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Topic: Receptor proteomics

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Integral membrane protein

In the News (Tue 15 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Drosophila nuclear receptor proteomics
		Nuclear receptors comprise a large family of important and versatile DNA binding transcription factors.
		The ability to respond to such chemicals empowers these receptors with the capacity to coordinate tissue patterning, differentiation and growth in response to remotely synthesized molecules.
		All 16 receptors are studied in parallel in a series of complementary in vitro and in vivo approaches.
	www.utoronto.ca /AlEdwardsLab/nuclear_receptors_index.html (405 words)

	Receptor_(proteomics) (Site not responding. Last check: 2007-10-16)
		In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific factor (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates the cellular response to the ligand.
		Often, it is hard to determine whether the receptor is nonfunctional or the hormone is produced at decreased level; this gives rise to the "pseudo-hypo-" group of endocrine disorders, where there appears to be a decreased hormonal level while in fact it is the receptor that is not responding sufficiently to the hormone.
		These receptors are either coupled to G proteins or possess enzyme or ion channel activity that allow the activation of signal transduction pathways in response to the activation by the ligand.
	www.apawn.com /search.php?title=Receptor_(proteomics) (330 words)

	NIDA - Director's Report - September, 2004
		In clinical trials, sigma-1 receptor ligands failed to improve acute psychotic symptoms of schizophrenia but, interestingly, were shown in a few studies to attenuate negative symptomatology in schizophrenic patients.
		The appropriate "matching" of the pre- with the postsynaptic receptor mosaic can be thought of as the "clamping of the synapse to the external teaching signal." According to the present hypothesis the behavior of the molecular networks at plasma membrane level to which the receptor mosaics belong can be set in a "frozen" conformation (i.e.
		Most probably A(2A) receptor-D(2) receptor heteromerization is not static, but subject to a dynamic regulation, related to the phosphorylation dependence of the A(2A) receptor epitope and to the ability of the D(2) receptor epitope to bind different partners.
	www.drugabuse.gov /DirReports/DirRep904/DirectorReport10.html (6303 words)

	Chemical & Engineering News: SCIENCE/TECHNOLOGY - Proteomics
		Proteomics attempts to catalog and characterize these proteins, compare variations in their expression levels under different conditions (notably sickness versus health), study their interactions, and identify their functional roles.
		Proteomics is not the study of proteins one by one, as has traditionally been done, but in an automated, large-scale manner.
		Expression proteomics with rolling circle amplification appears to have significantly greater sensitivity and to be more scalable than with 2-D gels and mass spectrometry, according to Stephen F. Kingsmore, chief operating officer at Molecular Staging.
	pubs.acs.org /cen/coverstory/7831/7831scit1.html (4015 words)

	National Cancer Institute - Proteomics: Research for the 21st Century
		A clinical trial already under way is testing the ability of proteomic technology to reliably detect relapse of ovarian cancer before clinical symptoms appear.
		Another effort to use proteomics in the clinical setting involves a trial to monitor tumor cells' protein response to the cancer drug imatinib mesylate, commonly known as Gleevec.
		For this trial, researchers will use microarrays, a proteomics tool that will allow them to focus on a set of critical proteins they expect the drug to affect.
	newscenter.cancer.gov /newscenter/benchmarks-vol2-issue2/page2 (839 words)

	LICR \| Research Programs \| Biochemistry \| Proteomics (Site not responding. Last check: 2007-10-16)
		LICR investigators are using cutting-edge proteomic technologies to identify changes that occur during cancer progression in several cancers.
		The JPSL is involved in the development of new proteomics systems, and software and instrumentation for mass spectrometry, which increase the flexibility, speed, and sensitivity of protein identification and analysis.
		Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties.
	www.licr.org /D_programs/d2b2_proteomics.php (583 words)

	Molecular Biology Protocols \| Bioinformatics
		Local and cis Effects of the H Element on Expression of Odorant Receptor Gene...
		Receptor dimerization is followed by conformational changes that enable lateral interactions between membrane proximal Ig-like domains D4 and D5 of two KIT molecules.
		Since key hallmarks of KIT structures, ligand-induced receptor dimerization, and the critical residues in the D4-D4 interface, are conserved in other receptors, the mechanism of KIT stimulation unveiled in this report may apply for other receptor activation.
	www.molecularstation.com (1928 words)

