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Topic: RAS syndrome

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	Renal Artery Stenosis (RAS) & Renal Vascular Hypertension (RVH) - nephrologychannel
		Critical RAS is defined as at least 70% narrowing of the renal artery, based on angiographic (blood vessel x-ray) evaluation.
		AS-RAS is due to the build-up of cholesterol on the inner lining of the renal artery.
		Most RAS is caused by atherosclerosis or "hardening of the arteries." Atherosclerosis is the build up of cholesterol deposits, or plaque, in the lining of the arteries.
	www.nephrologychannel.com /ras (958 words)

	RAS syndrome - Wikipedia, the free encyclopedia
		RAS syndrome (Redundant Acronym Syndrome syndrome) is the common tendency to use one of the words which make up an acronym or initialism as well as the abbreviation itself, thus in effect repeating that word.
		"RAS syndrome" is itself an ironic self-referential example, coined in 2001 in the New Scientist.
		An office supply company called WB Mason is not really a RAS, but comes close to it because their trucks and many of their products are labeled "Who But W. Mason".
	en.wikipedia.org /wiki/RAS_syndrome (1309 words)

	RAS - Wikipedia, the free encyclopedia
		RAS genes and RAS proteins implicated in development of cancer
		RAS coordinates (in medicine, a patient relative set of axis: Right/Left, Anterior/Posterior, Superior/Inferior the first of each couple corresponding to positive)
		Rundfunk Anstalt Südtirol, a public broadcaster whose purpose is to relay programming from Germany, Austria, and Switzerland to the German-speaking population.
	en.wikipedia.org /wiki/RAS (156 words)

	Respiratory distress with acitretin, reversal by corticosteroid
		The retinoic acid syndrome (RAS), described with all- trans-retinoic acid (ATRA) in patients with promyelocytic leukemia, is characterized by fever and respiratory distress.
		The retinoic acid syndrome (RAS) was first described in 1991 with all- trans-retinoic acid (ATRA).[2] High dose corticosteroids effectively reverse this syndrome.
		RAS was described for the first time in 1991 by Frankel et al.[2] The syndrome was seen nine of 35 patients, beginning 2-21 days after treatment began.
	dermatology.cdlib.org /DOJvol7num2/case_reports/acitretin/cuhadaroglu.html (887 words)

	Rev Electron Biomed / Electron J Biomed 2003;1(2):95-100. Ibañez-Valdés et al. RENOVASCULAR HYPERTENSION ... IN ...
		Klippel-Trenaunay syndrome or Klippel-Trenaunay-Weber syndrome (KTWS) is generally accepted, when there are enlargement of the soft tissue, bony hypertrophy, port-wine stain, venous malformations and lymphatic abnormalities; in our patient we could not investigate arterio-venous fistulae by phlebography and arteriography because patient died after the surgical revascularization due to anesthetic and pulmonary complications.
		Alagille syndrome with associated renovascular hypertension should also be distinguished, the association of at least three of the following five abnormalities characterizes it: chronic cholestasis, peripheral pulmonary stenosis, vertebral arch defects, embryotoxon, and typical facies.
		Patients with Klippel-Feil Syndrome may be at increased of risk of significant genitourinary tract anomalies as ectopic kidney and renal agenesis, and have increase chance of developing nephrolitiasis.
	biomed.uninet.edu /2003/n2/ibanezv.html (2952 words)

	Benzene - Myelodysplastic Syndrome (MDS) Affects Bone Marrow & Blood
		Myelodysplasia is the term used to describe a group of disorders that is characterized by the deficiency of the bone marrow to produce enough normal red blood cells, white blood cells, and platelets.
		Refractory anemia (RA) – this is characterized by the bone marrow’s failure to produce enough healthy red blood cells.
		Patients who are suffering from myelodysplastic syndrome often experience symptoms that are very common to a variety of blood disorders and other medical problems, which makes the disease difficult to recognize.
	www.benzene411.org /benzene_exposure/benzene_myelodysplastic_syndrome.htm (797 words)

	Noonan syndrome
		The cause of Noonan syndrome is a mutation in one of two genes responsible for making a specific type of protein that plays an important role in the development of the heart, blood cells, bones and other tissues.
		Noonan syndrome is acquired when a child inherits a copy of an affected gene from a parent.
		A diagnosis of Noonan syndrome is usually made after a doctor observes some of the key signs and symptoms of the disease, but this can be difficult because some of the features associated with this disorder are subtle and can be hard to identify.
	edition.cnn.com /HEALTH/library/DS/00857.html (2850 words)

