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Topic: Rhabdomyolysis

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Muscle

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Creatine Phosphokinase

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	eMedicine - Rhabdomyolysis : Article by Sandy Craig, MD
		Hypocalcemia is noted early in the course of rhabdomyolysis and generally is not of clinical significance.
		Brumback RA, Feeback DL, Leech RW: Rhabdomyolysis in childhood.
		Wrenn KD, Oschner I: Rhabdomyolysis induced by a caffeine overdose.
	www.emedicine.com /emerg/topic508.htm (2995 words)

	Baycol and Rhabdomyolysis Symptoms
		Rhabdomyolysis is extremely rare as a drug side effect, but has been found to be associated with the use of one statin drug, cerivastatin or Baycol.
		The pain caused by Rhabdomyolysis may involve specific groups of muscles or may be generalized throughout the body.
		In some cases, the symptoms of rhabdomyolysis were mistaken for the flu, and the cause of the patient's illness not recognized as associated with Baycol.
	www.healthdangers.com /drugs/baycol/baycol-rhabdomyolysis.htm (217 words)

	s030205b - Rhabdomyolysis - Exercise Induced
		Cases of exercise-induced rhabdomyolysis have been reported in unfit individuals or those attempting exhaustive exercise such as marathon running or weight lifting but are unusual in fit individuals making modest changes to their normal fitness routine.
		Abstract: Rhabdomyolysis is a common disorder that occurs as a primary disease or as a complication of a broad spectrum of other diseases.
		Abstract: Rhabdomyolysis should be considered in the differential diagnosis of acute muscle weakness or pain in patients who have recently increased their level of exercise, no matter what their previous level of physical fitness.
	www.emory.edu /WHSCL/grady/amreport/litsrch02/s030205b.html (5320 words)

	eMedicine - Rhabdomyolysis : Article by Eyal Muscal
		Rhabdomyolysis is a syndrome caused by injury to skeletal muscle and involves leakage of large quantities of intracellular contents into plasma.
		Rhabdomyolysis is characterized by the triad of muscle weakness, myalgias, and dark urine; however, all 3 symptoms are rarely seen together.
		Rhabdomyolysis is believed to be responsible for 5-25% of all adult cases of acute renal failure.
	www.emedicine.com /ped/topic2003.htm (5165 words)

	Rhabdomyolysis And Myoglobinuria - MEDSTUDENTS - INTENSIVE CARE (Site not responding. Last check: )
		Rhabdomyolysis is a condition caused by skeletal muscle injury and release of muscle cell contents into the circulation.
		The presence of myoglobin in the urine establishes the diagnosis of rhabdomyolysis and myoglobinuria.
		It is also interesting to note that, although hypocalcemia predominates acutely in rhabdomyolysis and during oliguric myoglobinuric renal failure, hypercalcemia may complicate the diuretic phase of resolution of renal failure, as calcium is mobilized from those deposited in injured muscles and increased quntities of 1-25 dihydroxycholecalciferol produced by the recovering kidneys.
	www.medstudents.com.br /terin/terin3.htm (1812 words)

	Rhabdomyolysis
		Rhabdomyolysis is a common disorder which may result from a large variety of diseases, trauma, or toxic insults to skeletal muscle.
		Rhabdomyolysis is a common condition which complicates a a variety of genetic and acquired diseases.
		Brumback, R.A., Feeback, D.L., and Leech, R.W. (1992) Rhabdomyolysis in childhood.
	members.tripod.com /~baggas/rhabdo.html (2214 words)

	Rhabdomyolysis with statins [Jan 2005; 131-2]
		Potential cases of hospital admission for rhabdomyolysis were identified from records of members of the cohort using coded discharge diagnoses.
		Rhabdomyolysis was defined as severe muscle injury present at admission, plus a diagnosis of rhabdomyolysis or creatinine kinase more than 10 times the upper limit of normal.
		Rhabdomyolysis did not occur in the cohort when they were not taking statins or fibrates, as best we can judge.
	www.jr2.ox.ac.uk /bandolier/band131/b131-2.html (1114 words)

	Baycol : Rhabdomyolysis and Rhabdomyolysis Symptoms
		Rhabdomyolysis is extremely rare as a drug side effect, but has been found to be associated with the use of one statin drug, Baycol ®.
		During rhabdomyolysis, muscle protein becomes entrapped in the kidneys, clogging up the filtering process of the kidneys, leading to kidney or renal failure and other organ system disorders.
		In some cases, rhabdomyolysis symptoms were mistaken for the flu, and the cause of the patient's illness not recognized as associated with Baycol ®.
	www.jimsokolove.com /case_types/dangerous_drugs/baycol/baycol-rhabdomyolysis.php (299 words)

