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Topic: Robert G Roeder


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  Dickson Prize in Medicine awarded to pioneer in gene transcription research   (Site not responding. Last check: 2007-11-02)
Robert G. Roeder, a pioneer in the discovery and characterization of the fundamental molecular mechanisms of gene transcription, received the 2001 Dickson Prize in Medicine yesterday, Sept. 12, in conjunction with his presentation, "Regulation of Transcription in Human Cells: Complexities and Challenges."
Holding a doctorate from the University of Washington, Seattle, Roeder is a professor and head of the Laboratory of Biochemical and Molecular Biology at Rockefeller University in New York.
Roeder is a member of the National Academy of Sciences, the American Association for the Advancement of Science and the American Academy of Arts and Sciences, and a recipient of many awards.
www.pitt.edu /utimes/issues/34/010913/22.html   (257 words)

  
 Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
Robert G. Roeder, Ph.D., a biochemist whose research has led to major advances in understanding how human genes are switched "on" and "off," is this year's recipient of the highly prestigious Albert Lasker Award for Basic Medical Research, the Albert and Mary Lasker Foundation announced today.
Roeder is the 19th scientist associated with Rockefeller University to be honored with the Lasker Award, widely regarded not only as the "American Nobel" but also as a strong predictor of future Nobel Prize winners.
Roeder was born in Boonville, Indiana, in 1942.
www.eurekalert.org /pub_releases/2003-09/ru-lah090903.php   (2179 words)

  
 [No title]
Segall, J., Matsui, T. & Roeder, R.G. Multiple factors are required for the accurate transcription of purified genes by RNA polymerase III.
Roeder, R.G. The role of general initiation factors in transcription by RNA polymerase II.
Roeder, R.G. The role of general and gene-specific cofactors in the regulation of eukaryotic transcription.
www.wisc.edu /molpharm/Courses/pharm620/Roeder.doc   (2239 words)

  
 Rockefeller University Scientists Receive Prestigious Awards For Cancer Research
DETROIT - Arnold J. Levine, Ph.D., newly appointed president of The Rockefeller University, and Robert G. Roeder, Ph.D., professor and head of the Laboratory of Biochemistry and Molecular Biology, have been recognized by the General Motors Cancer Research Foundation for their major contributions to cancer research.
Roeder and co-winner Robert Tjian, Ph.D. of the University of California at Berkeley, were cited for their discoveries on the mechanism and regulation of gene transcription in eukaryotic cells.
Roeder explained that over the years he has become increasingly interested in the applications of his research.
www.eurekalert.org /pub_releases/1999-05/RU-RUSR-050599.php   (1114 words)

  
 Pitt Campaign Chronicle: Gene Transcription Pioneer to Receive Dickson Prize during Science2001
Robert G. Roeder, a pioneer in the discovery and characterization of the fundamental molecular mechanisms of gene transcription, will receive the 2001 Dickson Prize in Medicine in conjunction with his presentation, Regulation of Transcription in Human Cells: Complexities and Challenges, to be given at 9 a.m.
Most notably, he began the functional characterization of the three eukaryotic RNA polymerases, enabling the identification of molecular mechanisms that control the expression of families of genes in response to virus infection, cellular signaling, and differentiation.
A recipient of a doctorate from the University of Washington in Seattle, Roeder is a professor and head of the Laboratory of Biochemical and Molecular Biology at Rockefeller University in New York.
www.umc.pitt.edu /media/pcc010910/roeder.html   (267 words)

  
 Captain Roeder Biography   (Site not responding. Last check: 2007-11-02)
Roeder led his men in a fierce battle at close quarters, to repulse the attack with heavy losses to the Germans.
When Roeder fell, seriously wounded, his men carried him to his command post in the shelter of the ancient ruin.
The promise of relief had come none too soon for the 2nd Battalion: all officers of Company G had either been killed or wounded and the company was down to only fifty men; Companies E and F were in little better shape.
members.aol.com /Head0Class/Bios/CaptRoeder.htm   (2780 words)

  
 Washington University Commencement   (Site not responding. Last check: 2007-11-02)
Largely through a new technique for studying gene activation that he developed, Roeder has also revealed multiple intricate networks of many different molecules that can bind to or otherwise interact with DNA, RNA polymerase, and each other to control the activities of families of genes.
The basic knowledge Roeder has gathered has enormous potential for clinical benefit in fields ranging from cancer to genetic disorders to infectious diseases.
Roeder was a member of the biochemistry faculty at the Washington University School of Medicine from 1971-1982, for a time serving as the James S. McDonnell Professor of Biochemistry.
commencement.wustl.edu /degrees.htm   (1325 words)

