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Topic: Receptor (biochemistry)

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	Receptor (biochemistry) - Wikipedia, the free encyclopedia
		In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates the cellular response to the ligand.
		Many hormone receptors and neurotransmitter receptors are transmembrane proteins: transmembrane receptors are embedded in the lipid bilayer of cell membranes, that allow the activation of signal transduction pathways in response to the activation by the binding molecule, or ligand.
		Often, it is hard to determine whether the receptor is nonfunctional or the hormone is produced at decreased level; this gives rise to the "pseudo-hypo-" group of endocrine disorders, where there appears to be a decreased hormonal level while in fact it is the receptor that is not responding sufficiently to the hormone.
	en.wikipedia.org /wiki/Receptor_(biochemistry) (386 words)

	[No title]
		Weigel, J.A. and Weigel, P.H. (2003) Characterization of the recombinant rat 175-kDa hyaluronan receptor for endocytosis (HARE).
		Receptor reactivation in permeable rat hepatocytes is mediated by fatty acyl coenzyme A. J Biol Chem.
		McAbee, D.D. and Weigel, P.H. (1987) ATP depletion causes a reversible redistribution and inactivation of a subpopulation of galactosyl receptors in isolated rat hepatocytes.
	w3.ouhsc.edu /biochem/ocmg/Weigel.htm (3164 words)

	Receptor - Wikipedia, the free encyclopedia
		Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
		Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a neurotransmitter, hormone, or other substance
		Receptors (musician and artist) an 8-bit electronic artist since 2003.
	en.wikipedia.org /wiki/Receptor (165 words)

	Biochemistry of Neurotransmitters
		Two main classes of ACh receptors have been identified on the basis of their responsiveness to the toadstool alkaloid, muscarine, and to nicotine, respectively: the muscarinic receptors and the nicotinic receptors.
		receptors are suspected in control of food intake as mice lacking this gene become obese from increased food intake and are also subject to fatal seizures.
		receptors are present in the gastrointestinal tract and are related to vomiting.
	web.indstate.edu /thcme/mwking/nerves.html (1674 words)

	Platelet receptor biochemistry and regulation (Site not responding. Last check: 2007-10-21)
		Platelets also possess receptors for these molecules and these are also stimulatory, and thus platelets approaching injury also become activated and are incorporated into the developing thrombus.
		This results in the recruitment of specific signalling molecules that bind to the receptor and thereby stimulate the activation of a number of cell signalling pathways.
		We are particularly interested in identifying the mechanisms that allow the signalling pathways that either activate or inhibit platelets to talk to integrin receptors, and thereby regulate adhesion to collagen and aggregation by binding fibrinogen.
	www.ams.rdg.ac.uk /DMCB/platelets/plreceptbioch.html (484 words)

	University of Colorado at Boulder :: Chemistry and Biochemistry :: J. Falke
		Toward this end, the group is using a structure-based approach to probe the switching of receptors and signaling proteins between their 'on' and 'off' signaling states.
		Receptors under study include the yeast pheromone receptor, the mammalian somatostatin receptor, and a 2-adrenergic receptor, all of which can be overexpressed in yeast to yield large quantities of receptor protein for structural and mechanistic studies.
		Goals include the determination of receptor structure, the mechanism of transmembrane signaling, and the molecular basis of G protein regulation.
	www.colorado.edu /chem/DEC/people/falkej.html (937 words)

	The biochemistry of drugs
		The receptor, as specified by our DNA, is a folded protein whose major purpose is to form and maintain the size and shape of the active site.
		In order for ligand and receptor to interact, there must be a driving force that compels the ligand to leave the water and bind to the receptor.
		Since the hydrophobic portions of the ligand and receptor prefer to be juxtaposed, the arrangement of hydrophobic surfaces provides yet another way that receptors can limit the binding of inappropriate targets.
	www.newdrugdesign.com /Rachel_Theory_02.html (970 words)

	Expert: Biochemisty, Cell Biology Expert
		He is also familiar with characterizing the subunit composition of receptors as well as their purification, characterization, and cloning at the molecular level.
		Expert is an established expert in the field of receptor mediated endocytosis and has been publishing actively on this process as well as receptor characterization since 1980.
		For example, the group is purifying and cloning a liver specific receptor that removes circulating hyaluronic acid from the blood.
	www.intota.com /viewbio.asp?bioID=603815&perID=108471 (1055 words)

	The Falke Lab, Selected Publications
		Susanna E. Winston, R.S. Mehan, and J.J. Falke (2005) Evidence that the adaptation subdomain of the aspartate receptor is a dynamic four-helix bundle: Cysteine and disulfide scanning studies.
		Bass, R.B. and J.J. Falke (1998) Detection of a conserved a-helix in the kinase docking region of the aspartate receptor by cysteine and disulfide scanning.
		Careaga, C.L. and J.J. Falke (1992) Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor: Detection by disulfide trapping.
	spot.colorado.edu /~falke/Publications.html (1411 words)

