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Topic: Pyridostigmine

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	Pyridostigmine - Drugs & Vitamins - Drug Library - DrugDigest
		Pyridostigmine tablets may also be used by the military before an anticipated threat of exposure to certain nerve gas agents.
		Pyridostigmine tablets are only to be used prior to exposure to Soman.
		Pyridostigmine should not be used during or after exposure to Soman.
	www.drugdigest.org /DD/DVH/Uses/0,3915,578\|Pyridostigmine,00.html (657 words)

	The UK GulfWeb: NAPS, AHFS Drug Information 1990 (American society of hospital pharmacists, Bethseda, USA 1990
		Pyridostigmine bromide is a chemical which enhances the effectiveness of established drugs for the treatment of nerve agent poisoning.
		Pyridostigmine is also approved to reverse the effect of neuromuscular blocking agents after surgery.
		The researchers indicated that pyridostigmine should not be given to individuals who had bronchial asthma, peptic ulcer, liver, kidney, heart disease, or hypersensitivity to pyridostigmine or related drugs.
	www.gulflink.org /GulfWeb/naps/psb09.html (2206 words)

	MCF: Military Human Experimentation
		Pyridostigmine bromide is a chemical which enhances the effectiveness of two drugs, atropine and 2-PAM, which are proven effective for the treatment of nerve agent poisoning.
		Pyridostigmine bromide, according to DOD, improves the survival of animals exposed to soman and treated with atropine and 2-PAM.
		Pyridostigmine is approved by the FDA at a one-time dosage of 15 mg to reverse the effects of certain drugs given during anesthesia.
	www.mindcontrolforums.com /milexp.htm (18401 words)

	Acetylcholinesterase inhibition with pyridostigmine improves heart rate recovery after maximal exercise in patients ...
		Acetylcholinesterase inhibition with pyridostigmine improves heart rate recovery after maximal exercise in patients with chronic heart failure -- Androne et al.
		of pyridostigmine is attributable to inhibition of the enzymatic
		Pharmacokinetics and oral bioavailability of pyridostigmine in man. Eur J Clin Pharmacol 1980; 18 :423–8.
	heart.bmjjournals.com /cgi/content/full/89/8/854 (2933 words)

	Table of Contents: Rockefeller Report
		FDA and DOD officials claimed they were confident of the safety of pyridostigmine as an antidote enhancer for chemical warfare protection because it would be used at a much lower dose (Note 50) in combat than normally used for treating patients with myasthenia gravis.
		Whereas the dosage of pyridostigmine bromide for patients with myasthenia gravis may reach 120 mg every three hours, (Note 51) the dose for U.S. troops was only 30 mg every 8 hours.
		John Deutch, Deputy Secretary of Defense, wrote that, "Although pyridostigmine and botulinum toxoid were classified as investigational drugs as required by FDA regulations, they were not used for experimental purposes in [Operation Desert Storm] and the military personnel who received these products were not experimental subjects." (Note 95) Mr.
	www.mindcontrolforums.com /1994-rockefeller-report.htm (17827 words)

	Pyridostigmine Bromide - Current Issue (Site not responding. Last check: 2007-10-24)
		Pyridostigmine bromide (PB) is a drug the Food and Drug Administration approved in 1955 to treat myasthenia gravis, a neuromuscular condition characterized by weakness and muscle fatigue.
		Based on extensive scientific information, the FDA approved using pyridostigmine bromide as an "investigational new drug" as a pretreatment adjunct to protect US and some allied military personnel from death in a chemical warfare agent attack using soman.
		In 1999, the RAND Corporation released a report indicating pyridostigmine bromide could not be ruled out as a contributor to the development of some Gulf War veterans' unexplained or undiagnosed illnesses.
	deploymentlink.osd.mil /current_issues/info_papers/pb_info.shtml (532 words)

	Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement -- Horemans et al. 74 ...
		Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement -- Horemans et al.
		Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement
		Pyridostigmine treatment of post-polio syndrome fatigue: a single fibre EMG study.
	jnnp.bmjjournals.com /cgi/content/full/74/12/1655 (3013 words)

	Enhanced heart rate variability and baroreflex index after stress and cholinesterase inhibition in mice -- Joaquim et ...
		Cholinergic stimulation with pyridostigmine reduces ventricular arrhythmia and enhances heart rate variability in heart failure.
		The combined effects of pyridostigmine and chronic stress on brain cortical and blood acetylcholinesterase, corticosterone, prolactin and alternation performance in rats.
		Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat.
	ajpheart.physiology.org /cgi/content/full/287/1/H251 (4760 words)

	Gulf War and Health: Volume 1. Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines - Institute of Medicine
		Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines - Institute of Medicine
		In 1998, the IOM began a series of congressionally-mandated studies to examine the scientific and medical literature on the potential health effects of chemical and biological agents related to the Gulf War.
		The first study reviewed the scientific literature on depleted uranium, chemical warfare agents (sarin and cyclosarin), pyridostigmine bromide, and vaccines (anthrax and botulinum toxoid) and resulted in the report, Gulf War and Health Volume I: Depleted Uranium, Pyridostigimine Bromide, Sarin, Vaccines.
	www.iom.edu /CMS/4683/5534.aspx (122 words)

	IS MILITARY RESEARCH HAZARDOUS TO VETERANS' HEALTH?
		Dr. Arthur Caplan, who at the time he testified was Director of the Center of Biomedical Ethics at the University of Minnesota, addressed that issue at the May 6 hearing.
		Dr. Moss also studied the combination of DEET and pyridostigmine with other toxic substances that were present in the Gulf War, such as lindane (a treatment for lice) and a wide range of insecticides.
		Koplovitz, I., Harris, L.W., Anderson, D.R., Lennox, W.J., & Stewart, J.R. "Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents," Fundamental and Applied Toxicology, Vol.
	www.supremelaw.org /press/rels/rockrep.htm (18669 words)

	TopSearch10 - Search Results - pyridostigmine bromide (Site not responding. Last check: 2007-10-24)
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	pyridostigmine-bromide.tbl.sytes.net (74 words)

	Rockefeller Report
		Abbreviated Protocol, signed by Roger W. Wiley and Darcelle Delrie, and other documents regarding "The Effects of Pyridostigmine Bromide on Vision"; attached to a cover letter from Martha H. Myers, Acting Chief, Human Use Review and Regulatory Affairs Office, Department of the Army, August 15, 1990.
		There are several studies of the effects of a one-time dose of pyridostigmine on growth hormone in women, but the conditions of these studies, including fasting and use during one phase of the menstrual cycle, were not relevant to use of pyridostigmine in the Gulf War.
		All the men and women in the study were between 19-25 years old, were free of other medications, and were fasting; the women were all in the luteal phase of their menstrual cycle.
	www.prop1.org /2000/du/reports/941208rr.htm (19143 words)

	A multicenter, randomized, double-blinded trial of pyridostigmine in postpolio syndrome -- Trojan et al. 53 (6): 1225 ...
		A multicenter, randomized, double-blinded trial of pyridostigmine in postpolio syndrome -- Trojan et al.
		OBJECTIVES: To determine the effect of pyridostigmine in PPS
		placebo-controlled trial of a 6-month course of pyridostigmine
	www.neurology.org /cgi/content/abstract/53/6/1225 (616 words)

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