  
 Wabash College: Chemistry Crawfordsville, Indiana
Roeder adds, “My interest in transcription was stimulated, as a Wabash College undergraduate in 1963, by a biochemistry course that covered recent work in bacterial genetic regulatory mechanisms.”
Roeder continued his studies in graduate work at the University of Illinois and later at the University of Washington, where he worked with scientist Bill Rutter.
Roeder is the second Wabash College alumnus in the last four years to receive the prestigious Lasker Award.
www.wabash.edu /academics/chemistry/departments.cfm?pages_id=2&news_ID=1212   (528 words)

  
 CHRISTOPHER REEVE HEADLINES 2003 LASKER AWARDS (The Scientist) | Associazione Luca Coscioni
Roeder came to the bench nearly 40 years ago, and, in his last months as a graduate student in William Rutter's University of Washington lab, his work paid off.
Roeder subsequently characterized the actions of the three RNA polymerases (Pols): Pol I transcribes the bulk of ribosomal RNAs; Pol II transcribes premessenger RNAs; and Pol III transcribes transfer RNAs and some ribosomal RNA.
Roeder went on to define the first gene-specific activator, TFIIIa, required for Pol III transcription of 5S genes, and to define various transcription factors and accessory proteinsandamp;#8212;some of the more than 40 polypeptides minimally needed for gene recognition of the transcription start site and RNA synthesis.
www.lucacoscioni.it /node/845   (1363 words)

  
 Pitt Campaign Chronicle: BN: Dickson Prize in Medicine Presented
Robert G. Roeder, a pioneer in the discovery and characterization of the fundamental molecular mechanisms of gene transcription, received the 2001 Dickson Prize in Medicine in conjunction with his lecture, titled Regulation of Transcription in Human Cells: Complexities and Challenges.
Most notably, he began the functional characterization of the three eukaryotic RNA poly-merases, enabling the identification of molecular mechanisms that control the expression of families of genes in response to virus infection, cellular signaling, and differentiation.
The recipient of a doctorate from the University of Washington, Seattle, Roeder is a professor and head of the Laboratory of Biochemical and Molecular Biology at Rockefeller University in New York City.
www.umc.pitt.edu /media/pcc011203/BNdickson.html   (230 words)

  
 Robert E. Roeder, Captain, United States Army
Roeder was born in Summit Station, Pennsylvania on July 25, 1917.
During the sixth counterattack, the enemy, by using flamethrowers and taking advantage of the fog, succeeded in overrunning the position Captain Roeder led his men in a fierce battle at close quarters, to repulse the attack with heavy losses to the Germans.
Through Captain Roeder's able and intrepid leadership his men held Mount Battaglia against the aggressive and fanatical enemy attempts to retake this important and strategic height.
www.arlingtoncemetery.net /roberter.htm   (388 words)

  
 Rockefeller University - Wikipedia, the free encyclopedia
Barbara Ehrenreich, social commentator and author of the 2001 book Nickel and Dimed: On (Not) Getting By In America.
Robert Sapolsky, Stanford Professor, McArthur Grant recipient, and writer of numerous books on stress and natural history.
David Baltimore, Nobel Prize in Physiology and Medicine in 1975 for the discovery of reverse transcriptase.
en.wikipedia.org /wiki/Rockefeller_Institute   (384 words)

  
 Cloning and Characterization of Human TAF20/15. MULTIPLE INTERACTIONS SUGGEST A CENTRAL ROLE IN TFIID COMPLEX FORMATION ...
Rabbits were injected with 200 µg of protein (as an emulsion with Freund's adjuvant) once a month and bled twice a month for 18 months.
C65 were affinity-purified with the respective antigen to yield more than 10 mg of pure antibody; 1 mg was bound to 1 ml of protein A-Sepharose (Pharmacia) and cross-linked with DMP for use in immunoprecipitation experiments.
The volume of lysate employed in one interaction assay was titrated with lysate from bacteria containing the insertless vector to yield about 2 µg of fusion protein in a 200-µl reaction volume.
www.jbc.org /cgi/content/full/271/30/18194   (6879 words)

  
 CV
Bitter, G. and Roeder, R. Transcription of Viral Genes by RNA Polymerase II in Nuclei Isolated from Adenovirus 2 Transformed Cells.
Bitter, G. and Roeder, R. Transcription of Viral Genes in Chromatin from Adenovirus 2 Transformed Cells by Exogenous Eukaryotic RNA Polymerases.
Milich, D.R., Jones, J.E., McLachlin, A., Bitter, G. Moriarty, A. and Hughes, J. Importance of Subtype in the Immune Response to the Pre-S(2) Region of the Hepatitis B Surface Antigen II.
pages.prodigy.net /bittech/cv.htm   (892 words)

