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Topic: Rheb

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	Rheb - Wikipedia, the free encyclopedia
		Rheb, in molecular biology, is a protein, a recently discovered member of the Ras superfamily that may be involved in neural plasticity.
		This function is novel and not typically associated with the Ras proteins.
		The name Rheb is short for Ras homolog enriched in brain.
	en.wikipedia.org /wiki/Rheb (77 words)

	Rheb
		Overexpression of Rheb in the developing fly causes dramatic overgrowth of multiple tissues: in the wing, this is due to an increase in cell size; in cultured cells, Rheb overexpression results in accumulation of cells in S phase and an increase in cell size.
		Rheb is required in the whole organism for viability (growth) and for the growth of individual cells.
		Consistent with this interpretation, flies with reduced Rheb activity are hypersensitive to rapamycin, an inhibitor of the growth regulator target of rapamycin (TOR), a kinase required for growth factor-dependent phosphorylation of ribosomal S6 kinase (S6K).
	www.sdbonline.org /fly/sturtevant/rheb1.htm (2303 words)

	Rheb -
		Rheb is a homologue of RHEB (Ras homolog enriched in brain) from Homo sapiens.
		Rheb is a homologue of Rheb (RAS-homolog enriched in brain) from Mus musculus.
		Rheb is a homologue of F54C8.5 () from Caenorhabditis elegans.
	www.ihop-net.org /UniPub/iHOP/gg/69636.html (489 words)

	Rheb
		Rheb is unique, compared with many small GTPases, in that it exists in a highly activated state in mammalian cells.
		Studies of mammalian Rheb further implicated the existence of a Rheb-GAP that is normally present at relatively limiting concentrations, since overexpression of Rheb results in a progressive increase in the proportion of Rheb in the active GTP-bound state.
		Tsc and Rheb could either function as obligatory components between amino acids and TOR in a linear amino-acid sensing pathway, or in a parallel pathway that converges on TOR.
	www.sdbonline.org /fly/sturtevant/rheb3.htm (1641 words)

	UCLA ACCESS Faculty (Site not responding. Last check: 2007-10-31)
		Rheb is a novel and unique member of the Ras superfamily G-proteins.
		Rheb is a component of the TSC/TOR/S6K signaling pathway and is a direct activator of TOR.
		Rheb is downregulated by Tsc1/Tsc2 complex that acts as a GTPase activating protein (GAP) for Rheb.
	www.uclaaccess.ucla.edu /UCLAACCESS/Web/Faculty.aspx?type=30&id=155 (910 words)

	GeneCard for RHEB (Site not responding. Last check: 2007-10-31)
		RHEB for binary patterns associated with selected probe-sets
		Yee W.M. and Worley P.F. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novelRas-related protein.
		Kimball S.R. and Jefferson L.S. Rheb binds and regulates the mTOR kinase.
	www.genecards.org /cgi-bin/carddisp.pl?gene=RHEB (743 words)

	Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity -- Li et al. 24 (18): 7965 -- ...
		The GTP-to-GDP ratio of Rheb was measured in the presence of wild-type and mutant TSC2 as indicated.
		Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells.
		Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
	mcb.asm.org /cgi/content/full/24/18/7965 (6460 words)

	RHEB antibody (ab25976) datasheet (Site not responding. Last check: 2007-10-31)
		If RHEB antibody (ab25976) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure.
		Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
	www.abcam.com /?datasheet=25976 (550 words)

	UCLA´s Jonsson Comprehensive Cancer Center
		Rheb possesses a unique structural feature and is conserved in a number of organisms.
		This function of Rheb is mediated by its ability to activate the mTOR/S6K signaling pathway.
		Urano, J Tabancay, AP Yang, W Tamanoi, F The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake..
	www.cancer.mednet.ucla.edu /institution/personnel?personnel_id=45741 (995 words)

	Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling -- Inoki et al. 17 (15): 1829 -- Genes ...
		Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling -- Inoki et al.
		Rheb contains an arginine residue (the residue in bold) at the position corresponding to codon 12 of Ras, which has a glycine.
		Clark, G.J., Kinch, M.S., Rogers-Graham, K., Sebti, S.M., Hamilton, A.D., and Der, C.J. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.
	www.genesdev.org /cgi/content/full/17/15/1829 (4749 words)

	Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency -- Long et al. 280 (25): ...
		Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency -- Long et al.
		Rheb is sensitive to inhibition by rapamycin (Fig.
		C, the effect of amino acid withdrawal on Rheb binding to raptor carboxyl-terminal segment 1009–1335, to LST8, and to the mTOR carboxyl-terminal segment 2148–2549.
	www.jbc.org /cgi/content/full/280/25/23433 (3484 words)

	ExactAntigen rheb -- reagents, researchers, and patents (Site not responding. Last check: 2007-10-31)
		(2003) Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K J Biol Chem 278:39921-30.
		(1997) The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation J Biol Chem 272:10608-15.
		(2000) The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake J Biol Chem 275:11198-206.
	www.exactantigen.com /gene/rela/rheb.html (567 words)

	Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals -- ...
		Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
		Rheb is a recently described member of the Ras family that was originally
		Urano, J., Tabancay, A. P., Yang, W., Tamanoi, F. The Saccharomyces cerevisiae Rheb G-protein Is Involved in Regulating Canavanine Resistance and Arginine Uptake.
	mcb.asm.org /cgi/content/abstract/17/2/921 (626 words)

	CiteULike: Rheb binding to mTOR is regulated by amino acid sufficiency. (Site not responding. Last check: 2007-10-31)
		CiteULike: Rheb binding to mTOR is regulated by amino acid sufficiency.
		Rheb binds directly to the aminoterminal lobe of the mTOR catalytic domain, and activates mTOR kinase in a GTP dependent manner.
		Moreover, the binding of mTOR to Rheb mutants that are unable to bind guanyl nucleotide in vivo is also inhibited by amino withdrawal.
	www.citeulike.org /user/adiel/article/191273 (308 words)

	Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via ...
		Rheb (13–16), and activation of Rheb is reported in the
		Rheb expression was detected by immunoblotting with anti-myc 9B11 antibody.
		Rheb expression was confirmed by the use of anti-hemagglutinin antibody.
	mct.aacrjournals.org /cgi/content/full/4/6/918 (4385 words)

	The Tamanoi Lab - Website
		Initially, Rheb was found in brain, but was later found to be ubiquitously expressed.
		Genetic studies using fission yeast as well as Drosophila showed that Rheb plays critical roles in cell growth and regulation of cell cycle at the G1/S boundary.
		The effect of Rheb on cell growth is mediated by its role in the activation of the TOR/S6K signaling pathway.
	www.mimg.ucla.edu /faculty/tamanoi (567 words)

	Nutrition, Growth, and the Cell Cycle in Drosophila
		These and recent observations from other labs (3, 4) indicate that an essential function of insulin/PI3K signaling is to coordinate cellular metabolism with the availability of dietary protein.
		Like the insulin receptor (InR) or PI3K, Rheb is required for cell growth and, when overexpressed, it can drive cell growth and DNA replication in starved larvae.
		We have suggested that Rheb may stimulate cell growth and activate TOR by stimulating nutrient import, and will present data pertaining to this issue.
	www.med.miami.edu /mnbws/Edgar-.html (643 words)

	TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity -- Yang et al. 103 (18): 6811 -- Proceedings of ...
		TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity -- Yang et al.
		of Rheb in TORC1 activation remains to be determined.
		Rheb, have negative and positive effects on TORC1 and -2, respectively.
	www.pnas.org /cgi/content/short/103/18/6811?rss=1 (373 words)

	Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in ...
		Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in the Activation of p70S6K -- Tabancay et al.
		Articles by Tamanoi, F. Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in the Activation of p70S6K
		Rheb GTPases represent a unique family of the Ras superfamily
	www.jbc.org /cgi/content/abstract/278/41/39921 (782 words)

	Human protein: Q15382 - GTP-binding protein Rheb (Ras homolog enriched in brain). EMBL Bioinformatics Harvester
		Human protein: Q15382 - GTP-binding protein Rheb (Ras homolog enriched in brain).
		GTP-binding protein Rheb (Ras homolog enriched in brain).
		A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb.
	harvester.embl.de /harvester/Q153/Q15382.htm (612 words)

	TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity -- Yang et al., 10.1073/pnas.0602282103 -- ...
		TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity -- Yang et al., 10.1073/pnas.0602282103 -- Proceedings of the National Academy of Sciences
		brain (Rheb) small GTPase is known to be a key upstream activator
		of TORC1, although the mechanism of Rheb in TORC1 activation
	www.pnas.org /cgi/content/short/0602282103v1?rss=1 (338 words)

	CiteULike: Tag rheb (Site not responding. Last check: 2007-10-31)
		The FTI SCH66336 (Lonafarnib) inhibits Rheb farnesylation and mTOR signaling: Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
		Rheb binding to mTOR is regulated by amino acid sufficiency.
		posted to mtor nutrients rheb by qazwsx as
	www.citeulike.org /tag/rheb (79 words)

	Rheb's Candy : Boxed Assorted Chocolates : Boxed Assorted Candy
		Rheb's Candy : Boxed Assorted Chocolates : Boxed Assorted Candy
		boxed assorted chocolate clusters, boxed assorted chocolate creams at Rheb's Candy, Baltimore, Maryland.
		Specializing in boxed assorted dark chocolates, boxed assorted milk chocolates, boxed assorted chocolate fudge,
	www.rhebcandy.com (127 words)

	Loss of Rhb1, a Rheb-Related GTPase in Fission Yeast, Causes Growth Arrest With a Terminal Phenotype Similar to That ...
		Communicating editor: P. The Rheb GTPase is most similar in primary sequence to the Ras,
		Rap, R-Ras, and Ral GTPases, which regulate cell growth and
		of mammalian Rheb, which we designated Rhb1, was identified
	www.genetics.org /cgi/content/abstract/155/2/611 (792 words)

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