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Topic: Rotenone

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	Rotenone - Wikipedia, the free encyclopedia
		Rotenone (CAS number 83-79-4) is a colorless-to-blue, foul smelling solid.
		Rotenone is commonly used in powdered form to increase (?!) the amount of parasitic mites on chickens and other fowl.
		Rotenone is produced by extraction from the roots, seeds, and leaves of certain tropical legumes.
	en.wikipedia.org /wiki/Rotenone (252 words)

	Factsheet - Rotenone
		Rotenone is a naturally occurring chemical with insecticidal, acaricidal(1) (mite and spider-killing) and piscicidal (fish-killing) properties, obtained from the roots of several tropical and subtropical plant species belonging to the genus Lonchocarpus or Derris.
		Rotenone is believed to be moderately toxic to humans with an oral lethal dose estimated from 300 to 500 mg/kg(24).
		Rotenone is highly toxic to fish: most values for the 96 hour LC50 (lethal concentration required to kill half the test organisms) for different fish species and for daphnids (water fleas) lie in the range of 0.02 to 0.2 mg/litre.
	www.pan-uk.org /pestnews/Actives/rotenone.htm (1750 words)

	EXTOXNET PIP - ROTENONE
		Rotenone is used in home gardens for insect control, for lice and tick control on pets, and for fish eradications as part of water body management.
		Rotenone is a rotenoid plant extract obtained from such species as barbasco, cub, haiari, nekoe, and timbo.
		Rotenone is believed to be moderately toxic to humans with an oral lethal dose estimated from 300 to 500 mg/kg [2].
	extoxnet.orst.edu /pips/rotenone.htm (1538 words)

	P1954 Using Rotenone To Renovate Fish Populations in Farm Ponds
		Rotenone is a naturally occurring substance found in the roots and stems of several tropical plants.
		Rotenone works by inhibiting a biochemical process in the fish cells, resulting in an inability of fish to use oxygen in the release of energy during normal body processes.
		Although rotenone is considered nontoxic to humans at levels that would be found in a treated pond or fish, EPA and FDA have not established the maximum acceptable residue level permitted in fish for human consumption.
	msucares.com /pubs/publications/p1954.htm (1817 words)

	Relationship Between Rotenone Use in Fisheries Management and Parkinson's Disease (Site not responding. Last check: 2007-10-14)
		Rotenone is very unstable in the environment (half-life measured in days), is oxidized (neutralized) through enzymatic action in the gut of mammals and birds, is metabolized to very polar (water soluble) compounds in the body, and these compounds are excreted by the liver and kidney (Finlayson et al.
		Rotenone is toxic to fish because it is taken up rapidly across the gills and gets directly into the bloodstream, thus, bypassing the gut.
		Rotenone is considered safe for the environment because it loses all its toxicity in a few days.
	www.fisheries.org /rotenone/parkinsonstudy.shtml (1252 words)

	Rotenone (HSG 73, 1992)
		1.4 Uses Rotenone is a selective, nonsystemic insecticide used on fruit trees, such as apple, apricot, peach, persimmon, pomegranate, and quince, to control aphids, maggots, bagworms, codling moths, Japanese beetles, leaf hoppers, Mexican bean beetles, cabbage worms, thrips, stinkbugs, flea beetles, and vegetable weevils.
		Rotenone is available as a technical-grade solution at concentrations of 35%, 90%, or 95%, as a formulation intermediate at a concentration of 50%, and as a wettable powder containing 5% or 20% active substance.
		Rotenone by the oral route is less toxic for the mouse and hamster than for the rat; the pig seems to be especially sensitive.
	www.inchem.org /documents/hsg/hsg/hsg073.htm (2142 words)

	FISHERIES MANAGEMENT PRODUCTS Q&A
		Rotenone is a naturally occurring substance which is extracted from the roots of a shrub which grows in the high forests of Amazonian Peru.
		Rotenone chemically inhibits the ability of fish to use the dissolved oxygen in water for their bodily functions.
		The amount of Rotenone applied for fish control is smaller thant the amount which would be required for it to have an effect on most other aquatic organisms.
	www.prentiss.com /Products/fishman.htm (781 words)

	Rotenone (PIM 474)
		Rotenone is extracted from plants, particularly from Derris spp grown in Malaya, East Indies, and South America, and Lonchocarpus also known as "cubé", grown in Central and South America.
		Rotenone is readily racemised by alkali and readily oxidized especially in the presence of light and alkali.
		Rotenone is used alone or in combination with pyrethrins, pyrethrum, and piperonyl butoxide to control a wide variety of insects on food crops.
	www.inchem.org /documents/pims/chemical/pim474.htm (2400 words)

	Use of Rotenone for Management of Fish Populations
		Rotenone, also known as derris or cube, is used as an insecticide as well as a piscicide (fish poison).
		Rotenone, used as a piscicide, is a restricted use chemical, and a license is required for its purchase and application.
		To calculate the amount of rotenone required to treat a pond, it is necessary to first determine the volume of the pond in acre feet (ac ft) and multiply this figure by the amount of liquid or powder called for in the table above.
	hgic.clemson.edu /factsheets/HGIC1713.htm (1268 words)

	Rotenone
		Rotenone containing extracts are taken from the roots, seeds and leaves of the various plants (13).
		Mice have a rotenone induced oral LD50 of 350 mg/kg; rabbits an LD50 of 600-2,000; and guinea pigs an LD50 of 12-200.
		A spray of 5% rotenone in 80 imperial gallons of water was fatal to a 100-pound pig when exposed to 250 cucm (cubic centimeters) of the mixture.
	pmep.cce.cornell.edu /profiles/extoxnet/pyrethrins-ziram/rotenone-ext.html (1485 words)

