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Topic: Pyruvate kinase

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ATP

Kinase

Protein kinase

Enzyme

DNA polymerase

	Pyruvate Kinase - Health Encyclopedia
		Pyruvate kinase is a blood test to detect abnormally low levels of pyruvate kinase (PK), an enzyme that helps convert glucose to energy when oxygen is low (termed anaerobic metabolism).
		A deficiency in pyruvate kinase is fairly rare, and this test helps your health care provider determine the cause of your anemia.
		The pyruvate kinase level is measured in relation to the amount of hemoglobin (a normal part of red blood cells) in the sample.
	www.nbc5.com /encyclopedia/6864351/detail.html (701 words)

	Pyruvate kinase - Wikipedia, the free encyclopedia
		Pyruvate kinase is an enzyme involved in glycolysis.
		Pyruvate kinase also serves as a regulatory enzyme for gluconeogenesis, a biochemical pathway in which the liver generates glucose from pyruvate and other substrates.
		When pyruvate kinase is inhibited by phosphorylation (which occurs in the fasting state, via glucagon), phosphoenolpyruvate is prevented from conversion to pyruvate.
	en.wikipedia.org /wiki/Pyruvate_kinase (376 words)

	Pyruvate Kinase Deficiency
		Pyruvate Kinase Deficiency is a hereditary blood disorder characterized by a deficiency of the enzyme pyruvate kinase.
		Pyruvate Kinase Deficiency is characterized by hemolytic anemia.
		Pyruvate Kinase Deficiency is a hereditary disorder, transmitted by autosomal recessive genes.
	hw.healthdialog.com /kbase/nord/nord465.htm (926 words)

	Pyruvate
		Pyruvate and pyruvic acid are frequently use interchangeably, even though pyruvate is the anion of pyruvic acid and the form that occurs in living organisms.
		Pyruvate serves as a biological fuel by being converted to acetyl coenzyme A, which enters the tricarboxylic acid or Krebs cycle where it is metabolized to produce ATP aerobically.
		Pyruvate is absorbed from the gastrointestinal tract from whence it is transported to the liver via the portal circulation.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/pyr_0218.shtml (1397 words)

	Pyruvate Kinase Deficiency \| AHealthyMe.com
		PKD is caused by a deficiency in the enzyme, pyruvate kinase.
		Since pyruvate kinase is one of the key components in glycolysis, when there is a problem with this enzyme in the red blood cells, there is a problem with the production of energy, causing the red blood cells not to function properly.
		The four isozymes of pyruvate kinase are labeled M1, M2, L, and R. The isozyme M1 is found in the skeletal muscle and brain, isozyme M2 can be found in most fetal and adult tissues, isozyme L works in the liver, and isozyme R works in the red blood cells.
	www.ahealthyme.com /topic/topic103549037 (1592 words)

	AllRefer Health - Pyruvate Kinase Deficiency
		Pyruvate kinase deficiency is an inherited deficiency of the enzyme pyruvate kinase, which is used by red blood cells.
		Pyruvate kinase deficiency is transmitted as an autosomal recessive trait, which means that a child must get the defective gene from both parents to develop the disorder.
		Although pyruvate kinase deficiency is found in people of all ethnic backgrounds, certain populations, such as the Amish, have a somewhat higher incidence.
	health.allrefer.com /health/pyruvate-kinase-deficiency-info.html (395 words)

	eMedicine - Pyruvate Kinase Deficiency : Article by Richard E Frye
		Pyruvate kinase deficiency (PKD) is one of the most common enzymatic defects of the erythrocyte.
		Carey PJ, Chandler J, Hendrick A, et al. Prevalence of pyruvate kinase deficiency in northern European population in the north of England.
		Mentzer WC. Pyruvate Kinase Deficiency and Disorders of Glycolysis.
	www.emedicine.com /med/topic1980.htm (2828 words)

