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Topic: Rhoa

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	Overexpression of Small GTP-binding Protein RhoA Promotes Invasion of Tumor Cells -- Yoshioka et al. 59 (8): 2004 -- ...
		LPA-stimulated translocation of RhoA to the membrane and the
		RhoA and Cdc42 from the cytosol to the membrane (Fig.
		the translocation of RhoA from the cytosol to the membrane and
	cancerres.aacrjournals.org /cgi/content/full/59/8/2004 (6430 words)

	Thrombin-induced Rapid Geranylgeranylation of RhoA as an Essential Process for RhoA Activation in Endothelial Cells -- ...
		RhoA activation in ECs by a statin (22).
		of RhoA was markedly attenuated in ECs by pretreatment with
		and increased the proportion of geranylgeranylated RhoA by
	www.jbc.org /cgi/content/full/280/11/10182 (4034 words)

	HSP27 modulates agonist-induced association of translocated RhoA and PKC-alpha in muscle cells of the colon -- Bitar et ...
		RhoA belongs to the superfamily of ras-related proteins (38).
		Translocation of RhoA and association of translocated RhoA with HSP27 in the particulate fraction, in response to contraction induced by acetylcholine or by ceramide.
		inhibit RhoA translocation from the cytosol to the membrane.
	jap.physiology.org /cgi/content/full/92/1/41 (4900 words)

	Respiratory Research \| Full text \| RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; ...
		Interestingly, RhoA is also known to be instrumental in the kinetics of cyclin D1 expression, specifically in G1 phase of the cell cycle [8].
		RhoA G14V (a construct containing a mutation at G14V to render it constitutively active) and RhoA T19N (a construct containing a mutation at T19N, giving it a dominant negative phenotype) constructs were utilized in a cDNA3.1+ vector and were obtained from the Guthrie research institute http://www.cdna.org.
		Transient transfection of dominant-negative RhoA (RhoA T19N) and constitutively active (RhoA G14V) constructs were utilised to confirm the regulatory role of Rho in cyclin D1 induction (Fig 3a).
	respiratory-research.com /content/7/1/88 (5738 words)

	The Role of RhoA in Early Heart Development
		RhoA is a small GTPase that acts as a molecular switch to control a variety of signal transduction pathways in eukaryotes.
		In earlier studies from this laboratory that employed differential display and in situ hybridisation, RhoA was indicated as being up-regulated during the stages of early heart development in the developing chick embryo.
		To investigate such a mechanism as a possible explanation for the requirement of RhoA in cardiomyocyte differentiation, the P19CL6 inducible cell system over-expressing different forms of RhoA was analysed through real-time PCR to quantify the levels of transcription of genes known to play an important role in early heart development.
	www4.gu.edu.au:8080 /adt-root/public/adt-QGU20060105.091005/index.html (815 words)

	The Insert Region of RhoA Is Essential for Rho Kinase Activation and Cellular Transformation -- Zong et al. 21 (16): ...
		The Insert Region of RhoA Is Essential for Rho Kinase Activation and Cellular Transformation -- Zong et al.
		RhoA is involved in multiple cellular processes, including cytoskeletal organization, gene expression, and transformation.
		RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.
	mcb.asm.org /cgi/content/full/21/16/5287 (5503 words)

	Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability -- Breslin and Yuan 286 (3): ...
		RhoA detected from cell lysates not subjected to the pull-down assay is shown in the bottom blots in A and B.
		RhoA detected from cell lysates not subjected to the pull-down assay is shown in the bottom blot.
		Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases.
	ajpheart.physiology.org /cgi/content/full/286/3/H1057 (3657 words)

	Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure ...
		The levels of each transcript in transgenic samples (right) were calculated as a ratio of the levels seen in nontransgenic mice, with a mean value of >1 representing induction and a value of <1 representing inhibition of gene expression in transgenic mice relative to nontransgenic mice.
		Cardiac and hepatic pathology in RhoA transgenic mice.
		the bradycardia in RhoA transgenic mice was not reversed.
	www.jci.org /cgi/content/full/103/12/1627 (5131 words)

	Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II -- Gong et al. 281 (1): C257 ...
		GDI and translocates to the surface membrane (13, 14).
		Note that all RhoA present in smooth muscle cytosol was immunoprecipitated with GDI, indicating that there is little or no free RhoA in the cytosol.
		G14V RhoA and FLAG-GDI were coexpressed in yeast and purified as a complex from yeast cytosol (46).
	ajpcell.physiology.org /cgi/content/full/281/1/C257 (7939 words)

	Isoprenylcysteine Carboxyl Methyltransferase Modulates Endothelial Monolayer Permeability: Involvement of RhoA Carboxyl ... (Site not responding. Last check: 2007-10-16)
		RhoA methylation is presented as the mean±SE of the ratio of methylated RhoA to total RhoA (A).
		RhoA in PAECs stably overexpressing GFP or ICMT-GFP by infection
		Overexpression of RhoA protein was confirmed by immunoblot analysis (A), and the effects of dominant-negative RhoA on endothelial monolayer permeability were determined by measuring the electrical resistance across the monolayers (B).
	circres.ahajournals.org /cgi/content/full/94/3/306 (4261 words)

	Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA -- Charron et al. 15 (20): 2702 -- ...
		RhoA in cardiomyocytes and is involved in sarcomere assembly.
		RhoA V14 does not affect (a) GATA-4 protein level or (b) GATA-4 DNA-binding activity, as assessed by Western blot and EMSA, using nuclear extracts of NIH 3T3 cells ectopically expressing either one or both proteins respectively.
		RhoA was recently shown to be a potent activator of the p38 mitogen-activated protein kinases (Marinissen et al.
	www.genesdev.org /cgi/content/full/15/20/2702 (7920 words)

	Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity -- Leung et al. ...
		R622E, the RhoA activity was similar to that of the mock-transfected and parental cells.
		The RhoA activity of a RhoDA (dominant active)-transfected cell was taken as a positive control of the RhoA activity assay.
		RhoA, could suppress the motility of HCC cells (14).
	www.pnas.org /cgi/content/full/102/42/15207 (3674 words)

	Raf and RhoA Cooperate to Transform Intestinal Epithelial Cells and Induce Growth Resistance to Transforming Growth ...
		Relative levels of RhoA and Raf in singly and dually transfected cells.
		that is transforming in the context of Raf or RhoA activation.
		Effect of dominant-negative RhoA expression on growth-related protein levels in RIE cells transformed by Ras(12V).
	mcr.aacrjournals.org /cgi/content/full/2/4/233 (4599 words)

	RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity -- Guo et al. 285 (4): 704 -- ...
		RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity -- Guo et al.
		RhoA is a member of the Rho subfamily of the Ras-like small
		RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion.
	ajpgi.physiology.org /cgi/content/full/285/4/G704 (4586 words)

	Hypoxia Up-Regulates Hypoxia-Inducible Factor-1{alpha} Expression through RhoA Activation in Trophoblast Cells -- ...
		Effect of low levels of oxygen on RhoA protein expression in first-trimester human trophoblast cells, BeWo cells, and JAR cells.
		The activation state of RhoA protein was evaluated by affinity precipitation with Rhotekin RBD-agarose.
		RhoA induction is one of cellular adaptations to changes in
	jcem.endojournals.org /cgi/content/full/90/3/1712 (5049 words)

	Involvement of p42/44 MAPK and RhoA protein in augmentation of ACh-induced bronchial smooth muscle contraction by ...
		Involvement of p42/44 MAPK and RhoA protein in augmentation of ACh-induced bronchial smooth muscle contraction by TNF-{alpha} in rats -- Sakai et al.
		Representative RhoA and GAPDH immunoblots of the TNF-
		presence of the RhoA inhibitor, C3 exoenzyme (13).
	jap.physiology.org /cgi/content/full/97/6/2154 (3458 words)

