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Topic: Rhabdomyosarcoma

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  Rhabdomyosarcoma - Wikipedia, the free encyclopedia
In a rhabdomyosarcoma, the accumulation in a variable proportion of the malignant cells of large amounts of the particular isomers of the proteins that are responsible for the contractile properties of skeletal muscle typically result in large cells with cytoplasm that stains deeply red with eosin.
This may be exploited as a means to identify malignant neoplasms that contain cells that show determination towards rhabdomyosarcoma, even when there is insufficient differentiation to allow phenotypic assessment to be used for the diagnosis.
As this protein may also be present in the cytoplasm of cells of other neoplasms whose other characteristics show that they are not rhabdomyosarcomas, demonstration of the presence of myo D1 should be considered supportive for rhabdomyosarcoma only if the protein is present in the cell nuclei.
en.wikipedia.org /wiki/Rhabdomyosarcoma   (893 words)

 Rhabdomyosarcoma   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma is a cancerous tumor that originates in the soft tissues of the body, including the muscles, tendons and connective tissues.
Rhabdomyosarcoma can also be found in places where skeletal muscles are absent or very small, such as in the prostate, middle ear and bile duct system.
Rhabdomyosarcomas usually have some type of chromosome abnormality in the cells of the tumor, which are responsible for the tumor formation.
www.chw.org /display/PPF/DocID/2005/router.asp   (1252 words)

 Sydney Children's Hospital - Centre for Cancer & Blood Disorders - Rhabdomyosarcoma
Rhabdomyosarcoma is a cancer of striated muscle tissue.
Rhabdomyosarcoma tends to metastasize to the lung, bone, brain and bone marrow.
It has been shown that if a child with rhabdomyosarcoma is alive three and a half years from diagnosis with no evidence of tumour, the chance of the cancer ever returning is very small.
www.kids-cancer.org /rhabdomyosarcoma%20.htm   (1097 words)

 [No title]
Rhabdomyosarcoma is a cancer made up of cells that, under a microscope, resemble rhabdomyoblasts of a fetus (baby still in the womb).
Rhabdomyosarcoma is a cancer made up of cells that normally develop into skeletal muscles of the body.
Rhabdomyosarcoma does occur in adults, but it is uncommon.
www.cancer.org /docroot/CRI/content/CRI_2_4_1X_What_is_rhabdomyosarcoma_53.asp?sitearea=   (442 words)

 www.patientcenters.com -- Childhood Cancer Center -- Soft Tissue Sarcomas
Childhood rhabdomyosarcoma is a soft tissue cancer that arises in the muscles.
Rhabdomyosarcoma can start anywhere in the body; however, the point of tumor origin is often associated with age at diagnosis.
Rhabdomyosarcoma can appear very similar to other childhood cancers at the microscopic level, and extra tests may be needed to help differentiate between malignancies and establish the proper diagnosis.
www.patientcenters.com /childcancer/news/soft_sarcomas.html   (4779 words)

 What is Rhabdomyosarcoma?   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma is a cancer, which is a vicious killer of children.
Rhabdomyosarcoma is a type of cancer which can affect people of any age but predominantly occurs in children.
Rhabdomyosarcoma is a complicated sounding word which oncologists use to describe a tumour that has arisen in "striped muscle" tissue in the body (in Greek, "rhabdo-" means "striped", "my-" means muscle and "sarcoma" means "malignant tumour of connective tissue").
www.jg-rabdo.com /rhabdocancer.htm   (177 words)

 Rhabdomyosarcoma in children : CancerBACUP   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma is the most common of the soft tissue sarcomas.
Treatment of rhabdomyosarcoma usually includes surgery, radiotherapy or chemotherapy, or a combination of these.
Longer-term side effects depend on the type of treatment used, and may include possible reduced growth, infertility, a change in the way the heart and the kidneys work, hearing problems and a small increase in the risk of developing another cancer in later life.
www.cancerbacup.org.uk /Cancertype/Childrenscancers/Typesofchildrenscancers/Rhabdomyosarcoma   (1455 words)

 Rhabdomyosarcoma   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma is a cancer made up of cells that, under a microscope,...
Rhabdomyosarcoma of the bladder and prostate in children.
Rhabdomyosarcoma is an uncommon cancer that is seen in children more than adults.
www.rhabdomyosarcoma.info   (302 words)

 Rhabdomyosarcoma - Cancer Overviews
Rhabdomyosarcoma is a disease in which cancerous cells grow in muscle tissue.
Rhabdomyosarcoma begins in the soft tissues in a type of muscle called striated muscle.
Rhabdomyosarcoma is the most common type of soft tissue sarcoma found in children.
www.umm.edu /cancer/overview/rhab.html   (160 words)

