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Topic: Randy Schekman


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In the News (Sun 27 Dec 09)

  
  The Lasker Foundation | This Year's Winners, Basic
Randy Schekman is a professor in the department of molecular and cell biology at the University of California at Berkeley.
Schekman: Biochemically, by enzyme activity, we could tell that secretory enzymes were accumulating inside the cell and it was a temperature sensitive growth mutant.
Schekman: This is of course an important question because a lot of students come to me and I think they have the impression that it's spent, you know, that it's now a mature subject and there aren't new opportunities.
www.laskerfoundation.org /awards/library/2002schekman_int.shtml   (4465 words)

  
 [No title]
The key insight by Schekman and graduate student Peter Novick, now a professor at Yale University, was that the best way to track down genes involved in the secretion pathway was to look for mutant yeast that die, since the pathway is critical to the life of the cell.
Schekman admits that his once isolated research niche is now crowded, in part because his research opened up many new avenues for exploration.
Schekman's daughter, Lauren, is a junior majoring in economics at UC Berkeley.
www.berkeley.edu /news/media/releases/2002/09/schekman_p.html   (1690 words)

  
 Randy Schekman, Ph.D.
Randy Schekman, Ph.D. Dr. Schekman is also Professor of Molecular and Cell Biology at the University of California, Berkeley, and Adjunct Professor of Biochemistry and Biophysics at the University of California, San Francisco.
Schekman is a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
Randy Schekman’s research is focused on the process of membrane assembly, vesicular transport, and membrane fusion among organelles of the secretory pathway.
www.hhmi.org /research/investigators/schekman_bio.html   (207 words)

  
 UC biologist wins prestigious award / Lasker recipients often go on to win Nobel
Schekman has known for years that he was on a short list for such a prize, but has tried to keep it in perspective.
Schekman is a professor of biochemistry and cell biology as well as an investigator for the Howard Hughes Medical Institutes, which funds research at universities throughout the nation.
Schekman said he is frustrated that the Bush administration has limited research of embryonic stem cells, which he believes could be coaxed into producing dopamine producing cells and transplanted safely into humans.
www.sfgate.com /cgi-bin/article.cgi?f=/c/a/2002/09/22/MN128163.DTL   (849 words)

  
 Randy Schekman Receives Lasker Award
Schekman, 53, a professor of molecular and cell biology at the University of California, Berkeley, and an investigator in the Howard Hughes Medical Institute, will share the 2002 Lasker Award for Basic Medical Research with James E. Rothman of the Sloan-Kettering Institute in New York City, the Lasker Foundation announced today (Sunday, Sept. 22).
Schekman and Rothman separately mapped out one of the body's critical networks, the system in all cells that shuttles hormones and enzymes out and adds to the cell surface so it can grow and divide.
In what some thought was a foolish decision, Schekman decided in 1976, when he first joined the College of Letters and Science at UC Berkeley, to explore this system in yeast.
www.berkeley.edu /news/media/releases/2002/09/22_lasker.html   (608 words)

  
 The Lasker Foundation | Awards | 2002 Winners
Randy began his career at Berkeley, where biochemistry was dominated by Daniel Koshland, himself a Lasker awardee, and a firm believer in the power of biochemistry to unlock all mysteries.
Schekman was young, and like Rothman he had an idea and the courage to try it out.
Rothman's grandfather was the village rabbi, a flamboyant orator, and Schekman's grandfather was the tailor.
www.laskerfoundation.org /awards/library/2002_brown_intro.shtml   (1417 words)

  
 ASCB Newsletter, December 1998   (Site not responding. Last check: 2007-09-11)
Schekman describes Kornberg as "demanding and with the highest standards that you can imagine," whose approach was to "define a problem worthy of study, pick the simplest system in which one can study that problem, and unremittingly attack it." This experience committed Schekman to the reductionist approach.
Schekman recalls, "you could see in the electron microscope cells that looked like they had measles because they were filled with vesicles." Schekman's work for many years to come would be to clone these yeast genes, but most of the sequences were not instructive.
Schekman continues to be impressed that the Society "brings young people in at the very earliest stages of their careers." He recognized early that "this is a Society that is doing important things not just for cell biology but for science." Schekman served on Council from 1991-1994, and was elected President for 1999.
www.ascb.org /news/vol21no11/profile.htm   (1741 words)

  
 Randy Schekman
We are attempting to define the genetic and biochemical requirements for this unusual example of regulated transport in yeast.
The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late Golgi membrane proteins.
Dynamics of the COPII coat with GTP and stable analogues.
mcb.berkeley.edu /faculty/CDB/schekmanr.html   (721 words)

