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Topic: RNA

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  The RNASociety WebSite
The RNA Society was formed in 1993 to facilitate sharing and dissemination of experimental results and emerging concepts in ribonucleic acid research.
The Society encompasses RNA research in the broadest sense: from the ribosome to the spliceosome, from RNA viruses to catalytic RNAs.
The RNA journal is a publication of the RNA Society.
www.rnasociety.org   (318 words)

  RNA - Wikipedia, the free encyclopedia
RNA serves as the template for translation of genes into proteins, transferring amino acids to the ribosome to form proteins, and also translating the transcript into proteins.
Ribosomal RNA (rRNA) is a component of the ribosomes, the protein synthetic factories in the cell.
RNA genes (sometimes referred to as non-coding RNA or small RNA) are genes that encode RNA that is not translated into a protein.
en.wikipedia.org /wiki/RNA   (1259 words)

 RNA Synthesis
Transcription is the mechanism by which a template strand of DNA is utilized by specific RNA polymerases to generate one of the three different classifications of RNA.
Messenger RNAs (mRNAs): This class of RNAs are the genetic coding templates used by the translational machinery to determine the order of amino acids incorporated into an elongating polypeptide in the process of translation.
The resultant RNA is, therefore, complimentary to the template strand of the DNA duplex and identical to the non-template strand.
web.indstate.edu /thcme/mwking/rna.html   (2011 words)

The RNA triphosphatases of fungi and protozoa are structurally and mechanistically unrelated to the analogous mammalian enzyme, a situation that recommends RNA triphosphatase as an anti-infective target.
The structural heterogeneity of HDV genotype III RNA is significant because not only are both conformations of the RNA functionally important for viral replication, but the ratio of the two forms could modulate editing by determining the amount of substrate RNA available for modification.
Using an RNA affinity technique, Western blotting, mass spectrometry, and a supershift assay, the protein was identified as Elongation factor 1alpha (eEF1alpha).
barf.jcowboy.org /rna.xml   (8956 words)

 Ribonucleic Acid - MSN Encarta
RNA differs chemically from DNA in two ways: The RNA sugar molecule contains an oxygen atom not found in DNA, and RNA contains the base uracil in the place of the base thymine in DNA.
The base of each RNA nucleotide in one chain pairs with a complementary base in the second chain—that is, adenine pairs with uracil, and guanine pairs with cytosine.
Based on this evidence, some scientists suspect that the RNA portion of ribonuclease-P may be the modern equivalent of the earliest genetic molecule, the molecule that first enabled replication to occur in primitive cells.
encarta.msn.com /encyclopedia_761559887/Ribonucleic_Acid.html   (786 words)

 RNA structure   (Site not responding. Last check: 2007-10-30)
The covalent structure of RNA differs from that of DNA in two basic ways (a) ribonucleic acid so the sugar unit in the nucleotides is ribose rather than deoxyribose (b) no thymine found in RNA its replaced by uracil U. Uracil can base pair with adenine.
RNA molecules are single stranded except in some viruses however it is possible for RNA molecules to fold on themselves to form short regions of double helix by forming a hair-pin loop.
Base pairing in RNA hairpin loops is frequently imperfect, often opposite bases cannot base pair, and one or more bases along a strand may be looped out in order for base pairing to occur by proper base pairing.
www-biol.paisley.ac.uk /courses/stfunmac/glossary/RNA.html   (350 words)

 Subverting the Genetic Text
The whole RNA underworld also resembles an enormous espionage network in which genetic information is stolen, or gets re-routed as it is transmitted, or transformed, corrupted, destroyed, and in some cases, returned to the source file in a totally different form.
And B2 RNA is required for the concomitant inhibition of RNA polymerase II during heat shock, by interacting directly with the enzyme, preventing it from working.
RNA polymerase II is involved in the transcription of all protein-coding RNA.
www.i-sis.org.uk /RNASTGT.php   (2650 words)

