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Topic: Replication fork

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	DNA replication - Wikipedia, the free encyclopedia
		DNA replication or DNA synthesis is the process of copying a double-stranded DNA strand, prior to cell division (in eukaryotes, during the S phase of mitosis and meiosis).
		This origin of replication is unwound, and the partially unwound strands form a "replication bubble", with one replication fork on either end.
		Each group of enzymes at the replication fork moves away from the origin, unwinding and replicating the original DNA strands as they proceed.
	en.wikipedia.org /wiki/DNA_replication (954 words)

	Replication of DNA (Site not responding. Last check: 2007-10-18)
		DNA replication begins with a partial unwinding of the double helix at an area known as the replication fork.
		This unwound section appears under electron microscopes as a "bubble" and is thus known as a replication bubble.
		To replicate such huge molecules as human DNA at this speed requires not one, but many replication forks, forming replication bubbles and producing many segments of DNA strands that eventually meet up together and are joined to form the newly synthesized double helix.
	www.ncc.gmu.edu /dna/replicat.htm (909 words)

	Nat' Academies Press, (NAS Colloquium) Links Between Recombination and Replication: Vital Roles of Recombination (2002)
		Collapse of the fork appears to be essential when a fork encounters a lesion that blocks progression of the replicative helicase, DnaB, and which therefore might necessitate recombination with a sister duplex to bypass the lesion (8).
		RecG provides the cell with a second pathway for replication restart that may allow replication to continue in the face of lesions affecting a single strand of the template, but which does not necessitate breakage of the fork (8).
		The modification of replication fork structures is emerging as a crucial factor in the maintenance of fork progression in E.
	www.nap.edu /books/030907424X/html/57.html (2065 words)

	Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats -- Ohki and Ishikawa 32 (5): 1627 -- ...
		(A) The replication fork is stalled in the replication reaction from pT2AG3-beads with TRF1.
		Replication fork stall at telomeres by TRF-overexpression in vivo
		of TRF1 overexpression is the replication fork stall at telomeres,
	nar.oxfordjournals.org /cgi/content/full/32/5/1627 (6748 words)

	Swi1 Prevents Replication Fork Collapse and Controls Checkpoint Kinase Cds1 -- Noguchi et al. 23 (21): 7861 -- ...
		Stalled replication forks are prone to collapse, regression,
		Foss (16) proposed that Tof1 and Rad9 have overlapping
		The DNA replication checkpoint response stabilizes stalled replication forks.
	mcb.asm.org /cgi/content/full/23/21/7861 (7218 words)

	January 13: Genome Structure and DNA replication (Site not responding. Last check: 2007-10-18)
		Replication begins at a fixed origin of replication and most often is bidirectional (i.e.
		As the replication fork opens up, a single primer is laid down and the polymerase continuously synthesizes DNA from it - there is no need to stop.
		As the replication fork opens up, a primer is laid down and the DNA is replicated until it reaches the end of the DNA chain (or the previous DNA fragment for internal fragments).
	www.biosci.ohio-state.edu /~mgonzalez/Micro521/04.html (1217 words)

	Replication fork pausing and recombination or "gimme a break" -- Rothstein et al. 14 (1): 1 -- Genes and Development
		Orderly replication of DNA is a prerequisite to the faithful segregation of the chromosomes before cell division.
		that coordinate the reconstitution of the replication fork.
		Replication fork assembly at recombination intermediates is required for bacterial growth.
	www.genesdev.org /cgi/content/full/14/1/1 (5959 words)

	WRN Helicase and FEN-1 Form a Complex upon Replication Arrest and Together Process Branchmigrating DNA Structures ...
		Progression of a replication fork is blocked by a DNA lesion.
		A potential role of WRN or a related RecQ helicase in the rescue of a stalled fork is to catalyze reverse branch migration past the lesion to reset the replication fork and the lesion can be subsequently corrected by DNA repair (IIIa).
		Bambara, R.A., Murante, R.S., and Henricksen, L.A. Enzymes and reactions at the eukaryotic DNA replication fork.
	www.molbiolcell.org /cgi/content/full/15/2/734 (8997 words)

