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Mackay Homepage QTL methods will prove to be important tools for gene discovery and analysis in this post-genomic era, in which we need to assess the subtle functional effects of variation at loci that have been identified by whole genome sequencing, but whose functions are unknown. Further, the nature of genetic variation for quantitative traits is expected to differ depending on the relationship of the trait to fitness. We are using linkage disequilibrium, or association, between nucleotide and insertion/deletion polymorphisms at candidate genes with quantitative phenotypes in random breeding populations to assess the contribution of candidate genes to phenotypic variation, and to identify the causal QTN. www.cals.ncsu.edu /genetics/mackay/mackay.html   (2229 words)

Quantitative trait locus - Wikipedia, the free encyclopedia Inheritance of quantitative traits refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to the interactions between two or more genes and their environment (also called Polygenic inheritance). QTL mapping is the statistical study of the alleles which occur in a locus and the phenotypes (physical forms or traits) that they produce. QTLs identify a particular region of the genome as containing a gene that is associated with the trait being assayed or measured. en.wikipedia.org /wiki/Quantitative_trait_locus   (1108 words)

Congruency of Quantitative Trait Loci Detected for Agronomic Traits in Testcrosses of Five Populations of European ... Quantitative trait loci for plant height in four maize populations and their associations with qualitative genetic loci. Estimation of the contribution of quantitative trait loci (QTL) to the variance of a quantitative trait by means of genetic markers. Quantitative trait locus (QTL) mapping using different testers and independent population samples in maize reveals low power of QTL detection and large bias in estimates of QTL effects. crop.scijournals.org /cgi/content/full/44/1/114   (5859 words)

Mapping Quantitative Trait Loci   (Site not responding. Last check: 2007-10-28) These types of traits are called continuous traits and cannot be analyzed in the same manner as discontinuous traits. Because continuous traits are often given a quantitative value, they are often referred to as quantitative traits, and the area of genetics that studies their mode of inheritance is called quantitative genetics. Because many important agricultural traits such as crop yield, weight gain in animals, fat content of meat are quantitative traits, much of the pioneering research into the modes of inheritance of these traits was performed by agricultural geneticists. www.ndsu.nodak.edu /instruct/mcclean/plsc731/quant/quant1.htm   (343 words)

Zhao-Bang Zeng This includes research on developing theoretical models and statistical methods to map quantitative trait loci (QTL) and to estimate basic genetic parameters of quantitative trait variation, such as number, genomic positions, effects, interaction, and pleiotropy of genes responsible for the variation. Currently, this research is mostly concentrated on developing statistical methods for analyzing genetic architecture of quantitative traits as a whole using multiple interval mapping approach. The long-term goal of the research is to develop quantitative genetic theories and statistical methods for characterizing and analyzing variation of quantitative traits and to learn genetic and evolutionary bases of the variation within and between natural and experimental populations. statgen.ncsu.edu /zeng/zeng.html   (688 words)

BioMed Central | Full text | Linkage disequilibrium interval mapping of quantitative trait loci However, QTL mapping remains a statistical challenge due to the weak phenotype-genotype correlation and the influence of environmental or multigene factors. We consider a single quantitative trait whose value is partly controlled by a biallelic locus with alleles Q and q. The QTL was in the middle of the chromosome region. www.biomedcentral.com /1471-2164/7/54   (8074 words)

Mapping Quantitative Trait Loci Affecting Dairy Conformation to Chromosome 27 in Two Holstein Grandsire Families -- Van ... the magnitude of QTL for DF on this chromosome. F-statistics, degrees of freedom (df), approximate likelihood ratio (LR) test statistics, estimates of marker effects for dairy conformation and production traits at the location on the chromosome where each trait was most significant in family 8 and where dairy conformation test statistic was maximized (74 cM), fitting one QTL in the model. Quantitative trait loci affecting growth and carcass composition of cattle segregating alternate forms of myostatin. www.dairy-science.org /cgi/content/full/87/2/450   (3505 words)

QTL (Quantitative Trait Loci) Linkage between loci of quantitative traits and marker loci: multi-trait analysis with single marker. The efficiency of experimental designs for the detection of linkage between a marker locus and a locus affecting a quantitative trait loci in segregating populations. Application of a canonical transformation to detection of quantitative trait loci with the aid of genetic markers in a multi-trait experiment. www.inra.fr /Internet/Departements/MIA/T/schiex/Genome/node32.html   (475 words)

Quantitative Trait Loci: A Meta-analysis -- Goffinet and Gerber 155 (1): 463 -- Genetics Quantitative Trait Loci: A Meta-analysis -- Goffinet and Gerber 155 (1): 463 -- Genetics QTL effect is different from one male to the other. QTL related to yield on linkage group 3 of the maize genome. www.genetics.org /cgi/content/full/155/1/463   (3728 words)

Mapping Quantitative Trait Loci   (Site not responding. Last check: 2007-10-28) Mapping markers linked to QTLs identifies regions of the genome that may contain genes involved in the expression of the quantitative trait. The authors further were able to demonstrate that a number of the QTLs identified by the molecular markers mapped to regions containing genes known to have a qualitative effect on plant height. Molecular analysis of quantitative traits now provides new tools, not only as selection tools for plant breeding, but as starting points for the cloning of these genes. www.ndsu.nodak.edu /instruct/mcclean/plsc731/quant/quant4.htm   (471 words)

