micrograms/ml, 0.23 sec at 100 micrograms/ml, and 0.29 sec at 200 micrograms/ml.
	jpen.aspenjournals.org /cgi/content/abstract/14/2/201 (252 words)

	Prothrombin Time (PT) - Health Centers
		For a person on full anticoagulant therapy, the PT should be 2 to 3 times the laboratory "control" value.
		For example, Factor I is also called fibrinogen, Factor II is prothrombin, and Factor XII is Hageman factor.
		Warfarin inhibits prothrombin, thus interrupting the clotting cascade.
	www.wsbtv.com /encyclopedia/6864717/detail.html (903 words)

	Prothrombin Time (PT)
		Prothrombin time reagent containing thromboplastin and calcium chloride is mixed with the patient plasma and the time to clot formation is measured photo-optically.
		The prolongation of the clotting time correlates with the degree of deficiency or inhibition of the extrinsic pathway factors.
		Prothrombin time results are reported in seconds and are also converted to international normalized ratio (INR) values.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/cg003800.htm (1088 words)

	Prothrombin time definition - Medical Dictionary definitions of popular medical terms
		Prothrombin time: A clotting test, the prothrombin time is done to test the integrity of part of the clotting scheme.
		Prothrombin is a coagulation (clotting) factor needed for the normal clotting of blood.
		In this cascade, prothrombin is a precursor to thrombin.
	www.medterms.com /script/main/art.asp?articlekey=8386 (246 words)

	Prothrombin Time - [Medical Test]
		A method of standardizing prothrombin time results, called the international normalized ratio (INR) system, has been developed to compare prothrombin time results among labs using different test methods.
		The warfarin (Coumadin) dosage for people being treated to prevent the formation of blood clots is usually adjusted so that the prothrombin time is about 1.5 to 2.5 times the normal value (or INR values 2 to 3).
		Prothrombin times are also kept at higher levels for people with artificial heart valves, for the same reason.
	www.peacehealth.org /kbase/topic/medtest/hw203083/results.htm (225 words)

	Prothrombin Time
		time reported in seconds is between 11 and 13 seconds, depending on the method used by the laboratory.
		Therapeutic levels are generally between 1 1/2 and 2 times normal, depending on the patient's need for anticoagulation.
		The INR is increasingly becoming an important way to measure and report prothrombin time.
	www.rnceus.com /coag/coagpt.html (447 words)

	UMHS -Prothrombin Time/Anticoagulation, Pediatric
		The service is provided by a clinical nurse specialist who follows the child's prothrombin time results along with the cardiologist.
		The prothrombin time can be drawn by most health facilities and the results sent to the Pediatric Cardiology Clinic for evaluation and follow-up.
		Prothrombin times can be affected by other medications or major dietary changes that the child requires.
	www.med.umich.edu /1libr/tests/testpq08.htm (590 words)

	Simple FactSheet: Liver Function Tests
		Prothrombin (also called factor II) is a protein that helps to clot blood.
		The normal time needed for blood to clot is between 10 and 15 seconds.
		A person with an abnormally long prothrombin time may be at risk for excessive bleeding.
	www.aegis.com /factshts/network/simple/liverfun.html (903 words)

	Home Prothrombin Time Monitoring
		Therefore, monitoring of the prothrombin time is recommended to ensure that the dose levels are within the therapeutic range.
		The time in therapeutic range also increased in the self-monitoring group, from 32% in the usual care group to 56% in the self-monitoring group.
		In summary, the data consistently demonstrate that the use of self-monitoring and self-management results in an increased time in the therapeutic range, possibly leading to a reduction in hemorrhagic or embolic events.
	www.regence.com /trgmedpol/dme/dme44.html (1291 words)

	Physicians Reference Laboratory - Prothrombin
		The test that measures its function (and several others as well) is called the prothrombin time, "pro-time" or "PT" test.
		Your medication causes your liver to produce less prothrombin; with less prothrombin in your blood, your blood takes longer to clot and this amount of time for clotting is measured against the clotting time of normal blood.
		The amount of time it takes for blood to clot in the PT test is very dependent upon the specific chemicals added to your blood in the test, so the time taken to clot can actually vary slightly between laboratories.
	www.prlnet.com /Prothrombin.htm (380 words)

