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Topic: Quantitative trait locus


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In the News (Mon 19 Aug 19)

  
  Quantitative trait locus Summary
A quantitative trait locus (QTL) is a region of DNA that is associated with a particular phenotypic trait (e.g., plant height).
QTL mapping is the statistical study of the alleles which occur in a locus and the phenotypes (physical forms or traits) that they produce.
QTLs identify a particular region of the genome as containing a gene that is associated with the trait being assayed or measured.
www.bookrags.com /Quantitative_trait_locus   (2310 words)

  
 Quantitative trait locus - Wikipedia, the free encyclopedia
Inheritance of quantitative traits refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to the interactions between two or more genes and their environment (also called Polygenic inheritance).
Statistical research suggested that for quantitative traits the offspring of a cross tended to be intermediate in appearance between the two parents.
A quantitative trait locus (QTL) is a region of DNA that is associated with a particular phenotypic trait - these QTLs are often found on different chromosomes.
en.wikipedia.org /wiki/Quantitative_trait_locus   (1095 words)

  
 Mapping Quantitative Trait Loci   (Site not responding. Last check: 2007-09-10)
From this information it was then possible to estimate the heritability of the trait and predict the response of the trait to selection.
Mapping markers linked to QTLs identifies regions of the genome that may contain genes involved in the expression of the quantitative trait.
The authors further were able to demonstrate that a number of the QTLs identified by the molecular markers mapped to regions containing genes known to have a qualitative effect on plant height.
www.ndsu.nodak.edu /instruct/mcclean/plsc731/quant/quant4.htm   (471 words)

  
 Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with ...   (Site not responding. Last check: 2007-09-10)
Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q -- Wallace et al.
Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q
In conclusion, the characterization of the locus Nidd/gk2 in
physiolgenomics.physiology.org /cgi/content/full/19/1/1   (5361 words)

  
 BioMed Central | Full text | Assessing the power of tag SNPs in the mapping of quantitative trait loci (QTL) with ...   (Site not responding. Last check: 2007-09-10)
For each set of haplotypes, we chose a marker locus as the candidate trait locus if it satisfied two conditions: (1) the frequency of the minor allele is in a designated range, and (2) the position of the trait locus is between 0.40 and 0.60.
In addition, the trait locus is not one of the marker loci used in mapping and is away at least 0.005 from the closest marker locus.
For the family samples in extremal sampling, we chose 125 individuals with trait values in the top 20% of the population distribution of the trait values together with their parents and 125 individuals with trait values in the lower 20% of the population distribution of the trait values together with their parents.
www.biomedcentral.com /1471-2156/6/51   (7121 words)

  
 Quantitative Trait Locus Analysis Alcohol Research & Health - Find Articles
One such strategy uses congenic strains--mice in which a particular region of DNA (e.g., a QTL) from one strain is transferred (i.e., introgressed) into the genome of another strain, followed again by inbreeding (for a more detailed description of this process, see Crabbe et al.
Despite its limitations, QTL mapping is a powerful method for widespread analyses of the genetic influences underlying quantitative traits, such as those contributing to alcoholism.
QTL mapping in animals provides a valuable, though preliminary, contribution to the search for genes contributing to human alcoholism.
www.findarticles.com /p/articles/mi_m0CXH/is_3_24/ai_71560024/pg_5   (593 words)

  
 The Individualist: Quantitative trait locus analysis
A quantitative trait locus (QTL) is a region of DNA that is associated with a particular trait (e.g., plant height).
Genes may be on the same or different chromosomes and each gene may have two or more alleles.Once a region of DNA is identified as contributing to a phenotype, it can be sequenced.
A candidate gene is a gene, located in a chromosome region suspected of being involved in the expression of a trait such as a disease, whose protein product suggests that it could be the gene in question.
www.dadamo.com /wiki/wiki.pl/Quantitative_trait_locus_analysis   (910 words)

  
 Quantitative trait locus detection in commercial broiler lines using candidate regions -- de Koning et al. 81 (5): 1158 ...   (Site not responding. Last check: 2007-09-10)
Quantitative trait locus detection in commercial broiler lines using candidate regions -- de Koning et al.
Fine mapping of a quantitative trait locus for twinning rate using combined linkage and linkage disequilibrium mapping.
Mapping of Quantitative Trait Loci (QTL) for body weight at 3, 6, and 9 weeks of age in a broiler layer cross.
jas.fass.org /cgi/content/full/81/5/1158   (4159 words)