	Nitric Oxide Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA Inactivation -- Krepinsky et al. ...
		RhoA activation temporally precedes that of Erk; we therefore
		RhoA signaling is required for stretch-induced Erk activation.
		MC were infected with the empty vector pBabe or with the RhoA mutant RhoA-Ala188.
	jasn.asnjournals.org /cgi/content/full/14/11/2790 (5562 words)

	RhoA Biological Activity Is Dependent on Prenylation but Independent of Specific Isoprenoid Modification -- Solski et ...
		RhoA Biological Activity Is Dependent on Prenylation but Independent of Specific Isoprenoid Modification -- Solski et al.
		RhoA was unchanged in function and subcellular location.
		was crucial for RhoA inhibition of HIV-1 replication (18).
	cgd.aacrjournals.org /cgi/content/full/13/8/363 (6637 words)

	Rhoa - Wikipedia, the free encyclopedia
		RhoA is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers.
		It acts upon two known effector proteins: Rho kinase (ROCK) and mdia (Diaphenous protein).
		RhoA is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division.
	en.wikipedia.org /wiki/Rhoa (89 words)

	{beta}1 integrin and organized actin filaments facilitate cardiomyocyte-specific RhoA-dependent activation of the ...
		Cultured neonatal cardiomyocytes were transfected with 0.5 µg SK-Luc reporter plasmid together with either the control vector plasmid (1 µg) or expression plasmid encoding RhoA (0.1, 0.25, or 0.5 µg), V14-RhoA (0.1, 0.25, or 0.5 µg), SRFpm1 (0.25 µg), SRFpm1 (0.25 µg) with V14-RhoA (0.5 µg), N19-RhoA (0.5 µg), or C3 transferase (0.25 µg).
		The effect of each transfection dose on the activity of the reporter gene was measured in duplicate or triplicate, and the results indicated are representative of three to five independent experiments.
		RhoA is required for the clustering of the integrin in fibroblasts through
	www.fasebj.org /cgi/content/full/15/3/785 (6174 words)

	RhoA- and RhoD-dependent regulatory switch of G{alpha} subunit signaling by PAR-1 receptors in cellular invasion -- ...
		RhoA- and RhoD-dependent regulatory switch of G{alpha} subunit signaling by PAR-1 receptors in cellular invasion -- NGUYEN et al.
		As controls, MDCKT23-DNRac cells were continuously grown in the presence of the DOX repressor (20 ng/ml) to block expression of the dominant-negative form of Rac1 (+DOX).
		Lower panel: induction of invasion by TRAP (10 µM) in stably transfected MDCKts.src-DCRhoD cells expressing the constitutively activated form of the RhoA inhibitor RhoD harboring a myc epitope.
	www.fasebj.org /cgi/content/full/16/6/565 (6693 words)

	The Cross Talk Between Protein Kinase A- and RhoA-Mediated Signaling in Cancer Cells -- Chen et al. 230 (10): 731 -- ...
		LPA-induced RhoA activation and caused phosphorylation of RhoA
		in live cells revealed that RhoA was distributed in both the
		for PKA to exert its inhibitory effect on RhoA activation.
	www.ebmonline.org /cgi/content/abstract/230/10/731 (329 words)

	ARHA - RAS homolog gene family, member A - aka: ARH12, RhoA - Cancer GeneticsWeb (Site not responding. Last check: 2007-10-16)
		ARHA - RAS homolog gene family, member A - aka: ARH12, RhoA - Cancer GeneticsWeb
		Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
		Medline Search: breast cancer AND (rhoa OR arha) (PubMed)
	www.cancerindex.org /geneweb/ARHA.htm (110 words)

	GeneCard for RHOA
		Antibodies from Abcam (Rho, RhoA), each with their Abpromise
		the gene RHOA for the pathways selected above.
		Expression variation in blood from EXPOLDB for RHOA
	www.genecards.org /cgi-bin/carddisp.pl?gene=RHOA (616 words)

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