| | HIV Report November 1997 - Assessment of Pruritus in the HIV-Infected Patient (Site not responding. Last check: 2007-10-23) |
 | | It is not uncommon for HIV patients with pruritus to develop a vicious cycle of "itch/scratch/itch" caused by the excoriation of skin, the stimulation of free nerve endings leading to pruritus and further mechanical trauma inducing thickening of the skin, hyperkeratosis, and hyperpigmentation. |
 | | It is important to stress that these conditions are secondary to pruritus and excoriation, and even though the lesions themselves are pruritic, they are a consequence of trauma to a primary lesion such as folliculitis or insect bites. |
 | | Histamine is the classic mediator of pruritus, and it is responsible, directly or indirectly, for the development of symptoms; therefore, therapy with H1 blocking antihistamine agents should be attempted in all patients for symptomatic relief. |
| www.hopkins-aids.edu /publications/report/nov97_1_4.html (1557 words) |