  
 BioMed Central | Full text | Linkage disequilibrium interval mapping of quantitative trait loci   (Site not responding. Last check: 2007-09-10)
However, QTL mapping remains a statistical challenge due to the weak phenotype-genotype correlation and the influence of environmental or multigene factors.
We consider a single quantitative trait whose value is partly controlled by a biallelic locus with alleles Q and q.
The QTL was in the middle of the chromosome region.
www.biomedcentral.com /1471-2164/7/54   (8074 words)

  
 Pyramiding Quantitative Trait Locus (QTL) Alleles Determining Resistance to Barley Stripe Rust: Effects on Resistance ...   (Site not responding. Last check: 2007-09-10)
Also shown are QTL and QTL and isolate main and interaction effects for the combined analysis of all isolates.
Quantitative trait locus (QTL) mapping using different testers and independent population samples in maize reveals low power of QTL detection and large bias in estimates of QTL effects.
Detection of quantitative trait loci for agronomic, yield, grain and disease characters in spring barley (Hordeum vulgare L.).
crop.scijournals.org /cgi/content/full/43/2/651   (5118 words)

  
 quantitative trait locus
A locus where allelic variation is associated with variation in a quantitative trait.
The presence of a QTL is inferred from genetic mapping, where the total variation is partitioned into components linked to a number of discrete chromosome regions.(From Glossary of Biotechnology for Food and Agriculture)
The latter group used a technique called quantitative trait locus analyses.
www.mongabay.com /igapo/biotech/quantitative_trait_locus.html   (80 words)

  
 Trait (biology) - Wikipedia, the free encyclopedia
The term phenotype is sometimes used as a synonym for trait in common use, but strictly speaking, does not indicate the trait, but the state of that trait (e.g., the trait eye color has the phenotypes blue, brown and hazel).
An important reference point along this string is the centromere; the distance from a gene to the centromere is referred to as the gene's locus or map location.
A chromosomal region known to control a trait while the responsible gene within not being identified is referred to as a quantitative trait locus.
en.wikipedia.org /wiki/Trait_(biological)   (629 words)

  
 Mapping Quantitative Trait Loci   (Site not responding. Last check: 2007-09-10)
These types of traits are called continuous traits and cannot be analyzed in the same manner as discontinuous traits.
Because continuous traits are often given a quantitative value, they are often referred to as quantitative traits, and the area of genetics that studies their mode of inheritance is called quantitative genetics.
Because many important agricultural traits such as crop yield, weight gain in animals, fat content of meat are quantitative traits, much of the pioneering research into the modes of inheritance of these traits was performed by agricultural geneticists.
www.ndsu.nodak.edu /instruct/mcclean/plsc731/quant/quant1.htm   (343 words)

  
 Semiparametric Quantitative-Trait-Locus Mapping: I. on Functional Growth Curves
The genetic study of certain quantitative traits in growth curves as a function of time has recently been of major scientific interest to explore the developmental evolution processes of biological subjects.
In this article, we view the growth curves as functional quantitative traits and propose some semiparametric models to relax the strong parametric assumptions which may not be always practical in reality.
Appropriate inference procedures are developed to estimate the parameters of interest which characterise the possible QTLs of the growth curves in the models.
www.bepress.com /ucbbiostat/paper151   (266 words)

  
 RatMap: The Rat Genome Database. Locus Detail   (Site not responding. Last check: 2007-09-10)
Laes, J.F., et al., Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response, Cytogenetics and Cell Genetics, 92:130-133, 2001.
Deng, A. Y., et al., Congeneic strains for the blood pressure quantitative trait locus on rat chromosome 2.
Deng, A. Y., et al., Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
ratmap.gen.gu.se /ShowSingleLocus.htm?accno=34211   (146 words)

  
 Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane ...   (Site not responding. Last check: 2007-09-10)
Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition -- Blott et al.
Molecular Dissection of a Quantitative Trait Locus: A Phenylalanine-to-Tyrosine Substitution in the Transmembrane Domain of the Bovine Growth Hormone Receptor Is Associated With a Major Effect on Milk Yield and Composition
Estimation of genetic parameters for quantitative trait Loci for dairy traits in the French holstein population.
www.genetics.org /cgi/content/abstract/163/1/253   (1117 words)

  
 Characterization of a Major X-Linked Quantitative Trait Locus Influencing Body Weight of Mice -- Liu et al. 92 (4): 355 ...   (Site not responding. Last check: 2007-09-10)
Key to traits: hea, spl, kid, liv, eca: weights of heart, spleen, kidneys, liver, and empty carcass, respectively, at 10 weeks of age; tfi: total food intake; fig: food intake per gram gain; fid: food intake per day.
High resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing.
Mapping quantitative trait loci for body weight on the X chromosome in mice.
jhered.oxfordjournals.org /cgi/content/full/92/4/355   (1872 words)

