| | Respiratory Epithelium in Usual Interstitial Pneumonia/Idiopathic Pulmonary Fibrosis: Spark or Destructive Flame? ... (Site not responding. Last check: 2007-10-10) |
 | | Alveolitis, as historically defined, cannot suffice as an explanation for the characteristic pattern of fibrosis and disordered lung architecture that define usual interstitial pneumonia (UIP), the morphologic counterpart of idiopathic pulmonary fibrosis (IPF). |
 | | Following epithelial injury, surviving and regenerating respiratory epithelium contributes to abnormal antifibrinolytic activity at sites of injury and also elaborates various fibrogenic cytokines/growth factors important in recruitment and phenotypic modulation of fibroblasts and myofibroblasts (2, 7). |
 | | Furthermore, immunoreactivity for surfactant associated protein A was limited to hyperplastic epithelium associated with fibroblast foci in UIP/IPF, suggesting that pneumocytes are the primary players in UIP/IPF while bronchiolar epithelium or more primitive stem cells participate in cryptogenic organizing pneumonia. |
| www.findarticles.com /p/articles/mi_qa4085/is_200401/ai_n9360769 (834 words) |