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Topic: Resolvins

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	Sona.ie - Information Centre
		Resolvins are made from the omega-3 fatty acids by cellular enzymes and can reduce inflammation in mice.
		Volunteers given omega-3 fatty acids and aspirin were found to have resolvins in their plasma.
		Human resolvins were shown to inhibit the movement of inflammatory cells.
	www.sona.ie /newsd.asp?id=12941 (189 words)

	Oily fish helps cut inflammation
		Resolvins are made from the omega-3 fatty acids, found in high concentration in oily fish.
		One form of resolvin - E1 - is thought to play a particularly significant role in controlling inflammation.
		The enzyme COX-2 is involved in making resolvin E1, and the researchers suspect that taking the drugs may disrupt the body's ability to synthesise the fat.
	www.thehealthnews.org /news/1335/oil_inflamation.html (434 words)

	Naturallythere4you (Site not responding. Last check: 2007-10-20)
		Researchers at Brigham and Women's Hospital and Harvard Medical School in Boston identified a new class of aspirin-triggered bioactive lipids, called resolvins that may partly explainthe beneficial effects of omega-3 fatty acids.
		The main bioactive component of this class of lipids was identified in mice and named resolvin E1.
		Human resolvin E1 inhibits both the migration of inflammatory cells to sites of inflammation and the turning on of otherinflammatory cells, the authors conclude in the Journal of Experimental Medicine.
	forums.naturallythere4you.com /print.php?sid=3656 (126 words)

	resolvins, Primary Sclerosing Cholangitis Literature
		Arita M, Yoshida M, Hong S, Tjonahen E, Glickman JN, Petasis NA, Blumberg RS, Serhan CN 2005 Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.
		Serhan CN, Arita M, Hong S, Gotlinger K 2004 Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers.
		Serhan CN, Gotlinger K, Hong S, Arita M 2004 Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis.
	www.psc-literature.org /resolvins.htm (325 words)

	Eating oily fish may reduce inflammation (Site not responding. Last check: 2007-10-20)
		This research group recently identified a new class of aspirin-triggered bioactive lipids, called resolvins, the activity of which may in part explain the beneficial effects of omega-3 fatty acids.
		Human resolvin E1, the authors show, inhibits both the migration of inflammatory cells to sites of inflammation and the turning on of other inflammatory cells.
		COX-2 is involved in making resolvin E1 and the authors suggest that inhibition of vascular COX-2 by these inhibitors might block the synthesis of resolvin E1, which would eliminate an important anti-inflammatory pathway.
	i-newswire.com /goprint9496.html (386 words)

	The Resolution of Inflammation: A Nutritional Issue
		Resolvins create "stop signals" and thus dampen inflammation; they appear to reduce cytokine activity and the chemotactic recruitment of neutrophils and their pro-inflammatory activity,
		This is because the same enzymes are utilized in the biosynthesis of n-6 eicosanoids and n-3 eicosanoids and resolvins, such that our substantial n-6 intake serves to functionally inhibit the production of n-3-derived anti-inflammatory mediators.
		Without resolvins, it is likely that inflammation will persist without resolution, leading to chronic inflammatory disease in the long term and persistent pain throughout life.
	www.nutritionalwellness.com /columnists/seaman (941 words)

	Treatment of Inflammation Stricken by the Law of Unintended Consequences
		Further evidence of the role of aspirin in triggering the endogenous formation of resolvins and docosatrienes was presented in 2004 and of their potent anti-inflammatory actions.
		Further work is being done on resolvin E1 and attempts to scale up the manufacture of synthetic resolvin E1 will produce it cheaply in bulk for use in well controlled human trials.
		Resolvins, docosatrienes, and neuroproteins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabiasis, Serhan, C.N., et al, Prostaglandins Other Lipid Mediat.
	www.cancerlynx.com /cox2.html (1296 words)