	Rhabdomyolysis American Family Physician - Find Articles
		Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation.
		Rhabdomyolysis, which literally means striated muscle dissolution or disintegration,(1) is a potentially lethal clinical and biochemical syndrome.(2) Approximately 26,000 cases of rhabdomyolysis are reported annually in the United States.(3) Prompt recognition and early intervention are vital.
		In crush injury, rhabdomyolysis occurs because of the release of necrotic muscle material into the circulation after compression is relieved in, for example, persons trapped in crashed cars or collapsed buildings.
	findarticles.com /p/articles/mi_m3225/is_5_65/ai_83711795 (615 words)

	DRUG-INDUCED RHABDOMYOLYSIS
		The syndrome of rhabdomyolysis is the result of skeletal muscle injury that alters the integrity of the sarcolemma and leads to the eventual release of intracellular contents into the plasma.
		Estimation of myoglobin in the serum and urine is useful for the diagnosis of rhabdomyolysis, particularly in the early phases of the disease.
		Rhabdomyolysis should be suspected in patients presenting with drug poisoning, altered levels of consciousness, severe fluid and electrolyte abnormality, hyperthermia, hypotension, hypoxia, and states of increased muscular activity, such as seizures, agitation, strenuous muscle exercise or dystonia, particularly in patients with alcohol or substance abuse.
	www.kfshrc.edu.sa /annals/186/98-069.html (3345 words)

	CiteULike: Rhabdomyolysis: an evaluation of 475 hospitalized patients. (Site not responding. Last check: )
		Rhabdomyolysis is a common and potentially lethal clinical syndrome that results from acute muscle fiber necrosis with leakage of muscle constituents into blood.
		Rhabdomyolysis occurs from inherited diseases, toxins, muscle compression or overexertion, or inflammatory processes, among other disorders.
		Exogenous toxins were the most common cause of rhabdomyolysis, with illicit drugs, alcohol, and prescribed drugs responsible for 46%.
	www.citeulike.org /user/brian/article/1029140 (780 words)

	The Physician and Sportsmedicine: Exertional Rhabdomyolysis
		The treatment of rhabdomyolysis consists of early detection, therapy for the underlying cause, measures to prevent renal failure, and correction of metabolic complications.
		Exertional rhabdomyolysis should be considered in the differential diagnosis of any patient who reports recent exercise with myalgias, dark urine, and tenderness or swelling of muscles, but only 50% of patients who have rhabdomyolysis will present with these classic symptoms.
		Alkalization of the urine is often used in the treatment of rhabdomyolysis, because myoglobin and urate are toxic to the tubules in an acidic environment.
	www.physsportsmed.com /issues/2004/0404/brown.htm (2906 words)

	Acute exertional rhabdomyolysis American Family Physician - Find Articles
		Acute exertional rhabdomyolysis is a potentially serious clinical illness caused by an injury to skeletal muscle that results in the release of myoglobin and other cellular contents, including creatine kinase (CK-MM fraction) and aldolase, into the circulatory system.
		Beause acute exertional rhabdomyolysis is a common and underdiagnosed condition, a knowledge of early clinical manifestations and the potential for serious complications is essential so that appropriate therapy may be instituted early in the course of the illness.
		Acute exertional rhabdomyolysis is a problem in athletes as well as workers whose jobs require extreme physical labor.
	www.findarticles.com /p/articles/mi_m3225/is_n2_v52/ai_17281983 (566 words)

	Pharmacy Times: Many Potential Sources for Drug-induced Rhabdomyolysis
		Rhabdomyolysis is a potentially life-threatening condition resulting from skeletal muscle injury and a rapidly rising intracytoplasmic calcium concentration.
		The true incidence of statin-associated rhabdomyolysis is not exactly clear because of the rarity of this condition and underreporting during the drug's postmarketing period.
		Rhabdomyolysis may occur secondary to generalized tonic-clonic seizures; prolonged physical compression of a major muscle group and coma; or prolonged vasoconstriction of intramuscular arteries.
	www.pharmacytimes.com /Article.cfm?Menu=1&ID=3981 (797 words)

	Rhabdomyolysis
		Rhabdomyolysis results from skeletal muscle injury with release of muscle cell contents into the plasma.
		Rhabdomyolysis was first reported in 1881, in the German literature but the major clinical sequelae were described in 1941 by Bywaters (3), during the blitz of London, in patients with crush injuries.
		Rhabdomyolysis may occur after trauma, ischemia (including acute myocardial ischemia), excessive exertion (marathon runners), bacterial and viral sepsis, electrical burns, other injuries related to heat or cold, prolonged muscle compression as often seen in the unconscious state after alcohol or drug intoxication, seizures, hypokalemia and shock.
	www.med.harvard.edu /JPNM/BoneTF/Case18/WriteUp18.html (774 words)