	LICR \| Research Programs \| Biochemistry \| Non-receptor Kinases & Phosphatases
		Signal transduction begins with the phosphorylation of a receptor kinase on the cell surface, which acts as a sensor of the cell’s environment, and is activated by the binding of specific extracellular ‘ligands’; (hormones, growth factors, or cytokines).
		When the receptor senses that the cell no longer needs to respond to the environment, the proteins in the signal transduction pathway driving the process are dephosphorylated, causing the signal transduction and the gene expression to stop.
		Cancer may subvert normal cell processes by causing kinases to be constitutively activated, thus continuously phosphorylating signal transduction pathways, or by causing phosphatases to be deactivated, thus removing the normal control for the cessation of signal transduction.
	www.licr.org /D_programs/d2a2_nonrecept.php (555 words)

	RWJMS Research Day: Abstracts (Biochemistry)
		In the present study, the specific MMP-13 receptor purified from rat primary osteoblastic cells and LRP1 purified from rat liver and rat primary osteoblastic cells were used in solid phase binding assays.
		Soluble mini receptors representing each of the putative ligand binding domains (I, II, III and IV) of LRP1 as well as the transmembrane domain and cytoplasmic tail, termed mLRP1, mLRP2, mLRP3 and mLRP4 respectively, were stably expressed in CHO cells that lack endogenous LRP1.
		The results suggest that i) MMP-13 binds to both specific receptor and LRP1 independently, ii) the recognition site in LRP1 for MMP-13 is localized in cluster I and /or II and iii) the recognition site on LRP1 for MMP-13 is different from that for the specific receptor.
	www2.umdnj.edu /rdayweb/abstracts/biochemistry.htm (4156 words)

	Receptor Localization: Laboratory Methods and Procedures (Receptor Biochemistry and Methodology) by Marjorie A. Ariano ...
		The detection of neurotransmitter receptor locations and distribution densities within the central nervous system and peripheral tissues is receiving intense attention within the neuroscience research community.
		Neurotransmitter receptors, which receive the chemical signals sent from one neuron to another, are critical links in a highly complex information-processing chain.
		Receptor Localization: Laboratory Methods and Procedures is the first user-friendly guide to the latest techniques and approaches being employed to examine the localization of neurotransmitter receptors in the central nervous system and peripheral tissues.
	www.gettextbooks.com /isbn_0471165719.html (354 words)

	Prof. Gustafsson - lectures
		Nobel Symposium on Steroid Hormone Receptors: Structure and Function, Karlskoga, Sweden, September 1983: "On the use of poly- and monoclonal antibodies in studies on the structure and function of the glucocorticoid receptor".
		Argenteuil Symposium: The Role of Receptors in Biology, Brussels, Belgium, October 1984: "Purification and DNA binding of mammalian glucocorticoid receptor".
		Symposium on the Biochemistry of Exercise, Copenhagen, June 1985: "Characterization and regulation of growth hormone receptor in rat liver".
	www.mednut.ki.se /jag/lectures.html (9699 words)

	MBG: George Hess
		George Hess is a Professor of Biochemistry, Molecular and Cell Biology, a member of the National Academy of Sciences, and a Fellow of the American Association for the Advancement of Science.
		We are investigating the structure and function of membrane-bound proteins (neurotransmitter receptors) that control and integrate communication between the cells of the nervous system.
		Malfunction of the receptors is implicated in many diseases of the nervous system, and the receptor proteins are the targets of a large class of clinically important compounds and abused drugs.
	www.mbg.cornell.edu /MBG_Faculty_Detail.cfm?id=16 (1362 words)

	Gait Disorder Project
		One biochemical correlate of the compensation is an elevated ratio of the concentrations of dopamine metabolites:dopamine in striatum following severe dopamine depletion, reflecting upregulated metabolic activity in remaining neurons.
		The effects of dopamine receptors on neurons are modulatory, mediating a complex interaction of dopamine-acetylcholine-glutamate systems in the striatum; this may explain the fact that some symptoms of Parkinson's disease can be relieved by other neurotransmitters.
		are the subtypes of the dopamine receptor that are most abundant in the striatum, and are thought to be upregulated as a compensatory response in Parkinson's disease.
	sprojects.mmi.mcgill.ca /gait/parkinson/biochemistry.asp (839 words)

	[No title]
		The prototypic system for the D2 dopamine receptor is the anterior lobe of the pituitary, where the major consequence of dopamine action is the mediation of hormone release.
		The D2 dopamine receptor, in the anterior pituitary appears to function by activation of a complex set of intracellular signals, including inhibition of cAMP, activation of potassium channels and inhibition of calcium channels, all thought to be G protein-linked.
		The elucidation of the biochemical mechanisms employed by a single receptor to signal to multiple effector systems is the major goal of this project.
	drnelson.utmem.edu /faculty/senogles.html (843 words)

