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Topic: Pseudocholinesterase

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	eMedicine - Pseudocholinesterase Deficiency : Article by Daniel R Alexander, MD
		The gene that codes for the pseudocholinesterase enzyme is located at the E1 locus on the long arm of chromosome 3, and 96% of the population is homozygous for the normal pseudocholinesterase genotype, which is designated as EuEu.
		The dibucaine-resistant genetic variant form of pseudocholinesterase is identified by the percent inhibition of hydrolysis of benzyl choline caused by the addition of dibucaine to the pseudocholinesterase enzymatic assay.
		Pseudocholinesterase deficiency is a clinically silent condition in individuals who are not exposed to exogenous sources of choline esters.
	www.emedicine.com /med/topic1935.htm (2291 words)

	Science Fair Projects - Pseudocholinesterase deficiency
		Pseudocholinesterase deficiency is an inherited blood plasma enzyme abnormality.
		Succinylcholine is normally metabolized by the pseudocholinesterase enzyme.
		When anesthetists administer standard doses of succinylcholine to a person with pseudocholinesterase deficiency, the patient experiences prolonged paralysis of his respiratory muscles, requiring an extended period of time during which the patient must be mechanically ventilated.
	www.all-science-fair-projects.com /science_fair_projects_encyclopedia/Pseudocholinesterase_deficiency (292 words)

	NationMaster - Encyclopedia: Acetylcholinesterase (Site not responding. Last check: )
		Acetylcholinesterase; RBC (or erythrocyte) cholinesterase; Pseudocholinesterase; Plasma cholinesterase; Butyrylcholinesterase
		Serum cholinesterase is a test for the enzymes acetylcholinesterase (also known as RBC cholinesterase) and pseudocholinesterase (also known as butyrylcholinesterase or plasma cholinesterase), which act to break down acetylcholine, a chemical critical in the transmission of nerve impulses.
		Acetylcholinesterase is found in nerve tissue and red blood cells, and pseudocholinesterase is found primarily in the liver.
	www.nationmaster.com /encyclopedia/Acetylcholinesterase (312 words)

	Pseudocholinesterase deficiency
		When anesthetists administer standard doses of these drugs to a person with pseudocholinesterase deficiency, the patient experiences prolonged paralysis of his respiratory muscles, requiring an extended period of time during which the patient must be mechanically ventilated.
		This enzyme abnormality is a benign condition unless a person with pseudocholinesterase deficiency is exposed to the offending pharmacological agents (Alexander, 2002).
		Maiorana, Anthony and Roach, Robert B. "Heterozygous pseudocholinesterase deficiency: a case report and review of the literature".
	www.icorrection.com /Dis-P/Pseudocholinesterase_deficiency.php (164 words)

	Pseudocholinesterase Deficiency
		It is possible that the main title of the report Pseudocholinesterase Deficiency is not the name you expected.
		Pseudocholinesterase deficiency is an uncommon genetic disorder that makes an affected person very sensitive to any of several anesthetic agents, especially those derived from the drug known as choline.
		When anesthetic drugs such as succinylcholine or mivacurium are administered to a susceptible person, the muscles that work the lungs may become paralyzed.
	children.webmd.com /Pseudocholinesterase-Deficiency (0 words)

	CIGNA - Pseudocholinesterase Deficiency
		Pseudocholinesterase deficiency is an uncommon genetic disorder that makes an affected person very sensitive to any of several anesthetic agents, especially those derived from the drug known as choline.
		If the person with pseudocholinesterase deficiency is not exposed to a choline-derived anesthetic, he or she may never be aware of having a deficiency of the enzyme pseudocholinesterase.
		Pseudocholinesterase deficiency is inherited as an autosomal recessive trait.
	www.cigna.com /healthinfo/nord830.html (1130 words)

	Serum cholinesterase
		A pseudocholinesterase level is also used, although infrequently, to identify liver disease.
		This test may also be performed prior to anesthesia with succinylcholine (a paralyzing agent that is eliminated by these enzymes) to exclude a genetic deficiency of these enzymes.
		The normal value of acetylcholinesterase and pseudocholinesterase depends on the technique, and should be determined by the laboratory performing the test.
	www.healthtalk.com /crohnsdisease/encyclopedia/?p=1/003358.htm (544 words)

