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Topic: Racemethorphan

	DXM (robbo) \| Ask Dr. Shulgin Online
		It has been synthesized from a benzylisoquinoline (with a planar structure) by a process known as Grewe's cyclization (from the 1950's !) to give the corresponding morphinan (with a three dimensional structure).
		The isoquinoline is 1,2,3,4,5,6,7,8-octahydro-1-(4-methoxybenzyl)isoquinoline (there is just one residual double bond at the fusion position of the two rings of the isoquinoline) is converted into the N-formyl derivative, cyclized to the N- formyl normorphinan, and the formyl group reduced to an N-methyl group, to give 3-methoxy-17-methylmorphinan, or Racemethorphan.
		The racemic mixture (Racemethorphan) and the (-)-isomer (Levomethorphan) are both Schedule II drugs under the Controlled Substances Act, but the (+)-isomer (Dextromethorphan) has been exempted from scheduling (see 21 U.S.C. 812 (g)(2)).
	www.cognitiveliberty.org /shulgin/adsarchive/dxm.htm (333 words)

	Beauty in Dissonance - The Official Website of the Internet (Site not responding. Last check: 2007-10-04)
		Both the optical isomer of DXM (levomethorphan) and the racemic mixture of levomethorphan and dextromethorphan (racemethorphan) are Schedule II in the United States.
		DXM has been synthesized from a benzylisoquinoline (with a planar structure) by a process known as Grewe's cyclization to give the corresponding morphinan (with a three dimensional structure).
		The racemic mixture (Racemethorphan) and the (-)-isomer (Levomethorphan) are both Schedule II drugs under the Controlled Substances Act, but the (+)-isomer (Dextromethorphan) has been exempted from scheduling.
	spud.pureinsanity.net /articles/dxm.php (1285 words)

	United States Patent Application: 0010018457
		The improvement of claim 1, wherein said desmethylselegiline is administered to treat one or more withdrawal symptoms resulting from an addictive narcotic.
		The improvement of claim 7, wherein said addictive narcotic is selected from the group consisting of: alphaprodine, anileridine, bezitramide, codeine, dihydrocodeine, diphenoxylate, fentanyl, hydrocodone, hydromorphone, isomethadone, levomethorphan, levorphanol, metazocine, methadone, metopon, oxycodone, oxymorphone, pethidine, phenazocine, piminodine, racemethorphan, racemorphon and thebaine.
		The improvement of claim 1, wherein said desmethylselegiline is administered to treat one or more withdrawal symptoms resulting from an addictive barbiturate.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=/netahtml/PTO/search-adv.html&r=1&f=G&l=50&d=PG01&p=1&S1=20010053798&OS=20010053798&RS=20010053798 (9985 words)

	UNDCP - E/NL. 1955/93: Public Notice No. 78 of 1955 M.P.1865/11
		3-Methoxy-N-methylmorphinan (that is to say, dextromethorphan, levomethorphan and racemethorphan), its salts and any preparation, admixture, extract or other substance containing any proportion of 3-methoxy-N-methylmorphinan."
		3-Methoxy-N-methylmorphinan other than dextromethorphan (that is to say, levomethorphan and racemethorphan) its salts and any preparation admixture, extract or other substance containing any proportion of 3-methoxy-N-methylmorphinan."
		The Dangerous Drugs (Amendment) Order in Council 1953, is hereby revoked.
	www.unodc.org /unodc/es/legal_library/sl/legal_library_1956-03-20_1955-93.html (191 words)

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