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Topic: RNA polymerase III

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RNA world hypothesis

messenger RNA

RNA gene

RNA polymerase

RNA interference

transfer RNA

small interfering RNAs

RNA World

RNAS Culdrose

RNAS Portland

synthesis of RNA

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	RNA polymerase - Wikipedia, the free encyclopedia
		RNA polymerase enzymes are essential and are found in all organisms and many viruses.
		RNA polymerase I synthesizes a pre-rRNA 45S, which matures into 28 S, 18S and 5,8S rRNAs which will form the major RNA sections of the ribosome.
		RNA polymerase III synthesizes tRNAs, rRNA 5S and other small RNAs found in the nucleus and cytosol.
	en.wikipedia.org /wiki/RNA_polymerase (928 words)

	RNA polymerase III - Wikipedia, the free encyclopedia
		The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions.
		Therefore the regulation of Pol III transcription is primarily tied to the regulation cell growth and the cell cycle, thus requiring fewer regulatory proteins than RNA polymerase II.
		TFIIIB (Transcription Factor for polymerase III B), consists of three subunits: TBP (TATA Binding Protein), the Pol II transcription factor TFIIB-related protein, Brf1 (or Brf2 for transcription of a subset of Pol III-transcribed genes in vertebrates) and Bdp1.
	en.wikipedia.org /wiki/RNA_polymerase_III (676 words)

	Transcription (genetics) - Wikipedia, the free encyclopedia
		The RNA polymerase transcribes the DNA, but produces about 10 abortive (short, non-productive) transcripts which are unable to leave the RNA polymerase because the exit channel is blocked by the σ-factor.
		RNA Polymerase III is localized to the nucleus (and possibly the nucleolus-nucleus interface), and transcribes transfer RNA (tRNA) and other small RNAs (including the small 5S rRNA).
		RNA synthesis by RNA polymerase had been established in vitro by several laboratories by 1965; however, the RNA synthesized by these enzymes had properties that suggested the existence of an additional factor needed to terminate transcription correctly.
	en.wikipedia.org /wiki/Transcription_(genetics) (1298 words)

	20
		RNA polymerases I and III terminate at discrete sequences in defined reactions, but the mode of termination by RNA polymerase II is not clear.
		RNA polymerase II synthesizes mRNA in the nucleoplasm.
		All eukaryotic RNA polymerases have ~12 subunits and are aggregates of >500 kD.
	www.lbcd.icb.ufmg.br /gd1/gd1.htm (5187 words)

	RpIII128 -
		The second C. elegans sequence detected with the Drosophila probe, named rpc-1, was found to encode a 4.8-kb transcript and hybridized strongly to the gene encoding the largest subunit of RNA polymerase III from yeast, implicating rpc-1 as encoding the analogous peptide in the nematode.
		RNA polymerase preparations of D. melanogaster were blotted and the second-largest subunits were identified with antibodies raised against polypeptides expressed from DmRP128 and DmRP135.
		RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system.
	www.ihop-net.org /UniPub/iHOP/gg/62050.html (1078 words)

	Untitled Document
		It may have primary responsibility for ensuring that RNA polymerase I is properly localized at the startpoint.
		TFIIIB remains bound in the vicinity of the startpoint and its presence is sufficient to allow RNA polymerase III to bind at the startpoint.
		RNA polymerase III terminates transcription with U's immediately after a GC-rich region (but there is no requirement for a stem-loop structure, unlike the prokaryotic factor-independent terminator that has a GC-rich stem-loop).
	www.oregonstate.edu /instruction/bb492/lectures/RegulationIV.html (1669 words)

	Rna Polymerase (Site not responding. Last check: 2007-10-12)
		The enzyme RNA polymerase or RNAP is a nucleotidyltransferase that polymerises ribonucleotides in accordance with the information present in DNA.
		RNA polymerase enzymes are essential and are found in all cells of all organisms.
		RNA polymerase III synthesizes tRNA, rRNA 5S and other small RNA's found in the nucleus and cytosol.
	www.wikiverse.org /rna-polymerase (383 words)

	Stumph, William E.
		The snRNAs are a special class of RNA molecules that are involved in messenger RNA (mRNA) splicing (the removal of intervening sequences from mRNA precursors).
		For example, most snRNA genes are transcribed by RNA polymerase II (the same enzyme that synthesizes mRNAs), but these Pol II-transcribed snRNA genes contain no introns and they lack the TATA sequences commonly found upstream of mRNA transcription units.
		Despite this difference in RNA polymerase specificity, the promoter sequences of U6 genes are actually very similar to the promoters of U1-U5 genes.
	www.bio.sdsu.edu /faculty/stumph.html (865 words)

