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Topic: RU486

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	RU486/prostaglandin briefing
		RU486 is a synthetic steroid which works by blocking the effects of progesterone, the natural hormone which is required to maintain the lining of the uterus during pregnancy.
		RU486 starves the womb of progesterone, the lining of the womb breaks down, and it is lost along with the developing embryo or foetus.
		Because of the way that RU486 is administered, the woman is involved in the whole process, she takes the tablets herself and is fully aware of the effects that the drugs are having on her body as they happen.
	www.spuc.org.uk /ethics/abortion/ru486 (1254 words)

	Abortion pill - RU486 (mifepristone) - Better Health Channel.
		If the administration of RU486 doesn’t work, and the woman changes her mind and decides to go ahead with the pregnancy, the baby is at increased risk of birth defects.
		RU486 is an oral pill that induces medical abortion by blocking the action of the pregnancy hormone progesterone.
		RU486 offers a safe, reliable and non-surgical means of abortion but is not currently available in Australia for the purposes of abortion.
	www.betterhealth.vic.gov.au /bhcv2/bhcarticles.nsf/pages/Abortion_pill_RU486_(mifepristone)?open (1019 words)

	Untitled Document
		The incidence of bleeding is actually higher for RU486 than for a surgical abortion; the average woman bleeds for 8-9 days with RU486, as opposed to 5 days for a surgical abortion.
		If surgery is required to end a pregnancy due to complications in using RU486, doctors have found that the procedure is actually easier as a result of the drug, because the cervix is already soft and open as a result of the abortifacient drugs.
		RU486 offers more privacy, as the woman is usually able to miscarry in her own home.
	www.brown.edu /Courses/BI0032/repro/ru486.htm (861 words)

	Leyden's Jar: RU486 - what the hell is it? (Site not responding. Last check: 2007-10-29)
		None of the debate over the past few days has seemed to even come close to examining what RU486 even is, how it could be used, and whether it is in the health minister's should have such control over it.
		RU486, the "abortion pill", was banned from Australian use back in 1996 when the then independant senator Brian Harradine made a deal with the Coalition government over the sale of Telstra.
		RU486 is commonly know by the medical establishment as mifepristone, and acts as an anti-progesterone.
	www.leydensjar.com /2006/02/ru486-what-hell-is-it.html (486 words)

	Green Left - Cover Story: RU486: Women, not politicians, should choose
		While RU486 was not banned by the amendment, potential sponsors were put off by the extra approval required and did not apply to market the drug in Australia.
		Holzapfel claims that Australians Against RU486 does not aim to widen the debate to the general availability of abortion, but argues that the TGA cannot adequately assess the ethics of a drug “in a league of its own”.
		RU486 could be cheaper than a surgical abortion and fulfil women’s needs for privacy and a less invasive abortion method.
	www.greenleft.org.au /2006/654/7532 (1458 words)

	TAP: Web Feature: Safe, Legal, and Unavailable:. by Yanna Krupnikov. September 20, 2001. (Site not responding. Last check: 2007-10-29)
		RU486 is taken in two doses, inducing a miscarriage.
		First, the introduction of RU486 drastically increases the number of available abortion providers by opening the field to physicians who are not necessarily trained to perform surgical abortions.
		Smeal says RU486 is a safe and effective alternative to surgical abortion, and sees few medical complications as a result of its availability on college campuses.
	www.prospect.org /webfeatures/2001/09/krupnikov-y-09-20.html (1159 words)

	Bio 32: Interruption of Reproduction
		RU486, also known as Mifepristone, Mifeprex, and "the Abortion Pill", is for women who have gotten pregnant and want to terminate the pregnancy early and non-surgically.
		In the US, women are able to use RU486 up to 49 days after the first day of the last menstrual cycle, although studies are showing that it could be effective up to 63 days, though the success rate may decrease slightly after 49 days.
		The first drug, generically called Mifepristone, better known by the brand name Mifeprex, blocks the receptors on the uterine wall for progesterone, a hormone that is necessary to maintain pregnancy; the Mifepristone is an antiprogestin.
	www.brown.edu /Courses/BI0032/repro/ru4861.htm (890 words)

