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Topic: Resistin

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	Resistin / Cushing's Help and Support (Site not responding. Last check: 2007-10-22)
		The hormone, dubbed resistin, is produced by fat cells and prompts tissues to resist insulin, the substance the body needs to process blood sugar, researchers reported in Thursday's issue of the journal Nature.
		Mice given resistin were not able to process blood sugar as well as those that were not given the hormone.
		Resistin "may form at least part of the missing link between obesity and diabetes,'' Jeffrey S. Flier of the Beth Israel Deaconess Medical Center in Boston said in an accompanying editorial.
	www.cushings-help.com /resistin.htm (672 words)

	Resistin - Wikipedia, the free encyclopedia
		The length of the resistin pre-peptide in human is 108 aminoacids (in the mouse and rat it's 114 aa); the molecular weight is ~12.5 kDa.
		Resistin is secreted by adipocytes and affects several other tissues in the body.
		Resistin was discovered in 2001 by the group of Dr Mitchell A. Lazar from University of Pennsylvania School of Medicine.
	en.wikipedia.org /wiki/Resistin (309 words)

	Resistin, an Adipokine with Potent Proinflammatory Properties -- Bokarewa et al. 174 (9): 5789 -- The Journal of ... (Site not responding. Last check: 2007-10-22)
		Lipopolysaccharide increases resistin gene expression in vivo and in vitro.
		Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes.
		Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro.
	www.jimmunol.org /cgi/content/full/174/9/5789 (4319 words)

	Plasma Resistin Levels, Correlated With Markers of Inflammation, are Predictive of Atherosclerosis in Human
		Resistin was not a measure of insulin resistance in multivariable analysis.
		Resistin levels were associated with increasing CAC after adjustment for age, sex and established risk factors (OR, 1.23 [CI, 1.03 to 1.52], P=0.03).
		While in rodents, resistin is expressed in adipose tissue and regulates glucose metabolism and insulin sensitivity, in humans, resistin is detectable in inflammatory cells.
	www.cardiologyonline.com /journal_articles/Plasma_resistin.htm (494 words)

	Mechanisms Regulating Adipocyte Expression of Resistin -- Hartman et al. 277 (22): 19754 -- Journal of Biological ... (Site not responding. Last check: 2007-10-22)
		resistin gene is remarkably divergent from that of the mouse gene
		Down-regulation of Resistin Gene Expression by TZDs-- Resistin was identified as a gene whose expression was down-regulated by TZDs in 3T3-L1 adipocytes (17).
		of resistin expression by rosiglitazone is similar to the ED for the induction of aP2 by rosiglitazone.
	www.jbc.org /cgi/content/full/277/22/19754 (4820 words)

	Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes -- Di Simone ... (Site not responding. Last check: 2007-10-22)
		Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes -- Di Simone et al.
		Articles by Di Simone, N. Articles by Caruso, A. Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes
		Resistin is a novel hormone that is secreted by human adipocytes
	joe.endocrinology-journals.org /cgi/content/abstract/189/3/691 (253 words)

	Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting -- Rajala et al. 53 (7): ... (Site not responding. Last check: 2007-10-22)
		and serum resistin increased in response to hyperinsulinemia
		in the resistin cDNA was mutated to tyrosine by PCR and subcloned
		Resistin concentrations in murine adipose tissue and serum measured by a new enzyme immunoassay.
	diabetes.diabetesjournals.org /cgi/content/full/53/7/1671 (4821 words)

	The irresistible biology of resistin -- Hotamisligil 111 (2): 173 -- Journal of Clinical Investigation (Site not responding. Last check: 2007-10-22)
		Resistin and RELMß impair glucose metabolism in the liver
		Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
		Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue.
	www.jci.org /cgi/content/full/111/2/173 (1611 words)

	Cardiovascular Diabetology \| Full text \| Relationship of serum adiponectin and resistin to glucose intolerance and fat ...
		Resistin levels had an inverse correlation with adiponectin levels, indicating an inverse relationship between pro-inflammatory cytokines and adiponectin.
		Serum resistin was measured using the enzyme immunoassay kit by Phoenix pharmaceuticals INC (530 Harbor Boulevard, Belmont, CA 94002, USA [21].
		Human resistin sensitivity is 4 ng/ml with interassay and between assays variability of <14% and <5% respectively.
	www.cardiab.com /content/5/1/10 (3408 words)

	Activation of SOCS-3 by Resistin -- Steppan et al. 25 (4): 1569 -- Molecular and Cellular Biology (Site not responding. Last check: 2007-10-22)
		Resistin inhibits insulin-stimulated tyrosine phosphorylation of IR and IRS-1 in 3T3-L1 adipocytes.
		Resistin inhibits glucose uptake in L6 skeletal muscle cells independent of changes in insulin signaling components and Glut-4 translocation.
		Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus.
	mcb.asm.org /cgi/content/full/25/4/1569 (4529 words)

	Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal-Regulated Kinase 1/2 and ... (Site not responding. Last check: 2007-10-22)
		HASMCs treated with resistin (100 ng/mL) for 10, 15, and 60 minutes (A) or treated with increasing does of resistin (10 to 100 ng/mL) for 15 minutes (B) were analyzed by Western blot for phosphorylated ERK 1/2 (p ERK 1/2).
		Resistin gene expression in human adipocytes is not related to insulin resistance.
		An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance.
	circ.ahajournals.org /cgi/content/full/110/21/3335 (4008 words)

