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Topic: Pyridazine

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	Pyridazine derivatives invention
		Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.
		Click on the above for other options relating to this Pyridazine derivatives patent application.
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	www.freshpatents.com /Pyridazine-derivatives-dt20061130ptan20060270681.php (157 words)

	ECCC3 Paper 37 (Site not responding. Last check: 2007-10-22)
		As a class, the pyridazines are the least studied and understood of the six-membered diazine heterocycles, both experimentally, and theoretically [ 1 ].
		With the resurgence of interest in pyridazine derivatives as novel bio-active molecules [ 2, 3, 4 ] and with the close structural similarity of some hydroxy-pyridazines to better known systems such as uracil, we expect these compounds to be the subject of further synthetic and medicinal study.
		Itai, Pyridazine N-oxides, The Chemistry of Heterocyclic Compounds, Interscience, 28 (8), 721 (1973)
	www.elsevier.com /homepage/saa/eccc3/paper37 (4214 words)

	Chapter 5. Synthesis of pyridazine amino acids (Site not responding. Last check: 2007-10-22)
		These two simple pyridazines 10 and 11 are apparently previously unreported, perhaps because of the difficulties of separation and the chlorination reaction.
		6-Alkoxy pyridazines are intermediate in nature between an ester and an aromatic ether because of the lactim structure and the strongly acidic hydroxyl of the parent compound, and are thus easier to cleave than other aromatic ethers.
		Preparation of the pyridazine aldehyde directly, or the pyridazine carboxylic acid by oxidation of the 4-methyl group in the hope of reduction to the aldehyde showed no promise.
	www.pharmacol.usyd.edu.au /thesis/5 (4877 words)

	Characterization of Imidazo[4,5-d]Pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile ...
		The amounts of viral RNA extracted from the cells infected in the absence of imidazo[4,5- d ]pyridazine nucleosides were referred to as 100%.
		Activating effect of preincubation of the DNA substrate with imidazo[4,5- d ]pyridazine nucleosides on the helicase activity of WN virus NTPase/helicase.
		pyridazines on the NTPase and helicase activities of the WN virus NTPase/helicase.
	aac.asm.org /cgi/content/full/46/5/1231 (5721 words)

	Unsubstituted pyrido[3,4-d]pyridazine as an electron- deficient azadiene in [4+2] cycloaddition reactions: a short ... (Site not responding. Last check: 2007-10-22)
		Pyrido[3,4- d ]pyridazine was shown to undergo thermally induced Diels—Alder reactions (inverse electron-demand) with enamines as electron-rich dienophiles, yielding isoquinoline derivatives.
		A solution of pyrido[3,4- d ]pyridazine ( 1) (131 mg, 1 mmol) and 1-pyrrolidino-1-cyclohexene (604 mg, 4 mmol) in dry 1,4-dioxane (10 mL) was heated in a closed vessel at 110 °C under an Ar atmosphere for 7 d.
		A solution of pyrido[3,4- d ]pyridazine ( 1) (66 mg, 0.5 mmol) and 1-pyrrolidino-1-cyclooctene (359 mg, 2 mmol) in dry 1,4-dioxane (5 mL) was heated in a closed vessel at 110 °C under an Ar atmosphere for 7 d.
	www.arkat-usa.org /ark/journal/2001/I02_Sauter/135/135.asp (1929 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ... (Site not responding. Last check: 2007-10-22)
		Further evidence for the formation of an electrophilic intermediate in suprofen-P450 2C9 incubations was obtained via the characterization of a novel pyridazine adduct upon addition of semicarbazide to the microsomal mixtures.
		The pyridazine derivative had a protonated monoisotopic mass of 257.0895 that was consistent with an elemental composition of C14H13O3N2.
		The formation of the stable pyridazine adduct suggested the generation of an electrophilic gamma-thioketo-alpha, beta-unsaturated aldehyde, analogous to that observed during the cytochrome P450-mediated bioactivation of furan.
	www.wellstreetpharmacy.com /ref-diclofenac/diclofenac-research-abs3.400.html (922 words)

	Morehead State University - Focus Magazine Online
		Enzymes are typically very large molecules and the task in research such as his, is to develop compounds that will fit on target sites along the enzyme surface and inhibit the action of that enzyme.
		Blankenbuehler worked with pyridazines as a graduate student and recognized the molecule is similar to the chemical structure of Celebrex.
		As he stands at the flboard in his office, diagramming pyridazine molecules and explaining how one molecule attaches to another, it becomes apparent that after only three years as a full-time professor, he has developed a penchant for instruction.
	www.morehead-st.edu /focus/focus02/blankenbuehler.html (1270 words)

	Norbert Haider, Conference contributions
		Symposium on the Chemistry and Pharmacology of Pyridazines, 1988, 20.
		Symposium on the Chemistry and Pharmacology of Pyridazine, 1994, 7 (PL-5).
		Pyridazine Analogs of Pyridocarbazole Alkaloids: 3-Azaolivacine and 3-Azaellipticine;
	merian.pch.univie.ac.at /pch/nh_conf.html (1423 words)