	Background on Pyruvate Kinase (Site not responding. Last check: 2007-11-03)
		Pyruvate kinase is a key enzyme in glycolysis.
		The reduced energy is probably the cause of poor maintenance of cellular integrity which accounts for the diminished life span of affected erythrocytes in severe PK deficiency.
		Pyruvate kinase deficiency of the red cell is transmitted as an autosomal recessive trait.
	www.hscbklyn.edu /SUNY/Biochem/BioModules/PyKin_Bkgnd.html (236 words)

	Lecture 18-19 Answers
		The reactions in question are phosphoenolpyruvate being converted into pyruvate (pyruvate kinase) and the pyruvate being converted into oxaloacetate (pyruvate carboxylase) and then into phosphoenolpyruvate (phosphoenolpyruvte carboxylase).
		ATP is especially important in blocking the activity of phosphofructokinase 1 and in inhibiting pyruvate kinase.
		This protein kinase, activated by the action of glucagon, also acts on the enzyme that forms fructose 2,6-bis phosphate and also on the enzyme that destroys this effector compound - the fructose 2,6-bis phosphate phosphatase.
	www.uic.edu /depts/mcam/mcbc/531leq1819ans.html (2039 words)

	Glycolysis--The Details
		Under anaerobic conditions, pyruvate is converted to lactate or ethanol depending on the organism.
		Pyruvate kinase is also controlled by a covalent modification, phosphorylation.
		The phosphorylation/dephosphorylation control of pyruvate kinase prevents the liver from using glucose when it is needed by these other tissues.
	www.db.uth.tmc.edu /faculty/alevine/1521_2000/glydetail.htm (1447 words)

	ENLmedical.com: Conditions And Concerns: Medical Encyclopedia: Pyruvate kinase deficiency
		Pyruvate kinase deficiency is transmitted as an autosomal recessive trait.
		However, pyruvate kinase deficiency is important because it is the second most common cause (G-6-PD, glucose-6-phosphatase dehydrogenase is number one) of enzymatic-related hemolytic anemia.
		Although pyruvate kinase deficiency is universal; certain populations, such as the Amish, have a somewhat higher incidence.
	www.enlmedical.com /article/001197.htm (290 words)

	Recombinant Human Tumour Type M2 Pyruvate Kinase - PKA-326
		Pyruvate kinase is a key enzyme in the glycolytic pathway.
		The M2 isoenzyme of pyruvate kinase is specifically expressed at high levels in tumour cells, and can be measured in plasma of patients with advanced breast cancer.
		Identification of pyruvate kinase as an antigen associated with Tourette syndrome.
	www.prospec.co.il /~prospec/cart/catalog/rHuPKM2.html (311 words)

	Pyruvat Kinase (PK) Defiency - med0072 (Site not responding. Last check: 2007-11-03)
		Pyruvate Kinase Deficiency, also known as erythrocyte pyruvate kinase deficiency, is a syndrome of hemolytic anemia.
		Pyruvate Kinase (PK) is a regulatory enzyme found within red blood cells.
		Most cases of pyruvate kinase deficiency die between the ages of one to four years, due to progressive anemia or liver failure.
	www.barkbytes.com /medical/med0072.htm (235 words)

	MedlinePlus Medical Encyclopedia: Pyruvate kinase deficiency
		Pyruvate kinase deficiency is the second most common cause, followingG-6-PD deficiency.
		Pyruvate kinase deficiency may produce mild or severe hemolysis (red cell breakdown) and anemia.
		Genetic counseling is of value to prospective parents with a family history of pyruvate kinase deficiency.
	www.nlm.nih.gov /medlineplus/ency/article/001197.htm (582 words)

	The TCA Cycle
		During the course of the reaction the acetyl group derived from decarboxylation of pyruvate is bound to TPP.
		The activity of the kinase is enhanced when cellular energy charge is high which is reflected by an increase in the level of ATP, NADH and acetyl-CoA.
		The pyruvate dehydrogenase activities of the PDH complex are regulated by their state of phosphorylation.
	web.indstate.edu /thcme/mwking/tca-cycle.html (2336 words)