	Proteomics Pubs (Site not responding. Last check: 2007-10-16)
		Second, emerging new technologies, combinatorial chemistry, recombinant DNA techniques, and high-throughput analysis, are extending the potential of photoaffinity labeling to become a rapid and more sensitive means for the identification of drug-receptor pairs as well as the elucidation of molecular recognition mechanism at drug-receptor interfaces.
		One was given partly in jest: "Proteomics is what connects genomics to the money!" Proteomics has the potential of connecting the discoveries made in genomics with the development of blockbuster drugs that pharmaceutical companies seek.
		Proteomic image analysis -Spotting the difference on a gel might just lead to a new drug or target.
	www.altcorp.com /AffinityLabeling/proteomepubs.htm (686 words)

	Integrated signalling group
		Proteomics, being unbiased and comprehensive technology, is an efficient tool to unveil novel mechanisms of carcinogenic transformation.
		Proteomics is also used for profiling of TGFß signalling in human breast epithelial cells: protein expression, turnover and phosphorylation are studied.
		Proteomics may also lead to discovery of novel tumor suppressors and oncogenes.
	www.licr.uu.se /groups/is (1970 words)

	Press Release - Scientists Discover New Molecule of the Immune System; a Chemokine that Binds One of the HIV ... (Site not responding. Last check: 2007-10-16)
		Although its association with a chemokine was a discovery, the receptor turned out to be one that had already been isolated by other researchers in cell studies as one of the receptors exploited by invading HIV viruses to gain entry into human cells.
		Cytotoxic CD8 T cells, known for the ability to kill virally infected cells, were found to express the chemokine receptor and to be able to migrate towards a source of the chemokine.
		In addition to CD8 T cells, the receptor was found on subpopulations of CD4 T cells, including a specialized population of CD4 T cells that live in the gut and that are known as intra-epithelial T cells.
	www.cgen.com /news/press/press100500a.html (1016 words)

	CNC
		Glutamate receptors mediate the majority of excitatory neurotransmission in the central nervous system, and changes in the characteristics and cellular localization of these receptors are thought to underlie the mechanisms for synaptic plasticity.
		We are studying the regulation of the GluR4 subunit of AMPA receptors by phosphorylation, and find that GluR4 is phosphorylated, and its phosphorylation regulates receptor activity (Carvalho et al, 1998 J. Neurochem., 1999 J. Neurosci., 2002 Eur.
		We have particular interest for interacting partners of GluR4, since this AMPA receptor subunit is the first to be targeted to functional synapses in the hippocampus during development, and its synaptic targeting relies on synaptic activity.
	www.uc.pt /cnc/GroupsEng/glutamate.php (346 words)

	BioCarta - Charting Pathways of Life
		The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells.
		This receptor is composed of three polypeptide chains, the alpha, beta and gamma chains.
		The IL-2 receptor beta chain is essential for IL-2 signaling and is also a component of the IL-15 receptor complex.
	www.biocarta.com /pathfiles/h_il2rbPathway.asp (613 words)

	MUSC Nephrology (Site not responding. Last check: 2007-10-16)
		My research goal is to establish the mechanisms by which the expression of G-protein coupled receptors are regulated employing b2-adrenergic receptors as the prototype for this class of more than 300 receptors.
		Work in the laboratory is focused on the post-transcriptional mechanisms that regulate receptor expression or how receptor expression is controlled by proteins that bind to the adenine- and uridine-rich elements (AREs) present in the 3'-untranslated region of the receptor mRNA.
		A 20-nucleotide A+U-rich element of b2-adrenergic receptor mRNA mediates binding to bARB protein and is obligate for agonist-induced destabilization of receptor mRNA.
	www.musc.edu /nephrology/BGT1.html (340 words)

	Ligand-Receptor-G-Protein Molecular Assemblies on Beads for Mechanistic Studies and Screening by Flow Cytometry -- ...
		for the receptor, and the concentration of the receptor.
		), the reconstitution of the formyl peptide receptor
		epitope-tagged receptors from a crude mixture of solubilized
	molpharm.aspetjournals.org /cgi/content/full/64/5/1227 (7509 words)

