
	Where results make sense

Topic: Rapamycin

	RapamycinInterview
		Rapamycin is known to inhibit the proliferation of smooth muscle cells that contribute to recurrent blockage of coronary arteries after stent placement.
		Rapamycin for tuberous sclerosis and LAM is an elegant example of molecular therapy targeted at the precise cellular defect that causes disease.
		Patients on rapamycin in moderate or full doses are therefore at risk for infections with common organisms and organisms that would not threaten a patient with a completely normal immune system.
	lam.uc.edu /html/body_RapamycinInterview.html (1945 words)

	Rapamycin, H5
		Rapamycin inhibits the activity of a protein called mTOR which, among its other functions, inhibits a process called autophagy.
		Rapamycin could be an especially promising treatment if started before or shortly after the onset of symptoms in people with HD, when the levels of huntingtin aggregates in the nerve cells are still manageable.
		This finding offers hope that rapamycin could be used early in patients that have tested to be at risk for developing HD in order to delay the onset of symptoms even further.
	www.stanford.edu /group/hopes/treatmts/pbuildup/h5.html (2486 words)

	Rapamycin (Sirolimus), 99% pure, by LC Laboratories
		On the subject of rapamycin purity: HPLC analysis of rapamycin is somewhat complicated.
		Rapamycin forms several chromatographically separable species in solution, consisting perhaps of different conformers, tautomers, hydrates and/or isomers, but they are all in equilibrium with the major form, trans-rapamycin.
		http://circ.ahajournals.org/cgi/content/full/99/16/2164 describes a vehicle for rapamycin injection consisting of a rapamycin suspension in 0.2% carboxymethyl cellulose and 0.25% polysorbate-80.
	www.lclabs.com /PRODFILE/P-R/R-5000.php4 (898 words)

	Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27kip1 Down-regulation and bcl-xL Induction, and Is ...
		and anti-CD28 in the presence or absence of rapamycin (Fig.
		T cells were pretreated with rapamycin or vehicle control (ethanol) and plated with the indicated concentration of rapamycin.
		phosphorylation was inhibited by rapamycin, as we and
	www.jbc.org /cgi/content/full/279/2/910 (6636 words)

	TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin -- Lorenz and Heitman 270 ...
		Rapamycin is a natural product with both antifungal and immunosuppressive activities (reviewed in (1, 2, 3)).
		Several studies have shown that rapamycin and the structurally related macrolide FK506 are mutually antagonistic inhibitors of T-cell activation(10, 11).
		Rapamycin stimulated a complex between wild-type TOR2 and FKBP12 in the two-hybrid assay (Fig.
	www.jbc.org /cgi/content/full/270/46/27531 (5940 words)

	Rapamycin Potentiates Transforming Growth Factor {beta}-Induced Growth Arrest in Nontransformed, Oncogene-Transformed, ... (Site not responding. Last check: 2007-10-22)
		Rapamycin cooperation with TGF-ß to induce growth arrest is mediated by rapamycin binding to FK506 binding protein(s).
		Rapamycin potentiation of TGF-ß-induced growth arrest is mediated by rapamycin binding to FK506 binding protein(s).
		Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability.
	mcb.asm.org /cgi/content/full/22/23/8184 (8078 words)

	Production of Novel Rapamycin Analogs by Precursor-Directed Biosynthesis -- Ritacco et al. 71 (4): 1971 -- Applied and ...
		The IC of the rapamycin control was 1.6 nM, and the IC of 20-thiarapamycin was 53.6 nM.
		The IC of the rapamycin control was 4.9 nM, and the IC of 15-deoxo-19-sulfoxylrapamycin was 800 nM.
		The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
	aem.asm.org /cgi/content/full/71/4/1971 (2373 words)

	Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin -- Weisman et al. 169 (2): ...
		Rapamycin sensitivity of leucine auxotrophs is rescued by a tor1 allele defective in rapamycin binding:
		Rapamycin growth inhibition of leucine auxotrophs is suppressed by excess of leucine or by replacing the nitrogen source in the medium:
		Rapamycin sensitivity of leucine auxotrophs is suppressed by mutations in the stress-activated MAPK cascade:
	www.genetics.org /cgi/content/full/169/2/539 (4958 words)