	DNA Replication (Site not responding. Last check: 2007-10-18)
		While Meselson and Stahl's experiment and subsequent studies have confirmed that DNA replication occurs by the mechanism first envisioned by Watson and Crick, the details of the process are quite complex -- particularly in eukaryotes.
		As the replication fork moves forward, it is easy to see how one new strand (the 'leading' strand) is synthesized in the 5' to 3' direction.
		The fork is moving in the opposite direction to its synthesis.
	mbclserver.rutgers.edu /~sofer/genetics/Week5/Lecture6-2.html (531 words)

	A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases -- ...
		Brewer, B.J. and Fangman, W.L. A replication fork barrier at the 3` end of yeast ribosomal RNA genes.
		Brewer, B.J., Lockshon, D., and Fangman, W.L. The arrest of replication forks in the rDNA of yeast occurs independently of transcription.
		Kobayashi, T., Heck, D.J., Nomura, M., and Horiuchi, T. Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: Requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes Dev.
	www.proteinscience.org /cgi/content/full/11/5/1274 (2329 words)

	Sloan-Kettering - Projects: Processing of Regressed Replication Forks
		As the replication fork progresses, the negative supercoils are converted to positive ones.
		The influence of superhelicity on nascent strand regression at stalled replication forks.
		Thus, if NSR plays a role in replication fork repair in the cell, there is likely to be an enzyme(s) that catalyzes the reaction.
	www.mskcc.org /mskcc/html/50622.cfm (481 words)

	Multiple pathways process stalled replication forks -- Michel et al. 101 (35): 12783 -- Proceedings of the National ...
		Replication fork reversal model (adapted from ref. 9).
		A mutation in the gene encoding the replicative helicase DnaB,
		because replication restart is inefficient in the absence of
	www.pnas.org /cgi/content/full/101/35/12783 (4889 words)

	Replication Terminator Protein-Based Replication Fork-Arrest Systems in Various Bacillus Species -- Griffiths et al. ...
		the replicative helicase to arrest replication in vitro (26).
		Franks, A. and Wake, R. Replication fork arrest at relocated replication terminators on the Bacillus subtilis chromosome.
		Williams, N. and Wake, R. Sequence limits of DNA strands in the arrested replication fork at the Bacillus subtilis chromosome terminus.
	jb.asm.org /cgi/content/full/180/13/3360 (6031 words)

	The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants -- Flores et al. 5 (10): ... (Site not responding. Last check: 2007-10-18)
		The reversed fork forms a four-armed structure (Holliday junction, two alternative representations of this structure are shown, open X and parallel stacked X).
		The replication mutants that undergo replication fork reversal
		Kuhn B, Abdel-Monem M (1982) DNA synthesis at a fork in the presence of DNA helicases.
	emboreports.npgjournals.com /cgi/content/full/5/10/983 (3676 words)

	Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast -- Noguchi et al. 24 (19): 8342 ...
		Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast -- Noguchi et al.
		of fork arrest and for activation of the replication checkpoint
		DNA replication correlated with movement of the replication
	mcb.asm.org /cgi/content/abstract/24/19/8342 (340 words)

	Evidence that replication fork components catalyze establishment of cohesion between sister chromatids -- Carson and ...
		Evidence that replication fork components catalyze establishment of cohesion between sister chromatids -- Carson and Christman 98 (15): 8270 -- Proceedings of the National Academy of Sciences
		Replicated linear chromosomes are intertwined after DNA synthesis because of the helical structure of the DNA molecule and
		fork pause is known to occur at yeast centromeres (74), the
	www.pnas.org /cgi/content/full/98/15/8270 (4644 words)