	Pyruvate Kinase Deficiency
		It is possible that the main title of the report Pyruvate Kinase Deficiency is not the name you expected.
		Red cell pyruvate kinase deficiency is a hereditary blood disorder characterized by a deficiency of the enzyme pyruvate kinase.
		Pyruvate kinase deficiency is inherited as an autosomal recessive genetic trait.
	www.webmd.com /hw/health_guide_atoz/nord465.asp (441 words)

	Pyruvate kinase (Test)... Fort Lauderdale, Florida
		Pyruvate kinase (PK) is an enzyme that helps in the conversion of glucose to energy when there is not adequate oxygen (termed anaerobicmetabolism).
		This test determines whether there is an abnormally low level of the pyruvate kinase enzyme.
		The Pyruvate kinase level is measured in relation to the amount of hemoglobin (a normal constituent of red blood cells) in the sample.
	www.browardhealth.org /18166.cfm (592 words)

	ENLmedical.com: Conditions And Concerns: Medical Encyclopedia
		In the laboratory white blood cells are removed, since they can alter test results, and the level of pyruvate kinase is analyzed.
		A deficiency in pyruvate kinase is fairly rare, and this test helps your health care provider differentiate the cause of your anemia.
		Pyruvate kinase level results can range from 2 to 8.8 U/g of hemoglobin.
	www.enlmedical.com /article/003357.htm (343 words)

	Pyruvate Kinase Deficiency - Patient UK
		Pyruvate Kinase Deficiency - Patient UK PatientPlus articles are written for doctors and so the language can be technical.
		Pyruvate kinase deficiency is one of the most common enzyme defects of the erythrocyte.
		Carey PJ et al; Prevalence of pyruvate kinase deficiency in a northern European population in the north of England.
	www.patient.co.uk /showdoc/40001770 (927 words)

	Product :: 151999 PYRUVATE KINASE
		Betts, G. and Evans, H., "The effect of cations on the electrophoretic mobility and substrate binding properties of pyruvate kinase." Biochim.
		Holmsen, H. and Storm, E., "The adenosine triphosphate inhibition of the pyruvate kinase reaction and its dependence on the total magnesium ion concentration." Biochem.
		Melamud, E. and Mildvan, A., "Magnetic resonance studies of the interaction of Co2+ and phosphoenolpyruvate with pyruvate kinase." J.
	www.mpbio.com /product_info.php?products_id=151999 (713 words)

	Westie Health Concerns - Pyruvate Kinase (PK) Deficiency
		Description: Pyruvate Kinase deficiency (synonym: erythrocyte pyruvate kinase deficiency) in red blood cells (erythrocytes) causes a severe hemolytic (red cell rupture) anemia as a result of the premature destruction of PK deficient red blood cells.
		PK is a key regulatory enzyme in a metabolic pathway that generates almost all energy from glucose (sugar) in red blood cells.
		Pyruvate Kinase (PK) is an enzyme in glycolysis which is essential for the metabolism of glucose into an energy source utilized by cells such as red blood cells.
	www.westieclubamerica.com /health/pk.html (881 words)

	Kinase - Wikipedia, the free encyclopedia
		In biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules (substrates); the process is termed phosphorylation.
		In some settings, the purpose of phosphorylation is to "activate" or "energize" a molecule, increasing its energy so it is able to participate in a subsequent reaction with a negative free-energy change.
		The largest group of kinases are Protein kinases, which act on and modify the activity of specific proteins.
	en.wikipedia.org /wiki/Kinase (349 words)

	Stoddard Lab: Pyruvate Kinase and Allostery (Site not responding. Last check: 2007-11-03)
		The activation of regulated isozymes of pyruvate kinase (PK) by fructose-1,6-bis-phosphate (FBP) directly influences cytosolic levels of ATP and GTP and the flux of glycolytic carbon into fermentation pathways and the Krebs cycle.
		This pattern of regulation affects cell cycle progression, as demonstrated by the re-expression of an allosterically regulated, fetal isozyme of PK in tumor cells, and also by the effect of mutations in yeast that interfere with the regulation of PK.
		We have determined the structure of allosterically regulated pyruvate kinase from Saccharomyces cerevisia complexed with phosphoglycolate (a substrate analogue), Mn2+, and K+ in the presence and absence of FBP.
	www.fhcrc.org /labs/stoddard/pk_index.html (355 words)