	RU486 for Australia?
		RU486 is the common name for the drug mifepristone, a synthetic steroid that can be used to induce what is known as medical abortion—an alternative method to surgical termination of pregnancy.
		RU486 works by blocking the effects of the hormone progesterone, which is crucial to starting and maintaining pregnancy.
		RU486 is mainly used during the first nine weeks of pregnancy, though is also effective for second trimester termination, again in conjunction with a prostaglandin.
	www.aph.gov.au /library/pubs/rn/2005-06/06rn19.htm (2967 words)

	Women's Choice Clinic: RU486 Medical Abortion (Site not responding. Last check: 2007-10-29)
		RU486 was approved by the FDA in September 2000 and we were one of the first local clinics to provide this medication.
		It was developed in France over 15 years ago, and is currently widely available in France, China and the U.S. In 1996, RU486 was approved by the FDA for study in the United States.
		While a federal judge ruled RU486 to be released for use as an abortifacient, that decision was blocked by the US Court of Appeals, Second Circuit.
	www.womenschoiceclinic.org /pages/RU486.html (347 words)

	Green Left - Feminist column: ... and ain't i a woman?: RU486
		RU486 could be dispensed by general practitioners, allowing far easier access to abortion than currently exists.
		While RU486 is not a suitable fertility control treatment for all women, the rate of death and side effects from its use is similar to that for surgical abortion and minute compared to childbirth.
		RU486 is an alternative to surgical abortion procedures.
	www.greenleft.org.au /2001/435/26775 (614 words)

	FMF - The Fight to make RU486 Legal
		RU486 may also be effective in treating fibroid tumors, endometriosis, Cushing's Syndrome, meningiomas, some types of breast cancer, and a myriad of other diseases and conditions that primarily affect women.
		Clinical trials on the use of RU486 as a method of early abortion begin in the United States at the University of Southern California.
		RU486 becomes available in France in October 1988, after the French Minister of Health declares RU486 "the moral property of women" and orders Roussel Uclaf to return RU486 to the market following the company's decision to withdraw the drug in the wake of anti-abortion pressure.
	www.feminist.org /welcome/ru486two.html (1657 words)

	RU486 Abortion Pill
		The RU486 pill breaks down the lining of the uterus so that it can't sustain the foetus (baby) and it is as you say, rejected by the body.
		While women might still be able to access RU486 overseas on the internet, the application of the pill is time-sensitive and the length of the process would probably mean the window of opportunity for its effective use would be missed.
		As an authorised prescriber she has begun the process of asking the TGA to allow her to import RU486 and has approached the New Zealand not-for-profit company Ista, which sells RU486 in that country, to provide a supply of the drug.
	www.ebroadcast.com.au /eblah/b-newsauspolitics/m-1139458138/s-15 (2643 words)

	News in Science - Infections linked to RU486 on the rise - 12/05/2006
		The cause of increasing rare but deadly bacterial infections, including a handful of cases in women who have taken the controversial RU486 abortion pill, is still unclear and needs further study, US health experts say.
		Drawing the most scrutiny are cases involving RU486, a drug that is taken with another called misoprostol early in pregnancy to trigger an abortion.
		Several women's groups and others RU486 supporters say the infections need more study, while abortion opponents say the data shows the pill is too risky to stay on the market.
	www.abc.net.au /science/news/stories/s1636929.htm (600 words)

	Ru486: See what people are saying right now on Technorati (Site not responding. Last check: 2007-10-29)
		RU486 www.sjwc.net - Board certified GYN in Cherry Hill, NJ providing medical abortions with RU486 and surgical abortions in private office setting since 1978.
		RU486: oltre a Morresi e Roccella, ci si mettono...
		Ennesime polemiche riguardo alla RU486, ennesime cattive motivazioni a sostegno della condanna.
	technorati.com /tag/ru486 (427 words)

