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Topic: Respiratory chain


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In the News (Mon 13 Feb 12)

  
  Electron transport chain - Wikipedia, the free encyclopedia
The chemiosmotic coupling hypothesis, as proposed by Nobel Prize in Chemistry winner Peter D. Mitchell explains that the electron transport chain and oxidative phosphorylation are coupled by a proton gradient across the inner mitochondrial membrane.
Note that electrons can enter the chain at three levels: at the level of a dehydrogenase, at the level of the quinone pool, or at the level of a mobile cytochrome electron carrier.
Photosynthetic electron transport chains are discussed in greater detail in the articles Photophosphorylation, Photosynthesis, Photosynthetic reaction center and Light-dependent reaction.
en.wikipedia.org /wiki/Electron_transfer_chain   (3120 words)

  
 Botany online: Evolution - Energy-Conversion - Procaryotes - Eucaryotes - Diversification
In the course of the evolution of photosynthesis and the respiratory chain, proton gradients developed.
Among the similarities of photosynthesis and the respiratory chain is the use of the same proteins: ferredoxin, cytochrome c, cytochrome b, and several others.
The respiratory chain is thus a variation of photosynthesis.
www.biologie.uni-hamburg.de /b-online/e42/42.htm   (671 words)

  
 Research: Diagnostic challenges of respiratory chain disorders
In summary, I agree that respiratory chain defects are very difficult to analyze in any form or type of tissue and that there are many potentially confounding factors.
The study compared patients in each group who had a respiratory chain defect vs. those with an undefined mitochondrial disease (i.e., no enzyme deficiency found but other criteria of high suspicion were met such as increased mitochondrial content in muscle), vs. those with no or low suspicion for mitochondrial disease.
Respiratory chain enzymes and citrate synthase were quantified in homogenates of frozen muscle.
www.rgbgl.org /research/respiratorychain.htm   (1082 words)

  
 Oxidative Phosphorylation--Respiratory chain and Chemiosmotic hypothesis
The respiratory chain is found in the inner mitochondrial membrane and is composed of 3 enzyme complexes and 2 mobile carriers.
The mitochondrial respiratory chain is composed of 4 enzyme complexes.
The respiratory chain and the ATPase are assymetrically oriented in the membrane.
www.dentistry.leeds.ac.uk /biochem/uttb/OXPHOS2.HTM   (1629 words)

  
 Oxidative Phosphorylation--Respiratory chain and Chemiosmotic hypothesis
The respiratory chain is found in the inner mitochondrial membrane and is composed of 4 enzyme complexes and 2 mobile carriers.
The respiratory chain is arranged in a defined sequence as shown.
The respiratory chain and the ATPase are asymetrically oriented in the membrane.
www.db.uth.tmc.edu /faculty/amoretti/alevine/1521_2000/oxphos2.htm   (1635 words)

  
 Botany online: Basic Metabolism - Electron Transport - Oxidative Phosphorylation - Respiratory Chain
The citric acid cycle and the respiratory chain are located in another compartment: within mitochondria at the inner mitochondrial membrane.
In the respiratory chain, this energy is gradually set free in a number of intermediate steps (an electron transport chain) and can thus be used for the generation of energy-rich compounds.
In the respiratory chain, the Fe of cytochrome b is at first changed into Fe In plant cells, at least three different cytochrome b-types are in series.
www.biologie.uni-hamburg.de /b-online/e19/19d.htm   (928 words)

  
 Bioenergetics
Many respiratory chain components were first identified in crude homogenates through their spectral properties, which frequently change when a carrier is oxidised or reduced.
The sequence of of the carriers in the respiratory chain was clarified by the use of specific inhibitors to block the flow of electrons from substrates to oxygen.
Note 2: The proton pumping stoichiometry for complex 3 and complex 4 is difficult because the electron acceptor for complex 3 (cytochrome c) is located on the outside of the inner membrane, whereas the oxidant for complex 4 (molecular oxygen) is reduced on the inside face of the inner membrane.
www.bmb.leeds.ac.uk /illingworth/oxphos/carriers.htm   (995 words)

  
 Understanding Brain Aging ~ Oxygen Utilization ~ Amyloid Plaque
Respiratory processes and oxidation of fats are highly regulated by hormones, neurotransmitters, and other methods.
The decline in respiratory processes and the increase of oxidation processes can be considered the root cause of brain aging and degeneration.
Also, "which allows the respiratory chain to function at the maximum rate until the tissue has become virtually depleted of O2 (Page140)." Thus the primary rate limiting factor in the respiratory chain, where glucose is converted to ATP, is availability of oxygen.
www.restoreunity.org /brain_oxygen.htm   (1793 words)