	Sirolimus - Wikipedia, the free encyclopedia
		Interestingly, rapamycin originally was developed as an antifungal agent.
		However, this was abandoned when it was discovered that rapamycin had potent immunosuppressive and antiproliferative properties.
		Rapamycin blocks Akt signalling and the cells lose their resistance to the chemotherapy.
	en.wikipedia.org /wiki/Rapamycin (742 words)

	Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian ...
		Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin -- Sakakibara et al.
		as an effector for rapamycin are not conclusive.
		Effect of p27 deficiency and rapamycin on intimal hyperplasia: in vivo and in vitro studies using a p27 knockout mouse model.
	ajpheart.physiology.org /cgi/content/full/288/6/H2861 (4824 words)

	The Immunosuppressant Rapamycin Represses Human Immunodeficiency Virus Type 1 Replication -- Roy et al. 46 (11): 3447 ...
		Rapamycin (Rapamune, Sirolimus) is a macrolide exhibiting potent
		Rapamycin abolishes infection with amphotropic murine leukemia virus (A-MLV)- and vesicular stomatitis virus envelope glycoprotein G (VSV-G)-pseudotyped HIV-1 particles.
		The rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5' long terminal repeat.
	aac.asm.org /cgi/content/full/46/11/3447 (6380 words)

	Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via ...
		Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR -- Cruz et al.
		Rapamycin analogs 2 and 23, and to a lesser extent
		Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin).
	aac.asm.org /cgi/content/full/45/11/3162 (4380 words)

	rapamycin, pure, from Fermentek
		Rapamycin inhibits T-lymphocyte activation / proliferation occuring in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressing agents.
		Liu Y. Rapamycin and chronic kidney disease: beyond the inhibition of inflammation.
		Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs.
	www.fermentek.co.il /rapamycin.htm (410 words)

	Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae -- Crespo and Hall 66 (4): 579 -- ...
		Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor.
		Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
		Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
	mmbr.asm.org /cgi/content/full/66/4/579 (7326 words)

	Differential Effects of Rapamycin on Mammalian Target of Rapamycin Signaling Functions in Mammalian Cells -- Edinger et ... (Site not responding. Last check: 2007-10-22)
		Rat brain extract was incubated for 2 h with GST-FKBP12 in the absence or presence of rapamycin.
		sensitive to rapamycin in optimal growth medium (41, 42).
		Nave B. T., Ouwens M., Withers D. J., Alessi D. R., Shepherd P. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
	cancerres.aacrjournals.org /cgi/content/full/63/23/8451 (7191 words)

	Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer -- Boffa et al. 10 (1): 293 -- ...
		Rapamycin inhibits the growth of an established s.c.
		Rapamycin was also effective in preventing tumor growth in mice treated with CsA.
		Rapamycin remained effective at limiting the growth of individual lesions and was able to reduce overall tumor burden in the combination group.
	clincancerres.aacrjournals.org /cgi/content/full/10/1/293 (4076 words)

	Rapamycin, but Not FK-506, Increases Endothelial Tissue Factor Expression: Implications for Drug-Eluting Stent Design ...
		E, Rapamycin enhances thrombin-induced TF surface activity in a concentration-dependent manner.
		Rapamycin does not alter this pattern of induction after stimulation for 0.5, 1, and 2 hours.
		Rapamycin does not alter this pattern of MAP kinase activation.
	circ.ahajournals.org /cgi/content/full/112/13/2002 (4569 words)

	Effects of Rapamycin on Cardiac and Skeletal Muscle Contraction and Crossbridge Cycling -- Schoffstall et al. 312 (1): ...
		Effects of Rapamycin on Cardiac and Skeletal Muscle Contraction and Crossbridge Cycling -- Schoffstall et al.
		Articles by Schoffstall, B. Articles by Chase, P. Effects of Rapamycin on Cardiac and Skeletal Muscle Contraction and Crossbridge Cycling
		Although rapamycin's inhibition of mammalian target of rapamycin
	jpet.aspetjournals.org /cgi/content/abstract/312/1/12 (289 words)

Try your search on: Qwika (all wikis)