	UNSW Embryology- Human Menstrual Cycle - RU486
		Mifepristone (RU486) is a progesterone receptor antagonist (antiprogesterone) which can prevent between 92-100% of pregnancies on oral intake of a 10-600 mg dose within 72 h of unprotected intercourse.
		Recently the drug RU486, which is an abortive rather contraceptive drug, has been the centre of political and medical discussions in Australia.
		RU486 is the only medicine that is subject to the restricted goods condition.
	embryology.med.unsw.edu.au /WWWHuman/MCycle/RU486.htm (673 words)

	No room at the inn for RU486 - The Pulse - Health Matters
		RU486 (also known as mifepristone) is a hormone treatment that prevents the fertilised egg from implanting in the uterus.
		They argued the dangers of RU486 were being overstated, and the Harradine amendment was introduced and passed for ideological and political rather than health reasons (in other words, a fear that RU486 might encourage more women to have abortions).
		There’s no evidence that RU486 encourages abortion - in those countries where RU486 is available, there’s been no increase in abortion rates, says Ms Cait Calcutt, Coordinator of Children by Choice, a lobby group that advises women on contraception and abortion issues.
	www.abc.net.au /health/thepulse/s1246252.htm (824 words)

	Mifepristone The French Abortion Pill The
		RU486 is an artificial steroid that interferes with the action of progesterone, a hormone crucial to the early progress of pregnancy.
		When women who have had RU486 abortions begin to deal with their experience, they will have more vivid memories and a greater sense of responsibility to deal with than those who underwent surgical abortions.
		Actually, because RU486 is effective only if taken early on in pregnancy, and because a substantial number women would not be allowed to take the drug because of disqualifying physical conditions, the potential market is likely to be much smaller.
	www.nrlc.org /ru486all.html (8782 words)

	Australians for RU486 - About Us
		RU486 has the potential to provide Australian women with a safe and effective method of having a medical abortion.
		Dr Bennett has assessed the extensive research on RU486 and agrees with the 2005 WHO statement that this drug is a population priority health care need.
		She empathises with women who prefer medical rather than surgical abortions and believes that the decision regarding the availability of RU486 should not be politically determined.
	www.ru486.org.au /about.html (493 words)

	Australians Against RU486 - TGA Problems and RU486 (Site not responding. Last check: 2007-10-29)
		Given the controversial nature of RU486, Women’s Forum Australia believes that the risk of this perception is a further reason why it would be inappropriate for the TGA to be responsible for approving this drug.
		Yet, in the case of RU486, it is the medical professionals and pharmacists who are likely to be made aware of adverse effects.
		Experience in the USA demonstrates that it is essential that reporting of adverse effects of RU486, a drug which has caused deaths, must be mandatory and that whoever approves the use of RU486 must able to require such reporting regardless of whom becomes aware of adverse events.
	www.aaru486.com.au /index.php?option=com_content&task=view&id=39&Itemid=31 (839 words)

	RU486: Don’t go there - On Line Opinion - 1/12/2005
		RU486 starves the embryo of blood by blocking placental progesterone receptors; misoprostol induces uterine contractions to expel the dead embryo and other tissue.
		RU486 cannot be administered safely, and Australians will be ill-served by political efforts to hastily approve a drug whose true safety profile is only now being accurately discerned.
		She is Chairperson of the AAPLOG subcommittee on RU486, and coauthored the Citizen Petition filed with the FDA to remove RU486 from the market.
	www.onlineopinion.com.au /view.asp?article=3900 (931 words)

	RU486 divides Australia like no other pill since The Pill - WomensHealth
		RU486 was specifically prohibited in Australia under a 1996 act of federal parliament, yet it has been licensed for use in France since 1988, in the United Kingdom since 1991 and in the United States since 2000.
		When used in combination with another drug, such as misoprostol, RU486 results in complete abortion in between 93 and 98 per cent of cases.
		Such women often have to travel hundreds of kilometres at their own expense to a private clinic in the nearest large town, a cost she says is sometimes beyond their resources.
	smh.com.au /news/womenshealth/ru486-divides-australia-like-no-other-pill-since-the-pill/2006/02/17/1140064236328.html (819 words)