Mapping quantitative trait loci in humans: achievements and limitations -- Majumder and Ghosh 115 (6): 1419 -- Journal ... loci (multipoint estimate) on a chromosome (24, 25). QTL are very skewed, efforts in mapping the QTL may be unsuccessful. Doerge, R.W. Mapping and analysis of quantitative trait loci in experimental populations. www.jci.org /cgi/content/full/115/6/1419   (4348 words)

Quantitative Trait Loci (QTL) References Doerge RW (2002) Mapping and analysis of quantitative trait loci in experimental populations. Luo ZW, Kearsey MJ (1992) Interval mapping of quantitative trait loci in an F2 population. Mackay TFC (2001b) Quantitative trait loci in Drosophila. www.stat.wisc.edu /~yandell/statgen/reference/qtl.html   (6456 words)

Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains -- Grisel et al. 17 ... Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains -- Grisel et al. Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains Belknap JK, Dubay C, Crabbe JC, Buck KJ (1996b) Mapping quantitative trait loci for behavioral traits in the mouse. www.jneurosci.org /cgi/content/full/17/2/745   (6345 words)

Precision Mapping of Quantitative Trait Loci -- Zeng 136 (4): 1457 -- Genetics QTLs is increased, and the precision of QTL mapping can be improved. Quantitative Trait Loci for Locomotor Behavior in Drosophila melanogaster Quantitative Trait Loci Affecting Life Span in Replicated Populations of Drosophila melanogaster. www.genetics.org /cgi/content/abstract/136/4/1457   (2608 words)

Dienekes' Anthropology Blog: Quantitative trait loci for intelligence The ingredients themselves (e.g., salt, lettuce, or chicken) are themselves unremarkable, but it is the way that they are put together and turned on and off by internal and external stimuli (the pot, the temperature, time, etc.) that makes a good dish. Progress towards identifying quantitative trait loci (QTLs) for complex traits like intelligence and common disorders like mental retardation has been slower than expected. An important factor is that most QTL effects may be much smaller than expected—not just 1% effect sizes but perhaps effects as small as.1%. dienekes.blogspot.com /2006/02/quantitative-trait-loci-for.html   (417 words)

STAT 610: Quantitative Trait Loci: Course Page: NCSU Libraries Sources of information are as recent as possible and include information on statistical methods used for genetic linkage map construction, mapping quantitative trait loci, quantitative genetic markers, molecular marker data, and related topics. Quantitative trait locus mapping using near-isogenic lines of maize Scholarly articles on all aspects of quantitative trait loci are found in dozens of journals. www.lib.ncsu.edu /courses/stat610   (445 words)

Quantitative Trait Loci Associated with Milling and Baking Quality in a Soft Hard Wheat Cross -- Campbell et al. 41 ... QTLs were not detected in Environment 2 (Table 1). Quantitative trait loci associated with kernel traits in a soft by hard wheat cross. Quantitative trait loci for flour viscosity in winter wheat. crop.scijournals.org /cgi/content/full/41/4/1275   (5152 words)

Medical Dictionary: Quantitative trait loci - WrongDiagnosis.com Quantitative trait loci : chromosome site containing alleles that influence a continuously distributed or quantitative trait. Other terms that may be related to Quantitative trait loci: The description of Quantitative trait loci may also be used for the following terms: www.wrongdiagnosis.com /medical/quantitative_trait_loci.htm   (195 words)

Announcing the Journal of Quantitative Trait Loci Columbia, MO The Journal of Quantitative Trait Loci (JQTL), sponsored by the Crop Science Society of America (CSSA), will provide a peer-reviewed, fully electronic forum in which articles dealing with the theory and practice of QTL analysis will be published. We are defining quantitative characters as those for which the phenotypic variation among genotypes is continuous and cannot be separated into discrete classes. This definition of QTL makes no assumptions regarding thenumber of genes controlling such characters, nor the magnitude of genetic effects. www.nal.usda.gov /pgdic/Probe/v5n2/jqtl.html   (888 words)

Mixed model analysis of quantitative trait loci -- Xu and Yi 97 (26): 14542 -- Proceedings of the National Academy of ... Mixed model analysis of quantitative trait loci -- Xu and Yi 97 (26): 14542 -- Proceedings of the National Academy of Sciences We develop a mixed model approach of quantitative trait locus (QTL) mapping for a hybrid population derived from the crosses of the QTL parameters is obtained by using the Bayesian method www.pnas.org /cgi/content/abstract/97/26/14542   (359 words)

CiteULike: Tag loci   (Site not responding. Last check: 2007-10-28) Single nucleotide polymorphism (SNP) analysis of mouse quantitative trait loci for identification of candidate genes. Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. www.citeulike.org /tag/loci   (153 words)

www.QTL.com: QTL (quantitative trait loci) discussion forum :: Index   (Site not responding. Last check: 2007-10-28) www.QTL.com: QTL (quantitative trait loci) discussion forum :: Index www.QTL.com: QTL (quantitative trait loci) discussion forum Forum Index The 3rd International Conference of Quantitative Genetics Zhejiang University, Hangzhou, China August 18-24, 2007 www.qtl.com   (129 words)

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