  
 Mitocnol: FAQ
This is achieved in a metabolic pathway called respiratory chain, which is located in the inner membrane of the mitochondrion.
The respiratory chain is also important for the homeostasis of intracellular triglycerides (fat droplets), and for the synthesis of pyrimidines, which are required for the formation of DNA.
The respiratory chain is peculiar in that it is genetically encoded by two distinct systems: The first system consists of our chromosomes (which are located in the cell nucleus); the second system consists of a small circular DNA-molecule called mitochondrial DNA (mtDNA).
www.mitocnol.com /index.php?id=81   (1156 words)

  
 Evaluation of a quantitative real-time PCR for the detection of respiratory syncytial virus in pulmonary diseases -- ...
pathogens, as causes for infections, is the polymerase chain
Respiratory syncytial virus and influenza A infections in the hospitalized elderly.
Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease.
erj.ersjournals.com /cgi/content/full/21/6/944   (4669 words)

  
 Regulation of the aerobic respiratory chain in the facultatively aerobic and hyperthermophilic archaeon Pyrobaculum ...
Regulation of the aerobic respiratory chain in the facultatively aerobic and hyperthermophilic archaeon Pyrobaculum oguniense -- Nunoura et al.
Regulation of the aerobic respiratory chain in the facultatively aerobic and hyperthermophilic archaeon Pyrobaculum oguniense
of the aerobic respiratory chain in the membranes.
mic.sgmjournals.org /cgi/content/full/149/3/673   (6247 words)

  
 Diagnosis of fatal infantile defects of the mitochondrial respiratory chain: age dependence and postmortem analysis of ...   (Site not responding. Last check: 2007-10-29)
Diagnosis of fatal infantile defects of the mitochondrial respiratory chain: age dependence and postmortem analysis of enzyme activities.
We studied two diagnostic aspects of fatal infantile defects of the mitochondrial respiratory chain: the age dependence of muscle mitochondrial enzyme activities and the reliability of diagnosis from autopsy samples.
Using age-matched controls and autopsy samples, we diagnosed a respiratory chain enzyme deficiency in two infants, and the defects were confirmed in cultured skin fibroblasts.
www.arclab.org /medlineupdates/abstract_8747850.html   (180 words)

  
 Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a ...
Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes -- Kwast et al.
Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes
Effect of respiratory inhibitors and mutations in the respiratory chain on the expression of OLE1 and CYC7 under aerobic and anoxic conditions.
www.pnas.org /cgi/content/full/96/10/5446   (5277 words)

  
 Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency - Nature ...
This is the first report of a nuclear gene mutation causing a mitochondrial respiratory chain deficiency in humans.
Walker, J.E. The NADH: ubiquinone oxidoreductase (complex I) of respiratory chain.
Deficiency in complex II of the respiratory chain presenting as a leukodystrophy in two sisters with Leigh syndrome.
www.nature.com /doifinder/10.1038/ng1095-144   (761 words)

  
 Ceramide Interaction with the Respiratory Chain of Heart Mitochondria
A study is presented on the interaction of ceramide with the respiratory chain of rat heart mitochondria, and a comparison is made between the effects elicited by short- and long-chain ceramides.
Similar effects were observed on the activity of the individual respiratory complexes isolated from bovine heart.
Finally, only short-chain ceramides inhibited markedly the reactive oxygen species generation associated with membrane potential-dependent reverse electron flow from succinate to complex I. The emerging indication is that the short-chain ceramide-dependent collapse of membrane potential is a consequence of their ability to perturb the membrane structure, leading to an unspecific increase of its permeability.
pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2000/39/i22/abs/bi9924415.html   (324 words)

  
 Respiratory Enzymes
Some of the questions we wish to address include, how these bacteria control the composition of their respiratory chain to respond to the presence or absence of specific electron donors or acceptors, the varying concentration of those materials or choose which donor or acceptor to use when multiple material are available.
These compounds can be used to provide electrons to the respiratory chain of the bacterium.
Therefore, these changes in the respiratory chain of the bacteroid are reflected in the amounts and types of cytochromes present.
web.umr.edu /~djwesten/respiratory_enzymes.html   (959 words)

  
 The Tumor Suppressor cybL, a Component of the Respiratory Chain, Mediates Apoptosis Induction -- Albayrak et al. 14 ...
Thirteen hours after starting the transfection, the mitochondria were isolated and complex II activity of the respiratory chain was assessed with succinate, which reduces dichlorophenylindophenol whose concentration was measured photometrically.
II of the mitochondrial respiratory chain to be such a sensor.
Higuchi, M., Proske, R.J., and Yeh, E.T. Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis.
www.molbiolcell.org /cgi/content/full/14/8/3082   (6886 words)

  
 JCI -- eLetters for Zhou et al., 108 (8) 1167-1174
The authors recognise that this is consistent with the drug inhibiting complex I of the respiratory chain as demonstrated in this laboratory (2) and by El-Mir et al.
This might appear unlikely, since metformin is a remarkably safe drug, whereas excessive inhibition of the respiratory chain would lead to catastrophic tissue ATP depletion, such as occurs with cyanide poisoning.
As the drug accumulates, the increasing inhibition of the respiratory chain leads to a decrease in membrane potential that in turn prevents further drug uptake.
www.jci.org /cgi/eletters/108/8/1167   (566 words)