	Ken Siddle: Department of Clinical Biochemistry
		and White, M.F. (1991) Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells.
		(1992) A monoclonal anti-peptide antibody reacting with the insulin receptor b-subunit: characterization of the antibody and its epitope, and use in immunoaffinity purification of intact insulin receptors.
		and Häring, H.U. (1995) Mechanism of insulin receptor kinase inhibition in NIDDM patients: Phosphorylation of serine 1327 or threonine 1348 is unaltered.
	www.clbc.cam.ac.uk /Siddle/siddle2.html (2380 words)

	Biochemistry
		Thyrotropin receptor mediated diseases - A paradigm for receptor autoimmunity.
		Requirement of glycosylation of the human thyrotropin receptor ectodomain for its reactivity with autoantibodies in patients’ sera.
		Influence of adjuvants on the induction of autoantibodies to the thyrotropin receptor.
	shaw.medlib.iupui.edu /ecme/ramlab.htm (480 words)

	Wells' Lab Publications
		Epidermal growth factor receptor- mediated cell motility: Phospholipase C activity is required, but MAP kinase activity is not sufficient for induced cell motility.
		EGF receptor activation of calpain is required for fibroblast motility and occurs via and ERK/MAP kinase signaling pathway.
		Mitogenic signaling from the EGF receptor is attenuated by a phospholipase C-g/protein kinase C feedback mechanism.
	path.upmc.edu /divisions/wells-lab/labpubs.html (1338 words)

	Brown Medical School
		Pharmacology and medicinal chemistry of sigma receptors and opioid receptors; signal transduction mechanisms in receptor-mediated apoptosis and regulation of cell proliferation.
		Lysosphingolipids act via specific G-protein coupled receptors on the cell surface, as well as through certain intracellular targets, and ceramides are known to modulate the activity of various protein kinases and phosphatases involved in cell growth.
		In contrast to sigma-2 receptors, activation of sigma-1 receptors appears to exert neuroprotective and perhaps trophic effects on neurons.
	brown.edu /Divisions/Medical_School/andera/profile.php?id=1100923760 (2417 words)

	PUBLICATIONS OF BARBARA BAIRD (Site not responding. Last check: 2007-10-21)
		Holowka, D. and B. Baird: Lactoperoxidase-catalyzed iodination of the receptor for immunoglobulin E at the cytoplasmic side of the plasma membrane.
		Hammes, S., D. Holowka and B. Baird: Proteolytic digestion of the ß and g subunits of the receptor for immunoglobulin E at the cytoplasmic face of the plasma membrane.
		permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic cells.
	www.chem.cornell.edu /faculty/bairdpublications.htm (2137 words)

	Roman Osman Laboratory - Publications
		A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation.
		Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor.
		Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotropin-releasing hormone receptor.
	fulcrum.physbio.mssm.edu /~osmanlab/fullpubl.html (1287 words)

	Jheem D. Medh
		We are studying various components of the atherogenesis pathway including apolipoproteins, lipases and lipoprotein receptors.
		Recent studies have established that LPL and HTGL also function as apoproteins and ligands for lipoprotein receptors, associate with lipoprotein particles and hepatic lipoprotein receptors, and thereby enhance lipoprotein catabolism and clearance.
		In a related study, we are employing in vitro studies in cultured cells to examine the cellular mechanisms of cholesterol efflux from cultured macrophages.
	www.csun.edu /chemistry/chemjm.html (811 words)

	Bjorklab Publications
		West, A.P., Jr., Herr, A.B., and Bjorkman, P.J. (2004) The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog.
		Sprague, E.R., Martin, W.L., Bjorkman, P.J. pH-dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI.
		Chapman, T.L., Heikema, A.P. and Bjorkman, P.J. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral MHC homolog UL18.
	www.its.caltech.edu /~bjorker/publications.html (2564 words)

	[No title]
		BBMB 301, "Survey of Biochemistry", 3 credit non-majors biochemistry course for Iowa State University Department of Biochemistry, Biophysics and Molecular Biology, spring 2002,2003 and 2004, summer 2002, 2003, 2004 and 2005, and fall 2002 (team-taught), 2003 and 2004.
		Team-taught BBMB 311L, "Biochemistry Laboratory", 2 credit general laboratory course for Iowa State University Department of Biochemistry, Biophysics and Molecular Biology, spring 2002 and 2003.
		Heck, D.A. and D.B. Bylund, Role of the third intracellular loop of the alpha-2B adrenergic receptor in regulating receptor density, Pharmacol Rev. Commuun.
	www.iccc.cc.ia.us /mathscience/heck/don_heck_curriculum_vitae.doc (1155 words)

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