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Topic: Regulatory T cell

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Cytotoxic T cell

T cell

Humoral immunity

Cancer immunotherapy

Immune system

	Regulatory T cell - Wikipedia, the free encyclopedia
		Regulatory T cells (also known as suppressor T cells) are a specialized subpopulation of T cells that act to suppress activation of the immune system and thereby maintain immune system homeostasis and tolerance to self.
		Interest in regulatory T cells has been heightened by evidence from experimental mouse models demonstrating that the immunosuppressive potential of these cells can be harnessed therapeutically to treat autoimmune diseases and facilitate transplantation tolerance or specifically eliminated to potentiate cancer immunotherapy.
		regulatory T cell population is a subset of the total Foxp3-expressing regulatory T cell population.
	en.wikipedia.org /wiki/Regulatory_T_cell (1224 words)

	Stem cell - Wikipedia, the free encyclopedia
		Embryonic stem cells are cultured cells obtained from the undifferentiated inner mass cells of an early stage human embryo (sometimes called a blastocyst, which is an embryo that is between 50 to 150 cells).
		Cancer stem cells arising through malignant transformation of adult stem cells are proposed to be the source of some or all tumors and cause metastasis and relapse of the disease.
		Embryonic stem cell research is particularly controversial because, with the present state of technology, starting a stem cell 'line' requires the destruction of a human embryo and/or therapeutic cloning.
	en.wikipedia.org /wiki/Stem_cell (1724 words)

	T cell - Wikipedia, the free encyclopedia
		T cells are a type of white blood cell that play a central role in cell-mediated immunity.
		Regulatory T cells, formerly known as suppressor T cells, are crucial for the maintenance of immunological tolerance.
		T cell activation can be gauged using the ELISPOT technique, which can determine the percentage of T cells that secrete any particular cytokine.
	en.wikipedia.org /wiki/T_cell (585 words)

	Regulatory T cell function in a transgenic mouse model
		Regulatory T cells are required to prevent inflammatory and autoimmune disease, both in animal models and in humans.
		Regulatory T cells are selected in the thymus after exposure to self antigen.
		This generates a large population of regulatory T cells with the transgenic specificity, and allows us to harness the power of the transgenic approach to study this important cell population.
	www.centenary.org.au /files/fazekas_hons_2006_1.htm (367 words)

	Control of Regulatory T Cell Development by the Transcription Factor Foxp3 -- Hori et al. 299 (5609): 1057 -- Science (Site not responding. Last check: 2007-10-26)
		Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes.
		Regulatory T Cell Responses Develop in Parallel to Th Responses and Control the Magnitude and Phenotype of the Th Effector Populatio.
		Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD.
	www.sciencemag.org /cgi/content/abstract/299/5609/1057 (2967 words)

	Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance -- ...
		T cells present in the spleen of wild-type (WT) and Jak3 knockout (JAK3KO) mice (n = 3) was assayed by staining and flow cytometry.
		Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
		Developmental biology of T cells in T cell-receptor transgenic mice.
	www.jimmunol.org /cgi/content/full/171/7/3435 (4897 words)

	Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases -- Alyanakian et al. 100 ...
		T cells (3) induces the onset of gastritis,
		T cells, known to be mandatory for diabetes induction (15).
		T cell depletion induced the onset of gastritis in 95% of recipients.
	www.pnas.org /cgi/content/full/100/26/15806 (3997 words)

	Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus ...
		T cell population represents a distinct lineage of T cells.
		T cell phenotype in the absence of homeostatic proliferation
		T cells, as this population of cells is dramatically decreased
	www.jem.org /cgi/content/full/201/1/127 (5242 words)

	Arthritis Research & Therapy \| Full text \| Defective CD4+CD25+regulatory T cell functioning in collagen-induced ... (Site not responding. Last check: 2007-10-26)
		T cells prevent spontaneous autoimmune encephalomyelitis in TCR-transgenic mice deficient in the recombination activating gene RAG-1 [15].
		T cell population in lymphoid organs of naive and immunised IFN-γ receptor knock-out and wild-type (WT) DBA/1 mice
		In co-cultures of cells from immunised wild-type mice, the T
	arthritis-research.com /content/7/2/R402 (7461 words)