	Flame Health
		The new class of fats, called resolvins, controls inflammation by stopping the migration of inflammatory cells to sites of inflammation, and turning on other inflammatory cells.
		Resolvins are made from the Omega-3 fatty acids, found in high concentration in oily fish, and their production also appeared to be stimulated by taking aspirin.
		The enzyme COX-2 is involved in making Resolvin E1, which is thought to play a particularly significant role in controlling inflammation, and researchers suspect that taking COX-2 inhibitors may disrupt the body’s ability to synthesize the fat, undermining one of the body’s most important methods for reducing inflammation.
	www.flamehealth.com /news_article.asp?article_id=240 (232 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		According to a new study published in the March 7 issue of the Journal of Experimental Medicine, scientists have identified a new class of aspirin-triggered bioactive lipids, called resolvins, the activity of which may in part explain the beneficial effects of omega-3 fatty acids.
		Resolvins are synthesized from the omega-3 fatty acids by cellular enzymes and are potent counter-regulators of inflammation in mice.
		Omega 3 fatty acids are known for its benefits to patients with cardiovascular disease and arthritis and fatty fish like mackerel, lake trout, herring, sardines, albacore tuna and salmon are high in two kinds of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
	www.worldseafoodmarket.com /NewsDigest/NewsDisplay.jsp?category=General&&filename=GEN685.html (178 words)

	Resolvins : by Ray Sahelian, M.D. (Site not responding. Last check: 2007-10-20)
		Resolvins : by Ray Sahelian, M.D. RESOLVINS by Ray Sahelian, M.D. Eicosapentaenoic acid and docosahexaenoic acid are precursors to potent bioactive mediators that possess both anti-inflammatory and protective properties.
		These mediators are coined resolvins, docosatrienes, and protectins as general classes.
		Twice a month we email a brief abstract of several studies on various supplements and natural medicine topics, including resolvins, and their practical interpretation by Ray Sahelian, M.D.
	www.raysahelian.com /resolvins.html (220 words)

	Health Tips ... from UPI - (United Press International) (Site not responding. Last check: 2007-10-20)
		Researchers at Brigham and Women's Hospital and Harvard Medical School in Boston identified a new class of aspirin-triggered bioactive lipids, called resolvins that may partly explain the beneficial effects of omega-3 fatty acids.
		Human resolvin E1 inhibits both the migration of inflammatory cells to sites of inflammation and the turning on of other inflammatory cells, the authors conclude in the Journal of Experimental Medicine.
		U.S. college students have higher rates alcohol use than peers not in college, but don't appear to be at greater alcohol dependence risk.
	washingtontimes.com /upi-breaking/20050317-023011-2337r.htm (433 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		Makoto Arita from the Brigham and Women's Hospital and Harvard Medical School and US-based colleagues have recently identified a new class of aspirin-triggered bioactive lipids in humans, called resolvins, that could partly explain fish oils’ anti-inflammatory effects on joints and blood flow.
		Writing in the 7 March issue of The Journal of Experimental Medicine (vol 201, no 5, 713-722), the authors said that human resolvin E1 inhibits both the migration of inflammatory cells to sites of inflammation and the turning on of other inflammatory cells.
		COX-2 is involved in making resolvin E1 and the authors suggest that inhibition of vascular COX-2 by these drugs might block the synthesis of resolvin E1, which would eliminate an important anti-inflammatory pathway.
	www.lohasjournal.com /app/cda/nbpCDAArticlePrint.php?articleId=5332&categoryId=5 (282 words)

	Omega 3 Fights Inflammation
		In fact, it was discovered that a diet high in oily fish might be the most beneficial, as a key anti-inflammatory fat in humans is derived from a fatty acid found in fish oil.
		The anti-inflammatory fats are resolvins, specifically made from the omega-3 fatty acids found in oily fish.
		However, one form of resolvins in particular, known as E1, is thought to play a critical role in inflammation.
	naturalbiology.com /om3fiin.html (264 words)

	PacificHealth.info » Health \| Oily fish helps cut inflammation (Site not responding. Last check: 2007-10-20)
		One form of resolvin – E1 - is thought to play a particularly significant role in controlling inflammation.
		The study also reveals a potential pitfall of COX -2 inhibitors, drugs designed to block inflammation, which have been shown to have negative cardiovascular side effects.
		The enzyme COX -2 is involved in making resolvin E1, and the researchers suspect that taking the drugs may disrupt the body’s ability to synthesise the fat.
	pacifichealth.info /healthblog/2005/03/13/health-oily-fish-helps-cut-inflammation (500 words)