  
 The Non-MHC Quantitative Trait Locus Cia5 Contains Three Major Arthritis Genes That Differentially Regulate Disease ...   (Site not responding. Last check: 2007-09-10)
Localization of quantitative trait loci regulating adjuvant induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.
Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats.
Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis susceptibility loci.
www.jimmunol.org /cgi/content/full/174/12/7894   (7109 words)

  
 Quantitative Trait Locus Analysis of Longitudinal Quantitative Trait Data in Complex Pedigrees -- Macgregor et al. 171 ...   (Site not responding. Last check: 2007-09-10)
Quantitative Trait Locus Analysis of Longitudinal Quantitative Trait Data in Complex Pedigrees -- Macgregor et al.
QTL correlations across multiple measures are 1 and that their
QTL variance is 0.33 with when it is 0.4, see Tables 4 and 5)
www.genetics.org /cgi/content/full/171/3/1365   (6640 words)

  
 Quantitative Trait Locus Mapping of Loci Influencing Elongation Factor 1{alpha} Content in Maize Endosperm -- Wang et ...   (Site not responding. Last check: 2007-09-10)
QTL near the centromere of chromosome 7 is near the locus encoding
One value of QTL mapping is the potential to identify genes responsible for a trait of interest.
Darvasi A, Soller M (1992) Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus.
www.plantphysiol.org /cgi/content/full/125/3/1271   (6547 words)

  
 R/qtl software for mapping quantitative trait loci
R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in experimental crosses.
Our goal is to make complex QTL mapping methods widely accessible and allow users to focus on modeling rather than computing.
A key component of computational methods for QTL mapping is the hidden Markov model (HMM) technology for dealing with missing genotype data.
www.rqtl.org   (586 words)

  
 Quantitative Genetics
For each individual, the measurement of one phenotypic trait and the measurement of a second phenotypic trait.
For each phenotypic category, the measurement of one phenotypic trait and the measurement of a second phenotypic trait.
Describe a possible experiment for estimating the environmental variance of a quantitative trait.
web.nmsu.edu /~brook/courses/genetics/questions/node6.html   (153 words)

  
 Analysis of a Quantitative Trait Locus Allele from Wild Soybean That Increases Seed Protein Concentration in Soybean -- ...   (Site not responding. Last check: 2007-09-10)
Analysis of a Quantitative Trait Locus Allele from Wild Soybean That Increases Seed Protein Concentration in Soybean -- Sebolt et al.
QTL allele on LG I were associated with an increase in protein
the population for all seed and agronomic traits.
crop.scijournals.org /cgi/content/full/40/5/1438   (3450 words)

  
 Steinmetz et al. QTLs in yeast
The failures are thought to be due to the different contributions of many underlying genes to the phenotype and the ability of different combinations of genes and environmental factors to produce similar phenotypes.
Functional linkages both in cis and in trans were found between three tightly linked quantitative trait genes that are neither necessary nor sufficient in isolation.
It also demonstrates a deficiency in current approaches to QTL dissection with implications extending to traits in other organisms, including human genetic diseases.
www-sequence.stanford.edu /nature_web_page/mainpage.html   (205 words)

  
 IngentaConnect Quantitative-trait-locus Mapping in the Presence of Locus Heterog...   (Site not responding. Last check: 2007-09-10)
IngentaConnect Quantitative-trait-locus Mapping in the Presence of Locus Heterog...
Locus heterogeneity is a concern for quantitative trait locus mapping where phenotypes are likely to be influenced by more than one gene.
We introduce a model which generalizes the locus heterogeneity model of Smith (1961) from dichotomous traits to quantitative traits and consider some test statistics for this model.
www.ingentaconnect.com /content/bsc/ahg/2006/00000070/00000006/art00020   (174 words)

  
 Successful Isolation of a Rat Chromosome 1 Blood Pressure Quantitative Trait Locus in Reciprocal Congenic Strains -- ...   (Site not responding. Last check: 2007-09-10)
Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.
Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.
Quantitative trait loci in genetically hypertensive rats: possible sex specificity.
hyper.ahajournals.org /cgi/content/full/32/4/639   (5510 words)

  
 Protein C Levels Are Regulated by a Quantitative Trait Locus on Chromosome 16: Results from the Genetic Analysis of ...   (Site not responding. Last check: 2007-09-10)
Protein C Levels Are Regulated by a Quantitative Trait Locus on Chromosome 16: Results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) Project -- Buil et al.
Protein C Levels Are Regulated by a Quantitative Trait Locus on Chromosome 16
This locus is likely the NQO1 gene that influences PC levels.
atvb.ahajournals.org /cgi/content/abstract/24/7/1321   (362 words)

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