	New type of regulatory T cell that reduces asthma and airway inflammation (Site not responding. Last check: 2007-10-26)
		For the second time in two years, scientists at the Stanford University School of Medicine have discovered a new type of regulatory T cell that reduces asthma and airway inflammation in mice, bolstering the theory that a deficiency of such cells is a prime cause of the breathing disorder as well as allergies.
		Adaptive regulatory T cells, the type studied by Umetsu and his colleagues, develop in response to incoming invaders and have been thought be to quite distinct from natural Tregs.
		Although an excess of one of the Th cells is associated with autoimmune diseases such as multiple sclerosis and type 1-diabetes, and an excess of the other is linked to allergies and asthma, both Th cells cause inflammation.
	www.news-medical.net /?id=5061 (897 words)

	Focus - Nature Immunology
		Five specially commissioned articles analyze the biology and function of regulatory T cells.
		A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 pp331 - 337
		Mechanisms of suppression by suppressor T cells pp338 - 344
	www.nature.com /ni/focus/regulatory_tcells/index.html (86 words)

	CD4+CD25+ Regulatory T Cell Isolation Kit - T cells
		Regulatory T Cell Isolation Kit were used in co-culture experiments with dendritic cells to study priming of dendritic cells for tolerance induction in vitro and after adoptive transfer of primed dendritic cells in vivo.
		In this context, the role of regulatory T cells for induction and elicitation of hapten-specific tolerance was analyzed.
		Regulatory T Cell Isolation Kit, an LD and two MS Columns, a MidiMACS™ Separator, and a MiniMACS™.
	www.miltenyibiotec.com /index.php?site=pp-130-091-041 (262 words)

	ScienceDaily: Stanford/Packard Researchers Find T Cell That Relieves Asthma In Mice
		STANFORD, Calif. For the second time in two years, scientists at the Stanford University School of Medicine have discovered a new type of regulatory T cell that reduces asthma and airway inflammation in mice, bolstering the theory that a deficiency of such cells is a prime cause of the breathing disorder as well as allergies.
		Gamma/Delta T Cells Essential To Regulating Airway Hyperresponsiveness In Asthma, Other Lung Diseases, According To National Jewish Researchers (September 28, 1999) -- Airway hyperresponsiveness, a feature of asthma, chronic obstructive pulmonary disease and environmental lung diseases, may be linked to a lack of gamma/delta T cells in the lungs National Jewish...
		T cell -- T cells are a subset of lymphocytes that play a large role in the immune response.
	www.sciencedaily.com /releases/2004/10/041006080939.htm (2046 words)

	ScienceDaily: Foxd3 Gene Allows Stem Cells To Remain Stem Cells
		Philadelphia, PA In the search to understand the nature of stem cells, researchers at the University of Pennsylvania School of Medicine have identified a regulatory gene that is crucial in maintaining a stem cell's ability to self-renew.
		Embryonic stem cell -- Embryonic stem cells (ESCs) are stem cells derived from the undifferentiated inner mass cells of a human embryo.
		Adult stem cell -- Adult stem cells are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues.
	www.sciencedaily.com /releases/2002/10/021015073342.htm (1832 words)

	mouse Mouse Regulatory T Cell Staining Set (containing FJK)
		Cells in the lymphocyte gate were used for analysis.
		Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in ‘scurfy’ (sf) mice.
		Regulatory T cell lineage specification by the forkhead transcription factor foxp3.
	www.ebioscience.com /ebioscience/specs/antibody_88/88-8111.htm (1082 words)

	BLOOD PLASMA : Comprehensive Encyclopedia (Site not responding. Last check: 2007-10-26)
		Blood plasma is the liquid component of blood, in which the blood cells are suspended.
		(Oxygen transport capacity of plasma is much lower than that of the hemoglobin in the red blood cells; it may increase under hyperbaric conditions.) Plasma is the storage and transport medium of clotting factors and its protein content is necessary to maintain the oncotic pressure of the blood.
		This is because the serum provides the cells with numerous proteins, nutrients, hormones and attachment factors that are beneficial.
	bibleproupdate2.com /Definitions/Blood_plasma (739 words)