	Signal Transduction and Cardio-Facial Syndromes
		Recently, mutations of one of the RAS proteins known as HRAS were identified in several patients with Costello syndrome.
		Based on the suggestion that Noonan and Costello syndromes might reflect activation of this pathway, a group headed by Aoki speculated that CFC syndrome might be due to mutations in genes encoding other proteins in this cascade.
		Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
	www.gghjournal.com /volume22/2/ab02.cfm (655 words)

	RAS syndrome - 19 March 2005 - New Scientist
		RAS syndrome - 19 March 2005 - New Scientist
		In response to your running piece about "RAS syndrome" (Feedback, 26 February), I thought I should add my tuppen'orth.
		In our chemistry test today we were asked a question about "OFC copper", with an explanation that OFC stood for "oxygen-free copper".
	www.newscientist.com /article/mg18524911.500-ras-syndrome.html (112 words)

	Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome -- ...
		subsequent resolution of the syndrome in 7 of the 8.
		idarubicin concurrently with ATRA, the incidence of the syndrome
		The "retinoic acid syndrome" in acute promyelocytic leukemia.
	www.bloodjournal.org /cgi/content/full/95/1/90 (4472 words)

	Metabolic Syndrome
		This syndrome is emerging as one of the major medical and public health problems both in the United States and worldwide.
		The metabolic syndrome is constellation of individual risk factors that in aggregate greatly raise the risk for coronary heart disease.
		If a proinflammatory state is in fact one of the risk factors of the metabolic syndrome, as it appears to be, it could contribute importantly to the development of premature coronary heart disease, and perhaps even to type 2 diabetes.
	www.utsouthwestern.edu /utsw/cda/dept27717/files/148948.html (6242 words)

	Human protein: Q9UM97 - N-ras protein (Fragment). EMBL Bioinformatics Harvester
		The mammalian ras gene family consists of the harvey and kirsten ras genes (c-Hras1 and c-Kras2), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene.
		These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth.
		jmml is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (mds) and 2% of leukemia.
	harvester.embl.de /harvester/Q9UM/Q9UM97.htm (932 words)

	Behçet's Disease and Recurrent Aphthous Stomatitis
		Behçet's disease (BD) is a chronic multisystem disorder characterized mainly by a triad of (1) recurrent aphthous stomatitis (RAS), (2) genital ulcers, and (3) ocular lesions.
		RAS is a common disease which probably afflicts at least 20% of the population.
		Endocrine factors: In some women, RAS are clearly related to a fall in progestogens in the luteal phase of the menstrual cycle.
	www.geocities.com /stantonios/mc/aphthous.html (727 words)

	Faculty Areas of Research Interest
		The RAS group had a more rapid rate of decline in renal function and greater likelihood of progression to end-stage renal disease even though the majority (17/18) had only mild and moderate stenosis (< 65%).
		Future investigation is planned to determine the effect of aggressive medical management in an effort to slow the rate of progression of atherosclerotic renal disease in diabetic and non-diabetic patients.
		Education of the medical community is a priority in identifying further cases of this under-diagnosed disease with therapeutic implications for affected family members.
	www.hopkinsmedicine.org /Nephrology/Myers.html (469 words)

	Paradoxic Activation of the Renin-Angiotensin System in Twin-Twin Transfusion Syndrome: An Explanation for ... (Site not responding. Last check: 2007-10-26)
		RAS, which is functional early in pregnancy (19).
		Saunders NJ, Snijders RJ, Nicolaides KH 1991 Twin-twin transfusion syndrome during the 2nd trimester is associated with small intertwin hemoglobin differences.
		Umur A, van Gemert MJ, Ross MG 2001 Fetal urine and amniotic fluid in monochorionic twins with twin-twin transfusion syndrome: simulations of therapy.
	www.pedresearch.org /cgi/content/full/58/4/685 (2511 words)

	Renal artery stenosis in the antiphospholipid (Hughes) syndrome and hypertension -- Sangle et al. 62 (10): 999 -- ...
		Renal artery stenosis in the antiphospholipid (Hughes) syndrome and hypertension -- Sangle et al.
		Renal artery stenosis in the antiphospholipid (Hughes) syndrome and hypertension
		Arterial disease and thrombosis in the antiphospholipid syndrome, a pathogenic role for endothelin 1.
	ard.bmjjournals.com /cgi/content/full/62/10/999 (2603 words)