	Rhabdomyolysis (Treatment Guide)
		RHABDOMYOLYSIS DEFINITION Rhabdomyolysis is a syndrome caused by injury to skeletal muscles and the resultant leakage of muscle cell contents (myoglobin, potassium, phosphate, etc.) into the plasma.
		TOXIC CAUSES Rhabdomyolysis has been associated with a variety of toxins and drugs.
		In rhabdomyolysis due to severe poisoning, muscle signs can be overlooked if signs indicative of the underlying disorder (e.g., extreme agitation, seizures, hyperthermia) dominate the clinical picture.
	www.intox.org /databank/documents/treat/treate/trt43_e.htm (618 words)

	Search: Rhabdomyolysis
		Rhabdomyolysis is the rapid breakdown of skeletal tissue due to traumatic injury, either mechanical, physical or chemical.
		Rhabdomyolysis - Rhabdomyolysis is a syndrome caused by injury to skeletal muscle and involves leakage of the intracellular contents into plasma.
		Rhabdomyolysis - Rhabdomyolysis was first described in the victims of crush injury during the 1940-1941 London, England, bombing raids of World War II.
	www.haggle.com /webmkt.haggle/search/web/Rhabdomyolysis/-/-/1/-/-/-/1/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/302349/right (197 words)

	Exercise-Induced Rhabdomyolysis
		Rhabdomyolysis appears to be a relatively common sequela of strenuous exercise.
		The clinical significance of rhabdomyolysis lies in its association with myoglobinuric acute renal failure and its subsequent mineral and electrolyte derangements.
		Olerud JE, Homer LD, Carroll HW: Incidence of acute exertional rhabdomyolysis.
	www.charlydmiller.com /LIB04/1994exerciserhabdo.html (2741 words)

	Rhabdomyolysis - March 1, 2002 - American Family Physician
		Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation.
		In crush injury, rhabdomyolysis occurs because of the release of necrotic muscle material into the circulation after compression is relieved in, for example, persons trapped in crashed cars or collapsed buildings.
		Traumatic, Heat-Related, Ischemic and Exertional Causes of Rhabdomyolysis
	www.aafp.org /afp/20020301/907.html (2564 words)

	Louisiana Injury Attorneys, Ask Our Doctors, Rhabdomyolysis
		RHABDOMYOLYSIS may involve many organ systems, but the life threatening consequences are related to electrolyte abnormalities, i.e., acute hyperkalemia, hypocalcemia, and acute renal failure.
		The symptoms of Rhabdomyolysis are nonspecific and consist of an increase in ventilation, in an effort to blow off acidic CO2, and central nervous system function depression, manifesting itself as headache, lethargy, stupor and even coma, as well as severe
		Low potassium conditions which may potentiate the possibility of Rhabdomyolysis are seen with chronic administration of long-acting thiazide diuretics, certain antibiotics, and even ingestion of mineral corticoid-like substances, such as licorice.
	www.louisianaattorneystoday.com /askourdoctors-rhabdomyolitis.html (2013 words)

	Rhabdomyolysis: symptoms, cause, treatment, prevention, risk, long-term outlook, complications
		Rhabdomyolysis is a disorder involving injury to the kidney.
		Rhabdomyolysis is caused by toxic effects of the contents of muscle cells.
		Rhabdomyolysis is often caused by excessive muscle exercise, electric shock, lightning stroke, hypothyroidism, and heat stroke.
	www.mamashealth.com /rhab.asp (280 words)

	Crestor: Adverse Drug Reactions: Drug Side Effects: Rhabdomyolysis, Myoglobinuria, Kidney Damage
		Rhabdomyolysis is the breakdown of muscle fibers resulting in the release of muscle fiber contents into the blood circulation.
		Rhabdomyolysis and kidney problems are associated with the use of drugs in the statin class, including AstraZeneca's cholesterol-lowering drug Crestor.
		Cases of rhabdomyolysis were seen with this new statin during drug trials, particularly with the 80 mg dose.
	www.lamblawoffice.com /Crestor-rhabdomyolysis.html (479 words)

	Isotretinoin and Rhabdomyolysis
		Elevated serum CK is the cornerstone for the diagnosis of rhabdomyolysis, a potentially lethal syndrome with variable clinical presentations.
		Nontraumatic etiologic factors associated with rhabdomyolysis include muscle exertion, infectious diseases, metabolic conditions, toxins, and drugs.[4] Moreover, nontraumatic rhabdomyolysis may be responsible for 5-70f all cases of acute renal failure.[5,6] We report a patient with a significant elevation in CK after beginning therapy with isotretinoin for DCS.
		Moreover, elevated CK levels in the range for rhabdomyolysis are associated with an increased risk of acute renal failure and death.[8] The expanding body of literature regarding the association of elevated CK levels with isotretinoin should alert physicians to consider routine evaluation of CK levels in all patients being treated with isotretinoin.
	dermatology.cdlib.org /DOJvol5num2/case_reports/trauner.html (913 words)

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