 Rhabdomyosarcoma - Yale-New Haven Children's Hospital
Rhabdomyosarcoma is a type of soft tissue cancer that occurs in striated muscle tissue.
Some cases of rhabdomyosarcoma are detected early when children or parents notice tumors on the arms or legs or upper neck.
Rhabdomyosarcoma is classified into four groups: group 1 or localized cancer; group 2 with evidence of lymph node involvement; group 3 with some tumor remaining after surgery; and group 4 with spread to distant areas at time of diagnosis.
www.ynhh.org /pediatrics/cancer/conditions/rhabdo.html   (488 words)

 Gale Encyclopedia of Cancer: Rhabdomyosarcoma
Rhabdomyosarcomas can start in any organ that contains skeletal muscle cells, but most commonly tumors are found in the head and neck and in the prostate, bladder, and vagina.
Immediate family members of children with rhabdomyosarcoma are at increased risk of developing certain cancers that are not rhabdomyosarcomas, such as breast and brain tumors.
Treatment for rhabdomyosarcoma varies depending on the location of the tumor, its size and grade, and the extent of its spread.
www.findarticles.com /p/articles/mi_gGEC/is_0013/ai_2699001385   (1385 words)

Rhabdomyosarcoma in the area of the head and neck causes drainage from the nasal passages, sinuses, or ears, as well as palsy (tremor) of the head.
Rhabdomyosarcoma is diagnosed through computed tomography (CT) or magnetic resonance imaging (MRI) scans of the area where the tumor is suspected.
Rhabdomyosarcoma in the arms or legs may require amputation, which is the surgical removal of the affected portion of the limb.
www.hmc.psu.edu /childrens/healthinfo/r/rhabdomyosarcoma.htm   (756 words)

 eMedicine - Pathology: Rhabdomyosarcoma : Article by Michael O Ferguson, MD   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma of the head and neck is primarily a disease of the first decade of life, and it is the most common soft tissue sarcoma in childhood.
The orbit is involved in nearly one third of head and neck rhabdomyosarcomas, followed by those in the oral cavity and oropharynx (29%), face and neck (24%), and middle ear and/or mastoid and sinonasal cavity (9%).
Embryonal rhabdomyosarcoma is evidenced by a variable cell population consisting of small, round tumor cells with hyperchromatic nuclei and of large, polygonal-shaped tumor cells with abundant eosinophilic cytoplasm, which often contains diagnostic cross striations (arrow).
www.emedicine.com /ent/topic641.htm   (4026 words)

 Retinoblastoma   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma often causes a noticeable lump on a child's body.
Rhabdomyosarcoma tumors arise from a cell called a "rhabdomyoblast", which is a primitive muscle cell.
Rhabdomyosarcoma is treated by a combination of surgery, chemotherapy, and radiation.
www.acor.org /diseases/ped-onc/diseases/rhabdo.html   (593 words)

 Childhood Rhabdomyosarcoma
Childhood rhabdomyosarcoma, a soft tissue malignant tumor of skeletal muscle origin, accounts for approximately 3.5% of the cases of cancer among children 0 to 14 years and 2% of the cases among adolescents and young adults 15 to 19 years of age.
The prognosis for a child or adolescent with rhabdomyosarcoma is related to the age of the child or adolescent, site of origin, resectability, presence of metastases, number of metastatic sites, histopathology, [4] [5] [16] [17] [18] [19] [20] and unique biological characteristics of rhabdomyosarcoma tumor cells.
The basic principle for the initial surgical treatment of children with rhabdomyosarcoma is complete resection of the primary tumor with a surrounding margin of normal tissue and lymph node sampling of the draining nodal basin.
imsdd.meb.uni-bonn.de /cancer.gov/CDR0000062792.html   (10915 words)

 Rhabdomyosarcoma : St. Louis Children's Hospital   (Site not responding. Last check: 2007-09-19)
Rhabdomyosarcoma accounts for about 3 percent of childhood cancers.
Rhabdomyosarcomas are also more common in children with neurofibromatosis or Li-Fraumeni syndrome, which are genetic disorders.
Li-Fraumeni syndrome is a clustering of soft tissue cancers in a family, caused by mutations in a tumor suppressor gene called p53, which results in uncontrolled cell growth.
www.stlouischildrens.org /articles/content.asp?pageid=P02743   (1253 words)

 National Cancer Institute - Childhood Rhabdomyosarcoma Treatment
Rhabdomyosarcoma is a disease in which cancer (malignant) cells begin growing in muscle tissue.
Rhabdomyosarcoma is a type of a sarcoma, which means a cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage).
The cancer cells must be looked at under a microscope to tell which type of sarcoma it is. Rhabdomyosarcoma is the most common type of sarcoma found in the soft tissues of children.
www.cancer.gov /cancerinfo/pdq/treatment/childrhabdomyosarcoma/patient   (222 words)

 From the Grand Rounds Archive at Baylor
During the 1950's, rhabdomyosarcomas were recognized when a malignant tumor had the appearance of embryonal (i.e.
The pathologic diagnosis on the tissue specimen was interpreted as embryonal rhabdomyosarcoma.
She was enrolled in the Intergroup Rhabdomyosarcoma Study (IRS) protocol and subsequently treated with external beam radiotherapy to the tumor and cranial cavity as well as pulse chemotherapy.
www.bcm.tmc.edu /oto/grand/82491.html   (1789 words)