	[No title]
		A family with an unusual mode of inheritance of atypical pseudocholinesterase A serious objection to this theory has been that it predicts the existence of homozygotes for the 'silent' gene with no pseudocholinesterase activity in their sera.
		The family of the propositus with an absence of pseudocholinesterase activity It thus seems that there are a number of pseudocholinesterase variants.
		The position is not unlike that found for human hasmo-globins, and the 'silent' pseudocholinesterase gene presents a similar problem to that of thalasssemia.
	www.nature.com /nature/journal/v193/n4815/ris/193561a0refs.ris (1217 words)

	Cholinesterase, Serum
		Pseudocholinesterase is low also in some instances of liver disease, including decompensated cirrhosis, hepatitis, metastatic carcinoma, CHF, and in malnutrition, but not sufficiently consistently enough to be a useful clinical test for such disorders.
		Two types of cholinesterase are found in blood: “true” cholinesterase (acetylcholinesterase) in red cells and “pseudocholinesterase” (acylcholine acylhydrolase) in serum (plasma).
		A low level of activity of pseudocholinesterase has been demonstrated in cerebrospinal fluid, at about 1/20 to 1/100 the activity present in the corresponding plasma.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sc019100.htm (811 words)

	pseudocholinesterase - General Practice Notebook (Site not responding. Last check: )
		Pseudocholinesterase describes a family of enzymes produced mainly in the liver but widely found in:
		The nature of the variants determines sensitivity to suxamethonium; the extreme is pseudocholinesterase deficiency.
		Pseudocholinesterases are irreversibly inhibited by organophosphate compounds; the reduction in plasma activity is a means of monitoring exposure of individuals to organophosphates.
	www.gpnotebook.co.uk /cache/-73793477.htm (136 words)

	Pseudocholinesterase Deficiency
		Individuals with Pseudocholinesterase Deficiency have a shortage or absence of the enzyme pseudocholinesterase.
		Pseudocholinesterase Deficiency is present at birth and occurs in approximately 1 out of every 2500 people in the United States.
		If testing for Pseudocholinesterase Deficiency has not been done beforehand, and the patient stops breathing for a prolonged period of time during surgery, artificial respiration (mechanical ventilation) can be administered until the patient is able to resume normal breathing.
	hw.healthdialog.com /kbase/nord/nord830.htm (956 words)

	physics - Cholinesterase
		The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
		An absence or mutation of the pseudochlinesterase enzyme leads to a medical condition known simply as pseudocholinesterase deficiency.
		This is a silent condition that only manifests itself when people who have the deficiency receive the anaestetic agent succinylcholine during a surgery.
	www.physicsdaily.com /physics/Pseudocholinesterase (245 words)

	pseudocholinesterase deficiency - General Practice Notebook (Site not responding. Last check: )
		If recovery of muscle power was delayed then it is likely the patient has pseudocholinesterase deficiency.
		Pseudocholinesterase is a family of enzymes which are widely distributed throughout the body including plasma, liver, skin and gastrointestinal tract.
		Pseudocholinesterase is less specific for acetylcholine and will hydrolyse other esters, including important drugs:
	www.gpnotebook.co.uk /cache/221577248.htm (203 words)

	MEDLINE_1966-1995 - Resultado de la búsqueda <página 1>
		The mean pseudocholinesterase level of the workers was significantly lower than that of 36 other workers without a history of similar exposure.
		Although there was a high incidence of clinical features suggestive of OP compound toxicity in the exposed workers, no significant correlation between serum pseudocholinesterase levels and clinical symptoms and signs was found.
		Six exposed workers, found to have low serum pseudocholinesterase levels, were transferred for 6 months to work areas which did not involve OP exposure, whereupon their levels rose significantly back to the normal range.
	www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1966-1995&exprSearch=1679650&indexSearch=UI&lang=e (181 words)