	Replication Terminator Protein-Based Replication Fork-Arrest Systems in Various Bacillus Species -- Griffiths et al. ...
		The replication terminator protein (RTP) of Bacillus subtilis interacts with its cognate DNA terminators to cause replication
		Lemon, K. P., Kurtser, I., Grossman, A. Effects of replication termination mutants on chromosome partitioning in Bacillussubtilis.
		Griffiths, A. A., Wake, R. Utilization of Subsidiary Chromosomal Replication Terminators in Bacillus subtilis.
	jb.asm.org /cgi/content/abstract/180/13/3360 (384 words)

	Regulation of DNA Replication Fork Genes by 17{beta}-Estradiol -- Lobenhofer et al. 16 (6): 1215 -- Molecular ...
		Regulation of DNA Replication Fork Genes by 17{beta}-Estradiol -- Lobenhofer et al.
		In the absence of a mitogen, unphosphorylated Rb is bound to E2F, preventing the transcription of E2F-responsive genes, such as those involved in DNA replication.
		Phosphorylation of Rb causes the dissociation of the Rb/E2F complex, thereby relieving the transcriptional repression of genes involved in DNA replication.
	mend.endojournals.org /cgi/content/full/16/6/1215 (7734 words)

	Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53 -- ...
		Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53 -- Osborn and Elledge 17 (14): 1755 -- Genes and Development
		Articles by Osborn, A. Articles by Elledge, S. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
		and for activation of Rad53, is present at replication forks.
	www.genesdev.org /cgi/content/abstract/17/14/1755 (1121 words)

	DNA-PROTEIN INTERACTIONS AT THE REPLICATION FORK
		The folding of the lagging strand at a moving T7 replication fork will continued to be probed using new mini- circle DNA templates.
		EM will be used to explore the question of now Okazaki fragment size is controlled and the role of newly discovered novel structural 'spools' created by the binding of single stranded DNA on the lagging strand by the T7 SSB.
		Using the T4 replication system studies will continue on the looping of the lagging strand in coordinating replication.
	www.med.unc.edu /wrkunits/1dean/research/Griffith135.html (424 words)

	DNA Replication (Site not responding. Last check: 2007-10-18)
		This is semiconservative replication, because each new strand is half comprised of molecules from the old strand.
		We will approach the study of the moelcular mechanism of DNA replication from the point of view of the machinery that is required to accomplish it.
		Single-stranded binding proteins are important to maintain the stability of the replication fork.
	web.mit.edu /esgbio/www/dogma/repl.html (924 words)

	DNA Replicating Itself
		To reproduce, a cell must copy and transmit its genetic information (DNA) to all of its progeny.
		To do so, DNA replicates, following the process of semiconservative replication.
		Each strand of the original molecule acts as a template for the synthesis of a new complementary DNA molecule.
	www.accessexcellence.org /AB/GG/dna_replicating.html (132 words)

	The Collaboration of Proteins During Replication
		The major types of proteins, which must work together during the replication of DNA, are illustrated,
		The two parent strands are unwound with the help of DNA helicases.
		Finally, each new Okazaki fragment is attached to the completed portion of the lagging strand in a reaction catalyzed by DNA ligase.
	www.accessexcellence.org /AB/GG/collaboration.html (159 words)

	Replication
		DNA replication is initiated at a region on a chromosome called an origin of replication.
		As the DNA is unwound specific single stranded DNA binding proteins (Replication factor A) prevent the strands from reannealing.
		RNA primers are produced by primase which bind to the DNA.
	bioweb.uwlax.edu /GenWeb/Molecular/Theory/Replication/replication.htm (137 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations (Site not responding. Last check: 2007-10-18)
		Energy Citations Database (ECD) Document #5638418 - Structure of the replication fork in ultraviolet light-irradiated human cells
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Structure of the replication fork in ultraviolet light-irradiated human cells
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=5638418 (121 words)

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