 Sourcefire Network Security - RNA Sensor
Sourcefire Real-time Network Awareness™ (RNA) enables organizations to more confidently protect their networks through a unique patent pending combination of passive network discovery, behavioral profiling, and integrated vulnerability analysis to deliver the benefits of real-time network profiling and change management without the drawbacks of traditional approaches to identifying network assets and vulnerabilities.
By leveraging RNA, Sourcefire addresses a fundamental shortcoming of all other intrusion technologies which is the absence of any way to correlate in real time, a security event data with a target's contextual information.
RNA builds a 'host record' of every device it discovers on the network, including a vulnerability database associated with its respective operating system.
www.sourcefire.com /products/rna.html   (621 words)

 An RNA Structure Primer   (Site not responding. Last check: 2007-10-30)
RNA is ribonucleic acid, a close cousin of deoxyribonucleic acid or DNA.
RNA molecules are built from three basic components: ribose, a five-carbon suger, phosphate, and a family of four heterocyclic bases.
Although RNA molecules are linear polymers, they fold back on themselves to make intricate secondary and tertiary structures that are essential for them to perform their biological roles.
www.rnabase.org /primer   (962 words)

 The RNA World: A Critique - Origins & Design 17:1. Mills, Gordon and Kenyon, Dean
Naturally occuring RNA catalytic activities are actually restricted to a small set of highly specialized reactions, e.g., the processing of RNA transcripts primarily in eukaryotic cells.
Moreover, molecular biologists may discover additional catalytic roles of RNA in living cells, although the variety of such roles is not expected to rival that of the protein enzymes.
RNA molecules with catalytic activity that are known today predominantly have nuclease or nucleotidyl transferase activity with some minimal esterase actitivy22.
www.arn.org /docs/odesign/od171/rnaworld171.htm   (3431 words)

 The Central Dogma of Biology   (Site not responding. Last check: 2007-10-30)
RNA has a hydroxyl group on the 2' carbon of the sugar (thus, the difference between deoxyribonucleic acid and ribonucleic acid.
Because of the extra hydroxyl group on the sugar, RNA is too bulky to form a a stable double helix.
The RNA molecule with its hairpin loops is said to have a secondary structure.
web.mit.edu /esgbio/www/dogma/dogma.html   (650 words)

 Pharmaceutical RNA glossary
RNA- RNA interactions are at the very core of the complex process of RNA processing -- not only as substrate, but in structural and catalytic roles as well.
Ribosomal RNA, RNA molecules which are essential structural and functional components of ribosomes, the subcellular units responsible for protein synthesis.
Structural genomics of RNA will be most interesting when integrated with experimental and computational methods for identifying novel RNA genes and determining their biological relevance: an approach defined previously as 'ribonomics' [11].
www.genomicglossaries.com /content/RNA.asp   (5124 words)

 Birgid Schlindwein's Hypermedia Glossary Of Genetic Terms - Search results   (Site not responding. Last check: 2007-10-30)
The structure of RNA is similar to that of DNA.
RNA that serves as a template for protein synthesis or for synthesis of cDNA.
A class of RNA having structures with triplet nucleotide sequences that are complementary sequences to the triplet nucleotide coding sequences of mRNA.
hal.weihenstephan.de /genglos/asp/genreq.asp?nr=199   (192 words)

 Dr Chromo's school: RNA structure
An RNA molecule is a linear polymer in which the monomers (nucleotides) are linked together by means of phosphodiester bridges, or bonds.
Although each RNA molecule has only a single polynucleotide chain, it is not a smooth linear structure.
In the base paired region, the RNA molecule adopts a helical structure as in DNA.
www.rothamsted.bbsrc.ac.uk /notebook/courses/guide/rnast.htm   (452 words)