  
 News in the College of Letters and Science, UC Berkeley
This year, Cell and Developmental Biology Professor Randy Schekman from the Department of Molecular and Cell Biology garnered this high honor for his work in understanding how cells transport proteins beyond their membrane walls to communicate with other cells.
Exploring secretion from a genetic perspective, Randy Schekman knew that yeast cells exposed to chemicals that cause mutations may acquire genetic abnormalities that would compromise secretion and lead to the cell's death.
Through this technique, Schekman and his colleagues were able to identify 21 more genes responsible for secretion, as well as the specific order in which the steps in secretion were achieved.
ls.berkeley.edu /new/02/schekman.html   (841 words)

  
 Randy Schekman - Wikipedia, the free encyclopedia
Randy Schekman received the Albert Lasker Award for Basic Medical Research in 2002.
Randy Schekman's homepage on the University of California website
Randy Schekman's research into the Intracellular Transport of Proteins
en.wikipedia.org /wiki/Randy_Schekman   (75 words)

  
 Discover Cal in Southern California - Speaker Bios   (Site not responding. Last check: 2007-09-11)
Randy Schekman, Professor of Molecular and Cell Biology
Current chair of the Chancellor's Advisory Committee on Biology, Randy Schekman is also an adjunct professor of biochemistry and biophysics at UC San Francisco.
A Howard Hughes Medical Investigator, Schekman received his Ph.D. in biochemistry at Stanford University and did postdoctoral work at UC San Diego.
www.urel.berkeley.edu /socal/speakers.cfm   (288 words)

  
 HHMI News: Structure Reveals Details of Cell’s Cargo-Carriers   (Site not responding. Last check: 2007-09-11)
Randy Schekman, a pioneer in vesicle studies at the University of California, Berkeley.
According to Schekman, “the structure reveals the mechanism by which the complex anchors to the ER membrane and how its curvature might impart curvature to the membrane; and in doing so initiate the shape change that accompanies vesicle budding.”
“We suspect — and it is a model that Randy Schekman put forward several years ago — that the COPII coat is selecting many of the proteins directly,” said Goldberg.
www.practicingsafescience.org /news/goldbergj2.html   (827 words)

  
 [No title]
Genetics is the key to understanding the role that coat proteins play in sorting and packaging protein cargo for transport, said Randy Schekman, chair of the Department of Molecular and Cell Biology at the University of California, Berkeley, during the biennial Fawcett Lecture at HMS on May 28.
Schekman studies protein secretion in test tubes, reconstituting the elements of the budding reaction in the yeast Saccharomyces cerevisiae to see how vesicles dock, fuse, and deliver their proteins.
These genes could be turned on and off by altering the temperature, thereby stopping at will the transport of proteins from the cytosol into the endoplasmic reticulum, the sorting of proteins within the Golgi, and the transport of secretory vesicles to the plasma membrane.
focus.hms.harvard.edu /1998/July17_1998/cellbio.html   (279 words)

  
 Curriculum Vitae
Deshaies, R.J., and Schekman, R. A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.
Deshaies, R.J. and Schekman, R. Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.
Esnault, Y., Blondel, M.O., Deshaies, R.J., Schekman, R. and Kepes, F. The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum.
www.cco.caltech.edu /~rjdlab/deshaiescv.html   (2227 words)

  
 Cal tries for first dibs on Prop 71 cash - 2005-03-21
The center is also close to leasing off-campus lab space to set up its operations, according to Randy Schekman, chairman of the tentatively named Berkeley Human Stem Cell Center.
The Berkeley center is seeking funding from the university to hire a scientist familiar with cell and developmental biology to help craft funding proposals, and Schekman said he is confident the group will secure the funding.
Schekman said the university is interviewing a prospective faculty member who is training at the Salk Institute in La Jolla and wants to remain in California because of the promise of Prop.
eastbay.bizjournals.com /eastbay/stories/2005/03/21/story2.html?...   (679 words)

  
 eastbayexpress.com | Bestpeople | Thought-Provokingest Professor | 2005-04-06   (Site not responding. Last check: 2007-09-11)
Schekman's own research on the development of membranes in cells bearing nuclei won him a Lasker Foundation award, commonly a precursor to the Nobel Prize.
Schekman not only oversees all life sciences at Cal, but also is working to determine how mutant forms of a protein called presenilin-1 contribute to the pathology of Alzheimer's.
It's known that the deviant presenilins lead to the creation of protein fragments called peptides that accumulate in plaques in the brains of Alzheimer's patients.
www.eastbayexpress.com /issues/2005-04-06/bestpeople/bestpeople23.html   (244 words)

