Pyrene - Factbites

Pyrene - Factbites
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Topic: Pyrene

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In the News (Wed 23 Dec 09)

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	ABC News: Tobacco Industry Worked to Thwart Lung Cancer Link: Report
		In the 1990s, exposure to benzo[a]pyrene was shown to cause changes in the p53 gene.
		The carcinogen benzo[a]pyrene was first identified in cigarette smoke in 1952.
		In 1996, researchers showed that benzo[a]pyrene's interaction with p53 mirrored mutations found in human lung tumors, a discovery that provided molecular evidence of how cigarettes cause cancer.
	abcnews.go.com /Health/Healthology/story?id=414376

	Hazardous Substance Fact Sheet
		If Benzo(a)pyrene is on your skin when you are being exposed to sunlight or UV light, the risk of skin cancer is increased.
		Benzo(a)pyrene has caused cancer in the offspring of animals exposed during pregnancy and may also damage the developing fetus in other ways.
		Benzo(a)pyrene may be transferred to nursing infants through the exposed mother's milk.
	home.earthlink.net /~clearh2orev/toxbenzoapyr.html

	Detection of DNA adducts in basal and non-basal cells of the hamster trachea exposed to benzo(a)pyrene in organ culture -- Roggeband et al. 42 (11): 1427 -- Journal of Histochemistry and Cytochemistry
		Detection of DNA adducts in basal and non-basal cells of the hamster trachea exposed to benzo(a)pyrene in organ culture -- Roggeband et al.
	www.jhc.org /cgi/reprint/42/11/1427

	Wood Stove Changeout Campaign : Clean Burning Wood Stoves & Fireplaces : EPA
		While focusing on reductions of benzo(a)pyrene and particulate matter (PM), the wood stove changeout program also led to reductions in other air toxics (scroll 3/4 down the page).
		The Great Wood Stove and Fireplace Changeout, carried out in Canada and the United States from February through April 2001, accelerated the turnover of old wood stoves by educating the public about the environmental benefits of replacing old wood stoves and inserts and by providing financial incentives for the purchase of cleaner burning appliances.
	www.epa.gov /woodstoves/changeout.html

	Biological monitoring of firefighter exposure to benzo(a)pyrene (BaP) and aromatic amines during a fire at a tire dump
		The results revealed low exposure to benzo(a)pyrene and exposure to aromatic amines at concentrations significantly higher than background levels.
		Firefighters involved in extinguishing a fire at a tire dump in Saint-Amable may have suffered acute or subacute exposure to benzo(a)pyrene or aromatic amines.
		Although such exposure is almost impossible to evaluate from environmental measurements, it appears feasible to evaluate it through the measurement of protein adducts, complexes formed between certain toxic products or their metabolites and molecules occurring naturally in the body.
	www.irsst.qc.ca /en/_projet_2070.html

	RIVM Rapport 711701012: Bioaccessibility of contaminants from ingested soil in humans. Method development and research on the bioaccessibility of lead and benzo[a]pyrene
		Lead and benzo[a]pyrene were chosen as test contaminants.
		Effects of 1) type of contaminant, 2) contamination level, 3) type of soil, 4) pH of soil, 5) ageing of the soil, and 6) metal speciation on bioaccessibility were investigated.
		The results suggest in many cases a non-linear relationship between the level of lead contamination and the amount of contaminant mobilised from soil into digestion juice, i.e.
	www.rivm.nl /bibliotheek/rapporten/711701012.html

	FORCES - BENZO(A)PYRENE AND THE PSEUDO-SCIENCE OF STANTON GLANTZ
		Benzo(a)pyrene and other polycyclic aromatic hydrocarbons are generic products of fossil fuel combustion.
		Glantz's cockerels would eat a lot of dirt in an ordinary barnyard, and rabbits eat leafy vegetation; so, like humans, they would be exposed to more BaP in their normal diets than from a few whiffs of cigarette smoke in his lab.
		He has received massive and uncritical publicity from the media for his claim that secondhand smoke causes heart disease in non-smokers, and he has testified to Congress and various federal agencies as a representative of the American Heart Association and other anti-smoking groups.
	www.forces.org /evidence/carol/carol10.htm