	Pongor, Gábor: selected publications (Site not responding. Last check: 2007-10-22)
		For the ground electronic state of pyridazine, two kinds of molecular data, the molecular geometry and the harmonic force field, have been determined theoretically at the ab initio Hartree-Fock level using the 4-21G basis set.
		In order to compensate for the systematic errors of both sets of computed molecular data, empirical corrections were used with the help of a few parameters whose values have been calibrated previously on model molecule(s).
		Thus, the resulting corrected data are a priori for pyridazine.
	theop8.chem.elte.hu /pongor/pongpub.htm (1736 words)

	6.5 Degenerate four wave mixing versus laser induced fluorescence of pyrazine and pyridazine (Site not responding. Last check: 2007-10-22)
		Pyrazine is believed to follow the prototypical example of the intermediate transitions in the radiationless theory: for example, the phosphorescence quantum yield is strongly depending upon collision conditions.
		The dynamics of pyridazine in the gaseous phase is very different from the one of pyrazine.
		The behavior of the pyridazine molecule under laser excitation is pretty much different from the one of pyrazine [4].
	www.magniel.com /hmtj/annual/605.html (846 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair ... (Site not responding. Last check: 2007-10-22)
		These results are consistent with the possibility that activation of peripheral beta 1 receptors may substantially contribute to withdrawal-induced anxiety and that beta-adrenergic antagonists could be useful in treating in cocaine and morphine dependent addicts.
		F 2692 [1-(3'-trifluoromethyl phenyl) 1,4-dihydro 3-amino 4-oxo 6-methyl pyridazine] exhibited dose-dependent "anxiolytic" properties in the elevated plus-maze and the punished drinking tests in rats.
		In contrast, under the same experimental conditions, F 2692 [1-(3'-trifluoromethyl phenyl) 1,4-dihydro 3-amino 4-oxo 6-methyl pyridazine] (3-30 mg/kg/day) exhibited no tolerance to either the sedative effect or the "anxiolytic" activity and showed no "anxiogenic rebound" response after withdrawal.
	www.darwinpharmacy.com /ref-anxiety-004/anxiety-004-research-abs3.326.html (595 words)

	Thieme-connect - Abstract (Site not responding. Last check: 2007-10-22)
		Regioselective Synthesis of Linear and Angular Pyridazine Furocoumarins
		With a view to develop a general regioselective route to pyridazine analogues of benzofurocoumarins, the angular compound
		In both cases the key step in the construction of the fused pyridazine ring was a Diels-Alder reaction of the intermediate dihydrofura-3-ones with 3,6-bis(trifluoromethyl)-1,2,4,5-tetrazine.
	www.thieme-connect.com /ejournals/abstract/synthesis/doi/10.1055/s-2002-19292 (140 words)

	Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their ... (Site not responding. Last check: 2007-10-22)
		Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
		Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.The potential antidepressant effects of two pyridazine derivatives, 5-benzyl 6-methyl 2-[4-(3-trifluoro-methyl phenyl) piperazin-1-yl] methylpyridazin-3-one ( PC4) and 5-benzyl 6-methyl 2-[4-(3-chlorophenyl) piperazin-1-yl] methylpyridazin-3-one (PC13), were evaluated using classical psychopharmacological tests in mice.
		Head twitches produced either by L-5-hydroxytryptophan (4 mg kg-1, i.p.) in mice pretreated with pargyline (100 mg kg-1, i.p.) or by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (3 mg kg-1, i.p.) were antagonized by both pyridazine derivatives (20 mg kg-1, i.p.).
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/279295.html (249 words)

	British Journal of Pharmacology - Vasorelaxant and antiplatelet activity of ... (Site not responding. Last check: 2007-10-22)
		The pharmacological activity of the furoxan derivative condensed with pyridazine di-N-oxide 4,7-dimethyl-1,2,5-oxadiazolo[3,4- d ]pyridazine 1,5,6-trioxide (FPTO) and the corresponding furazan (FPDO) was studied.
		The molecule of FPTO is composed of a furoxan ring condensed with a pyridazine di-N-oxide moiety resulting in a unique substance with two potentially active groups known to release nitric oxide.
		The pyridazine di-N-oxide moiety itself is responsible for the reaction with low molecular weight and protein thiols and oxidation of oxyHb to metHb but not for nitric oxide formation.
	www.nature.com /bjp/journal/v129/n6/full/0703156a.html (9544 words)

	Pasano B (Site not responding. Last check: 2007-10-22)
		The challenge is to synthesize cyclopenta[d]pyridazine based compounds that are similar to existing pyridazines or pyrazoles with known biological activity such as Celebrex.
		Parent pyridazine derivatives and fused-pyridazines are being synthesized.
		The synthesis and characterization of N-substituted cyclopenta [d]pyridazines structurally similar to Celebrex via reaction of an appropriate hydroxyfulvene with 4-hydrazinobenzenesulfonamide will be discussed.
	campus.murraystate.edu /services/ursa/web2/DavidRiffe.htm (162 words)