	CHI's BEYOND GENOME (Site not responding. Last check: 2007-10-16)
		In spite of significant improvements in separation technologies and mass-spectrometric instrumentation a proteomic investigation of membrane proteins is still experimentally challenging in a terms of qualitative and quantitative analysis of this important class of proteins.
		The prospects for proteomics research to elucidate all protein post-translational modifications is challenging.
		Most of the analytical approaches are targeted towards a specific modification either by using dedicated affinity approaches to enrich the selected type of modified peptides or by investigating the peptides for a modification specific marker ion in tandem MS mode.
	www.beyondgenome.com /pro.asp (3746 words)

	UPENN \|\| Graduate Studies in Pharmalogical Sciences Graduate Group (Site not responding. Last check: 2007-10-16)
		Molecular endocrinology of the prolactin receptor complex as it pertains to the pathogenesis of human breast cancer.
		The PRL receptor (PRLr) is a member of the growth factor/cytokine receptor family, which includes the receptors for interleukin 2-7, GM-CSF, erythropoietin, and growth hormone.
		Study roles of cyclophilins A and B in the function of the prolactin receptor and the nuclear retrotranslocation of prolactin.
	www.med.upenn.edu /pharmgg/bios/clevenger.html (573 words)

	Proteomics Methods for Probing Molecular Mechanisms in Signal Transduction -- Sheffield and Gavinski 86 (13 ...
		Bovine serum or A431 cell membranes (a human epidermoid carcinoma that expresses high levels of EGF receptor and is used as a positive control) were separated by SDS-PAGE (10% gel), transferred to polyvinylidene fluoride (PVDF) membranes and probed with anti-EGF receptor as previously described (Hendrix et al., 1996).
		Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells.
		Proteomic analysis of two functional states of the Golgi complex in mammary epithelial cells.
	jds.fass.org /cgi/content/full/86/13_suppl/E115 (4822 words)

	NIDA - What's New - Past Meetings - Structural Biology & Structural Genomics/Proteomics
		Rest of the symposium consisted of four sessions, and the sessions were on, structure determination, receptors, transporters and mechanisms, structural genomics and proteomics and, ligands and therapeutics.
		Kobilka's talk was on the ligand-specific conformational changes of the beta-2 adrenergic receptor, Dr. Javitch's talk was on oligomerization of the human dopamine receptor and the molecular mechanisms involved and Dr. Rudnick's presentation was on the serotonin transporter.
		In the third session, Dr. Patterson gave a summary of how proteomics techniques can be helpful in drug discovery, Dr. Cravatt gave an update on chemical approaches for functional proteomics and Dr. Gavin MaBeath gave an overview on protein microarrays and their applications to functional genomics and high-throughput screening.
	www.nida.nih.gov /whatsnew/meetings/Proteomics5-8-02.html (853 words)

	Cardiovascular Proteomics : Evolution and Potential -- Arrell et al. 88 (8): 763 -- Circulation Research (Site not responding. Last check: 2007-10-16)
		Proteomics of rat liver Golgi complex: minor proteins are identified through sequential fractionation.
		Progress with proteomic projects: why all proteins expressed by a genome should be identified and how to do it.
		An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy.
	circres.ahajournals.org /cgi/content/full/88/8/763 (6283 words)

	Proteomics Glossary
		The concept of the proteome is fundamentally different to that of the genome: while the genome is virtually static and can be well defined for an organism, the proteome continually changes in response to external and internal events.
		The most useful definition of proteomics is likely to be the broadest: proteomics represents the effort to establish the identities, quantities, structures and biochemical and cellular functions of all proteins in an organism, organ, or organelle, and how these properties vary in space, time and physiological state.
		The application of proteomics technologies to clinical research and public health in general is an immediate goal of proteomics.
	www.genomicglossaries.com /content/proteomics.asp (6869 words)

	New Developments in Therapeutic Enzyme Inhibitors and Blockers
		This $75 billion market is undergoing rapid change as new technologies such as genomics, proteomics, high-throughput screening, rational drug design, and combinatorial chemistry are being integrated into drug development and discovery.
		This study surveys small-molecule enzyme inhibitors and receptor blockers which are either already used or will be used as medicine within the next 5 years (by the end of 2006).
		Promising inhibitors and blockers in the early stages of development are profiled, but the emphasis is strongly upon drugs that are either on the market, or will be on the market within the time frame of this study.
	www.marketresearch.com /researchindex/802091.html (861 words)