	CHEMINFO: Benzo(a)pyrene
		Benzo(a)pyrene is widely distributed in the environment as a by-product of the incomplete combustion and thermal decomposition (pyrolysis) of fossil fuels and organic matter.
		Infertility in mice exposed in utero to benzo(a)pyrene.
		Mutagenicity of benzo(a)pyrene and dibenzopyrenes in the Salmonella Typhimurium TM677 and the MCL-5 human cell forward mutation assays.
	www.intox.org /databank/documents/chemical/benzopyr/cie698.htm

	Benzo [a] pyrene (BaP) (CASRN 50-32-8), IRIS, Environmental Protection Agency
		Benzo[a]pyrene has been shown to cause genotoxic effects in a broad range of prokaryotic and mammalian cell assay systems (U.S. EPA, 1991a).
		At the June 1992 CRAVE Work Group meeting, it was noted that an error had been made in the 1991 document "Dose-Response Analysis of Ingested Benzo[a]pyrene" which is quoted in the Drinking Water Criteria Document for PAH.
		This section provides information on three aspects of the carcinogenic risk assessment for the agent in question; the U.S. EPA classification, and quantitative estimates of risk from oral exposure and from inhalation exposure.
	www.epa.gov /iris/subst/0136.htm

	Toxicology :: Analysis of Benzo[a]pyrene Partitioning and Cellular Homeostasis in a Rat Liver :: Pharmaceutical Information and Articles
		The uptake and subcellular partitioning of benzo[a]pyrene (BaP) were examined in a rat-liver cell line (Clone 9) using confocal and multiphoton microscopy.
		Analysis of Benzo[a]pyrene Partitioning and Cellular Homeostasis in a Rat Liver
		Following a 16-h treatment, intracellular accumulation of BaP increased with increasing concentration, and cytoplasmic BaP fluorescence reached saturation at 10 µM. Analysis of the kinetics of BaP uptake at this concentration indicated that BaP is rapidly partitioned into all cytoplasmic membranes within several min, although saturation was not reached until 4 h.
	www.pharmainfo.net /displayarticle3326.html

	GLBTS: BaP/HCB - Draft Report for BaP: Reduction Options
		Benzo(a)pyrene [B(a)P, CAS number 50-32-8] is a member of a class of compounds known as polycyclic aromatic hydrocarbons (PAHs).
		They are called "Level 1 substances." Benzo(a)pyrene (B(a)P) is one of the Level 1 substances.
		The Binational Toxics Strategy identified twelve bioaccumulative substances having sufficient toxicity and presence in water, sediments and/or aquatic biota of the Great Lakes system to warrant concerted action to eliminate their input to the Great Lakes.
	www.epa.gov /grtlakes/bns/baphcb/BaP_Rdcn.html

	Letter: Differentiation of isomeric mercapturic acid pathway metabolites of benzo[a]pyrene
		Keywords: benzo[a]pyrene, mercapturic acid, metabolites, diolepoxides, electrospray, tandem mass spectrometry, mass spectrometry, N -acetylcysteine.
		Isomeric forms of the mercapturic acid pathway metabolites of benzo[a]pyrene (BP) can be differentiated by positive-ion electrospray collision-induced dissociation (CID) mass spectrometry at the nanogram level.
		Letter: Differentiation of isomeric mercapturic acid pathway metabolites of benzo[a]pyrene
	www.impub.co.uk /abs/EMS03_0396.html

	benzo(a)pyrene
		One of the most studied of the PAHs is benzo(a)pyrene, also called B(a)P. The B(a)P content of coal tar is between 0.1 percent and 1 percent and it contributes to the serious potential health effects for employees exposed to coke oven emissions.
		Among these chemicals is a group of multi-ring hydro- gen and carbon compounds known as polycyclic aromatic hydrocarbons, or PAHS, which are commonly found in the emissions from burned plant and petroleum products.
		The largest sources of B(a)P are open burning and home heating with wood and coal.
	www.lehigh.edu /kaf3/public/www-data/background/background.html

