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Topic: Quetiapine

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	Pharmacy Update, September / October 1999 (Site not responding. Last check: 2007-10-11)
		Quetiapine was initiated at a dose of 25 mg TID and titrated upward until an adequate therapeutic effect was achieved (maximum dose 750 mg/day).
		Quetiapine was associated with low rates of EPS, approximately 4 to 8 percent (compared to 10 percent placebo and 29 percent haloperidol).
		Quetiapine is the newest psychotropic agent to join the class of atypical antipsychotics which include clozapine, risperidone, and olanzapine.
	www.cc.nih.gov /phar/updates/99sept-oct.html (2245 words)

	Quetiapine - a novel antipsychotic manufactured by Zeneca
		Quetiapine’s general efficacy and side effect profile suggest that, unless there are unforeseen post-marketing complications, quetiapine deserves a major place in the initial and long term management of schizophreniform disorders.
		Quetiapine is totally devoid of D4 activity, (Schotte et al, 1996).
		Quetiapine was not associated with an increase in serum prolactin supporting the preclinical profile of quetiapine as an atypical antipsychotic agent.
	www.priory.com /focus4.htm (2969 words)

	NAMI \| Seroquel (quetiapine)
		Quetiapine is used to treat schizophrenia and acute manic episodes of bipolar disorder, and is manufactured by AstraZeneca Pharmaceuticals.
		Quetiapine is effective in the treatment of both positive (e.g., delusions, thought disorder, and hallucinations) and negative (e.g., social withdrawal, lack of energy, apathy, and reduced ability to express emotion) symptoms of schizophrenia.
		Quetiapine is also effective in the treatment of symptoms that occur in the manic phase of bipolar disorder (e.g., elevated mood, increased physical activity and pressured speech).
	www.nami.org /Template.cfm?Section=About_Medications&template=/ContentManagement/ContentDisplay.cfm&ContentID=8190 (1765 words)

	Seroquel quetiapine
		Quetiapine was assayed in biological specimens by basic extraction with n-butyl chloride and derivatized with 50 microL of MTBSTFA and separation by GC-NPD.
		In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.
		Quetiapine, a new atypical antipsychotic, was added to ongoing treatment of bipolar I outpatients (n=15) for symptoms of illness (mood lability, irritability, psychosis and/or difficulty sleeping).
	www.rxbyfax.com /seroquel.htm (4371 words)

	QUETIAPINE
		The efficacy of quetiapine was assessed using symptom scales, predominantly the CGI scale to evaluate global state, and the Brief Psychiatric Rating Scale (BPRS) to assess changes in psychotic symptoms.
		The SPC for quetiapine states that in clinical trials, quetiapine was not associated with a persistent increase in QTc interval, but as with other antipsychotics, caution should be exercised when quetiapine is prescribed with drugs known to prolong the QTc interval, especially in the elderly.
		Quetiapine is an atypical antipsychotic licensed for the treatment of schizophrenia.
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/summaries/Q/QUETIAPINEs.html (1314 words)

	Quetiapine fumarate examined as monotherapy for acute mania
		Quetiapine fumarate is currently indicated for the treatment of schizophrenia in adults.
		Patients who responded to quetiapine fumarate were receiving an average dose of 575.5 mg/day by their third week of treatment.
		The labeling for quetiapine fumarate (quetiapine fumarate) Tablets includes a warning relative to a condition known as tardive dyskinesia (which is often associated with long-term use of antipsychotic agents) and a rare condition known as neuroleptic malignant syndrome (NMS symptoms include muscle rigidity, fever, and irregular pulse).
	www.eurekalert.org /pub_releases/2003-05/epr-qfe051903.php (1025 words)

	Anxiety Zone - Quetiapine
		Quetiapine has FDA and international approvals for the treatment of schizophrenia and acute mania in bipolar disorder.
		Quetiapine is a dopamine, specifically D1 and D2 dopamine, inhibitor or antagonist.
		Quetiapine is believed to be less likely to cause tardive dyskinesia than typical antipsychotics.
	www.anxietyzone.com /drugs/quetiapine.html (283 words)

	Antipsychotic Medications Anti-psychotic Drugs quetiapine, Seroquel
		Quetiapine, a dibenzothiazepine derivative, is an antipsychotic agent which interacts with a broad range of neurotransmitters.
		Quetiapine is indicated for the management of the manifestations of schizophrenia.
		Quetiapine is contraindicated in patients with a known hypersensitivity to this medication or any of its ingredients.
	www.support4hope.com /medications/antipsychotic/quetiapine_seroquel.htm (692 words)

	quetiapine (Seroquel) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Quetiapine should only be used in pregnancy if the physician feels that it is absolutely necessary and that the potential benefits justify the unknown risks.
		Quetiapine can cause orthostatic hypotension (a drop in blood pressure upon standing that can lead to dizziness or fainting) especially during the first 3-5 day period of treatment, when it is restarted after temporary discontinuation, and after an increase in the dose.
		Although it is not clear if quetiapine is responsible for the cataracts seen in humans, eye examinations by slit-lamp (to identify cataracts before they impair vision) are recommended at the beginning of treatment and every six months during treatment.
	www.medicinenet.com /quetiapine/article.htm (977 words)