	Worthington Pyruvate Kinase
		Pyruvate kinase (PK) is a key enzyme in glycogen metabolism.
		The pyruvate kinase most readily obtainable and hence most widely studied, is that from rabbit muscle.
		P NMR Quantitation of the Displacement of Equilibria of Arginine, Creatine, Pyruvate, and 3-P-Glycerate Kinase Reactions by Substitution of Sulfur for Oxygen in the beta Phosphate of ATP, J Biol Chem 255, 8756, 1980
	www.worthington-biochem.com /pkl/default.html (3276 words)

	VetGen, Basenji Pyruvate Kinase deficiency (Site not responding. Last check: 2007-11-03)
		For further information about the OFA's registry for Pyruvate Kinase deficiency in Basenjis, contact: Orthopedic Foundation for Animals, 2300 E. Nifong Boulevard, Columbia, MO 65201-3856, or telephone (573) 442-0418.
		Pyruvate kinase deficiency in Basenji dogs is an inherited lack of an enzyme (pyruvate kinase) in the red blood cells of an affected animal.
		This enzyme is required for red blood cells to survive for a normal length of time in the blood of the animal, and when it is missing, the red blood cells break down and are destroyed prematurely.
	www.vetgen.com /basenji.html (643 words)

	In Vivo and in Vitro Phosphorylation of Two Isoforms of Yeast Pyruvate Kinase by Protein Kinase A -- Portela et al. 277 ...
		Saccharomyces cerevisiae pyruvate kinase 1 (Pyk1) was demonstrated to be associated to an immunoprecipitate of yeast protein
		Panel B shows the pyruvate kinase activities and kinetic parameters derived from the experiments in Panel A.
		Pyruvate kinase catalyzes the final step in glycolysis, producing the second of two ATP molecules generated in the glycolytic
	www.jbc.org /cgi/content/full/277/34/30477 (6941 words)

	Pyruvate Kinase Deficiency Support Group
		Pyruvate Kinase Deficiency by Hassan M Yaish, MD
		Pyruvate Kinase Deficiency by Richard E Frye,MD, PhD
		All messages to Pyruvate Kinase Deficiecy Support Group will be screened by managers due to a high volumn of junk mail.
	groups.msn.com /PyruvateKinaseDeficiencySupportGroup/_whatsnew.msnw (258 words)

	Erythrocyte pyruvate kinase (PK) deficiency in Abyssinian and Somali cats causing intermittent anemia (Site not responding. Last check: 2007-11-03)
		Although acquired conditions such as infections, immune disorders, intoxications, blood loss and chronic organ failures represent the main causes of anemia, hereditary blood diseases leading to anemia are also important in clinical practice.
		Several hereditary erythrocyte defects have been reported in cats and a molecular basis of the erythrocyte pyruvate kinase defect has recently been determined.
		Pyruvate kinase is a key regulatory enzyme in the metabolism of sugar.
	www.abyssinianbc.org /PKDef_ursgeiger.htm (568 words)

	Medical Dictionary: Pyruvate kinase deficiency - WrongDiagnosis.com
		Pyruvate kinase deficiency : autosomal recessive deficiency of the erythrocytic isozyme of pyruvate kinase, the most common glycolytic enzyme defect in the Embden\-Meyerhof pathway; deficient product (ATP) causes chronic hemolytic anemia of widely variable severity.
		They list Pyruvate kinase deficiency as a "rare disease".
		Other terms that may be related to Pyruvate kinase deficiency:
	www.wrongdiagnosis.com /medical/pyruvate_kinase_deficiency.htm (260 words)

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