	Faculty Page (Site not responding. Last check: 2007-10-20)
		We have recently elucidated several novel classes of lipid-derived mediators, the lipoxins, Resolvins, Docosatrienes, and Neuroprotectins, as well as their endogenous aspirin-triggered forms that dampen inflammatory responses and have designed novel therapeutic approaches using some of these structures as biotemplates.
		In eye inflammation, new drugs built with the knowledge of these biochemical signaling pathways could be more potent and better tolerated since they are based on structures of endogenous natural compounds.
		Also, since the eye is rich in DHA, the novel neuroprotectins may have a physiological role in protecting the eye from inflammation-initiated injury.
	www.hms.harvard.edu /dms/bbs/fac/serhanchn.html (280 words)

	Better Nutrition: Study spawns arthritis hope
		The scientists found a new and important class of anti-inflammatory fats in humans--called resolvins--that are derived from omega-3 fatty acids found in high concentration in fish oil.
		Resolvins stop the migration of inflammatory cells to sites of inflammation as well as halt the turning on of other inflammatory cells.
		The study also reveals a potential pitfall of COX-2 inhibitors, drags designed to block inflammation, which have been shown to have negative cardiovascular side effects.
	www.findarticles.com /p/articles/mi_m0FKA/is_6_67/ai_n13779513 (351 words)

	Inflammation control gets fishy (Site not responding. Last check: 2007-10-20)
		class of lipids was identified in mice and named resolvin E1.
		fatty acids to a precursor of resolvin E1.
		The structure of resolvin E1, a potent antiinflammatory lipid derived from omega-3 fatty acids.
	www.1stvitality.co.uk /artman/publish/printer_55.shtml (261 words)

	(WO 2004/014835) RESOLVINS: BIOTEMPLATES FOR THERAPEUTIC INTERVENTIONS [Repub: 08.07.2004] (Site not responding. Last check: 2007-10-20)
		(57) The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA).
		Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties.
		The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example.
	www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=04/14835.040708 (249 words)

	The World's Healthiest Foods: Feeling Great
		As a result, it is important to ensure proper balance of omega 3 and omega 6 fats in the diet.
		Resolvins, which have been shown to reduce inflammation in animal studies, are made from EPA by our cellular enzymes, and work by inhibiting the production and regulating the migration of inflammatory cells and chemicals to sites of inflammation.
		Resolvins: a family of boactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
	www.whfoods.com /genpage.php?tname=nutrient&dbid=84 (2629 words)

	Natural Products Magazine
		The discovery may prove why a diet high in oily fish such as salmon and mackerel seems to help improve inflammatory conditions such as arthritis.
		Researchers from Harvard Medical School say that a new class of fats, known as resolvins, appear to control inflammation in the body.
		The scientists also discovered that their production in the human body seemed to be stimulated by taking a low dose of asprin alongside the fish oils.
	www.naturalproductsonline.co.uk /home.asp?ItemID=513&rcid=70&pcid=69&cid=70 (500 words)

	DHEA, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair growth, buy Rx ... (Site not responding. Last check: 2007-10-20)
		Here, we report that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid (DHA) (C22:6) produce a novel family of bioactive 17R-hydroxy-containing di- and tri-hydroxy-docosanoids termed resolvins.
		These results indicate that exudates, vascular, leukocytes and neural cells treated with aspirin convert DHA to novel 17R-hydroxy series of docosanoids that are potent regulators.
		These biosynthetic pathways utilize omega-3 DHA and EPA during multicellular events in resolution to produce a family of protective compounds, i.e., resolvins, that enhance proresolution status.
	twinpharm.com /ref-glial-cell/glial-cell-research-abs4.63.html (1315 words)

	PUFA: Newsletter (Site not responding. Last check: 2007-10-20)
		Recent studies have identified a novel group of mediators -- termed E-series resolvins -- formed from EPA by COX-2 in the presence of aspirin, which appear to exert anti-inflammatory actions (12).
		In addition, DHA-derived mediators termed D-series resolvins, docosatrienes and neuroprotectins, also produced by COX-2, have been identified and appear to be anti-inflammatory (13).
		This is an exciting new area of research in n-3 fatty acids and anti-inflammatory mediators, with implications for a variety of conditions that may be of great importance.
	www.fatsoflife.com /article.asp?i=l&id=197 (1717 words)

