| | What is the closing volume? |
 | | However, these alveoli are also vulnerable: as they have the lowest resting volume, they also have the lowest resting pressure and by inference the lowest gradient to the mouth: and are the first airways to be compressed during active expiration. |
 | | This is important because, during active emptying of the lungs, these airways close off long before residual volume is reached: the point at which this begins to occur is known as the closing volume (the closing volume plus the residual volume is the closing capacity). |
 | | In pathological conditions, or where tidal volumes are low or where the patient does not sigh or yawn, airways may remain collapsed throughout the respiratory cycle: this lead to a situation whereby lung units may be ventilated but not perfused (low V/Q) – shunt and venous admixture. |
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