	Seroquel Indications, Dosage, Storage, Stability - Quetiapine Fumarate - RxList Monographs
		The elimination of quetiapine was enhanced in the presence of phenytoin.
		Quetiapine caused a dose-related increase in pigment deposition in thyroid gland in rat toxicity studies which were 4 weeks in duration or longer and in a mouse 2 year carcinogenicity study.
		Quetiapine caused a dose related reduction in plasma cholesterol levels in repeat-dose dog and monkey studies; however, there was no correlation between plasma cholesterol and the presence of cataracts in individual dogs.
	www.rxlist.com /cgi/generic2/quetiap_ids.htm (1325 words)

	QUETIAPINE
		Three of the 11 studies compared quetiapine solely with placebo, and 7 to typical antipsychotics (chiefly haloperidol).
		Limited longer-term data on quetiapine treatment of up to 4 years have been reported in poster presentations and as data on file.
		Caution is advised when quetiapine is prescribed with drugs known to prolong the QTc interval, especially in the elderly.
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/verdicts/Q/QUETIAPINEv.html (562 words)

	Quetiapine ( Seroquel ) in mood disorders (Site not responding. Last check: 2007-10-11)
		Quetiapine fumarate is an effective novel antipsychotic with mixed serotonergic (5-HT2) and dopaminergic (D2) activity.
		This is an open-label, 12-week prospective study to assess the efficacy and tolerability of quetiapine in the treatment of patients with bipolar and schizoaffective disorder who were suboptimally responsive to mood stabilizers alone.
		Quetiapine was added on an open-label basis and increased to optimum clinical dosage.
	www.biopsychiatry.com /quetiapine.htm (213 words)

	quetiapine Consumer Drug Information
		Quetiapine is not for use in psychotic conditions that are related to dementia.
		Quetiapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression).
		Quetiapine may cause you to have high blood sugar (hyperglycemia).
	www.drugs.com /mtm/quetiapine.html (1421 words)

	Quetiapine Drug Information, Professional
		The pharmacokinetics of quetiapine are linear within the clinical dose range of 50 to 600 mg/day, and are similar in both genders and in smokers and nonsmokers.
		Although the results were not definitive, quetiapine toxicity studies in rats and mice showed changes in thyroxine concentrations, thyroxine clearance, and TSH concentrations that are consistent with the proposed mechanism of increased thyroxine clearance leading to increased TSH concentrations and increased thyroid gland stimulation
		Quetiapine produced a reproducible increase in mutations in one of six strains in in vitro bacterial gene mutation assays in the presence of metabolic activation
	www.drugs.com /MMX/Quetiapine.html (3577 words)

	MedlinePlus Drug Information: Quetiapine (Systemic) (Site not responding. Last check: 2007-10-11)
		Quetiapine (kwe-TYE-a-peen) is used to treat psychotic disorders, such as schizophrenia.
		However, quetiapine may be removed from the body more slowly in older adults, so an older adult may receive a lower dose than a younger adult.
		Quetiapine may be taken with or without food on a full or empty stomach.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/203124.html (1572 words)

	quetiapine - [Medication]
		Quetiapine is used to treat the symptoms of psychotic conditions such as schizophrenia and mania associated with bipolar disorder.
		Quetiapine is in the FDA pregnancy category C. This means that it is not known whether quetiapine will be harmful to an unborn baby.
		Quetiapine may also increase the effects of drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and many others.
	www.peacehealth.org /kbase/multum/d04220a1.htm (1420 words)

	MedlinePlus Drug Information: Quetiapine
		Quetiapine is not approved by the FDA for use in the treatment of behavioral disorders in older adults with dementia.
		Quetiapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions).
		It is also used to treat episodes of mania (frenzied, abnormally excited or irritated mood) or mixed episodes (symptoms of mania and depression that happen together) in patients with bipolar I disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a698019.html (1110 words)

	Quetiapine (Seroquel)
		Quetiapine is an Atypical Antipsychotic, or Neuroleptic (sometimes incorrectly called a 'major tranquiliser').
		Quetiapine is usually prescribed to help treat conditions such as psychosis and schizophrenia; it has also been used in the treatment of acute manic episodes in Bipolar Disorder (described in the section on mood disorders).
		Alcohol should be avoided: Quetiapine (Seroquel) may cause drowsiness, and drinking alcohol in conjunction with the medication may exacerbate this effect.
	www.counsellingresource.com /medications/drug-pages/quetiapine.html (796 words)