 Biodirectory: RNA   (Site not responding. Last check: 2007-10-30)
Historical perspective on the role of RNA in the evolution of life.
Introduction to ribosomal RNA molecules from E. coli, with references and 3D-model for ribosomal structure in research led by Richard Brimacombe, Berlin, Germany.
RNA Biochemistry of catalytic RNA, short ribozymes, folding, FRET, fluorescence, atomic force microscopy.
www.biodirectory.com /directory/Nucleic_acids/RNA_314.html   (797 words)

 ☞ RNA | Rna Virus   (Site not responding. Last check: 2007-10-30)
Distemper is an RNA virus from the same viral mild depression as symptoms at the onset.
HCV is an positive-strand RNA virus, and its RNA genome is translated immediately after uncoating of the virus in the cytoplasm of infected (liver) cells.
These RNA molecules were of uniform length, estimated at 25 nucleotides, and their accumulation required either transgene sense transcription or RNA virus replication.
www.dnalabtesting.com /rna   (1384 words)

In eukaryotes, this requires — at least for protein-encoding genes — that the nucleosomes in front of the advancing RNA polymerase (RNAP II) be removed.
In vitro, at least, when RNA polymerase is immobilized, it spins the DNA molecule around and around as it moves along the molecule.
Several types of RNA are synthesized in the nucleus of eukaryotic cells.
users.rcn.com /jkimball.ma.ultranet/BiologyPages/T/Transcription.html   (2125 words)

 The RNA World
The phrase "The RNA World" was coined by Walter Gilbert in 1986 in a commentary on the then recent observations of the catalytic properties of various RNAs.
During this stage, proteins were not yet engaged in biochemical reactions and RNA carried out both the information storage task of genetic information and the full range of catalytic roles necessary in a very primitive self-replicating system.
We soon suggested that the RNA subunit of RNase P was part of the active center of the enzyme, by analogy to the then current picture of the ribosome.
nobelprize.org /nobel_prizes/chemistry/articles/altman   (850 words)

 HHMI's BioInteractive - The Double Life of RNA
Two of the major steps in human gene expression—messenger RNA splicing and messenger RNA translation—appear to be at least partly catalyzed by RNA.
RNA's ability to both store genetic information and catalyze biochemical reactions lends plausibility to the theory that RNA had a central role in the origin of life.
In these lectures, Dr. Cech explains the current state of knowledge of RNA in chemistry and in structural and cell biology and discusses the implications of ribozymes.
www.hhmi.org /biointeractive/rna/index.html   (295 words)

 RNABase: The RNA Structure Database
An analysis of properties of the entire RNA database such as growth rate over time, error rates for different techniques, etc.
A tabulation of all nucleotide conformations observed for RNA residues and their frequencies.
A brief introduction to the structure of RNA and the nomenclature used to describe it.
www.rnabase.org   (286 words)

 The RNA World. by Brig Klyce
It was prescient of Crick to guess that RNA could act as an enzyme, because that was not known for sure until it was proven in the 1980s by Nobel Prize-winning researcher Thomas R. Cech (2) and others.
RNA is then relegated to the intermediate role it has today—no longer the center of the stage, displaced by DNA and the more effective protein enzymes.
RNA is chemically fragile and difficult to synthesize abiotically.
www.panspermia.org /rnaworld.htm   (6350 words)

The basic components of RNA are the same than for DNA (see the DNA page) with two major differences.
For RNA, nucleosides are formed similarly to DNA with ribose replacing deoxyribose Uracil 5' monophosphate is given as an example.
RNA also contain "unusual" nucleotides (formed after the RNA synthesis is complete).
www-scf.usc.edu /~chem203/resources/DNA/rna_structure.html   (244 words)

 RNA Structure and Function   (Site not responding. Last check: 2007-10-30)
The sugar in RNA is ribose, not the deoxyribose in DNA (as we previously learned).
The base uracil is present in RNA instead of thymine.
Another difference between RNA and DNA is in function.
www.ncc.gmu.edu /dna/rna.htm   (182 words)

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