	Medical Policy DME.00001 \| Prothrombin Time Self-Monitoring Devices (Site not responding. Last check: 2007-11-02)
		Published studies are consistent in the demonstration that the use of home monitoring results in a significant increase in the time within the therapeutic range (TTR).
		Prothrombin Time (PT): The prothrombin time test belongs to a group of blood tests that assess the clotting ability of blood.
		Decentralized testing for prothrombin time and activated partial thromboplastin time using a dry chemistry portable analyzer.
	medpolicy.unicare.com /policies/DME/prothrombin.html (1115 words)

	MDAdvice.com - Health Library - Medical Tests
		Time before results are reported to the doctor or patient varies from a few minutes to a few days.
		Test results are determined by comparing clotting time with a control sample.
		In someone receiving oral anti-coagulants, PT is usually maintained between 1-1/2 and 2 times normal control.
	www.mdadvice.com /library/test/medtest316.html (630 words)

	Prothrombin Time
		Prothrombin levels are monitored along with other tests (such as aspartate aminotransferase and alanine aminotransferase) to help evaluate liver function.
		If diarrhea is caused by poor absorption of nutrients, vitamins, and minerals from the intestinal tract (malabsorption syndrome), PT may increase because of a vitamin K deficiency.
		A PT is usually done at the same time of day each time so test results can monitor the dosage of medication used to prevent blood clots.
	www.webmd.com /hw/health_guide_atoz/hw203083.asp (1178 words)

	Adult Health Advisor 2003.1: Prothrombin Time Test (PT) and INR
		The prothrombin time, or PT, test measures the time it takes your blood to form a clot.
		The results of the prothrombin time test may vary from lab to lab, so health care providers use a ratio called the INR (international normalized ratio) to be able to account for the differences.
		The prothrombin time test may also be done if you have abnormal bleeding or clotting.
	www.thedacare.org /crs/aha/aha_prothrom_crs.htm (512 words)

	Rare Thrombotic Diseases Consortium
		Common inherited causes of blood clots include factor V Leiden and the prothrombin gene mutation G20210A.
		This autoantibody is associated with an increased risk for blood clots.
		Prothrombin Time (PT): Is a measure of how long it takes blood to clot in a test tube.
	rarediseasesnetwork.epi.usf.edu /rtdc/learnmore/glossary.htm (1652 words)

	AccuChecker Web Site - AccuLibrary Article
		The prothrombin time (PT) is the primary assay used in monitoring warfarin therapy.
		The INR is the ratio of the patient’s population time compared to the mean prothrombin time for a group of normal individuals.
		Patient self-testing and self-management through the use of a home INR monitor may be used to improve the time in therapeutic rate for a select group of patients.
	www.accuchecker.com /AccuLibrary/Articles/prothrombininr.asp (586 words)

	Partial Thromboplastin Time
		Partial thromboplastin time (PTT) is a blood test that measures the time it takes blood to clot.
		The activated partial thromboplastin time (APTT) test is used after taking blood-thinners to determine the most effective dosage of medication that prevents blood clots.
		The activated partial thromboplastin time (APTT) test is used to determine the most effective dosage of some medications, such as heparin, that prevent blood clots.
	www.webmd.com /hw/lab_tests/hw203152.asp (1040 words)

	Prothrombin time (Site not responding. Last check: 2007-11-02)
		Prothrombin is a protein in the liquid part of blood (plasma) that is converted to thrombin as part of the clotting process.
		The prothrombin time of patients receiving warfarin therapy will also be prolonged-usually in the range of one and one half to two times the normal PT time.
		A protein in blood that converts prothrombin to thrombin.
	www.healthatoz.com /healthatoz/Atoz/ency/prothrombin_time.jsp (813 words)

