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Topic: Pyrimidine


  
  Amazon.ca: pyrimidine: Books   (Site not responding. Last check: )
Purine and Pyrimidine Metabolism in Man VII : Part A: Chemotherapy, ATP Depletion, and Gout by R. Angus Harkness, T.B. Elion, and Nepomuk Zöllner (Hardcover - Dec 31 1991)
Purine and Pyrimidine Metabolism in Man: Part B : Structural Biochemistry, Pathogenesis, and Metabolism by R. Angus Harkness, Gertrude B. Elion, and Nepomuk Zollner (Hardcover - Feb 1992)
Purine and Pyrimidine Nucleotide Metabolism : Volume 51: Purine and Purimidine Nucleotide Metabolism by Nathan P. Colowick, Patricia A. Hoffee, Mary Ellen Jones, and Nathan P. Kaplan (Hardcover - Jul 28 1978)
www.amazon.ca /s?ie=UTF8&keywords=pyrimidine&index=books&page=1   (500 words)

  
  Nucleotide Metabolism
The carbamoyl phosphate used for pyrimidine nucleotide synthesis is derived from glutamine and bicarbonate, within the cytosol, as opposed to the urea cycle carbamoyl phosphate derived from ammonia and bicarbonate in the mitochondrion.
The urea cycle reaction is catalyzed by carbamoyl phosphate synthetase I (CPS-I) whereas the pyrimidine nucleotide precursor is synthesized by CPS-II.
Carbamoyl phosphate utilized in pyrimidine nucleotide synthesis differs from that synthesized in the urea cycle; it is synthesized from glutamine instead of ammonia and is synthesized in the cytosol.
web.indstate.edu /thcme/mwking/nucleotide-metabolism.html   (3070 words)

  
  Highbeam Encyclopedia - Search Results for pyrimidine   (Site not responding. Last check: )
pyrimidine A basic, six-membered, heterocyclic compound; the principal pyrimidines (uracil, thymine, and cytosine) are important constituents of nucleic acids.
Thymine was the first pyrimidine to be purified from a natural source, having been isolated from calf thymus and beef spleen in 1893-4.
Reaction of isothiocyanates with active methylene reagent: a new approach for the synthesis of pyrazole, pyrimidine and pyrazolo/1,5-a~pyrimidine derivatives.
www.encyclopedia.com /SearchResults.aspx?Q=pyrimidine   (646 words)

  
  Pyrimidine Information Center - pyrimidine antidepressant
C1=NC=NC=C1 Pyrimidine is a heterocyclic aromatic organic compound, which is similar purine & pyrimidine to benzene and pyridine and that contains two nitrogen atoms at regulation of purine and pyrimidine biosynthesis positions 1 and 3 of the six-membered pyrimidine pathway ring.
Three nucleobases 2+2 cycloaddition of pyrimidine bases found in nucleic acids, namely cytosine, pyrimidine antidepressant thymine, and uracil, are pyrimidine derivatives.
Pyrimidines are ultimately catabolized (degraded) to CO O, and urea.
www.scipeeps.com /Sci-Chemistry_Topics_Pr_-_R/Pyrimidine.html   (312 words)

  
 Pyrimidine
Pyrimidine is a heterocyclic compound containing nitrogen atoms at positions 1 and 3 in six-membered ring structure molecule.
Pyrimidine nucleotides play a key role in RNA and DNA synthesis, in the activation of sugars as a prerequisite for glycosylation of proteins and lipids, polysaccharide synthesis and detoxification.
Pyrimidine and purine nucleoside analogues and anti-pyrimidine agents are among the most widely used drugs in chemotherapy, immunosuppression, viral infection and parasitic disease.
www.greatvistachemicals.com /proteins-sugars-nucleotides/pyrimidine.html   (245 words)

  
 BioMed Central | Full text | Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble ...
The transitions between pyrimidine and purine-rich regions of the genomes are rapid and are easily visible on a pyrimidine-purine walk graph.
A pyrimidine (C and T) – purine (A and G) walk of the (+) strand of human mtDNA (commonly called the "light" strand in vertebrates) is shown in Figure 1.
To clearly illustrate the relationship between protein hydrophobicity and the pyrimidine content of the genes, we plot in Figure 4 the percent pyrimidine in the protein transcript versus the grand average of hydropathicity (GRAVY) of the protein for four species with numerous mitochondrial-encoded soluble and membrane protein genes.
www.biomedcentral.com /1471-2164/6/136   (4270 words)

  
 Nucleotide Metabolism
The carbamoyl phosphate used for pyrimidine nucleotide synthesis is derived from glutamine and bicarbonate, within the cytosol, as opposed to the urea cycle carbamoyl phosphate derived from ammonia and bicarbonate in the mitochondrion.
The urea cycle reaction is catalyzed by carbamoyl phosphate synthetase I (CPS-I) whereas the pyrimidine nucleotide precursor is synthesized by CPS-II.
Carbamoyl phosphate utilized in pyrimidine nucleotide synthesis differs from that synthesized in the urea cycle; it is synthesized from glutamine instead of ammonia and is synthesized in the cytosol.
www.indstate.edu /thcme/mwking/nucleotide-metabolism.html   (3070 words)