	CD4+CD25+ Regulatory T Cell Isolation Kit - Regulatory T cells
		T cells act as regulatory T cells upon activation through their T cell receptor.
		regulatory T cells were originally discovered in mice, but a population with similar phenotypic and functional properties has also been characterized in humans.
		T cells seem to suppress harmful immunological reactions to self or foreign antigens.
	www.miltenyibiotec.com /index.php?site=pp-130-091-301 (200 words)

	A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 ...
		A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
		cells represent a dedicated T cell lineage and that Foxp3 functions as the T
		cells as vital mediators of immunological tolerance to self and Foxp3 as the mediator of the genetic mechanism of dominant tolerance.
	www.nature.com /ni/journal/v6/n4/abs/ni1179.html (194 words)

	Newly discovered T cell helps mice to breathe easier
		For the second time in two years, scientists at the School of Medicine have discovered a new type of regulatory T cell that reduces airway inflammation in mice, bolstering the theory that a deficiency of such cells is a prime cause of asthma and allergies.
		Humans have a variety of T cells – including regulatory (Tregs), helper (Th) and natural killer (NKTs) – and there are different types within each of those categories.
		Although an excess of one of the Th cells is associated with autoimmune diseases and an excess of the other is linked to allergies and asthma, both Th cells are known to cause inflammation.
	news-service.stanford.edu /news/2004/september29/med-umetsu-929.html (792 words)

	Clinical Trial: The Role of Regulatory T Cell in Patients With Type 1 Diabetes Mellitus
		Evaluate the regulatory T cell function in patients with type 1 diabetes mellitus, and find the pathogenesis of this autoimmune disease.
		Dysregulated B and T cells were reported in the animal model.
		The loss of maintenance of immune homeostasis is thought to be major mechanism and result in persistence of autoreactive T cell in the periphery.
	clinicaltrials.gov /ct/show/NCT00173641 (422 words)

	Cell Online (Site not responding. Last check: 2007-10-26)
		Cancer cells confirmed as the transmissible agent in canine transmissible venereal tumor
		Cell launches a new feature inviting thoughtful comments from our readers on a highlighted article in each issue.
		Cell's Leading Edge is a new section that highlights the social, political, economic, and ethical concerns surrounding biomedical research worldwide.
	www.cell.com /home.isa (477 words)

	Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function -- Furtado et al. 196 (6): 851 -- The Journal ...
		Quantitative assessment concerning the contribution of IL-2R{beta} for superantigen-mediated T cell responses in vivo
		Alloreactive T Cell Responses and Acute Rejection of Single Class II MHC-Disparate Heart Allografts Are under Strict Regulation by CD4+CD25+ T Cells
		Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells
	www.jem.org /cgi/content/abstract/196/6/851 (2202 words)

	Sasha Rudensky's Lab :: University of Washington :: Publications
		(2005) Regulatory T cell lineage specification by the forkhead transcription factor Foxp3.
		Honey K, Benlagha K, Beers C, Forbush K, Teyton L, Kleijmeer MJ, Rudensky AY (corresponding author), Bendelac A. (2002) Thymocyte expression of cathepsin L is essential for NK T cell development.
		(2002) Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands.
	pilgrim.immunol.washington.edu /publications.html (552 words)

	Publications - 1996 (Site not responding. Last check: 2007-10-26)
		Cheng LL, Lean CL, Bogdanova A, Wright SC (Jr), Ackerman JL, Brady TJ and Garrido L, Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic angle spinning, Mag Res in Med, 36:653-658, 1996.
		Cronin CS, Reeve TS, Robinson B, Clifton-Bligh P, Guinea A, Delbridge L, Primary Hyperparathyroidism in Childhood and Adolescence.
		Huschtscha LI, Bartier WA, Andersson Ross CE, Tattersall MHN, Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro, Brit J Cancer, 73:54-60, 1996.
	www.imrr.org.au /publications/1996.shtml (834 words)

	Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cell Responses -- POWRIE 1029 ...
		Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cell Responses -- POWRIE 1029 (1): 132 -- Annals of the New York Academy of Sciences
		populations of regulatory T cells control the immune response
		Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells
	www.annalsnyas.org /cgi/content/abstract/1029/1/132 (330 words)

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