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	Restenosis - Wikipedia, the free encyclopedia
		This is usually restenosis of an artery, or other blood vessel, but possibly any hollow organ that has been "unblocked".
		Stenting is becoming more commonplace; after balloon angioplasty, a metal mesh is pressed against the wall of the artery that has been opened, decreasing the risk of restenosis.
		Antisense knockdown of c-myc, a protein critical for progression of cell replication, is another approach to inhibit cell proliferation in the artery wall and has been through preliminary clinical trials using Morpholino oligos.
	en.wikipedia.org /wiki/Restenosis (232 words)

	CIB for Restenosis
		Restenosis occurs in about 20% of heart patients who have received a balloon angioplasty or coronary stent.
		Restenosis has been termed "the Achilles heel" of angioplasty, and has been the subject of major international research over the past 10 years.
		He was experiencing restenosis in the affected artery because of excessive tissue growth in the stented area.
	www.irmc.org /body.cfm?id=207 (846 words)

	Approaches to the prevention of restenosis following coronary intervention (Site not responding. Last check: 2007-11-01)
		Restenosis is the primary limitation to the long-term success of percutaneous coronary revascularization.
		Probucol was associated with a 60 percent reduction in angiographic restenosis (23 versus 58 percent for control, p = 0.001) and a 32 percent larger minimal lumen diameter at follow-up angiography (1.49 versus 1.13 mm, p = 0.02).
		Despite the uncertainty concerning prevention of restenosis, most patients who undergo a coronary intervention are treated with statin therapy for the benefits associated with lipid lowering.
	www.med.usf.edu /~msiddiqu/Restenosis.html (4914 words)

	Coronary Angioplasty - Heart Disease and other cardiovascular conditions on MedicineNet.com
		The rate of restenosis is greater in vein grafts, at the origins of vessels, in the beginning part of the left anterior descending coronary artery, and in those with suboptimal initial results.
		The widespread use of intracoronary stents has reduced the incidence of restenosis by as much as 50% or more; this is due to prevention of "elastic recoil" in the artery, as well as providing a larger initial channel in the treated artery.
		Restenosis can simply be observed or treated with medications if the narrowing is not critical and the patient is not symptomatic.
	www.medicinenet.com /coronary_angioplasty/page6.htm (623 words)

	Restenosis
		Restenosis is a renarrowing at the site of the angioplasty and is caused by the formation of scar-like tissue inside the artery that becomes obstructive.
		Restenosis develops within the first 3-6 months after angioplasty and continues to affect about 20% of patients despite the long list of therapies that have been developed in the past decade and have proven to be disappointing.
		Radiation therapy to the coronary arteries (coronary brachytherapy) promises to lower the incidence of restenosis and has been shown to be particularly effective following angioplasty that also includes a stent implant.
	www.irmc.org /body.cfm?id=214 (188 words)

	Troubleshooting Coronary In-Stent Restenosis: Endovascular Brachytherapy: Currents: UI Health Care
		Restenosis is defined as a re-narrowing of the treated segment, which equals or exceeds 50% of the lumen in the adjacent normal segment of the artery.
		Depending on the patient population studied, the restenosis rates range from 30% to 44% of lesions treated by balloon dilation.
		Restenosis is the result of the formation of neointima, a composition of smooth muscle-like cells in a collagen matrix.
	www.uihealthcare.com /news/currents/vol2issue4/4brachy.html (1023 words)

	Hendrick Health System - Restenosis
		Restenosis is a re-narrowing of a blood vessel due to growth of tissue at the site of angioplasty or stent implementation.
		Restenosis still develops in approximately 20 percent of patients with implanted stents.
		Restenosis is generally treated with a second balloon angioplasty and/or stent implementation procedure.
	www.ehendrick.org /heart/restenosis.htm (194 words)

	Sirolimus-Eluting Stent Implantation in Native Coronary Arteries shows a reduction of angiographic restenosis
		The restenosis was specifically in regard to (1) the lumen changes within the stent and its 5-mm nonstented edges; (2) the degree and incidence of angiographic renarrowing in patients with smaller vessels and longer lesions; (3) the pattern of angiographic restenosis; and (4) the occurrence of late untoward angiographic findings, including the frequency of aneurysms.
		The reduction of restenosis with the SES was consistent in patients at risk for restenosis, including those with small vessels, long lesions, and diabetes mellitus.
		When restenosis occurred with the SES treatment, it most often developed at the margins of the stent, whereas a diffuse pattern of restenosis occurred in patients treated with BMS.
	www.cardiologyonline.com /journal_articles/Sirolimus_eluting.htm (521 words)

	Intra-arterial Brachytherapy for Prevention and Management of Restenosis after Percutaneous Transluminal Angioplasty ...
		The risk of restenosis in patients who undergo PTCA for coronary artery disease is estimated at 30%-50%, based on angiographic studies.
		Placement of stents as an adjunct to PTCA is one strategy to reduce restenosis; it is estimated that approximately 75% of PTCAs performed in the United States include stent placement.
		Intravascular coronary brachytherapy as a treatment of in-stent restenosis of a native coronary artery or non-native coronary artery (e.g., saphenous vein graft) may be considered medically necessary.
	www.regence.com /trgmedpol/medicine/med76.html (2445 words)