	RU486 The Abortion Pill
		Mifeprex is the brand name of mifepristone in the U.S., and is sometimes referred to as non-surgical abortion, medical abortion, or RU486.
		Non-surgical abortions using RU486 are performed in the first 63 days of the first trimester.
		Mifeprex (RU486) is approved by the FDA for non-surgical abortion.
	www.ru486.com /topics/articles/article_73.asp (460 words)

	ESR \| May 29, 2006 \| RU486 or against it?
		It was just space-shipped to us from RU486 and is being distributed out of the interplanetary foreign offices in Hollywood.
		The unprincipled French got on their knees, just outside the cathedrals they want converted to town halls for the Aliens of RU486, and prayed a "higher form of intelligence" down from space.
		RU486 responded immediately and sent a squadron, commanded by an alien named Robespierre.
	www.enterstageright.com /archive/articles/0606/0606ru486.htm (1537 words)

	Maryland Right to Life: Issues: RU486 (Site not responding. Last check: 2007-10-29)
		Three researchers who reviewed much of the data on RU486 say "many of the women in these studies experienced pain for several days/weeks until the abortion was complete.
		There is additional concern because only about half of women who take RU486 actually abort at the doctor=s office, meaning 50% or more face their bleeding and aborting without medical supervision.
		I had thought she was having an incomplete miscarriage, but her husband took me into the hall and told me that she had taken RU486 approximately 2 weeks before.
	www.mdrtl.org /Site/Issues/issues_ru486.htm (1464 words)

	Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486 -- Liu et ...
		RU486 Acts as an Agonist in T47D Cells and an Antagonist in HeLa Cells.
		RU486 was an agonist with T47D nuclear extracts, and an antagonist with HeLa nuclear extracts in vitro.
		Transcription reactions were performed by using PR, HeLa NE, P, or RU486 in the absence or presence of exogenous SMRT (2.5 nM) or SRC-1 (0.5-1 nM) as indicated.
	www.pnas.org /cgi/content/full/99/12/7940 (3932 words)

	Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse ...
		Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum -- Ghoumari et al.
		of RU486 was not influenced by the presence of PROG in the
		The neuroprotective effect of RU486 is not mediated by the intracellular PR nor blocked by PROG.
	www.pnas.org /cgi/content/full/100/13/7953 (3659 words)

	RU486 - messy, unpredictable, unsafe - On Line Opinion - 23/12/2005 (Site not responding. Last check: 2007-10-29)
		RU486 tablets and prostaglandin, taken two days later, can draw out the abortion process to two weeks or more, with bleeding, nausea, vomiting and painful contractions.
		Conversely, in California, the four deaths were first attributed to contaminated prostaglandin tablets (in contravention of the approved US Food and Drug Administration protocol, a woman is given the prostaglandin tablets to insert into her vagina, instead of returning to a doctor's surgery and taking them orally).
		Dr Renate Klein, a biologist and social scientist, is co-author of RU486 Misconceptions, Myths and Morals.
	www.onlineopinion.com.au /view.asp?article=3991 (767 words)

	RU486-induced Glucocorticoid Receptor Agonism Is Controlled by the Receptor N Terminus and by Corepressor Binding -- ...
		the progesterone receptor occupied by the antagonist RU486 (18-20).
		CV1 cells were cotransfected with the MMTV-Luc reporter and expression vectors for either wild-type GR or GR fused to the Vp16 activation domain.
		RU486 is often classified as a type II antagonist leading to a
	www.jbc.org /cgi/content/full/277/29/26238 (4937 words)

	Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release -- ... (Site not responding. Last check: 2007-10-29)
		Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release -- Chivers et al.
		RU486 acting alone (data not shown and see Fig. 5A).
		Pariante, C.M., Pearce, B.D., Pisell, T.L., Su, C. and Miller, A.H. (2001) The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells.
	content.febsjournal.org /cgi/content/full/271/20/4042 (4642 words)

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