	THE GPM
		The Global Proteome Machine Organization was set up so that scientists involved in proteomics using tandem mass spectrometry could use that data to analyze proteomes.
		On Saturday (2007/02/24) we upgraded the search servers human, h066, and h112 to dual processor (Intel XEON E5345, 2.2 GHz), quad-core computers, improving search speed performance to be about three times faster than the fastest other computers we have in the system.
		They have published their results in a study entitled "Novel gene and gene model detection using a whole genome open reading frame analysis in proteomics" in the open access journal Genome Biology.
	www.thegpm.org (2600 words)

	MediChem and Neurocrine Biosciences Sign Proteomics Agreement on GPCR Drug Target for Depression, Anxiety
		Preliminary studies have shown that Neurocrine's proprietary CRF-1 receptor antagonists may be effective in depression, anxiety and irritable bowel syndrome (IBS).
		Using structural information derived through proteomics technologies such as MediChem's, scientists are able to visualize the drug compounds that will be the most effective against the target protein and have the least side effects -- a process known as structure-based drug design.
		The company's technologies and services are designed to enable its clients to reduce overall development time and costs, and to advance a greater number of discovery and development opportunities through to the marketplace.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-26-2001/0001522261&EDATE= (970 words)

	Steven T. Lund, Ph.D. Research (Site not responding. Last check: 2007-10-16)
		Due to intellectual property issues, I was not permitted to publish during this time.
		Starting in 2001, I took an opportunity to branch off from the receptor proteomics work to implement microarray capabilities for the company.
		Reduced expression of the tomato ethylene receptor gene LeETR4 enhances the hypersensitive response to Xanthomonas campestris pv.
	www.agsci.ubc.ca /wine/lund5.htm (761 words)

	Antisense therapy targeting GluR3 delays neurodegeneration in murine models - Genetic Disorders : Epilepsy.com
		Recent evidence suggests that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit (GluR) stoichiometry is a dominant factor leading to excess Ca2 loading in neurodegeneration.
		In particular, the Ca2 permeable glutamate receptor subunit 3 (GluR3) has been implicated in several neurologic conditions such as bipolar disorder and epilepsy, said A. Rembach and colleagues, University of Melbourne, Howard Florey Institute of Experimental Physiology and Medicine.
		These results suggest that interference with the GluR3 component of the AMPA receptor assembly may be a novel strategy for controlling excitotoxic destruction of motor neurons and may lead to new therapeutic opportunities for the treatment of human ALS, said Rembach and coauthors.
	www.epilepsy.com /newsfeed/pr_1097760612.html (460 words)

	Signaling Initiated by Overexpression of the Fibroblast Growth Factor Receptor-1 Investigated by Mass Spectrometry -- ...
		Proteomics, September 1, 2005; 4(9): 1240 - 1250.
		Proteomics, May 1, 2003; 2(5): 281 - 291.
		Proteomics, March 1, 2003; 2(3): 138 - 145.
	www.mcponline.org /cgi/content/abstract/2/1/29 (461 words)

	Genomics and Proteomics - Protein Patents: A Case Study
		Kendrew's group succeeded in crystallizing the receptor protein, and from that, deduced its three-dimensional structure.
		Since no one knew before that the compound was a GPCR ligand, or had used it as a ligand for GPCR in a physical or virtual experiment, the combination of the two is novel and not obvious.
		In the patent claim, the sentence would describe the combination of receptor and ligand as being present in a cell (e.g., "A cell having a GPCR bound to the lead compound") because this is the state in which the receptor would occur when occupied by the lead compound.
	www.genpromag.com /PRArchivebyIssue.aspx?RELTYPE=EXP&YEAR=2003&MONTH=09 (787 words)

	Print Version
		Over the past ten to fifteen years [before 1987], receptor mapping has expanded from a very minor technique, besieged by problems and limited in its approach, to one that is widespread, extended beyond receptors and applied to clinical problems and populations with modern imaging and scanning techniques.
		Genomics, proteomics, and metabolomics are being employed to investigate the effect of these changes on cellular physiology and to optimize cellular re-design.
		Rapid accumulation of biological data from genome, proteome, transcriptome and metabolome projects can bring us to the point where it is no longer purely speculative to discuss how to construct virtual cells in silico.
	www.genomicglossaries.com /content/printpage.asp?REF=/content/molecular_modeling_gloss.asp (6021 words)

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