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| | [No title] (Site not responding. Last check: 2007-10-18) |
 | | Toyocamycin and some analogues have shown potent antitumor activities; however, none of them could be used clinically primarily owing to their cytotoxicity to normal human cells. |
 | | In order to overcome the weakness of these nucleoside analogues, substitution of a variety of modified sugars for the ribofuranose was explored in our laboratories with expectation that certain sugar-modified toyocamycin analogues may be selectively cytotoxic to cancer cells. |
 | | In this article, we report synthesis and cytotoxicity of 4´-C- and 5´-C-substituted toyocamycins, which were prepared via the condensations of 4-C- and 5-C-substituted ribofuranose derivatives 11, 12, 13, 20, 21, and 26 with the silylated form of 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine (27) and subsequent debromination and debenzoylation. |
| www.elsevier.com /cdweb/journals/09680896/articles/9/1/S096808960000221.abstract.en (173 words) |
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