  
 The membrane-bound respiratory chain of Pseudomonas pseudoalcaligenes KF707 cells grown in the presence or absence of ...
The membrane-bound respiratory chain of Pseudomonas pseudoalcaligenes KF707 cells grown in the presence or absence of potassium tellurite -- Di Tomaso et al.
The membrane-bound respiratory chain of Pseudomonas pseudoalcaligenes KF707 cells grown in the presence or absence of potassium tellurite
respiratory chain of cells grown in the absence of tellurite
mic.sgmjournals.org /cgi/content/full/148/6/1699   (4845 words)

  
 New Insights into the Respiratory Chain of Plant Mitochondria. Supercomplexes and a Unique Composition of Complex II -- ...   (Site not responding. Last check: 2007-10-29)
Schägger H, Pfeiffer K (2000) Supercomplexes in the respiratory chains of yeast and mammalian mitochondria.
Schägger H, Pfeiffer K (2001) The ratio of oxidative phosphorylation complexes I-V in bovine heart mitochondria and the composition of respiratory chain supercomplexes.
Zhang M, Mileykovskaya E, Dowhan W (2002) Gluing the respiratory chain together: Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane.
intl.plantphysiol.org /cgi/content/full/133/1/274   (6310 words)

  
 Decline with age of the respiratory chain activity in human skeletal muscle.
Decline with age of the respiratory chain activity in human skeletal muscle.
Mitochondrial respiratory systems have been screened in 63 orthopaedic patients of age ranging between 17 and 91 years.
This study provides evidence for a decline with age of mitochondrial respiratory activity in human skeletal muscle, affecting complex I, II and IV.
www.arclab.org /medlineupdates/abstract_8155742.html   (163 words)

  
 Apoptotic Death in Leishmania donovani Promastigotes in Response to Respiratory Chain Inhibition: COMPLEX II INHIBITION ...
respiratory chain that is essential for survival and growth,
respiratory chain favors cell survival and association of the
is intimately connected with the respiratory chain (11), we
www.jbc.org /cgi/content/full/279/12/11798   (6800 words)

  
 Structure of E. coli
This protein is similar to succinate dehydrogenase, which catalyzes the oxidation of succinate to fumarate while functioning as complex II in the aerobic bacterial respiratory chain and also as a member of the Krebs cycle in eukaryotes.
This reverse reaction shows up as a step in the Krebs cycle, which generates the molecules needed to produce ATP, and in the aerobic respiratory chain, where most of the ATP is actually produced.
The similarity of its subunits to other respiratory protein structures also gives intriguing clues to the functional origins of the protein.
www-als.lbl.gov /als/science/sci_archive/fumarate.html   (883 words)

  
 Kinetics of Electron Transfer through the Respiratory Chain -- Jin and Bethke 83 (4): 1797 -- Biophysical Journal
The respiratory electron transport chain in the inner membrane of mitochondria and cytoplasmic membrane of many bacteria conserves
1), the respiratory chain is composed of redox complexes and electron carriers.
Electron(s) derived from a donating species D are transferred through the chain containing coenzymes c1 and c2 to an accepting species A. Reaction centers (ovals) are, from left to right: primary reductase, coenzyme reductase, terminal reductase, and a proton-translocating enzyme, such as ATP synthase.
www.biophysj.org /cgi/content/full/83/4/1797   (4108 words)

  
 Respiratory chain is required to maintain oxidized states of the DsbA-DsbB disulfide bond formation system in ...
Respiratory chain is required to maintain oxidized states of the DsbA-DsbB disulfide bond formation system in aerobically growing Escherichia coli cells -- Kobayashi et al.
Respiratory chain is required to maintain oxidized states of the DsbA-DsbB disulfide bond formation system in aerobically growing Escherichia coli cells
In the absence of heme biosynthesis, respiratory cytochromes will remain in their apo-forms without activity (33).
www.pnas.org /cgi/content/full/94/22/11857   (5284 words)

  
 Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin ...
Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy -- Lebrecht et al.
COX and SDH are enzymes of the mitochondrial respiratory chain.
and composition of the respiratory chain, notably decreased
circ.ahajournals.org /cgi/content/full/108/19/2423   (3384 words)

  
 Cardiolipin Biosynthesis and Mitochondrial Respiratory Chain Function Are Interdependent -- Gohil et al. 279 (41): ...
Cardiolipin Biosynthesis and Mitochondrial Respiratory Chain Function Are Interdependent -- Gohil et al.
The current study addresses the interdependence of CL and the mitochondrial respiratory chain.
respiratory chain by genetic mutation led to decreased CL synthesis.
www.jbc.org /cgi/content/full/279/41/42612   (3715 words)

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