  
 Foreign Affairs - Book Review - Red Sunset: The Failure of Soviet Politics - Philip G. Roeder
The theory, called new institutionalism and borrowed from economics along with a core of rational-choice theory, roots the sources of political behavior in the rules, formal and informal, that determine political roles and relationships.
Putting Roeder's thesis so starkly does it a disservice: Fully developed, it is far from as self-evident as this would make it seem.
Although the book's primary audience is in the universities, the general reader will gain insight into the ultimate weaknesses of the Soviet system and a good idea of how new institutionalism stacks up as an explanation against traditional alternatives, particularly those stressing the importance of political culture.
www.foreignaffairs.org /19940301fabook8635/philip-g-roeder/red-sunset-the-failure-of-soviet-politics.html?mode=print   (301 words)

  
 The Lasker Foundation | Awards | This Year's Winners | Interviews
Robert G. Roeder Marc Feldmann Sir Ravinder N. Maini Christopher Reeve
The 2003 Albert Lasker Award for Basic Medical Research is presented to Robert G. Roeder for pioneering studies on eukaryotic RNA polymerases and the general transcriptional machinery, which opened gene expression in animal cells to biochemical analysis.
Robert Roeder is interviewed by James E. Darnell of Rockefeller University.
www.laskerfoundation.org /awards/2003_interviewscopy.html   (551 words)

  
 The RNA polymerase II core promoter: a key component in the regulation of gene expression -- Butler and Kadonaga 16 ...
Burley, S.K. and Roeder, R.G. Biochemistry and structural biology of transcription factor IID (TFIID).
Orphanides, G., Lagrange, T., and Reinberg, D. The general transcription factors of RNA polymerase II.
Orphanides, G. and Reinberg, D. A unified theory of gene expression.
www.genesdev.org /cgi/content/full/16/20/2583   (6263 words)

  
 Population Council Projects | Physiology of Sertoli Cells | Publications/Resources
Zhang, Di, Tarja-Leena Penttilä, Patricia L. Morris, and Robert G. Roeder.
Zhang, Di, Tarja-Leena Penttilä, Patricia L. Morris, Martin Teichmann, and Robert G. Roeder.
Boffa, Lidia C., Sonia Scarfi, Maria Rita Mariani, Gianluca Damonte, Vincent G. Allfrey, Umberto Benatti, and Patricia L. Morris.
www.popcouncil.org /projects/BIO_PhysSertoliCellsRI.html   (384 words)

  
 HHMI Bulletin: Peering Inside the Black Box
What little was known had been pioneered by biochemist Robert G. Roeder, who had discovered the enzyme RNA polymerase—the heart of the engine that drives the cell's DNA-reading machinery—in work he did at the University of Washington.
By the mid-1980s, Roeder and his colleagues at The Rockefeller University had detected several other basic, or basal, components that, along with RNA polymerase, made up the core engine of the transcription machine.
One critical basal transcription factor that Roeder's group found was TF Its main ingredient was thought to be a protein—dubbed TBP—known to seek out and bind to the TATA box that lies within many gene promoters.
www.hhmi.org /bulletin/june2002/blackbox/blackbox2.html   (2375 words)

  
 NAS Member Details
Election Citation: Roeder has made numerous seminal contributions to our understanding of eukaryotic gene expression, particularly the elements involved in transcriptional regulation.
He is a pioneer in the characterization of eukaryotic RNA polymerases and the development of in vitro transcription systems which have been used to define regulatory sequence elements and the protein factors that interact with them.
Research Interests: My research interests revolve around the structure and function of mammalian RNA polymerases and transcription initiation factors; the regulation of gene expression during cellular growth, differentiation, and virus infection; and special emphasis on structure, mechanism of action, and regulation of cellular and viral encoded transcriptional activators and coactivators.
nrc88.nas.edu /pnas_search/memberDetails.aspx?ctID=8908   (108 words)

  
 04.30.99 - UC Berkeley molecular biologist Robert Tjian is awarded GM prize in cancer research
DETROIT -- Robert Tjian, PhD, professor of molecular and cell biology at the University of California, Berkeley, has been recognized by the General Motors Cancer Research Foundation for his major contributions to cancer research.
Tjian and co-winner Robert G. Roeder, PhD, of New York's Rockefeller University were cited for their discoveries on the mechanism and regulation of gene transcription in eukaryotic cells.
The Kettering Prize recognizes the most outstanding recent contribution to the diagnosis or treatment of cancer, while the Mott Prize recognizes the most outstanding recent contribution to the discovery of the cause or ultimate prevention of human cancer.
www.berkeley.edu /news/media/releases/99legacy/4-30-1999.html   (771 words)