	PROTHROMBIN TIME Pathology Test - Baltimore Maryland MD
		At the time of change, an oral anticoagulated patients PT results in seconds may show a dramatic shift upward (more prolonged time), BUT the INR value should remain about the same.
		It is important that you monitor individuals receiving oral anticoagulant therapy with the INR value, NOT the PT result in seconds.
		Questions regarding the Prothrombin Time change and monitoring of oral anticoagulated patients and questions regarding PT results and INR values on specific individuals may be directed to the Coagulation Laboratory or Dr. Nuckols.
	www.lifebridgehealth.org /22802.cfm (264 words)

	INR - Page 5
		This test measures the time it takes for a patient to generate thromboplastin.
		It is known as the “partial thromboplastin” test because of the absence of certain factors along the coagulation cascade.
		A test in which three small scratches are made on the patient’s skin and then the time it takes for the bleeding to stop is recorded.
	heart.healthcentersonline.com /bloodtest/prothrombintime5.cfm (409 words)

	Medicare: Prothrombin Time (Site not responding. Last check: 2007-11-02)
		The prothrombin time (PT) test is one in-vitro laboratory test used to assess coagulation.
		Both tests also evaluate the common coagulation pathway involving all the reactions that occur after the activation of factor X. A prothrombin time is either expressed in seconds and/or as an international normalized ratio (INR).
		Since this is a calculation, the INR will not be paid separately from or in addition to the PT, but is considered part of the conventional prothrombin time, 85610.
	library.umsmed.edu /medi-prothro.html (750 words)

	Prothrombin Time (PT), Testing at Millenova Immunology Laboratories
		The Prothrombin Time (PT) Assay measures the time to convert fibrinogen to fibrin by the action of thrombin.
		Calcium thromboplastin is used for the simultaneous determination of protrombin time and fibrinogen in human plasma.
		Kelsey PR, Stevenson KJ, Pollan L. The diagnosis of lupus anticoagulants by the activated partial thromboplastin time.
	www.millenova.com /tests/pt.asp (243 words)

	PROTHROMBIN TIME
		If time from draw to receipt in the laboratory is to be greater than 24 hours, centrifuge the specimen; remove the plasma from red cells and snap freeze (-70°C) plasma.
		Therapeutic Range: Using the INR: Standardization of the Prothrombin Time (PT) with the International Normalized Ratio (INR) allows for uniform measurement of the anticoagulation status of patients on oral anticoagulants (Warfarin/Coumadin/Coumarin).
		The use of the INR has permitted development of effective recommendations for use of oral anticoagulants in a variety of clinical settings.
	www.utmb.edu /lsg/LabSurvivalGuide/hem/PROTHROMBIN_TIME.htm (328 words)

	Prothrombin Time Testing Practices in the U.S. Pacific Northwest, 2004
		Prothrombin Time Testing Practices in the U.S. Pacific Northwest, 2004
		Context: Coagulation and bleeding problems are associated with substantial morbidity and mortality; and certain inappropriate prothrombin time (PT) testing practices may lead to such complications.
		Objective: To evaluate reported PT testing practices in the U.S. Pacific Northwest and compliance with practice standards.
	www.phppo.cdc.gov /mlp/ProthrombinAbstract.aspx (518 words)

	COLA - LabFacts 32: Plasma Prothrombin Time and The International Normalized Ratio (INR)
		Define prothrombin time and what the test demonstrates.
		Explain why the introduction of international thromboplastin standards was necessary, and define the INR and how a patient INR value is determined.
		Describe the prothrombin test procedure, quality control procedures needed to monitor the protime testing process, and limitations of the test.
	www.cola.org /product.html?ProductID=70 (241 words)

	Hemostasis Reference Laboratory \| Prothrombin Time
		The prothrombin time (PT) is a kinetic screening test performed by adding a sensitive tissue thromboplastin reagent and calcium chloride to plasma using an automated method.
		The PT assesses the extrinsic pathway of coagulation that includes factors VII, X, V, prothrombin, and fibrinogen.
		Prolongation of the PT can be caused by factor deficiency or factor inhibitor.
	www.psbc.org /lab_hemostasis/test05.htm (128 words)

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