	Detection of benzo[a]pyrene diol epoxide-DNA adducts in embryos from smoking couples: evidence for transmission by spermatozoa -- Zenzes et al. 5 (2): 125 -- Molecular Human Reproduction
		Detection of benzo[a]pyrene diol epoxide-DNA adducts in embryos from smoking couples: evidence for transmission by spermatozoa -- Zenzes et al.
	molehr.oupjournals.org /cgi/content/abstract/5/2/125

	Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice -- Curfs et al. 164 (1): 101 -- American Journal of Pathology
		Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice -- Curfs et al.
		Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice
	ajp.amjpathol.org /cgi/content/abstract/164/1/101

	Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse
		Short-term benzo[a]pyrene (BaP)-induced and long-term spontaneous mutagenesis were monitored.
		Researchers investigated the effects of two levels of dietary lycopene, fed as a lycopene-rich tomato oleoresin (LTO), on in vivo mutagenesis in prostate, colon, and lungs of lacZ mice.
	www.ag.uiuc.edu /ffh/abstracts/high_lycopene.html

	Lung-Specific Expression of Dominant-Negative Mutant p53 in Transgenic Mice Increases Spontaneous and Benzo(a)pyrene-Induced Lung Cancer -- Tchou-Wong et al. 27 (2): 186 -- American Journal of Respiratory Cell and Molecular Biology
		of benzo(a)pyrene, the tumor incidence in wild-type and CCSP-dnp53
	ajrcmb.atsjournals.org /cgi/content/abstract/27/2/186

	Successive Mineralization and Detoxification of Benzo[a]pyrene by the White Rot Fungus Bjerkandera sp. Strain BOS55 and Indigenous Microflora -- Kotterman et al. 64 (8): 2853 -- Applied and Environmental Microbiology
		Steffen, K. T., Hatakka, A., Hofrichter, M. Degradation of Benzo[a]pyrene by the Litter-Decomposing Basidiomycete Stropharia coronilla: Role of Manganese Peroxidase.
		Successive Mineralization and Detoxification of Benzo[a]pyrene by the White Rot Fungus Bjerkandera sp.
		Strain BOS55 and Indigenous Microflora -- Kotterman et al.
	aem.asm.org /cgi/content/abstract/64/8/2853

	Safety (MSDS) data for benzo(a)pyrene
		Synonyms: 1,2-benzopyrene, 6,7-benzopyrene, benzo[a]pyrene, B(a)P, BP, 3,4-benzopyrene, benzo[d,e,f]chrysene, 3,4-benzpyrene, benzpyrene, 3,4-benzylpyrene, 3,4-benz[a]pyrene, 3,4-BP, 3,4-benzopyrene
		We have not verified this information, and cannot guarantee that it is up-to-date.
		Appearance: yellow crystals or powder [found in cigarette smoke, coal tar, fuel exhaust gas and in many other sources]
	ptcl.chem.ox.ac.uk /MSDS/BE/benzo(a)pyrene.html

	An Autoregulatory Loop Controlling CYP1A1 Gene Expression: Role of H2O2 and NFI -- Morel et al. 19 (10): 6825 -- Molecular and Cellular Biology
		Metabolism of benzo(a)pyrene and benzoapyrene-7,8-diol by human cytochrome P450 1B1.
		Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.
		formation and benzo(a)pyrene hydroxylation by substrates and flavone.
	mcb.asm.org /cgi/content/full/19/10/6825

	Spectrum Laboratories : Chemical Fact Sheet - Cas # 50328
		Benzo(a)pyrene's (BaP) release to the environment is quite wide spread since it is an
		TERRESTRIAL FATE: If benzo(a)pyrene is released to soil it will be expected to
		AQUATIC FATE: If released to water, benzo(a)pyrene (BaP) will be expected to adsorb very
	www.speclab.com /compound/c50328.htm