	AHA: Cilostazol Decreases Restenosis in Diabetic Patients (Site not responding. Last check: 2007-11-01)
		Subjects were drawn from the 705-patient Cilostazol for RESTenosis (CREST) trial in which patients were randomized to cilostazol or placebo in addition to aspirin and clopidogrel after stent placement.
		In the trial, restenosis rates of stented segments were determined angiographically at 6 months follow-up.
		That is, the in-segment restenosis rate in patients with smaller vessels was 14.29% in cilostazol patients versus 38.78% in placebo patients (P =.014).
	www.pslgroup.com /dg/247906.htm (454 words)

	What is Restenosis? Get information to help you understand Restenosis: What you need to know
		Restenosis is a re-narrowing or blockage of an artery at the same site where treatment, such as a balloon angioplasty or stent procedure, has already taken place.
		If restenosis occurs at the site where a stent has been placed in an artery, it is called in-stent restenosis.
		Whether it is restenosis or in-stent restenosis, the end result is a narrowing of the artery that may eventually block the flow of blood to your heart.
	www.cypherusa.com /cypher-j2ee/cypherjsp/understanding/what_is_restinosis.jsp (409 words)

	Restenosis: Repeat Narrowing of a Coronary Artery: Prevention and Treatment -- Dangas and Kuepper 105 (22): 2586 -- ... (Site not responding. Last check: 2007-11-01)
		E, Localized radiation therapy (brachytherapy) delivered to the location of in-stent restenosis by a special catheter to avoid recurrence of in-stent restenosis.
		Incidence of restenosis after successful coronary angioplasty: a time- related phenomenon: a quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months.
		Angiographic patterns of in-stent restenosis: classification and implications for long-term outcome.
	circ.ahajournals.org /cgi/content/full/105/22/2586 (1117 words)

	Open wide
		Restenosis can cause an eventual blockage of blood flow, resulting in life-threatening problems such as heart attack and angina.
		One form of restenosis is caused by blood clotting, or thrombosis, at the site of treatment.
		The second form of restenosis is caused by tissue growth at the site of the procedure typically within three to six months of treatment.
	www.advocatehealth.com /luth/info/library/ham/sum03/luth1.html (916 words)

	UpToDate Intracoronary stent restenosis
		The angiographic restenosis rate at six months after successful stent placement was significantly lower than with PTCA alone (32 versus 42 percent and 22 versus 32 percent, respectively).
		The frequency of clinical restenosis was defined as target lesion or target vessel revascularization beyond 30 days, death, or MI in the target vessel territory [3].
		Angiographic restenosis was not equivalent to clinical restenosis.
	patients.uptodate.com /print.asp?print=true&file=chd/55508 (624 words)

	UpToDate Use of intracoronary radiation to prevent restenosis
		The rate of angiographic restenosis following balloon angioplasty alone (defined as 50 percent or greater reduction in luminal diameter at follow-up angiography) is 40 to 50 percent [1].
		About half of the patients with angiographic restenosis manifest clinical restenosis with recurrent ischemia that leads to repeat revascularization of the targeted vessel [2].
		Intracoronary stents, by virtue of their ability to prevent elastic recoil and constrictive remodeling, initially reduced the frequency of angiographic restenosis to approximately 20 percent and the need for repeat revascularization to approximately 10 to 12 percent (show figure 1) [3,4].
	patients.uptodate.com /print.asp?print=true&file=chd/58001 (403 words)

	ESC: Repeat Brachytherapy May Prevent Repeat In-stent Restenosis (Site not responding. Last check: 2007-11-01)
		Recurrence of restenosis occurred an average of seven months after the first brachytherapy.
		This patient underwent coronary artery bypass grafting because of significant disease in a vessel that was not a target of this study.
		The average diameter of restenosis in these patients was approximately 12 percent.
	www.pslgroup.com /dg/21ce66.htm (442 words)

	VascularWeb: Restenosis Following Arterial Reconstruction
		Restenosis, simply defined, is a recurrent blockage at the site of earlier vascular reconstruction, typically for atherosclerotic occlusive disease.
		Decades of research have produced an in-depth understanding of the structural basis of restenosis and the cellular and molecular events regulating specific contributing events.
		Thus, the contribution of the plaque to the process of restenosis is not well defined.
	www.vascularweb.org /_CONTRIBUTION_PAGES/Research/Basic_Articles/Restenosis_Geary.html (1270 words)

	What is Restenosis?
		Restenosis is a potential complication of angioplasty, a procedure which removes an obstruction or alters a narrow artery.
		If the cardiologist determines the problem to be restenosis, the patient has three choices for treatment.
		Unfortunately, the risk of restenosis is higher with a second angioplasty than with the first.
	www.wisegeek.com /what-is-restenosis.htm (436 words)