	Pseudocholinesterase deficiency -
		When anesthetists administer standard doses of these drugs to a person with pseudocholinesterase deficiency, the patient pseudocholinesterase deficiency experiences prolonged paralysis of his respiratory muscles, requiring an extended period of time during which the patient must be mechanically ventilated.
		A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person.
		The broader body of knowledge about diseases and their treatments is medicine.
	www.medicalgeo.com /Med-Diseases-Po---Q/Pseudocholinesterase-deficiency.html (257 words)

	Irishhealth.com - Online Medical Dictionary
		Acetylcholinesterase is found in nerve tissue while pseudocholinesterase is found primarily in the liver.
		Measurement of pseudocholinesterase may be performed as a screening tool prior to the administration of electroconvulsive therapy.
		It is also useful in identifying organophosphate toxicity or congenital enzyme deficiencies.
	www.irishhealth.com /dictionary.html?query=pseudocholinesterase (63 words)

	Pseudocholinesterase (Site not responding. Last check: )
		Pseudocholinesterase (EC 3.1.1.8) (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver
		An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known simply as pseudocholinesterase deficiency.
		This is a silent condition that only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
	www.pillscatalog.net /Pseudocholinesterase.html (620 words)

	Pseudocholinesterase Deficiency - Quest Diagnostics Patient Health Library (Site not responding. Last check: )
		It is possible that the main title of the report Pseudocholinesterase Deficiency is not the name you expected.
		Pseudocholinesterase deficiency is an uncommon genetic disorder that makes an affected person very sensitive to any of several anesthetic agents, especially those derived from the drug known as choline.
		When anesthetic drugs such as succinylcholine or mivacurium are administered to a susceptible person, the muscles that work the lungs may become paralyzed.
	www.questdiagnostics.com /kbase/nord/nord830.htm (364 words)

	Formelsammlung Pseudocholinesterase (Site not responding. Last check: )
		O Produkte=Cholin + Carboxylat }} Die Pseudocholinesterase ist ein zur Gruppe III der EC-Klassifikation (Hydrolasen) gehörendes Enzym, das die Hydrolyse Spaltung der Esterbindung zwischen der OH-Gruppe des Cholins und der Carboxy-Gruppe einer organischen Säure unspezifisch katalysiert.
		Butyrylcholinesterase ist auch in der Lage, verschiedene Ester zu spalten, die eine andere Alkoholkomponente als Cholin enthalten, beispielsweise Aspirin, Cocain und Heroin.
		Deshalb kann ein Mangel an Pseudocholinesterase (schwere Leberfunktionsstörung) bzw.
	www.formel-sammlung.de /wiki_Pseudocholinesterase.html (344 words)

	Rare Disorders board: Pseudocholinesterase Deficiency [Archive] - HealthBoards.com Message Boards (Site not responding. Last check: )
		09-29-2001, 02:18 PM I have been diagnosed with a pseudocholinesterase deficiency after becoming temporarily paralysized after general anesthesia.
		The experience was extremely frightening to be totally awake following surgery but unable to move anything, and to have your breathing depressed but unable to tell anyone.
		If you are pseudocholinesterase deficient, your body will not eliminate succinylcholine efficiently.
	www.healthboards.com /boards/archive/index.php/t-140314/t-86794.html (464 words)

	Pseudocholinesterase activity and its relationship to suxamethonium apnoea,Nirmal Sen, Sumantra Chatterjee, Sharma KN: ...
		Pseudocholinesterase activity and its relationship to suxamethonium apnoea,Nirmal Sen, Sumantra Chatterjee, Sharma KN: Indian Journal of Pharmacology
		Pseudocholinesterase activity and its relationship to suxamethonium apnoea
		It may be concluded that estimation of PChE level and dibucaine number is an effective guide for the administration of suxamethonium chloride.
	www.ijp-online.com /article.asp?issn=0253-7613;year=1977;volume=9;issue=3;spage=211;epage=214;aulast=Nirmal;type=0 (106 words)

	eMedicine - Pseudocholinesterase Deficiency : Article Excerpt by: Daniel R Alexander, MD
		eMedicine - Pseudocholinesterase Deficiency : Article Excerpt by: Daniel R Alexander, MD Excerpt from Pseudocholinesterase Deficiency
		Synonyms, Key Words, and Related Terms: pseudocholinesterase deficiency, plasma cholinesterase deficiency, butyrylcholinesterase deficiency, cholinesterase II deficiency
		It specifically hydrolyzes exogenous choline esters; however, it has no known physiologic function.
	www.emedicine.com /med/byname/pseudocholinesterase-deficiency.htm (0 words)

