
	Where results make sense

Topic: Renal tubular acidosis, distal, type 3

Related Topics

January 3

March 3

November 3

October 3

April 3

September 3

May 3

February 3

December 3

June 3

July 3

August 3

In the News (Thu 24 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	s051114a - Distal Renal Tubular Acidosis
		However, systemic acidosis is not always evident and renal tubular acidosis can present with hypokalaemia, medullary nephrocalcinosis and recurrent calcium phosphate stone disease, as well as growth retardation and rickets in children, or short stature and osteomalacia in adults.
		The importance of plasma potassium and renal potassium excretion in the evaluation of patients with distal renal tubular acidosis is emphasized.
		In the presently studied patients, the impairment in renal conservation of sodium appeared to be in part the consequence of an impaired ability of the vasopressin-responsive segments of the distal nephron to generate and maintain appropriately steep transepithelial sodium concentration gradients.
	www.emory.edu /WHSCL/grady/amreport/litsrch05/s051114a.html (3774 words)

	Renal Tubular Acidosis
		Renal tubular acidosis is a condition or disease in which the kidney does not take acid out of blood and put it into urine like it should.
		Type III was formerly type I with a component of type II, and now that is just called type I. Some infants and small children with type I RTA also lose some bicarbonate into the urine at the level of the proximal tubule.
		Acidosis can also result from overproduction of acid, and the kidney can be working fine and getting rid of acid very well, but the amount produced can overwhelm the ability of the kidney to get rid of it.
	cnserver0.nkf.med.ualberta.ca /nephkids/rta.htm (1768 words)

	Distal renal tubular acidosis - Detroit, Michigan
		Distal renal tubular acidosis is caused by abnormal excretion of acid from the distal tubule of each nephron.
		Distal renal tubular acidosis (Type I RTA) is a disorder caused by a defect in the secretion of hydrogen ions in the distal renal tubule of each nephron.
		Type I RTA is caused by a variety of conditions including hereditary disorders, autoimmune diseases and certain drugs including amphotericin B, lithium, and analgesics.
	www.henryfordhealth.org /135413.cfm (692 words)

	Information about renal tubular acidosis
		Renal tubular acidosis is a disease that occurs when the kidneys fail to excrete acids into the urine, which causes a person's blood to remain too acidic.
		Type 3 is rarely used as a classification today because it is now thought to be a combination of type 1 and type 2.
		Type 4 renal tubular acidosis is caused by another defect in the distal tubule, but it is different from classic distal renal tubular acidosis and proximal renal tubular acidosis because it results in high levels of potassium in the blood instead of low levels.
	www.mamashealth.com /kidney/rta.asp (1066 words)

	8.5 Renal Tubular Acidosis
		Acidosis due to renal disease is considered in 2 categories depending on whether the predominant site of renal damage is in the gloweruli or in the tubules.
		Renal tubular acidosis is a form of hyperchloraemic metabolic acidosis which occurs when the renal damage primarily affects tubular function without much effect on glomerular function.
		Type 3 RTA is now considered a subtype of Type 1 where there is a proximal bicarbonate leak in addition to a distal acidification defect.
	www.anaesthesiamcq.com /AcidBaseBook/ab8_5.htm (919 words)

	Pediatric Oncall-RENAL TUBULAR ACIDOSIS (RTA) (Site not responding. Last check: 2007-10-29)
		Renal tubular acidosis (RTA) is one of the commonest causes of Vit D resistant rickets.
		Reabsorption of sodium bicarbonate (alkali) by proximal renal tubules.
		Renal acidification mechanism keeps the blood pH within a narrow range of 7.35 – 7.45 which is vital for normal functioning of cellular and tissue metabolism.
	www.pediatriconcall.com /forpatients/commonchild/renal_tubular.asp (389 words)

	THE MERCK MANUAL, Sec. 17, Ch. 229, Abnormal Renal Transport Syndromes
		Type I (distal) renal tubular acidosis (RTA) is usually a sporadic disorder in adults and a familial disorder in children.
		Type IV RTA is a sporadic disease associated with mild renal insufficiency in adults with diabetes mellitus, HIV nephropathy, or interstitial renal damage (SLE, obstructive uropathy, sickle cell disease).
		Type I or II RTA is associated with chronic metabolic acidosis, mild volume contraction, and hypokalemia.
	www.merck.com /mrkshared/mmanual/section17/chapter229/229a.jsp (659 words)