	Interleukin-1ß Regulation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Involves the p42/44 and p38 MAPK Signaling Pathways in Cardiac Myocytes -- LaPointe and Isenovic 33 (1): 276 -- Hypertension
		Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells.
	hyper.ahajournals.org /cgi/content/abstract/33/1/276

	Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor -- Shimizu et al. 97 (2): 779 -- Proceedings of the National Academy of Sciences
		Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor -- Shimizu et al.
		Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo
		DNA Adduct Formation in Precision-Cut Rat Liver and Lung Slices Exposed to Benzo[a]pyrene
	www.pnas.org /cgi/content/abstract/97/2/779

	Benzo(a)pyrene induces NF-kB in mouse hepatoma cells.
		Shneider A, Sherr D. Benzo(a)pyrene induces NF-kB in mouse hepatoma cells.
	www.gulflink.osd.mil /medsearch/EnvironmentalOccupationa/OilFires/VA4E_5.shtml

	Apoptotic Mitochondrial Dysfunction Induced by Benzo(a)pyrene in Liver Epithelial Cells: Role of p53 and pHi Changes -- HUC et al. 1010 (1): 167 -- Annals of the New York Academy of Sciences
		Apoptotic Mitochondrial Dysfunction Induced by Benzo(a)pyrene in Liver Epithelial Cells: Role of p53 and pHi Changes -- HUC et al.
		Key Words: benzo(a)pyrene • rat liver epithelial cell &; apoptosis • mitochondria • intracellular pH • p53 • reactive oxygen species
	www.annalsnyas.org /cgi/content/abstract/1010/1/167

	Embryonic prostaglandin H synthase-2 (PHS-2) expression and benzo[a]pyrene teratogenicity in PHS-2 knockout mice -- PARMAN and WELLS 16 (9): 1001 -- The FASEB Journal
		Embryonic prostaglandin H synthase-2 (PHS-2) expression and benzo[a]pyrene teratogenicity in PHS-2 knockout mice -- PARMAN and WELLS 16 (9): 1001 -- The FASEB Journal
	www.fasebj.org /cgi/reprint/16/9/1001

	Genomic profiles and predictive biological networks in oxidant-induced atherogenesis -- Johnson et al. 13 (3): 263 -- Physiological Genomics
		In the case of benzo[a]pyrene (BaP), a polycyclic aromatic
	physiolgenomics.physiology.org /cgi/content/abstract/13/3/263

	Effects of Sulfite on the Uptake and Binding of Benzo[a]pyrene Diol Epoxide in Cultured Murine Respiratory Epithelial Cells
		Effects of Sulfite on the Uptake and Binding of Benzo[a]pyrene Diol Epoxide in Cultured Murine Respiratory Epithelial Cells
		Effects of Sulfite on the Uptake and Binding of Benzo[a]pyrene Diol Epoxide in Cultured Murine Respiratory Epithelial Cells
		The full version of this article is available for free in HTML format.
	ehpnet1.niehs.nih.gov /docs/1994/102-2/green.html

	Benzo[a] pyrene Mutagenic Mechanisms
		Abstract: DESCRIPTION: (provided by applicant): Benzo[a]pyrene is a potent mutagen/carcinogen found ubiquitously in the environment.
	researchresources.bumc.bu.edu /abstract/5R01ES003775-16.htm

	Food Mutagens -- Goldman and Shields 133 (3): 965 -- Journal of Nutrition
		Waldman, J. M., Lioy, P. J., Greenberg, A. and Butler, J. P. (1991) Analysis of human exposure to benzo(a)pyrene via inhalation and food ingestion in the Total Human Environmental Exposure Study (THEES).
		Triolo, A. J., Aponte, G. and Herr, D. L. (1977) Induction of aryl hydrocarbon hydroxylase and forestomach tumors ben benzo(a)pyrene.
		Denissenko, M. F., Pao, A., Tang, M. and Pfeifer, G. P. (1996) Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.
	nutrition.org /cgi/content/full/133/3/965S

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In the News (Wed 23 Dec 09)