	Pseudocholinesterase
		pseudocholinesterase is a valid word in this word list.
		The word "pseudocholinesterase" uses 20 letters: A C D E E E E H I L N O O P R S S S T U.
		Words within pseudocholinesterase not shown as it has more than seven letters.
	www.morewords.com /word/pseudocholinesterase (212 words)

	RoundUp and Cholinesterase Inhibition
		On 6/4/96, after three major exposures to RoundUp, this patient's pseudocholinesterase was 2887.
		On 7/8/96, after an additional major exposure to RoundUp, this patient's pseudocholinesterase was 2700.
		The last reading during the period of this patient's exposures to RoundUp was 2733 on 8/7/96.
	www.naturescountrystore.com /roundup/page7.html (0 words)

	The effect of periodontal therapy on salivary pseudocholinesterase activity -- Yamalik et al. 70 (6): 988 -- Journal of ...
		The effect of periodontal therapy on salivary pseudocholinesterase activity -- Yamalik et al.
		The effect of periodontal therapy on salivary pseudocholinesterase activity
		pseudocholinesterase (PCE) activity in patients with periodontitis were
	jdr.iadrjournals.org /cgi/content/abstract/70/6/988 (241 words)

	A study of pseudocholinesterase induction in experimental obesity -- Kean et al. 5 (3): 253 -- Journal of the American ...
		A study of pseudocholinesterase induction in experimental obesity -- Kean et al.
		A study of pseudocholinesterase induction in experimental obesity
		Liver pseudocholinesterase (PChE) activity was significantly higher in
	www.jacn.org /cgi/content/abstract/5/3/253 (197 words)

	Pseudocholinesterase mivacurium - story of success
		Now follow one of the pseudocholinesterase mivacurium hyperlinks because they're top-notch.When you're interested in pseudocholinesterase mivacurium, as both you and I are, you can never get your hands on enough information.
		What I did then was study each and every one of them to find the pseudocholinesterase mivacurium info that exactly fits your and my own needs.
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	www.miva.link2city.com /pseudocholinesterase-mivacurium/index.htm (1583 words)

	Grand Mal Seizure in a Child 30 Minutes After Cyclogyl (Cyclopentolate Hydrochloride) and 10% Neo-Synephrine ...
		was 125 mEq/L, and he had low plasma pseudocholinesterase activity.
		other drugs with ester bonds metabolized by plasma pseudocholinesterase.
		Pseudocholinesterase hydrolysis is the likely pathway of cyclopentolate
	pediatrics.aappublications.org /cgi/content/full/113/5/e499 (1114 words)

	Thieme-connect - Abstract
		The pseudocholinesterase consists of four molecular forms as C1, C2, C3 and C4 according to their electrophoretic mobility.
		During jejunal feeding both the pre-albumin and pseudocholinesterase levels increased parallelly, but in some patients with quiescent disease the pre-albumin concentration was normal with lower level of pseudocholinesterase.
		Conclusion: The serum pseudocholinesterase activity and serum pre-albumin levels can be used as markers for inflammatory activity as well as nutritional state in Crohn's disease.
	www.thieme-connect.com /ejournals/abstract/zfg/doi/10.1055/s-2004-826955 (226 words)

	Determination of pseudocholinesterase activity in the gingival crevicular fluid, saliva, and serum from patients with ...
		Determination of pseudocholinesterase activity in the gingival crevicular fluid, saliva, and serum from patients with juvenile periodontitis and rapidly progressive periodontitis -- Yamalik et al.
		Determination of pseudocholinesterase activity in the gingival crevicular fluid, saliva, and serum from patients with juvenile periodontitis and rapidly progressive periodontitis
		By use of a spectrophotometric method, pseudocholinesterase (PCE)
	jdr.iadrjournals.org /cgi/content/abstract/69/1/87 (345 words)

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