	RENAL TUBULAR ACIDOSIS ----- normal anion gap hyperchloremic metabolic acidosis
		The normal renal response to acidemia is to reabsorb all of the filtered HCO3 and to increase H+ excretion primarily by enhancing excretion of ammonium ions in the urine.
		Distal tubule excretes the H+ in the form of ammonium ion(NH4+).
		Nephrolithiasis/Nephrocalcinosis secondary to increased urinary loss of calcium (due to effects of chronic acidosis on both bone resorption and renal tubular Ca resorption).
	intmedweb.wfubmc.edu /blurbs/neph/rta1.html (669 words)

	eMedicine - Hyperchloremic Acidosis : Article by Mahendra Agraharkar, MD, FACP
		A normal AG acidosis is characterized by a lowered bicarbonate concentration, which (in the presence of a normal sodium concentration) is counterbalanced by an equivalent increase in plasma chloride concentration.
		A metabolic acidosis occurring secondary to decreased renal acid secretion in the absence of marked decreases in the glomerular filtration rate and characterized by a normal AG is due to diseases that are usually grouped under the term dRTA.
		Depending on the type of RTA, the goals of therapy are to decrease the rate of progressive renal insufficiency by preventing nephrocalcinosis and nephrolithiasis; to neutralize metabolic bone disease; and, in children, to improve growth.
	emedicine.com /MED/topic1071.htm (6582 words)

	KIDNEY DISORDERS - Renal Tubular Acidosis (RTA)
		Renal tubular acidosis (RTA) is a disease that occurs when the kidneys fail to excrete acids into the urine, which causes a person's blood to remain too acidic.
		Type 4 RTA is caused by another defect in the distal tubule, but it is different from classic distal RTA and proximal RTA because it results in high levels of potassium in the blood instead of low levels.
		To treat type 4 RTA successfully, patients may require alkaline agents to correct acidosis as well as medication to lower the potassium in their blood.
	www.medic8.com /kidney-disorders/tubular-acidosis.htm (1358 words)

	Renal Tubular Acidosis
		Loss of tubular function affects the ability of the kidney to excrete hydrogen ions and retain bicarb, this will lead to non-gap acidoses.
		When the tubules fail without loss of glomerular function, bicarb is lost and instead of being replaced by phosphates, sulfates, and urea it is replaced by chloride leading to hyperchloremic, non anion gap metabolic acidoses, the sine qua non of RTA’s.
		In the distal tubule the remaining 20-30% of bicarb is reabsorbed in the same way.
	home.uchicago.edu /~adamcifu/RTA.htm (442 words)

	Molecular developments in renal tubulopathies -- VAN'T HOFF 83 (3): 189 -- Archives of Disease in Childhood
		The renal tubule is responsible for the reabsorption of more than 99% of the water and sodium in the glomerular ultrafiltrate.
		Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene.
		Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
	adc.bmjjournals.com /cgi/content/full/83/3/189 (2061 words)

	Renal Tubular Acidosis - New Treatments, May 2, 2006
		It is caused by a problem in the distal tubule with the inability to decrease the urine pH to 5.5 during acidosis.
		Ampho also gives you renal failure in very sick patients, but in patients that are not so sick and we are using lower doses of ampho, there is a tubular toxicity, and that’s amphotericin-B I’m talking about.
		Type II RTA is different than type I RTA.
	www.ccspublishing.com /journals5a/renal_tubular_acidosis.htm (602 words)

	Novel AE1 Mutations in Recessive Distal Renal Tubular Acidosis . Loss-of-Function Is Rescued by Glycophorin A -- ...
		and acidosis evident in a bovine cohort with a homozygous loss-of-function
		Nilwarangkur (1996) Prevalence of endemic distal renal tubular acidosis and renal stone in the northeast of Thailand.
		AE4 is a DIDS-sensitive Cl-/HCO3- exchanger in the basolateral membrane of the renal CCD and the SMG duct
	www.jci.org /cgi/content/full/102/12/2173 (4545 words)