	An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP -- Siaut et al. 23 ...
		RNA Pol III fractions (1 µg), purified from strains YMS1, YMS2, YMS3, and YMS4 containing C17, HsC17, HA-C17, or HA-HsC17 as indicated, were analyzed by SDS-PAGE on a 4 to 15% polyacrylamide gel and revealed by silver staining.
		sequences with Rpb7, with the A43 subunit of yeast RNA Pol I, and with the RpoE subunit of archaeal RNA polymerase (54, 62,
		The Rpb4 subunit of fission yeast Schizosaccharomyces pombe RNA polymerase II is essential for cell viability and similar in structure to the corresponding subunits of higher eukaryotes.
	mcb.asm.org /cgi/content/full/23/1/195 (7458 words)

	Searle Scholar Profile : David Alan Brow (1990)
		Few in vivo studies of pol III transcription complex assembly have been attempted, because of the difficulties posed by the intragenic location of the promoter elements and by the multiple genomic copies of the transcription units being examined.
		U6 RNA is an essential component of the spliceosome, and may act as a ribozyme to catalyze intron removal.
		Conformational switches in RNA have been intensively sought, so the dynamics of U6 RNA are of interest both for what they will tell us about the mechanism of splicing and as a paradigm for the biochemical activity of RNA in general.
	www.searlescholars.net /people/1990/brow.html (1123 words)

	Unusual Properties of Adenovirus E2E Transcription by RNA Polymerase III -- Huang and Flint 77 (7): 4015 -- The Journal ...
		Each RNA sample was hybridized to an oligonucleotide probe complementary to the 5' segment of the CAT gene, as indicated by the fl bar drawn below the gene in panel A and to DNA complementary to the external transcribed spacer of a human rRNA gene.
		Cytoplasmic RNA was prepared from HeLa cells infected with Ad5 for 12 h and then incubated in the presence of 10 µg of actinomycin D/ml for periods increasing from 0 to 120 min.
		An RNA polymerase III transcription unit located in the upstream control regions of the human proliferating-cell nucleolar protein p120 gene is transcribed in vitro and in vivo.
	jvi.asm.org /cgi/content/full/77/7/4015 (6524 words)

	Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters ...
		Kumar, A., Kassavetis, G.A., Geiduschek, E.P., Hambalko, M., and Brent, C.J. Functional dissection of the B'' component of RNA polymerase III transcription factor IIIB: A scaffolding protein with multiple roles in assembly and initiation of transcription.
		Leresche, A., Wolf, V.J., and Gottesfeld, J.M. Repression of RNA polymerase II and III transcription during M phase of the cell cycle.
		Parsons, G.G. and Spencer, C.A. Mitotic repression of RNA polymerase II transcription is accompanied by release of transcription elongation complexes.
	www.genesdev.org /cgi/content/full/14/20/2650 (8473 words)

	A Novel Subunit of Yeast RNA Polymerase III Interacts with the TFIIB-Related Domain of TFIIIB70 -- Ferri et al. 20 (2): ...
		by Pol III in vitro in the absence of TFIIIC (28, 29).
		RNA species were extracted and analyzed by electrophoresis on a 7 M urea gel (6% polyacrylamide), using equal amounts of RNA (6 µg per lane).
		A suppressor of TBP mutations encodes an RNA polymerase III transcription factor with homology to TFIIB.
	mcb.asm.org /cgi/content/full/20/2/488 (6355 words)

	Blaine Bartholomew
		First, gene expression is controlled to a large extent be regulating the four different stages of transcription; namely, (1) promoter binding and activation, (2) RNA chain initiation and promoter escape, (3) elongation and (4) termination and release of RNA transcripts.
		It is possible to determine which region of the protein interacts with specific positions in DNA or RNA by peptide mapping the DP and RP labeled proteins.
		The Regulation of RNA polymerase II Activity by Multisite Phosphorylation.
	www.siu.edu /departments/biochem/faculty/Bartholomew.html (942 words)

	Tagetin™ RNA Polymerase Inhibitor, EPICENTRE® Biotechnologies (Site not responding. Last check: 2007-10-12)
		First discovered as a bacterial phytotoxin responsible for inducing chlorosis, Tagetin™ RNA Polymerase Inhibitor is the only compound known to potently and selectively inhibit RNA polymerase III from a variety of eukaryotic organisms including mammalian cells, Saccharomyces cerevisiae, Drosophila melanogaster, Bombyx mori, and Xenopus laevis oocytes.
		With both eukaryotic and prokaryotic RNA polymerases, the degree of inhibition is template-dependent.
		Although the precise mechanism of inhibition is not understood, studies with yeast nuclear extracts indicate that the effect is due to increased pausing of the elongation complex at discrete points on the template.
	www.epicentre.com /item.asp?ID=364&CatID=30&SubCatID= (375 words)

