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Topic: Reuptake

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Human serotonin transporter gene

Monoamine transporter

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Neurotransmitter

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Selective serotonin reuptake inhibitor

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	Reuptake - Wikipedia, the free encyclopedia
		Reuptake is the reabsorption of a neurotransmitter by the molecular transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse.
		Reuptake: The reabsorption of a secreted substance by the cell that originally produced and secreted it.
		The serotonin either travels across that space and attaches to receptors on the surface of nearby nerves or it attaches to receptors on the surface of the nerve that produced it, to be taken up by the nerve, recycled, and released again.
	en.wikipedia.org /wiki/Reuptake (212 words)

	Serotonin-norepinephrine reuptake inhibitor - Wikipedia, the free encyclopedia
		Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders.
		Activity on norephinephine reuptake is thought necessary for an antidepressant to be effective on neuropathic pain, a property shared with the older tricyclic antidepressants but not with the SSRIs.
		After firing, most of the neurotransmitter is reabsorbed by the presynaptic cell in a process called reuptake.
	en.wikipedia.org /wiki/Serotonin-norepinephrine_reuptake_inhibitor (555 words)

	Selective serotonin reuptake inhibitor - Wikipedia, the free encyclopedia
		The neurotransmitters are then recognized by receptors on the surface of the recipient cell, which upon this stimulation, in turn, relays the signal.
		As a result, the serotonin stays in the synaptic gap longer than it normally would, and has the chance to be recognized again (and again) by the receptors of the recipient cell, which can finally be stimulated that way.
		It is well known that the selective serotonin reuptake inhibitors (SSRIs) can cause various types of sexual dysfunction such as anorgasmia, erectile dysfunction, and diminished libido.
	en.wikipedia.org /wiki/Selective_serotonin_reuptake_inhibitor (1585 words)

	In Vivo Criteria To Differentiate Monoamine Reuptake Inhibitors from Releasing Agents: Sibutramine Is a Reuptake ...
		its characterization as a 5-HT reuptake inhibitor and not a 5-HT releaser.
		affinity for the reuptake transporter was correlated with the
		as a 5-HT reuptake inhibitor in vivo, and not as a 5-HT releasing
	jpet.aspetjournals.org /cgi/content/full/283/2/581 (6100 words)

	Selective Serotonin Reuptake Inhibitors \| AHealthyMe.com
		Selective serotonin reuptake inhibitors are used to treat serious, continuing depression that interferes with a person's ability to function.
		Selective serotonin reuptake inhibitors also are used to treat panic disorder, obsessive compulsive disorder (OCD), and have shown promise for treating a variety of other conditions, such as premenstrual syndrome, eating disorders, obesity, self-mutilation, and migraine headache.
		Selective serotonin reuptake inhibitors, also known as SSRIs or serotonin boosters, are thought to work by correcting chemical imbalances in the brain.
	www.ahealthyme.com /topic/topic100587451 (1993 words)

	Re: what is the precise effect of reuptake inhibitors on synaptic transmission?
		Reuptake inhibitors, such as fluoxetine (prozac) and other drugs of the SSRI (Selective Serotonin Reuptake Inhibitor) category, function by inhibiting synaptic reuptake transporters.
		The concentration of synaptic serotonin is controlled directly by its reuptake into the pre- synaptic terminal and, thus, drugs blocking serotonin transport have been successfully used for the treatment of depression.
		The mode of action of these antidepressant drugs on their direct target, the serotonin transport protein, and possible regulatory mechanisms with respect to long-term alleviation of depression, although having been investigated both neurobiologically and clinically over the last years, are not yet understood.
	www.madsci.org /posts/archives/dec2000/976184427.Ns.r.html (1152 words)

	Assessment of the Serotonin and Norepinephrine Reuptake Blocking Properties of Duloxetine in Healthy Subjects (Site not responding. Last check: 2007-10-08)
		To insure maximal biological response during the reuptake assessments, participants were instructed to take their last dose of medication 2 to 3 hours prior to the beginning of testing.
		Blockade of NE reuptake was expected to manifest itself by a decrease in the elevation of BP that was shown prior to drug administration (effect of tyramine measured on day 0).
		Since the reuptake of 5-HT was inhibited in our human volunteers at the lowest dosage (20 mg/day), it seems unlikely that the 60 mg/day regimen was insufficient to block the NE carrier.
	www.nature.com /npp/journal/v24/n5/full/1395628a.html (6309 words)

	Dapoxetine: A novel, fast-acting serotonin reuptake inhibitor - Formulary
		Dapoxetine is a fast-acting inhibitor of the serotonin reuptake transporter.
		Dapoxetine exhibits its efficacy by primarily inhibiting the reuptake of the serotonin transporter.
		It was also shown to bind and inhibit the reuptake transporters of dopamine and norepinephrine.
	www.formularyjournal.com /formulary/article/articleDetail.jsp?id=172259 (2105 words)