  
 Purine and Pyrimidine Metabolism
In contrast to the synthesis of purines in which the purine ring is built onto a ribose ring, the synthesis of the pyrimidine nucleotides starts with the synthesis of the pyrimidine ring and then this is attached to a ribose phosphate.
In pyrimidine synthesis, the nitrogen is donated to form carbamoyl phosphate from glutamine instead of ammonia.
The formation of carbamoyl phosphate to be used in the synthesis of pyrimidines occurs in the cytosol.
www.dentistry.leeds.ac.uk /biochem/uttb/PYRSYN.HTM   (835 words)

  
 Pyrimidine - EvoWiki   (Site not responding. Last check: )
Pyrimidines are one of two categories of organic base found in nucleic acids.
The pyrimidines found in nucleic acids are thymine and cytosine (DNA) and uracil (RNA).
Pyrimidines are smaller than purines, containing only a six member carbon/nitrogen ring and side-groups.
wiki.cotch.net /index.php?title=Pyrimidine&redirect=no&printable=yes   (172 words)

  
 PURINES AND PYRIMIDINES
Catabolism of purines and pyrimidines occurs in a less useful fashion than did the catabolism of amino acids in that we do not derive any significant amount of energy from the catabolism of purines and pyrimidines.
Pyrimidine catabolism, however, does produce beta-alanine, and the endproduct of purine catabolism, which is uric acid in man, may serve as a scavenger of reactive oxygen species.
Pyrimidines from nucleic acids or the energy pool are acted upon by nucleotidases and pyrimidine nucleoside phosphorylase to yield the free bases.
library.med.utah.edu /NetBiochem/pupyr/pp.htm   (3844 words)

  
 pyrimidine - humpath.com - a website dedicated to human pathology.
The pyrimidines in DNA are cytosine and thymine.
Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring.
Three nucleobases found in nucleic acids, namely cytosine, thymine, and uracil, are pyrimidine derivatives.
www.humpath.com /spip.php?article6751   (105 words)

  
 Functional Analysis of the Pyrimidine De Novo Synthesis Pathway in Solanaceous Species1 - Health - RedOrbit   (Site not responding. Last check: )
Pyrimidines are particularly important in dividing tissues as building blocks for nucleic acids, but they are equally important for many biochemical processes, including sucrose and cell wall polysaccharide metabolism.
In the case of the enzymes of the pyrimidine pathway, the relatively small reduction of transcript and protein is clearly due to an incomplete inhibition of expression because each of these genes is encoded by a single gene.
As purines and pyrimidines are affected in the same way, it is presumably not a direct effect of the inhibition of pyrimidine nucleotide biosynthesis but an indirect effect due to adjustments in growth and physiology.
www.redorbit.com /news/display?id=229691&source=r_health   (8490 words)

  
 PURINE & PYRIMIDINE METABOLIC DISEASES : Contact a Family - for families with disabled children: information on ...
For those purine and pyrimidine disorders that do present with symptoms, almost any system can be affected.
Prenatal diagnosis is available for some of the purine and pyrimidine disorders.
Due to the large number of Purine and Pyrimidine Metabolic diseases the description given here is of a general nature.
www.cafamily.org.uk /Direct/p57.html   (591 words)

  
 Bioc 811
Pyrimidine metabolism is illustrated on the KEGG pathway maps at Pyrimidine Metabolism Under file menu go to page setup and select landscape orientation at 65% to print.
(you are not responsible for the pyrimidine breakdown pathways)
In pyrimidine biosynthesis CPSII in the de novo pathway and CPT synthase in the nucleotide interconversion pathways are blocked.
drnelson.utmem.edu /nucbio2.2002.html   (4091 words)

  
 REGULATION OF PYRIMIDINE METABOLISM IN PLANTS   (Site not responding. Last check: )
The first pyrimidine, UMP, is synthesized by a de novo pathway that appears to be mechanistically invariant in all organisms.
Pyrimidines are salvaged by converting the modified components into the free base, uracil for reutilization.
Finally, pyrimidines are degraded into simple cellular metabolites permitting reutilization of nitrogen and carbon from pyrimidine ring systems into cellular metabolic pools.
www.egeinfonet.i8.com /pub/2004/64.html   (214 words)