	Publications
		Hypertension often coexists with obesity, particularly with the android type of obesity in which fat is distributed primarily in the upper body (apple shape) rather than in the hips and legs (pear shape).4 This fat distribution pattern is a characteristic of the metabolic syndrome, also known as syndrome X and central obesity syndrome.
		Perhaps in some cases RAS overactivity stimulates fat cell differentiation and hypertrophy, as might be the case with certain candidate gene polymorphisms or with any process that might activate fat cell cortisol production.
		The challenge in clinical research is to explore and extend the more basic adipose RAS data into the human arena to determine their clinical relevance.
	www.mmaonline.net /publications/MNMed2003/January/Sibley.html (1837 words)

	[No title] (Site not responding. Last check: 2007-10-26)
		Clinical Features: RAS features localized, painful, shallow, round to oval uclers, often covered by a gray to tan fibromembraneous slough, and is surrounded by an erythematous halo.
		No currently exists no unifying theory of immunogenesis of RAS with immunologically mediated damage to epithelial cells as the antigen or antigens responsible for the initiation of this pathway remain obscure.
		Behcet’s Syndrome: oral, genital, ocular ulcerations MAGIC Syndrome:Mouth and Genital with Inflamed Cartilage FAPA syndrome: Fever, Aphthosis, Pharyngitis, Adenitis Cyclic Neutropenia Sweet’s Syndrome: acute febrile neutrophilic dermatosis HIV disease Hematlogic Deficiency: Iron, folic acid, Vit B12, Zinc Gluten sensitivity MANAGEMENT: Biopsy and virologic studies are not warranted and is rarely of diagnostic benefit.
	www.bethesda.med.navy.mil /Careers/Postgraduate_Dental_School/Oral_Medicine/Oral_Med_References/Topics/ras.doc (484 words)

	Oncology Forum - Articles (Site not responding. Last check: 2007-10-26)
		She was suspected to have developed retinoic acid syndrome (RAS).
		RAS is a well-described reaction of patients who receive ATRA.
		The exact aetiology is unknown but it is thought to be due to 'capillary leak' syndrome mediated by interleukin-2.
	www.scientific-com.com /oncology/vol4.1/articles/pictorial.htm (296 words)

	BioMed Central \| Full text \| Hyponatremic hypertensive syndrome (HHS) in an 18-month old-child presenting as malignant ...
		With renal artery stenosis (RAS), renin secretion is increased resulting in high circulating angiotensin II (A-II) levels, leading to HTN and hyperaldosteronism resulting in pressure natriuresis [5].
		The surgical correction of triple RAS on the left kidney was performed ex-vivo while the kidney was in an ice-bath (Figure 3).
		In some cases with RAS, an option is to remove the affected kidney as cure for HTN [12,13].
	www.biomedcentral.com /1471-2369/5/5 (1981 words)

	Specialty Laboratories ::: we help doctors help patients
		Patients with RAS mutations have a lower percentage of blasts in the bone marrow, which is the basis for the definition of MDS and therefore confounds the significance of RAS mutations as a prognostic factor.
		Prognostic importance of mutations in the RAS proto-oncogenes in de novo acute myeloid leukemia.
		Prevalence of NRAS mutations in children with myelodysplastic syndromes and acute myeloid leukemia.
	www.specialtylabs.com /books/display.asp?id=615 (673 words)

	(c) UrologyHealth.org - Adult Conditions - Adrenal & Kidney Diseases - Renovascular Disease
		The prevalence of AS-RAS increases with age, particularly in patients with diabetes, aortoiliac occlusive disease, coronary artery disease or hypertension.
		Of patients with AS-RAS, progressive abnormal narrowing of the renal artery has been reported in 51 percent five years after the diagnosis has been made and anywhere from 3 to16 percent of the arteries become totally blocked.
		AS-RAS is a common and progressive disease, particularly in patients with diabetes or other manifestations of hardening of the arteries.
	www.urologyhealth.org /adult/index.cfm?cat=02&topic=126 (1883 words)