	Articles - MSFYI - March 2005
		Researchers from Harvard Medical School in Boston, the National Institutes of Health in Bethesda, Maryland, and the university of Southern California in Los Angeles have identified an anti-inflammatory lipid in humans derived from an essential fatty acid in fish oil.
		Resolvins are produced from the omega-3 fatty acids by cellular enzymes and can reduce inflammation in mice.
		Volunteers given omega-3 fatty acids and aspirin were found to have resolvins in their plasma, which were shown to inhibit the movement of inflammatory cells.
	www.balancedpersonaltraining.com /articles/MSFYI0305.html (2035 words)

	Resolvins: A Family of Bioactive Products of Omega-3 Fatty Acid Transformation Circuits Initiated by Aspirin Treatment ...
		Resolvins: A Family of Bioactive Products of Omega-3 Fatty Acid Transformation Circuits Initiated by Aspirin Treatment that Counter Proinflammation Signals -- Serhan et al.
		Resolvin production by human PMNs exposed to microbial zymosan: novel 17 R di- and triHDHA.
		the term "resolvins" is introduced for this family of new compounds
	www.jem.org /cgi/content/full/196/8/1025 (7554 words)

	PUFA: Newsletter (Site not responding. Last check: 2007-10-20)
		Metabolic events: (a) regulation of the synthesis of eicosanoids derived from arachidonic acid, and (b) precursor of docosatrienes and 17S resolvins, novel anti-inflammatory mediators.
		Recently, DHA has been established as the precursor of a novel series of endogenous mediators in human blood, leukocytes, murine brain, and human glial cells.
		These mediators, called docosatrienes (17S-hydroxy-containing docosanoids) and 17S series resolvins, are biosynthesized via enzymatic oxygenation, and are potent regulators of both leukocytes (reducing infiltration in vivo) and glial cells (blocking their cytokine production
	www.fatsoflife.com /article.asp?i=c&id=212 (1306 words)

	Health Chat - Oily fish helps cut inflammation (Site not responding. Last check: 2007-10-20)
		called resolvins, which they showed can control inflammation.
		Resolvins are made from the omega-3 fatty acids, found in high
		One form of resolvin - E1 - is thought to play a particularly
	www.health-related-chat.com /detail-839242.html (732 words)

	mercola.com: The Inflammation-Fighting Component of Omega-3s
		Harvard scientists have discovered a new class of fats in the body -- resolvins -- that control inflammation.
		Made from omega-3 fatty acids, resolvins stop the migration of inflammatory cells to sites of inflammation and turn on other inflammatory cells.
		They also believe E1, one specific form of resolvin, plays a very important role in fighting inflammation.
	www.mercola.com /blog/2005/mar/15/the_inflammationfighting_component_of_omega3s (344 words)

	Omega-3 oils are the substrate for antiinflammatory resolvins (Site not responding. Last check: 2007-10-20)
		Omega-3 oils are the substrate for antiinflammatory resolvins
		Subject: Omega-3 oils are the substrate for antiinflammatory resolvins
		Resolvins are made from the omega-3 fatty acids by cellular
	www.hair-forum.com /hairloss/Omega3_oils_are_the_substrate_for_antiinflammatory_resolvins_261604.html (635 words)

	Coalition for Medical Progress - Reference
		A study in mice has led to the identification of a new class of anti-inflammatory substances in humans that are derived from the essential omega-3 fatty acids in fish oil, which are already known to help people with cardiovascular disease and arthritis.
		The newly discovered substances, called 'resolvins', were first identified and found to be of benefit in mice.
		Tests in humans have now found they have the same anti-inflammatory impact.
	www.medicalprogress.org /reference/news.cfm?news_id=275 (146 words)

	Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene ...
		E, time course for the accumulation of 17 R -series resolvins in hippocampi of mice pretreated with aspirin before MCA-O. Aspirin triggered a metabolic shift toward accumulation of 17 R -docosatrienes, 7,8,17 R -triHDHA, and 7,17 R -diHDHA, products of acetylated COX-2 enzyme.
		Proposed biosynthetic pathways for 10,17 S -docosatriene and the aspirin-triggered 17 R -series resolvins.
		The stereochemistry for compounds in both pathways is based on the biogenic total synthesis, lipidomic analyses, and alcohol-trapping profiles ( 22, 23).
	www.jbc.org /cgi/content/full/278/44/43807 (5182 words)

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