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| | Red Cell Substitutes Enter Phase III Trials |
 | | The modern era of development of red cell substitutes began in the 1960s with the discovery that if the toxic stroma of the hemoglobin molecule were removed, hemoglobin-based solutions would be safe. |
 | | Five groups at the present time are testing other types of red cell substitutes in phase I, II, and III clinical investigations of sepsis, coronary artery bypass, and vascular surgery. |
 | | Greenburg predicted that second generation hemoglobin-based red cell substitutes will have further modifications of the heme pocket, liposome composition and structure, and they will come from a variety of sources including plants, yeasts, bacteria, and transgenic animals. |
| www.meds.com /conrad/acs/cell.html (630 words) |
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