  
 The Individualist: Pyrimidine
Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring.
The second major step is the creation carbamoyl aspartic acid formed by aspartic transcarbamolyase (aspartate carbamoyl transferase).The next reaction involves dehydration of the acid catalysed by the enzyme dihhydroorotase to form hydroorotate.Dihydroorotate then enters the mitochondria where it is oxidised through removal of hydrogens to form orotate.
Pyrimidines are ultimately catabolized (degraded) to CO2, H2O, and urea.
www.dadamo.com /wiki/wiki.pl/Pyrimidine   (496 words)

  
 Pyrimidine compounds - Patent 6958332
Thus, a pyrimidine compound of this invention is obtained.
The carrier in the pharmaceutical composition must be "acceptable" in the sense of being compatible with the active ingredient of the formulation (and preferably, capable of stabilizing it) and not deleterious to the subject to be treated.
Oral administration of pyrimidine compounds of this invention reproducibly reduced the arthritic score and delayed the development of polyarthritis in a dose-dependent manner.
www.freepatentsonline.com /6958332.html   (4939 words)

  
 [No title]   (Site not responding. Last check: )
Both are dimeric enzymes that function in the salvage pathway to catalyse the reversible phosphorolysis of pyrimidine nucleosides to the free base and sugar moieties.
PyNP is typically the only pyrimidine nucleoside phosphorylase encoded by Gram positive bacteria, while eukaryotes and proteobacteria encode two: TP, and the unrelated uridine phosphorylase.
Pugmire M.J. Ealick S.E. The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.
www.ebi.ac.uk /interpro/IEntry?ac=IPR000053   (672 words)

  
 Inhibition of De Novo Pyrimidine Synthesis in Growing Potato Tubers Leads to a Compensatory Stimulation of the ...
Inhibition of De Novo Pyrimidine Synthesis in Growing Potato Tubers Leads to a Compensatory Stimulation of the Pyrimidine Salvage Pathway and a Subsequent Increase in Biosynthetic Performance(W) Pyrimidine nucleotides are of general importance for many aspects of cell function, but their role in the regulation of biosynthetic processes is still unclear.
This shift in the pathways of UMP synthesis was accompanied by increased levels of tuber uridine nucleotides, increased fluxes of [^sup 14^C]sucrose to starch and cell wall synthesis, and increased amounts of starch and cell wall components in the tubers, whereas there were no changes in uridine nucleotide levels in leaves.
UMPS is one of the key enzymes of de novo pyrimidine synthesis and is often regarded, both in mammalian and plant systems, as a key regulatory step of the pathway (Santoso and Thornburg, 1992; Traut and Jones, 1996).
www.redorbit.com /news/display/?id=192344&source=r_science   (7265 words)

  
 Kids.Net.Au - Encyclopedia > Pyrimidine   (Site not responding. Last check: )
Pyrimidine is an organic compound, similar to benzene, but with a heterocyclic ring: two nitrogen atoms taking the place of carbon atoms at positions 1 and 3 relative to each other around the six-member ring.
Three bases of the nucleic acids, namely cytosine, thymine, and uracil, are pyrimidine derivatives.
In DNA, these bases form hydrogen bonds with their complementary purines.
www.kids.net.au /encyclopedia-wiki/py/Pyrimidine   (134 words)

  
 Pyrimidine compounds patent invention
The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
[0001] The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
[0016] The present invention provides novel pyrimidine derivatives of formula (I) and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions containing these compounds or derivatives, and their use as CB2 receptor modulators, which are useful in the treatment of a variety of disorders.
www.freshpatents.com /Pyrimidine-compounds-dt20061102ptan20060247261.php   (1212 words)

  
 Extent of Genetic Lesions of the Arginine and Pyrimidine Biosynthetic Pathways in Lactobacillus plantarum, L. ...
Extent of Genetic Lesions of the Arginine and Pyrimidine Biosynthetic Pathways in Lactobacillus plantarum, L. paraplantarum, L. pentosus, and L. casei: Prevalence of CO2-Dependent Auxotrophs and Characterization of Deficient arg Genes in L. plantarum -- Bringel and Hubert 69 (5): 2674 -- Applied and Environmental Microbiology
Extent of Genetic Lesions of the Arginine and Pyrimidine Biosynthetic Pathways in Lactobacillus plantarum, L.
pyrimidines, the growth of 74 lactobacilli was CO dependent.
aem.asm.org /cgi/content/full/69/5/2674   (4694 words)

  
 Pyrimidine and purine metabolism
Nucleotides are derived from biosynthetic precursors of carbohydrate and amino acid metabolism, and from ammonia and carbon dioxide.
Pyrimidines are synthesized first from aspartate and carbamoyl-phosphate in the cytoplasm to the common precursor ring structure orotic acid (C00295), onto which a phosphorylated ribosyl unit is covalently linked.
While pyrimidine rings can be degraded completely to CO2 and NH3 (urea excretion), purine rings are degraded to the metabolically inert uric acid (C00366).
www.whatislife.com /reader2/Metabolism/pathway/nucleicacids.html   (1508 words)

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