  
 ACSH > Facts & Fears > Archives
Randy Schekman, a Berkeley cell researcher, says that by helping Parkinson's patients through therapeutic cloning, "you might have the possibility of using their own genetic material to replace dead cells in the brain that aren't producing dopamine.
So, it's not a question, then, of reproducing the whole organism...you're going right to the problem source, a small number of cells in a tissue of the brain in the case of Parkinson's, or a small piece of the pancreas in the case of diabetic patients, and simply engineering the production of those few cells.
We rarely think of the abortion issue in terms of a spectrum of possible positions, yet aren't the zygotean and infanticidist position really the two farthest ends of a nine-month spectrum?
www.acsh.org /factsfears/newsID.259/news_detail.asp   (2061 words)

  
 Pace/Off, an MCB95 Production
Scene1 Randy is sitting at his desk, reading Spin magazine.
Walk to "operating room" (other half of stage) Randy lies down on a table, Duesberg is on the other.
TOM wakes up PETE TOM: He'll be out cold for weeks, long enough for you to do the experiments you need to do to undo the damage, and get them published fast-track in Weekly World News PETE: We'll, I'm off to Stanley Hall.
www.ocf.berkeley.edu /~pcarlton/paceoff.html   (1396 words)

  
 Cell biology A channel for protein waste   (Site not responding. Last check: 2007-09-11)
Randy Schekman is in the Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.
Cells destroy misshapen proteins; viruses use the same methods to destroy healthy cellular proteins that are involved in antiviral defences.
Pilon, M., Schekman, R. and Römisch, K. Article
www.nature.com /nature/journal/v429/n6994/abs/429817a.html   (237 words)

  
 webcast.berkeley | Events | Details   (Site not responding. Last check: 2007-09-11)
In this third installment of "Bear in Mind," the chancellor's online radio-style show, listen in as Chancellor Berdahl talks to public-policy professor and defense expert Michael Nacht, Lasker Award winner Randy Schekman, Human Rights Fellowship recipient Krisjon Rae Olson, and Cal impresario Robert Cole, followed by Berdahl's farewell to beloved former chancellor Chang-Lin Tien.
Nacht shares with the chancellor the ways in which the U.S. remains vulnerable after 9/11, discusses whether war with Iraq will prove to be a costly distraction from the war on terrorism, and why in the messy laboratory of international affairs, you only get one crack at an experiment.
Molecular and cell biology professor Randy Schekman, winner of the prestigious Lasker Award, speculates on the future of basic cell research; makes the case for "creative tension" among scientific disciplines like biology, chemistry, and physics; and tells how the new buildings earmarked for Berkeley's Health Sciences Initiative will nurture that tension.
webcast.berkeley.edu /events/details.html?event_id=22   (414 words)

  
 The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma ...
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane -- Valdivia and Schekman 100 (18): 10287 -- Proceedings of the National Academy of Sciences
Articles by Valdivia, R. Articles by Schekman, R. Cell Biology
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
www.pnas.org /cgi/content/abstract/100/18/10287   (706 words)

  
 Sec16p potentiates the action of COPII proteins to bud transport vesicles -- Supek et al. 158 (6): 1029 -- The Journal ...
Articles by Supek, F. Articles by Schekman, R. Related Collections
The Journal of Cell Biology, Volume 158, Number 6, September 16, 2002 1029-1038
Address correspondence to Randy Schekman, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, 229 Stanley Hall, Berkeley, CA 94720-3206.
www.jcb.org /cgi/content/abstract/158/6/1029   (439 words)

  
 Concentrative sorting of secretory cargo proteins into COPII-coated vesicles -- Malkus et al. 159 (6): 915 -- The ...
Articles by Malkus, P. Articles by Schekman, R. The Rockefeller University Press, 0021-9525/2002/12/915 $5.00
The Journal of Cell Biology, Volume 159, Number 6, 915-921
Address correspondence to Randy Schekman, Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720.
www.jcb.org /cgi/content/abstract/159/6/915   (460 words)

  
 Grace Cathedral: The Forum: Randy Schekman
But is it, as some groups say, tantamount to abortion?
Randy Schekman is a Professor in the Department of Molecular and Cell Biology at the University of California, Berkeley, and will help us unravel the science and controversy behind this medical marvel.
Stem Cells: what's religion got to do with it?
www.gracecathedral.org /forum/for_20050313.shtml   (369 words)

  
 John L McKnight Books, Book Price Comparison at 75 Bookstores.
by James A. Spudich John Gerhart Steven L. Mcknight Randy Schekman
by Randy Schekman (Editor) Steven L. McKnight (Editor) John Gerhart (Editor) Larry Goldstein (Editor)
by James A. Spudich (Editor) John Gerhart Steven L. Mcknight Randy Schekman
www.bookfinder4u.com /search_author/John_L_McKnight.html   (272 words)

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