	Human Cytokine Data Sheets (Resistin) available from Research Diagnostics Inc (Site not responding. Last check: 2007-10-22)
		Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM.
		Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes.
		Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis.
	www.researchd.com /cytokines/rdi4519.htm (402 words)

	Linco Research, Inc. - Mouse Resistin RIA Kit (Site not responding. Last check: 2007-10-22)
		Mouse Resistin is implicated as the missing link between obesity and insulin resistance and type 2 diabetes.
		Measurement of mouse Resistin levels in circulation under different patho-physiological, nutritional and genetic manipulations should result in better understanding of the etiology of type 2 diabetes and obesity.
		Embo J. Banerjee, R.R. and Lazar, M.A. Dimerization of resistin and resistin-like molecules is determined by a single cystein.
	www.lincoresearch.com /products/mr-96hk.html (237 words)

	mouse Resistin
		Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which are termed the RELM family, and is also describes as ADSF (Adipose Tissue-Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone).
		Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26.
		Mouse resistin, specifically produced and secreted by adipocytes, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves to reduce their sensitivity to insulin.
	www.metachem.co.uk /muResistin.htm (343 words)

	Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance -- Seow et al. 19 (1): 48 -- Human ... (Site not responding. Last check: 2007-10-22)
		Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance -- Seow et al.
		resistin mRNA in adipocytes isolated from the omental adipose
		Ling C, Kindblom J, Wennbo H and Billig H (2001) Increased resistin expression in the adipose tissue of male prolactin transgenic mice and in male mice with elevated androgen levels.
	humrep.oxfordjournals.org /cgi/content/full/19/1/48 (3689 words)

	Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors ...
		At higher magnification (B), specific resistin immunoreactivity was clearly evident on interstitial Leydig cells and, at a lower intensity, in Sertoli cells within the seminiferous tubules.
		of the resistin gene in seminiferous tubules is stage-specific,
		Resistin is expressed in different rat tissues and is regulated in a tissue and gender specific manner.
	jcs.biologists.org /cgi/content/full/117/15/3247 (5867 words)

	Resistin and Type 2 Diabetes: Regulation of Resistin Expression by Insulin and Rosiglitazone and the Effects of ...
		Resistin and Type 2 Diabetes: Regulation of Resistin Expression by Insulin and Rosiglitazone and the Effects of Recombinant Resistin on Lipid and Glucose Metabolism in Human Differentiated Adipocytes -- McTernan et al.
		Serum resistin (nanograms per milliliter) and leptin (nanograms per milliliter) levels in nondiabetic subjects and diabetic subjects were correlated with their corresponding BMIs.
		Lu S-C, Scieh W-Y, Chen C-Y, Hsu S-C, Chen H-L 2002 Lipolysaccharide increases resistin gene expression in vivo and in vitro.
	jcem.endojournals.org /cgi/content/full/88/12/6098 (5348 words)

	Cell Type-Specific Expression and Coregulation of Murine Resistin and Resistin-Like Molecule-{alpha} in Adipose Tissue ...
		It is interesting that the secretion of resistin from 3T3-L1 adipocytes under basal conditions is very slow, with detectable levels in the supernatant appearing only after 2–3 h.
		Resistin transcription is up-regulated in response to acute
		Banerjee RR, Lazar MA 2001 Dimerization of resistin and resistin-like molecules is determined by a single cysteine.
	mend.endojournals.org /cgi/content/full/16/8/1920 (5339 words)

	Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction -- Verma et al. ...
		Resistin treatment resulted in induction of ET-1 promoter; however, AP-1–mutated promoter was no longer activated, which suggests that resistin induces ET-1 promoter activity via AP-1 site.
		role of resistin in the pathogenesis of insulin resistance.
		Resistin, obesity and insulin resistance: the emerging role of the adipocyte as an endocrine organ.
	circ.ahajournals.org /cgi/content/full/108/6/736 (3459 words)

	Transgenic and Recombinant Resistin Impair Skeletal Muscle Glucose Metabolism in the Spontaneously Hypertensive Rat -- ...
		of resistin or resistin expression in visceral or superficial
		transgene and endogenous rat resistin gene in adipose tissue.
		Two transcripts for the endogenous rat resistin gene were detected in epididymal fat tissue of transgene-positive rats and transgene-negative controls with molecular weights corresponding to those previously reported for rat resistin.
	www.jbc.org /cgi/content/full/278/46/45209 (5283 words)

	Resistin in Preterm and Term Newborns: Relation to Anthropometry, Leptin, and Insulin -- NG et al. 58 (4): 725 -- ... (Site not responding. Last check: 2007-10-22)
		Resistin in Preterm and Term Newborns: Relation to Anthropometry, Leptin, and Insulin -- NG et al.
		Resistin in Preterm and Term Newborns: Relation to Anthropometry, Leptin, and Insulin
		plasma resistin levels compared with those who were born by
	www.pedresearch.org /cgi/content/abstract/58/4/725 (239 words)

	Regulation of Resistin by Gonadal, Thyroid Hormone, and Nutritional Status -- Nogueiras et al. 11 (3): 408 -- Obesity
		Regulation of Resistin by Gonadal, Thyroid Hormone, and Nutritional Status -- Nogueiras et al.
		Resistin is also regulated by thyroid hormones; it
		Sexual Dimorphism and Regulation of Resistin, Adiponectin, and Leptin Expression in the Mouse
	www.obesityresearch.org /cgi/content/abstract/11/3/408 (606 words)

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