	Quetiapine
		Quetiapine was able to reverse such effects, and this offers encouragement that the compound may have enhanced clinical efficacy in combating the negative symptoms of schizophrenia.
		However, in patients receiving quetiapine at up to 750 mg/day there were significant improvements compared with placebo in BPRS score, CGI severity of illness and SANS score, again showing quetiapine to be effective in the treatment of both positive and negative symptoms of schizophrenia.
		These data suggest that quetiapine is effective over a wide dose range, from 150 to 750 mg/day, which offers the clinician flexibility to tailor the dose to the individual patient, although the most appropriate dose in clinical practice is likely to lie in the middle of this range.
	www.priory.com /psych/quetiapine.htm (3865 words)

	Quetiapine ( Seroquel ) in schizophrenia
		In clinical trials, the efficacy of quetiapine was consistently superior to placebo and it was effective against both positive and negative symptoms.
		Quetiapine was also at least as effective as chlorpromazine or haloperidol in improving the symptoms of acute schizophrenia and moreover was associated with higher response rates.
		The consistent, placebo-level incidence of EPS associated with quetiapine in clinical trials was not seen with haloperidol.
	www.biopsychiatry.com /quetschizo.htm (160 words)

	Quetiapine
		Quetiapine is used to treat the symptoms of schizophrenia and mania in those with bipolar disorder.
		Quetiapine works by restoring the balance of some natural chemicals in the brain (neurotransmitters).
		Quetiapine can also increase the effects of drugs that cause drowsiness, such as depression or anxiety medications, allergy medications, medications for sleep, pain relievers or muscle relaxants.
	www.healthyontario.com /Page7009.aspx (669 words)

	Buy Seroquel, Quetiapine - Order Seroquel, Quetiapine (Site not responding. Last check: 2007-10-11)
		Quetiapine is used to treat psychotic disorders and symptoms such as hallucinations, delusions, and hostility.
		Quetiapine controls the symptoms of a psychotic disorder but does not cure it.
		It should not be construed to indicate that use of Seroquel, Quetiapine is safe, appropriate, or effective for you.
	www.247-pharmacy.com /Seroquel.htm (191 words)

	Intravenous Quetiapine Abuse -- HUSSAIN et al. 162 (9): 1755 -- Am J Psychiatry (Site not responding. Last check: 2007-10-11)
		For these symptoms, she was given oral quetiapine, 600 mg at bedtime.
		She informed the guards that she had intravenously injected herself with quetiapine the previous evening and became rapidly sedated, falling asleep before she could remove the syringe.
		She additionally admitted to previous intranasal abuse of crushed quetiapine tablets.
	ajp.psychiatryonline.org /cgi/content/full/162/9/1755-a (532 words)

	Quetiapine(Systemic) - [Medication] (Site not responding. Last check: 2007-10-11)
		However, studies in rats and rabbits have shown that quetiapine at doses higher than the highest human dose causes reduced weight and other problems in the fetus.
		However, quetiapine is not recommended for use during breast-feeding, because it may cause unwanted effects in nursing babies.
		Quetiapine may make it more difficult for your body to cool down.
	www.luhs.org /health/kbase/htm/mdx-/drde/2031/24/mdx-drde203124.htm (1538 words)

	Possible hypothyroidism associated with quetiapine -- Feret and Caley 34 (4): 483 -- The Annals of Pharmacotherapy
		Transition from olanzapine to quetiapine was initiated and, approximately two months after adding quetiapine to a standing pharmacotherapeutic regimen, the patient developed an elevated thyroid-stimulating hormone (TSH) concentration of 8.45 microU/L. A diagnosis of hypothyroidism was subsequently made, treatment with levothyroxine was initiated, and the patient's thyroid function became stable.
		Quetiapine is an atypical antipsychotic with the potential to decrease thyroid hormone concentrations in some patients; this effect may be dose related.
		Despite this known adverse effect, the manufacturer of quetiapine reports that elevated TSH concentrations and subsequent treatment with thyroid hormone supplementation have occurred only rarely.
	www.theannals.com /cgi/content/abstract/34/4/483 (316 words)

	Quetiapine - Drugs & Vitamins - Drug Library - DrugDigest
		Quetiapine can help you to keep in touch with reality, stabilize the mood, and reduce your mental problems.
		It may be several weeks before you see the full effects of quetiapine.
		Your health care provider may suggest that you have your eyes examined prior to starting quetiapine, and every 6 months thereafter.
	www.drugdigest.org /DD/DVH/Uses/0,3915,580\|Quetiapine,00.html (692 words)

	Quetiapine
		Quetiapine is used to treat symptoms associated with psychiatric disorders, such as delusions, hallucinations, disorganized thinking and speech, and bizarre behavior.
		Problems may arise when individuals switch from taking quetiapine with a meal to taking it on an empty stomach and vice versa.
		Quetiapine aggravates the adverse effect of alcohol on mental and motor skills, which might have serious consequences.
	www.publix.com /wellness/notes/Display.do?id=Drug&childId=Quetiapine (408 words)

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