 Childhood Soft Tissue Sarcoma / Rhabdomyosarcoma
About half of all childhood soft tissue sarcomas are rhabdomyosarcoma, which arises from skeletal muscle, these are most common between the ages of 2 and 6.
Rhabdomyosarcoma (UK) a factsheet produced by the United Kingdom Children's Cancer Study Group and CancerBacup linked to the UKCCSG booklet "A Parent's Guide to Children's Cancers".
Physician's PDQ statement for Childhood Rhabdomyosarcoma (CancerNet) A referenced overview of the disease, cellular classification, staging, and current treatment overviews.
www.cancerindex.org /ccw/guide2t.htm   (531 words)

 AllRefer Health - Rhabdomyosarcoma (Alveolar Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma, Sarcoma Botryoides, Soft ...
Rhabdomyosarcoma is a malignant (cancerous), soft tissue tumor found in children.
Some children with certain birth defects are at increased risk, and some families have a gene mutation that elevates risk.
However, the vast majority of children with rhabdomyosarcoma do not have any known risk factors.
health.allrefer.com /health/rhabdomyosarcoma-info.html   (337 words)

 Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas -- Sebire and Malone 56 (6): 412 -- Journal of Clinical ...
in alveolar rhabdomyosarcomas: the fusion of PAX3 to FKHR and
In vivo amplification of the PAX3–FKHR and PAX7–FKHR fusion genes in alveolar rhabdomyosarcoma.
Strong immunostaining for myogenin in rhabdomyosarcoma is significantly associated with tumors of the alveolar subclass.
jcp.bmjjournals.com /cgi/content/full/56/6/412   (3440 words)

 Sloan-Kettering - Soft-Tissue Sarcomas
The most common is rhabdomyosarcoma, which is found in the skeletal muscles involved in voluntary movement.
The most common symptoms of rhabdomyosarcoma are pain or a detectable mass.
Systemic chemotherapy is the main treatment for rhabdomyosarcoma, and surgery, radiation therapy, or a combination of the two may be used to treat the primary tumor and any sites where the disease has spread.
www.mskcc.org /mskcc/html/9905.cfm   (159 words)

 MedlinePlus Medical Encyclopedia: Rhabdomyosarcoma
Diagnosis of rhabdomyosarcoma is often delayed because of lack of symptoms and because its appearance may coincide with a recent injury.
Early diagnosis is important because rhabdomyosarcoma is an aggressive tumor that metastasizes (spreads) quickly.
In general, surgery and radiation therapy are used to treat the primary site of the tumor, while chemotherapy is used to treat disease at all sites in the body.
www.nlm.nih.gov /medlineplus/ency/article/001429.htm   (578 words)

 Childhood Rhabdomyosarcoma
Once childhood rhabdomyosarcoma is found, more tests will be done to find out if the cancer cells have spread to other parts of the body.
Treatment for childhood rhabdomyosarcoma depends on where the cancer is, how far it has spread, and what the cancer cells look like under a microscope.
Your child may receive treatment that is considered standard based on its effectiveness in a number of patients in past studies, or you may choose to have your child go into a clinical trial.
imsdd.meb.uni-bonn.de /cancernet/200759.html   (1840 words)

 Childhood rhabdomyosarcoma
Rhabdomyosarcoma can be divided into several histologic subtypes: embryonal, embryonal-botryoid, alveolar, pleomorphic, and mixed histology.[1] The embryonal (including botryoid) subtype is the most frequently observed histologic subtype in children, accounting for approximately 80% of rhabdomyosarcomas of childhood.
Approximately 20% of children with rhabdomyosarcoma have the alveolar subtype, with an increased frequency of this subtype noted in adolescents and in patients with primary sites involving the extremities, trunk, and perineum/perirectal region.[1] Pleomorphic rhabdomyosarcoma occurs predominantly in patients aged 30-50 years and is rarely seen in children.
The combination of ifosfamide and etoposide has considerable activity in the treatment of recurrent rhabdomyosarcoma for children not previously treated with these agents.[3] Very intensive chemotherapy followed by autologous bone marrow re-infusion is also under investigation for patients with recurrent rhabdomyosarcoma.
www.uoc.muni.cz /guidelines/17sarkom/CHRHABSA.htm   (4051 words)

 Rhabdomyosarcoma treatment at Mayo Clinic
Rhabdomyosarcoma is a cancer that grows in soft tissues of the body, usually muscle.
In young children, rhabdomyosarcoma tends to occur in the head and neck, bladder, vagina, prostate or testes.
In adults, rhabdomyosarcoma usually occurs in the large muscles of the arms and legs.
www.mayoclinic.org /rhabdomyosarcoma   (323 words)

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