	Intracoronary Brachytherapy as an Adjunct to Percutaneous Revascularization to Prevent and Manage Restenosis
		The objective of intracoronary brachytherapy is to prevent or further reduce the rate of restenosis and thus improve overall health outcomes.
		Evidence from this well-designed and well-conducted trial is sufficient to permit conclusions concerning the effect of intracoronary brachytherapy with gamma radiation for instent restenosis of SVG (indication 5).
		Cohort trials suggest restenosis rates (to >50%) after treating in-stent restenosis in native vessels of 21–28% for either of these procedures, which is similar to rates obtained with intracoronary brachytherapy.
	www.bcbs.com /tec/vol17/17_09.html (1654 words)

	Complement Angioplasy, Reduce Restenosis
		Restenosis rates have been reduced somewhat by the use of stents.
		Cryoplasty seems to be much gentler on the arteries and doesn't appear to cause the scarring and reclogging (restenosis) that standard angioplasty can.
		If, however, you've had a successful angioplasty, then nutritional arterial plaque reduction, accompanied by regular screens for homocysteine and ferritin (iron storage), could be the finest route to prevent restenosis - and the safest way to avoid going back into the hospital and coming out only partially fixed again...
	www.full-health.com /partoneAA.htm (923 words)

	Use of drug-coated stents cuts restenosis rates - Tips from Other Journals American Family Physician - Find Articles
		Patients with diabetes, longer coronary artery lesions, or smaller vessels are at especially increased risk of restenosis.
		No significant differences were found between the stent types in the rates of death (0.6 percent to 0.9 percent) or MI (2.8 percent to 3.2 percent), but the need for repeat revascularization decreased in patients with sirolimus-coated stents (4.1 percent) compared with standard uncoated stents (16.6 percent).
		In the subgroup of patients with diabetes, restenosis occurred more often, but the need for revascularization was reduced similarly by sirolimus, from 22.3 percent to 6.9 percent.
	www.findarticles.com /p/articles/mi_m3225/is_6_69/ai_114608434 (623 words)

	Reverse Atherosclerosis: Complement Angioplasty, Reduce Restenosis
		Angioplasty often is the first choice of treatment for people with clogged arteries of the heart or legs, because it is relatively less invasive.
		Six (6) to nine (9) months after treatment, restenosis rates approach 50 to 60 percent in the leg arteries and 20 to 30 percent in the heart arteries.
		While reasonable effort has been made to ensure the accuracy of the information on atherosclerosis, Full-Health.com assumes no responsibility for errors or omissions, or for damages resulting from use of the information herein.
	www.full-health.com /partoneAAprint.htm (978 words)

	Molecular Basis of Restenosis and Drug-Eluting Stents -- Costa and Simon 111 (17): 2257 -- Circulation (Site not responding. Last check: 2007-11-01)
		Restenosis in noncomplex cases are mainly associated with technique-related failures and appears mostly at the stent edges or gaps between stents.
		Bifurcation lesion represents an exception to this general rule because it is usually associated with technique-related failures (ie, inability to effectively treat the ostium of the side branch) but may affect the body of the main branch stent.
		Quantitative assessment with intracoronary ultrasound of the mechanisms of restenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy.
	circ.ahajournals.org /cgi/content/full/111/17/2257 (5844 words)

	Intracoronary Radiation Therapy for the Prevention and Management of Restenosis
		Angiographic studies suggest that the risk of restenosis in individuals who undergo percutaneous transluminal coronary angioplasty (PTCA) for coronary artery disease is estimated at 30-50%.
		Placement of stents as an adjunct to PTCA is one strategy to reduce restenosis; it is estimated that 75% of PTCAs performed in the United States include stent placement.
		IRT has been investigated both as an alternative to stent placement to reduce the risk of restenosis and as a technique to reduce the risk of in-stent restenosis.
	www.bcbst.com /MPManual/Intracoronary_Radiation_Therapy_for_the_Prevention_and_Management_of_Restenosis.htm (1193 words)

	ACC: Taxus Stent Beats Radiation for Treating In-Stent Restenosis - CME Teaching Brief® - MedPage Today
		Explain to interested patients that this study, and results of a previously reported similar trial, indicate that in patients with in-stent restenosis of a bare-metal stent, inserting either a paclitaxel- or sirolimus-eluting stent appears to be more effective than vascular brachytherapy at preventing re-stenosis and overall cardiac events.
		All patients had in-stent restenosis of a bare-metal stent that had been implanted in a native coronary artery.
		Rates of cardiac death and myocardial infarction were similar between the groups, occurring in 10 (5.2%) of the radiation-treated patients, and in 7 (3.7%) of the stent-treated group.
	www.medpagetoday.com /Cardiology/AcuteCoronarySyndrome/tb/2838 (1573 words)

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