	A role for {beta}-actin in RNA polymerase III transcription -- Hu et al. 18 (24): 3010 -- Genes and Development
		Pol III was immunoprecipitated with an anti-RPC4 antibody, and the bound material was analyzed by immunoblotting with anti-RPC1 antibodies.
		Bartholomew, B., Durkovich, D., Kassavetis, G.A., and Geiduschek, E.P. Orientation and topography of RNA polymerase III in transcription complexes.
		Cramer, P., Bushnell, D.A., and Kornberg, R.D. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.
	www.genesdev.org /cgi/content/full/18/24/3010 (3980 words)

	Nouria Hernandez, Ph.D., Cold Spring Harbor Laboratory
		Another advantage is that in the case of the RNA polymerase III snRNA genes, we have recently been able to reconstitute transcription with well-defined factors.
		Transcription from the human RNA polymerase III U6 promoter can be reconstituted in vitro with a set of eight recombinant factors and RNA polymerase III highly purified from human cultured cells.
		In the reconstituted transcription system, treatment of RNA polymerase III with CK2 is required for transcription, whereas treatment of Bdp1, one of the factors required for promoter recognition by RNA polymerase III, is inhibitory.
	www.cshl.edu /gradschool/hernand_.html (401 words)

	Pharmaceutical Sequences, DNA & beyond glossary
		The primate Alu (ALU ELEMENTS) and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle.
		A sequence of DNA lying beyond the 3’ end of the coding segment of a gene which is recognized by RNA polymerase as a signal to stop synthesizing mRNA.
		Consists of the RNA polymerase II holoenzyme plus two additional “general transcriptions factors,” which are protein complexes and a histone acetyltransferase that theoretically exerts its transcriptional activity by modifying chromatin.
	www.genomicglossaries.com /content/sequencing_dna_beyond_gloss.asp (4617 words)

	Karen Sprague (Site not responding. Last check: 2007-10-12)
		I have been interested in the regulation of transcription by eukaryotic RNA polymerase III.
		The genes encoding alanine tRNA in the silkworm, Bombyx mori are a striking example of regulated polymerase III activity.
		(1993) A novel RNA polymerase III transcription factor fraction that is not required for template commitment.
	www.molbio.uoregon.edu /facres/spraguek.htm (437 words)

	RNA Polymerase III (Site not responding. Last check: 2007-10-12)
		Pol III is the largest of the nuclear RNA polymerases, with an aggregate molecular weight of 600700 kD (reviewed by Thuriaux and Sentenac
		This is, perhaps, surprising since pol II transcribes a much larger and more diverse set of templates, and so might have been expected to show the greatest complexity.
		Its function in the class III system, and those of the other pol II-associated factors, may possibly be performed by the additional subunits that copurify with pol III.
	www.eurekah.com /abstract.php?chapid=471&bookid=49&catid=30 (204 words)

	Graduate Program - Dr. Daniel Kenan
		Das, S., Kenan, D. J., Bocskai, D., Keene, J. D., and Dasgupta, A. Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.
		Maraia, R. J., Kenan, D. J., and Keene, J. Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
		Tsai, D. E., Kenan, D. J., and Keene, J. In vitro selection of an RNA epitope immunologically cross-reactive with a peptide.
	www.pathology.mc.duke.edu /website/webform.aspx?id=GradKenan (916 words)

	Reactome: RNA Polymerase III Transcription (Site not responding. Last check: 2007-10-12)
		RNA polymerase III is one of three types of nuclear RNA poly...
		RNA Polymerase III Transcriptional Pause at Terminator Sequence
		RNA Polymerase III Termination and release of transcribed mRNA
	reactome.org:8000 /cgi-bin/eventbrowser?DB=test_reactome_14&ID=74158 (182 words)

	A role for {beta}-actin in RNA polymerase III transcription -- Hu et al. 18 (24): 3010 -- Genes and Development
		A role for {beta}-actin in RNA polymerase III transcription -- Hu et al.
		III), pol III must be treated with CK2 to be active.
		Human La is found at RNA polymerase III-transcribed genes in vivo
	www.genesdev.org /cgi/content/abstract/18/24/3010 (304 words)

	Refs1700-1799
		M.R. Paule, R.J. White, “Survey and summary: transcription by RNA polymerases I and III,” Nucleic Acids Res.
		Huang, R.J. Maraia, “Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human,” Nucleic Acids Res.
		S.C. Agalarov, J.R. Williamson, “A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit,” RNA 6(March 2000):402-408.
	www.molecularassembler.com /KSRM/Refs1700-1799.htm (1977 words)

	RNA Polymerase III Transcription eBook
		The aim of this book is to review the substantial body of work that has been published concerning transcription by pol III, the largest and most complex of the eukaryotic RNA polymerases.
		A vast literature exists concerning transcription by pol III.
		The first edition of "RNA Polymerase III Transcription," which was written in 1993, provided the only comprehensive review of all aspects of this important field that has ever been published.
	www.ebook-library.co.uk /ebook-1597342483.htm (189 words)

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