	Myelodysplastic syndrome Encyclopedia of Medicine - Find Articles
		Myelodysplastic syndrome (MDS) is a disease that affects the production of all three major types of human blood cells.
		RA is characterized by an abnormal appearance of red cell blasts.
		RAS is similar to RA but has additional abnormalities in the red cells.
	www.findarticles.com /p/articles/mi_g2601/is_0009/ai_2601000932 (1079 words)

	Data Sheet
		RAS is characterised by fever, dyspnoea, acute respiratory distress, pulmonary infiltrates, hypotension, pleural and pericardial effusions, oedema, weight gain, hepatic, renal and multi-organ failure.
		RAS is frequently associated with hyperleukocytosis and may be fatal.
		RAS can be prevented by addition of full-dose anthracycline-based chemotherapy to the all-trans retinoic acid regimen based on the white blood cell (WBC) count.
	www.medsafe.govt.nz /profs/Datasheet/v/Vesanoidcap.htm (2015 words)

	GeneDx :: Genetic Testing and Diagnosis Company
		Costello (FCS) syndrome is a rare, complex developmental disorder that clinically overlaps with Noonan syndrome and Cardio-Facio-Cutaneous (CFC) syndrome.
		It has been shown that 82%-92% of patients with Costello syndrome have a germline mutation in the HRAS gene on chromosome 11p13.3, encoding a member of the superfamily of small GTP-binding proteins.
		In Costello syndrome, mutation analysis of the HRAS gene is provided in two tiers.
	www.genedx.com /services/dis_cos.php (372 words)

	[No title]
		Klippel-Trenaunay syndrome or Klippel-Trenaunay-Weber syndrome (KTWS), is generally accepted, when there are enlargement of the soft tissue, bony hypertrophy, port-wine stain, venous malfomations and lymphatic abnormalities; in our patient we could not investigate arterio-venous fistulae by phlebography and arteriography because patient died before to do that.
		KTWS is an uncommon disease (around 310 cases have been published) due to a congenital malformation of the deep venous system with agenesis, hypoplasia or segmental atresia, the etiology is not clear however seems to be related with diffuse mesodermal abnormalities during fetal development and genetic mutations.
		Alagille syndrome with associated renovascular hypertension should also be distinguished, the association of at least three of the following five abnormalities characterizes it: chronic cholestasis, peripheral pulmonary stenosis, vertebra arch defects, embryotoxon, and typical facies.
	www.ispub.com /ostia/index.php?xmlPrinter=true&xmlFilePath=journals/ijim/vol4n1/klippel.xml (2335 words)

	Ischemic Nephropathy - Diagnosis & Treatment - nephrologychannel
		The tests used to diagnose RAS and ischemic nephropathy are performed by radiologists (experts in imaging procedures, such as x-ray).
		Renal scan with ACE challenge is a safe, nuclear medicine test that helps the physician diagnose unilateral (one-sided) RAS in patients with renal vascular hypertension (high blood pressure in the kidney�s blood vessels).
		Patients who are unable to hold their breath have limited results, and patients with pacemakers cannot undergo this test because the MRI scanner is a large magnet.
	www.nephrologychannel.com /ischemicnephropathy/diagnosis.shtml (839 words)

	Acute promyelocytic leukemia: evolving therapeutic strategies -- Tallman et al. 99 (3): 759 -- Blood
		therapy, the incidence of the syndrome was 10%.
		syndrome with pulmonary infiltrates, reminiscent of the RAS, and
		Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated arsenic trioxide.
	www.bloodjournal.org /cgi/content/full/99/3/759 (7244 words)

	Tumor Suppressors
		They include the retinoblastoma susceptibility gene (RB), Wilms' tumors (WT1), neurofibromatosis type-1 (NF1), familial adenomatosis polyposis coli (FAP), von Hippel-Lindau syndrome, and those identified through loss of heterozygosity such as in colorectal carcinomas (called DCC for deleted in colon carcinoma) and p53 which was originally thought to be a proto-oncogene.
		It was first thought that P53 was a dominant oncogene since cDNA clones isolated from tumor lines were able to cooperate with the RAS oncogene in transformation assays.
		This proved to be a misleading since the cDNA clones used in all these studies were mutated forms of wild-type p53 and cDNAs from normal tissue were later shown to be incapable of RAS co-transformation.
	web.indstate.edu /thcme/mwking/tumor-suppressors.html (3567 words)

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