	Renal tubular acidosis - MayoClinic.com (Site not responding. Last check: 2007-10-29)
		Renal tubular acidosis (RTA) is a condition in which your kidneys are unable to excrete acids into urine.
		In renal tubular acidosis, the ability of your kidneys to excrete acids or to reabsorb bicarbonate is impaired, and acid levels build up in your blood.
		Renal tubular acidosis is a serious disease that can be life-threatening.
	www.mayoclinic.com /health/renal-tubular-acidosis/AN00642 (448 words)

	SJÖGREN’S SYNDROME PRESENTING WITH HYPOKALEMIC PARALYSIS DUE TO RENAL TUBULAR ACIDOSIS
		Renal tubular acidosis (RTA) is estimated to be present in 25%-30% of cases with SS.
		A renal biopsy was refused by the patient.
		Hypokalemic paralysis in Sjögren’s syndrome secondary to renal tubular acidosis.
	www.kfshrc.edu.sa /annals/182/97-181.html (1840 words)

	Primary gradient defect distal renal tubular acidosis presenting as hypokalaemic periodic paralysis -- Koul et al. 22 ...
		Validation of the difference in urine and blood carbon dioxide tension as an index of distal nephron acidification in experimental models of renal tubular acidosis.
		Primary distal renal tubular acidosis as a result of a gradient defect.
		Distal renal tubular acidosis and high urine carbon dioxide tension in a patient with Southeast Asian ovalocytosis.
	emj.bmjjournals.com /cgi/content/full/22/7/528 (1223 words)

	Impaired trafficking of distal renal tubular acidosis mutants of the human kidney anion exchanger kAE1 -- Quilty et al. ...
		Distal renal tubular acidosis (dRTA) is an inherited disease characterized by the failure of the kidneys to appropriately
		Figure 3 is a Western blot of lysates from transfected cells.
		Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl exchanger.
	ajprenal.physiology.org /cgi/content/full/282/5/F810 (7270 words)

	eMedicine - Metabolic Acidosis : Article by Karen L Stavile, MD
		Metabolic acidosis with a high AG is associated with the addition of endogenously- or exogenously-generated acids.
		Since metabolic acidosis is a condition that occurs in response to a variety of disease states, the prognosis is directly related to the underlying etiology and the ability to treat or correct that particular disorder.
		Kurtzman NA: Renal tubular acidosis: a constellation of syndromes.
	www.emedicine.com /emerg/topic312.htm (3498 words)

	Renal Tubular Acidosis - Causes, Symptoms & Treatment
		One researcher has theorized that Charles Dickens may have been describing a child with RTA when he created the character of Tiny Tim in his famous story, "A Christmas Carol." Tiny Tim's small stature, malformed limbs, and periods of weakness are all possible consequences of the chemical imbalance caused by RTA.
		If the blood is more acidic than it should be and the urine less acidic than it should be, RTA is possibly the reason, but additional information is needed first to rule out other causes.
		Type 3 is rarely used as a classification because it is now thought to be a combination of type 1 and type 2.
	www.healthnewsflash.com /conditions/renal_tubular_acidosis.php (1391 words)

	Familial Distal Renal Tubular Acidosis Is Associated with Mutations in the Red Cell Anion Exchanger (Band 3, AE1) Gene ...
		Familial Distal Renal Tubular Acidosis Is Associated with Mutations in the Red Cell Anion Exchanger (Band 3, AE1) Gene -- Bruce et al.
		The 35-kD band 3 chymotrypsin fragment of the affected members in families B and C showed a shift in mobility similar to that
		DNA sequencing of exons 2, 3, 4 and 5 of the
	www.jci.org /cgi/content/full/100/7/1693 (5434 words)

	Medical Dictionary: RTA, bicarbonate-wasting type - WrongDiagnosis.com
		RTA, bicarbonate-wasting type is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that RTA, bicarbonate-wasting type, or a subtype of RTA, bicarbonate-wasting type, affects less than 200,000 people in the US population.
		Terms that may be interchangeable with RTA, bicarbonate-wasting type:
	www.wrongdiagnosis.com /medical/rta_bicarbonate_wasting_type.htm (167 words)

	Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H+-K+-ATPase deficiency -- Simpson ...
		Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H+-K+-ATPase deficiency -- Simpson and Schwartz 84 (6): 504 -- Archives of Disease in Childhood
		Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H
		Renal ultrasound showed grade II bilateral hydronephrosis with excellent parenchymal preservation and no evidence of obstruction.
	adc.bmjjournals.com /cgi/content/full/84/6/504 (2600 words)

	Nitric Oxide Production Modulates Cyclosporin A-Induced Distal Renal Tubular Acidosis in the Rat -- Tsuruoka et al. 305 ...
		Cyclosporine A (CsA) causes distal renal tubular acidosis (dRTA)
		caused distal renal tubular acidosis in the rats.
		Wesson D (1997) Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.
	jpet.aspetjournals.org /cgi/content/full/305/3/840 (3680 words)

	Renal Tubular Acidosis Discussion
		Renal Tubular Acidosis is a scary diagnosis for any parent who hears it, but once understood, with support, ideas and help from other parents, it can make the road less worrisome.
		Types of RTA: Type 1: Classic Distal RTA
		This disorder may be inherited as a primary disorder or may be one symptom of a disease that affects many parts of the body.
	aaaaq.com /kidney_urologic/Renal_Tubular_Acidosis (1671 words)

	Autosomal Dominant Distal Renal Tubular Acidosis Is Associated in Three Families with Heterozygosity for the R589H ...
		Autosomal Dominant Distal Renal Tubular Acidosis Is Associated in Three Families with Heterozygosity for the R589H Mutation in the AE1 (Band 3) Cl-/HCO3- Exchanger -- Jarolim et al.
		Distal renal tubular acidosis (dRTA) is characterized by defective urinary acidification by the distal nephron.
		The IC of the renal collecting duct are exposed to extracellular pH values more acidic than are red cells.
	www.jbc.org /cgi/content/full/273/11/6380 (5417 words)

	Medical Dictionary: RTA, dislocation type - WrongDiagnosis.com
		RTA, dislocation type is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that RTA, dislocation type, or a subtype of RTA, dislocation type, affects less than 200,000 people in the US population.
		Terms that may be interchangeable with RTA, dislocation type:
	www.wrongdiagnosis.com /medical/rta_dislocation_type.htm (167 words)

	Renal Tubular Acidosis (Site not responding. Last check: 2007-10-29)
		One researcher, pediatric neurologist Donald Lewis, has theorized that Charles Dickens may have been describing a child with RTA when he created the character of Tiny Tim in his famous story, "A Christmas Carol." Tiny Tim's small stature, malformed limbs, and periods of weakness are all possible consequences of the chemical imbalance caused by RTA.
		The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducts and supports research into many kinds of kidney disease, including renal tubular acidosis.
		NIDDK-supported researchers are exploring the genetic and molecular mechanisms that control acid-base regulation in the kidney.
	kidney.niddk.nih.gov /kudiseases/pubs/tubularacidosis (1446 words)

	Trafficking Defects of a Novel Autosomal Recessive Distal Renal Tubular Acidosis Mutant (S773P) of the Human Kidney ...
		Trafficking Defects of a Novel Autosomal Recessive Distal Renal Tubular Acidosis Mutant (S773P) of the Human Kidney Anion Exchanger (kAE1) -- Kittanakom et al.
		Articles by Kittanakom, S. Articles by Reithmeier, R. Trafficking Defects of a Novel Autosomal Recessive Distal Renal Tubular Acidosis Mutant (S773P) of the Human Kidney Anion Exchanger (kAE1)
		Autosomal dominant and recessive distal renal tubular acidosis
	www.jbc.org /cgi/content/abstract/279/39/40960 (485 words)

	Metabolic acidosis without anion gap > 14-16 (Site not responding. Last check: 2007-10-29)
		or nephrolithiasis, and hyperchloremic metabolic acidosis with normal anion gap.
		Screening test with the second voided morning urine following an overnight fast and ingestion of a small water load.
		A urine pH < 6 is good evidence against distal RTA.
	members.tripod.com /~enotes/metacid2.htm (147 words)

Try your search on: Qwika (all wikis)