	New Research Explains Lithium’s Dual Anti-Manic/Anti-Depressive Effect (Site not responding. Last check: 2007-10-08)
		A structure on the end of the releasing nerve cell, called a reuptake transporter, then shuts off the signal by reabsorbing the glutamate, pumping it back into the cell for reuse.
		“We were especially interested to find that the reuptake mechanism in the 18 lithium-treated mice was stabilised in a very narrow range, compared to the 18 controls,” he said.
		What’s more, he added, lithium doesn’t change the moods of people who aren’t bipolar, suggesting that their glutamate levels may be positioned consistently within the set zone, and therefore would not be affected by the drug.
	www.pslgroup.com /dg/8CF9A.htm (641 words)

	Treatment discontinuation with selective serotonin reuptake inhibitors (SSRIs) versus tricyclic antidepressants (TCAs) ... (Site not responding. Last check: 2007-10-08)
		The selective serotonin reuptake inhibitors showed less participants dropping out compared to the tricyclic/heterocyclic group (odds ratio 1.21, 95% confidence interval 1.12 to 1.30).
		A statistically significant difference was found in total drop-outs between the selective serotonin reuptake inhibitors and the old tricyclics as well as the newer tricyclics.
		When the selective serotonin reuptake inhibitors were compared to the heterocyclic antidepressants, there was a non significant difference favouring the selective serotonin reuptake inhibitors.
	www.cochrane.org /cochrane/revabstr/ab002791.htm (486 words)

	The Body: Serotonin Reuptake Inhibitors
		Fluoxetine is an antidepressant that belongs to a class known as serotonin reuptake inhibitors.
		Paroxetine, an antidepressant belonging to a class known as serotonin reuptake inhibitors, is chemically unrelated to tricyclic, tetracyclic, or other known classes of antidepressants.
		Sertraline, an antidepressant, belongs to a class known as serotonin reuptake inhibitors.
	www.thebody.com /pinf/seroton.html (2403 words)

	Dopamine, but Not Norepinephrine or Serotonin, Reuptake Inhibition Reverses Motor Deficits in ...
		H]Monoamine uptake by BTS 74 398 and other reuptake inhibitors was determined from rat striatal (DA) or cortical (NE and 5-HT) synaptosomal preparations, as described in Cheetham et al.
		Agents that inhibit DA reuptake (BTS 74 398, GBR 12909, and nomifensine) reversed the locomotor deficits and motor disability
		However, three of the compounds examined are not selective DA reuptake inhibitors.
	jpet.aspetjournals.org /cgi/content/full/303/3/952 (4823 words)

	Role of the Neurotransmitter Reuptake-Blocking Activity of Antidepressants in Reversing Chloroquine Resistance In Vitro ... (Site not responding. Last check: 2007-10-08)
		reuptake of different neurotransmitters at the synaptic level.
		From Table 2, it can be seen that each of the neurotransmitter reuptake blockers is able to alter CQ resistance in P.
		Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
	aac.asm.org /cgi/content/full/44/10/2689 (2260 words)

	Not So Selective Serotonin Reuptake Inhibitors/Brainstorms July 1998 (Site not responding. Last check: 2007-10-08)
		The uniqueness of different SSRIs is most evident in the dramatic differences that individual patients can demonstrate in their clinical responses as well as side effects from one SSRI to another.
		There are at least 10 such secondary properties as potent or within 1 order of magnitude of serotonin reuptake potency (see figure), and the list grows as new receptors and enzymes are better clarified.
		Differences in binding to various neurotransmitter receptors are now generating hypotheses to explain differences in tolerability in anxious patients, in cognitive effects, in anticholinergic effects, and many others.
	www.psychiatrist.com /pcc/brainstorm/br5907.htm (569 words)

	Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based ...
		Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study -- de Abajo et al.
		Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study
		with non-selective serotonin reuptake inhibitors was 1.4 (1.1
	bmj.bmjjournals.com /cgi/content/full/319/7217/1106 (2786 words)

	Selective Serotonin Reuptake Inhibitors - Drug Comparisons - Compare Drugs - DrugDigest
		The selective serotonin reuptake inhibitors (SSRIs) block the ability of the nerve endings to bind and break down serotonin so that more serotonin is available to help the brain process nerves messages more efficiently and correctly.
		The studies that have been performed thus far show that all of the SSRIs are similar in effectiveness for the treatment of depression.
		Is baseline agitation a relative contraindication for a selective serotonin reuptake inhibitor: a comparative trial of fluoxetine versus imipramine.
	www.drugdigest.org /DD/Comparison/NewComparison/0,10621,67-11,00.html (1508 words)

	Reuptake
		Serotonis is cleared from the synapse by a reuptake pump that is powered by Na Cl and K
		Selective serotonin reuptake inhibitors (SSRIs like Prozac) act primarily at the 5HT transporter protein and have limited, if any, reaction with other neurotransmitter systems.
		Consequently, more serotonin remains in the cleft where it is free to travel further to more distant receptors as well as continue to react with nearby receptors.
	www.wellesley.edu /Chemistry/Chem101/brain/films/films4.html (143 words)

	Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: ...
		Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort -- van Walraven et al.
		Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study
		of serotonin reuptake by antidepressants and upper gastrointestinal
	bmj.com /cgi/content/abstract/323/7314/655 (708 words)

	Selective serotonin reuptake inhibitors (SSRIs) versus other antidepressants for depression (Cochrane Review) (Site not responding. Last check: 2007-10-08)
		Selection criteria: Randomised controlled trials comparing selective serotonin reuptake inhibitors with other kinds of antidepressants in the treatment of patients with depressive disorders.
		The standardised effect size for SSRIs and related drugs together versus alternative antidepressants using a fixed effects model was 0.035 (95% CI -0.006 to 0.076; Q = 149.25, df = 97, p < 0.001).
		Authors' conclusions: There are no clinically significant differences in effectiveness between selective serotonin reuptake inhibitors and tricyclic antidepressants.
	www.update-software.com /abstracts/ab001851.htm (446 words)

	MSN Encarta - Search Results - selective serotonin reuptake inhibitor (Site not responding. Last check: 2007-10-08)
		MSN Encarta - Search Results - selective serotonin reuptake inhibitor
		Another group of antidepressants, known as selective serotonin reuptake inhibitors (SSRI), became available in 1987.
		Exclusively for MSN Encarta Premium Subscribers--quickly search thousands of articles from magazines such as Time, Newsweek, The Atlantic Monthly, and Smithsonian.
	ca.encarta.msn.com /selective_serotonin_reuptake_inhibitor.html (94 words)

	Use of Factor-Analyzed Symptom Dimensions to Predict Outcome With Serotonin Reuptake Inhibitors and Placebo in the ... (Site not responding. Last check: 2007-10-08)
		Use of Factor-Analyzed Symptom Dimensions to Predict Outcome With Serotonin Reuptake Inhibitors and Placebo in the Treatment of Obsessive-Compulsive Disorder -- Mataix-Cols et al.
		Use of Factor-Analyzed Symptom Dimensions to Predict Outcome With Serotonin Reuptake Inhibitors and Placebo in the Treatment of Obsessive-Compulsive Disorder
		reuptake inhibitors were significantly superior to placebo on
	ajp.psychiatryonline.org /cgi/content/abstract/156/9/1409 (511 words)

	Selective serotonin reuptake inhibitors (SSRIs) for depression
		Selective serotonin reuptake inhibitors (SSRIs) relieve symptoms of depression by increasing the amount of serotonin available.
		Selective serotonin reuptake inhibitors are as effective in treating depression as other types of antidepressants, such as tricyclic antidepressants and MAOIs, but they have different and often less severe side effects.
		Selective serotonin reuptake inhibitors (SSRIs) can take 4 to 12 weeks to start working, although they may be effective much sooner.
	webmd.com /hw/depression/hw29716.asp?lastselectedguid={5FE84E90-BC77... (490 words)

	ESPE: Caution Urged For Diabetics Using Selective Serotonin Reuptake Inhibitors (Site not responding. Last check: 2007-10-08)
		MONTREAL, QC -- July 9, 2001 -- Diabetics patients with depression who are being treated with selective serotonin reuptake inhibitor agents need more rigorous blood glucose monitoring, May Clinic researchers recommend.
		Patients with diabetes who are being treated with selective serotonin reuptake inhibitors (SSRIs) should make sure their primary care doctor as well as their specialists know what drugs they are using to treat their depression.
		According to a small case study from the Mayo Clinic in Rochester, Minnesota, United States, SSRIs might have an impact on diabetics that leaves these patients susceptible to hypoglycemic reactions with devastating results.
	www.pslgroup.com /dg/2003B6.htm (532 words)

	Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a ...
		Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a meta-analysis
		In a meta-analysis of randomised, short term clinical trials selective serotonin reuptake inhibitors were associated with 10% fewer overall drop outs than tricyclic antidepressants (nine drop outs for every 10 with tricyclic agents)
		Further studies of the tolerability of selective serotonin reuptake inhibitors compared with that of tricyclic antidepressants are required over a longer period in the setting of clinical practice rather than clinical trials
	www.bmj.com /cgi/content/abstract/310/6992/1433 (1162 words)

	Selective serotonin reuptake inhibitors for premenstrual syndrome (Cochrane Review)
		Selective serotonin reuptake inhibitors (SSRIs) are increasingly being used as a front-line therapy for premenstrual syndrome (PMS).
		Withdrawals due to side effects were 2.5 times more likely to occur in the treatment group, particularly at higher doses.
		Authors' conclusions: There is now very good evidence to support the use of selective serotonin reuptake inhibitors in the management of severe premenstrual syndrome.
	www.update-software.com /abstracts/ab001396.htm (461 words)

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