	Synthesis of Phosphorescent Platinum Complexes with 3-Aryl Pyridazine as Prominent Emitting Materials in Organic ... (Site not responding. Last check: 2007-10-22)
		The conjugating ring on the pyridazine makes the emission more red shifted which is expected based on molecular orbital calculation.
		As shown in previous reports [5], aryl pyridazine ligand may be coordinated to pt(II) to give luminescent complexes of green to the red color (516-645 nm).
		Therefore, in the series of ary pyridazine complexes, the HOMO of the conjugated aryl group may cause the red-shift in luminescence, while the LUMO's of the pyridazines may not change dramatically.
	www.ttp.net /0-87849-958-x/1006.htm (1221 words)

	Pharmazeutische Chemie Ibk Forschung English (Site not responding. Last check: 2007-10-22)
		Synthesis and biological testing of novel tricyclic compounds containing a pyridazine moiety as potential HIV reverse transcriptase inhibitors (biological testing in collaboration with the Institut für Hygiene, University of Innsbruck).
		Systematic pharmacophore investigation and parameter determination of pyridazine derivatives
		Calculation and experimental determination of pKa and log P (for calculation: increment approach and use of 3D QSAR.
	info.uibk.ac.at /c/c7/c727/IPCI_FORSCHUNG/forschung_engl.html (282 words)

	MECHANISM-BASED INACTIVATION OF HUMAN RECOMBINANT P450 2C9 BY THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG SUPROFEN -- ...
		Collision-induced dissociation spectrum of the pyridazine adduct obtained after coincubation of suprofen and semicarbazide with P450 2C9.
		the pyridazine metabolite in suprofen-P450 2C9 incubations is
		characterization of the glutathione conjugates and the pyridazine
	dmd.aspetjournals.org /cgi/content/full/31/11/1369 (4902 words)

	Alibris: Pyridazine
		This new volume substantially updates the original pyridazines volume which was published in 1973.
		Condensed pyridazine and pyrazine rings (cinnolines, phthalazines, and quinoxalines)
		The Chemistry of Heterocyclic Compounds, Pyridazine and Pyrazine Rings
	www.alibris.com /search/books/subject/Pyridazine (226 words)

	A Direct Route to 4,5-Diazaphthalimides
		The remarkable increase of chemical shift at pyridine H3 is ascribed to the deshielding effect of pyridazine or ( s -tetrazine ring for 2a and 10a).
		C-2'/2''; because pyridazine ring was more electron-deficient ring than pyridine.
		C-4/5 because of the inductive effect of nitrogen atom and conjugated effect of carbonyl group in maleimide moiety.
	www.ch.ic.ac.uk /ectoc/echet98/pub/095/095.htm (2498 words)

	Current Patents - patent-based competitive intelligence for the pharmaceutical, medical, health, & related industry ... (Site not responding. Last check: 2007-10-22)
		The pyrazolo[1, 5B]pyridazine derivative may refer to GW-406381, a second-generation COX-2 inhibitor that is currently undergoing trials for various pain conditions.
		Our DOLPHIN database of all pharmaceutical inventions currently has 8 PCTs assigned to Glaxo that refer to similar pyridazine derivatives, several of which are linked to GW-406381.
		Merck Sharp and Dohme Ltd is another large company to be unusually explicit in revealing the subject of this week’s application.
	www.current-patents.com /news/2004/0410/10.asp (1235 words)

	Discovery of a 3-Amino-6-phenyl-pyridazine Derivative as a New Synthetic Antineuroinflammatory Compound (Site not responding. Last check: 2007-10-22)
		Overall, the results indicate that the contribution of the pyridazine and piperazine to activity is context-dependent.
		Finally, pyridazines are attractive starting points for future refinement because they have the potential for generating chemically diverse compounds as part of in-parallel syntheses, and slight modifications result in a range of pharmacological activities.
		Compound 1 is a new glial activation inhibitor that has desirable functional properties, targets different pathways compared to currently available experimental drugs, and is amenable to rapid chemical diversification with facile chemistries, making it an attractive starting point for future refinement.
	pubs.acs.org /cgi-bin/jcen?jmcmar/45/i03/html/jm015573g.html (2776 words)

	Lynmarie A. Posey
		In a second project, we are exploring the spectroscopy of probe ligands, such as s -tetrazine and pyridazine, clustered with the first row transition metal ions Fe (II), Co (II), and Ni (II) (Figure 2).
		The electronic absorption spectra of these neutral probe molecules reveal the electronic and structural perturbations which accompany coordination or electrostatic binding of neutral molecules to a doubly-charged transition metal ion.
		in methanol containing 5% pyridazine (pyrd) by volume.
	www.cem.msu.edu /~posey (586 words)

	Zindo - Tutorial--Standalone Mode
		In Lesson 3: Configuration interaction, you will perform a configuration interaction calculation on pyridazine and apply the self-consistent reaction field method to the excited states.
		The pyridazine model appears in the display area.
		The graph is a representation of the calculated UV/visible spectrum of pyridazine.
	www.hhmi.swmed.edu /Manuals/insight980/insight980/zindo/9_Tutorial_SA.html (2446 words)

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