  
 Kai Ge, Ph.D. : Faculty : NIDDK Laboratories
In February 2000, he moved to The Rockefeller University where he continued his postdoctoral training with Robert G. Roeder, studying the roles of TRAP220 and associated Mediator transcription coactivator complex in the regulation of adipogenesis by PPARgamma.
Park SW, Li G, Lin YP, Barrero MJ, Ge K, Roeder RG, Wei LN Thyroid Hormone-Induced Juxtaposition of Regulatory Elements/Factors and Chromatin Remodeling of Crabp1 Dependent on MED1/TRAP220.
Guermah M Ge K Chiang CM Roeder RG The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.
intramural.niddk.nih.gov /research/faculty.asp?People_ID=1637   (634 words)

  
 Transcription factor cCP2 controls gene expression in chicken embryonic stem cells -- Acloque et al. 32 (7): 2259 -- ...
The free (F) and retarded (R) probes were then sequenced and compared with the G+A sequence obtained with the non-methylated probes.
The G residues implicated were identified by a disappearance or a decrease in the signal.
The guanine nucleotides identified by methylation interference assays are presented in bold on a double-stranded DNA fragment.
nar.oxfordjournals.org /cgi/content/full/32/7/2259   (5882 words)

  
 Department of Chemistry and Biology
Very recently in collaboration with Dr. Ivan Sadowski (UBC) and Dr. R.G. Roeder (Rockefeller University), we have identified the proteins that compose RBF2 and are in the process of examining the binding of recombinant RBF2 components to the MFNLP/RBEIII sites.
Mario Clemente Estable, Mojgan Naghavi, Hiroyuki Kato, Hua Xiao, Jun Qin and Robert G. Roeder.
Bellemare G., Estable M.C., Paradis F. Minicell Isolation by Isopicnic sedimentation in gradients of silica: An updated protocol.
www.ryerson.ca /~cab/faculty/estable.html   (1259 words)

  
 Steven Clarke Lab Publications - 2004-present   (Site not responding. Last check: 2007-11-02)
Young, S. G., Clarke, S. G., Bergo, M. O., Philips, M., and Fong, L. (2006) "Genetic Approaches for Understanding the Physiological Importance of the Carboxyl Methylation of Isoprenylated Proteins" in Protein Methyltransferases, a volume of The Enzymes, 3rd edition (Clarke, S. and Tanamoni, F., eds), 24, 273-301.
Belcastro, Sarah T. Villa, Randy D. Dinkins, Steven G. Clarke, and A. Bruce Downie (2004) "A Second Protein L-Isoaspartyl Methyltransferase Gene in Arabidopis Produces Two Transcripts Whose Products are Sequestered in the Nucleus" Plant Physiology 136, 2552-2664.
Katz, J. E., Dumlao, D. S., Wasserman, J. I., Lansdown, M. G., Jung, M. E., Faull, K. F., and Clarke, S. "3-Isopropylmalate is the Major Endogenous Substrate of the Saccharomyces cerevisiae trans-Aconitate Methyltransferase" Biochemistry 43, 5976-5986.
www.biochemistry.ucla.edu /biochem/Faculty/SClarke/publications3.html   (758 words)

  
 Finnegan Henderson - Marcus Kretzschmar - Student Associate
Kretzschmar's scientific expertise is in biochemistry, molecular biology, cell biology, and cancer biology, and he has a background in immunology, microbiology, and virology.
His Ph.D. thesis in Dr. Robert G. Roeder's laboratory comprised the identification, isolation, and functional characterization of novel protein factors ("co-activators") that are involved in the regulation of eukaryotic and viral gene expression by transcription activators such as NF-kB.
As a Postdoctoral Fellow in Dr. Joan Massaguè's laboratory, he focused on the characterization of novel signal transduction pathways induced by TGF-b growth factors, and, in particular, on the regulation of the important SMAD signal transducers via phosphorylation by protein kinases, including the TGF-b receptor kinases.
www.finnegan.com /lawyers/index.cfm?id=1653   (434 words)

  
 Human TFIIIC Relieves Chromatin-Mediated Repression of RNA Polymerase III Transcription and Contains an Intrinsic ...
Hosohata, K., Li, P., Hosohata, Y., Qin, J., Roeder, R. G., Wang, Z. Purification and Identification of a Novel Complex Which Is Involved in Androgen Receptor-Dependent Transcription.
Larminie, C. G. C., Sutcliffe, J. E., Tosh, K., Winter, A. G., Felton-Edkins, Z. A., White, R. Activation of RNA Polymerase III Transcription in Cells Transformed by Simian Virus 40.
Winter, A. G., Sourvinos, G., Allison, S. J., Tosh, K., Scott, P. H., Spandidos, D. A., White, R. RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.
mcb.asm.org /cgi/content/abstract/19/2/1605   (938 words)

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