	Rotenone Can Remove Undesireable Fish From a Pond
		Rotenone is the piscicide most often used to kill fish.
		Rotenone is a naturally occurring compound derived from the roots of certain tropical and subtropical legume plants.
		Rotenone is sold both as a powder and a liquid.
	www.noble.org /Ag/Wildlife/Rotenone (717 words)

	RotenonePyrethrumInsecticide
		Rotenone is a natural plant derived substance contained in the stems and roots of certain tropical plants, such as the Jewel Vine or Flame tree (Derris Spp.), or Lacepod (Lonchocarpus spp.) which grow in Malaysia, East Indies and Peru.
		Rotenone is not a stable compound and breaks down when exposed to light, heat, oxygen and alkaline water.
		Rotenone has a longer residual life than most botanicals and is effective for about a week.
	www.ghorganics.com /RotenonePyrethrumInsecticide.html (346 words)

	Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone-Induced Apoptosis in Liver Cells -- ...
		A that inhibited the apoptogenicity of rotenone and atractyloside
		In cultures treated with rotenone for less than 12 h, upon removal of rotenone from the medium, DMSO was added such that the total duration of treatment was 12 h.
		Halestrap, A. P., and Davidson, A. Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase.
	toxsci.oxfordjournals.org /cgi/content/full/53/2/340 (6200 words)

	NTP: Abstract for TR-320 - Rotenone
		The estimated average amount of rotenone consumed per day was 1.7 mg/kg or 3.5 mg/kg for low dose or high dose rats and 115 mg/kg or 250 mg/kg for low dose and high dose mice.
		Rotenone induced forward mutations in the mouse L5178Y/TK lymphoma assay without activation; it was not tested in the presence of S9.
		Conclusions: Under the conditions of these 2-year feed studies, there was equivocal evidence of carcinogenic activity of rotenone for male F344/N rats, as indicated by an increased incidence of parathyroid gland adenomas (uncommon tumors).
	ntp.niehs.nih.gov /index.cfm?objectid=0707D8A3-0FEB-BB0E-BF69809ADEC7A487 (907 words)

	CNN.com - Health - Scientists say rat study provides intriguing clues to understanding Parkinson's disease - November ...
		Rotenone is an organic product made from extracts of tropical plants.
		They chose Rotenone because it was known to affect the so-called "power plants" inside cells, called mitochondria, said Dr. Tim Greenamyre, a neurologist in Emory University's medical school.
		Scientists acknowledged the pump method used in the experiment did not duplicate rotenone exposure in the real world, but said it was a more direct and reliable method for research purposes.
	archives.cnn.com /2000/HEALTH/11/05/parkinsons.pesticide (1056 words)

	Rotenone Stewardship Program (Site not responding. Last check: 2007-10-14)
		One of the most valuable tools is rotenone, a chemical commonly used by fishery professionals throughout North America for the past 50 years to control fish and as a sampling aid.
		Rotenone is the only sampling method that provides for an accurate estimate of diverse fish communities.
		It was the manner in which rotenone use used, not the chemical, that contributed to these incidents.
	www.fisheries.org /rotenone (758 words)

	Rotenone: Facts and details from Encyclopedia Topic (Site not responding. Last check: 2007-10-14)
		Rotenone (CAS number[Click link for more facts about this topic] 83-79-4) is a colorless-to-red, EHandler: no quick summary.
		Rotenone is produced by extraction from the roots, EHandler: no quick summary.
		The study does not suggest that rotenone exposure is responsible for Parkinson's Disease in humans, EHandler: no quick summary.
	www.absoluteastronomy.com /encyclopedia/r/ro/rotenone.htm (740 words)

	Selective Vulnerability of Dopaminergic Neurons to Microtubule Depolymerization -- Ren et al. 280 (40): 34105 -- ...
		Rotenone toxicity was significantly higher in TH than in TH neurons at each time point.
		Rotenone toxicity was dependent on its abilities to inhibit complex I and to depolymerize microtubules.
		By depolymerizing microtubules, rotenone disrupts the transport of DA vesicles, which results in their accumulation in the soma and, therefore, an increase in cytosolic DA concentration due to the leakage of vesicles.
	www.jbc.org /cgi/content/full/280/40/34105 (5621 words)

	Rotenone
		Located southwest of Panguitch in the Dixie National Forest, Panguitch Lake was treated with rotenone on May 2 to eradicate Utah chubs from its waters.
		On May 2, Panguitch Lake was treated with rotenone and declared a "dead" fishery.
		Now, less than a month later, 20,000 catchable rainbow trout have been reintroduced to its waters and the lake is well on its way to recovery.
	www.mrsci.com /Toxicology/Rotenone.php (570 words)

	Rotenone sensitivity in Candida utilis yeast: Exponential vs stationary phase
		Torulopsis utilis yeast cells growing exponentially on a synthetic medium with ethanol as carbon and energy source are insensitive to rotenone, acquiring the rotenone-sensitive component of the mitochondrial electron transport chain upon entering an ethanol-depleted stationary phase.
		The acquisition of rotenone sensitivity is apparently associated with an increased phosphorylation efficiency, as evidenced by measurements of P/O ratios.
		Following the ce8sation of growtli and tlie final drop in respiratory ra, there was an elisci(le of alight rotenone sensitivity (20 O/, or less), followed by a period of approxima ly 3 b of rotenone insensitivity.
	www.frogojt.com /Yeast2.html (1963 words)

	Mechanism of Toxicity in Rotenone Models of Parkinson's Disease -- Sherer et al. 23 (34): 10756 -- Journal of ... (Site not responding. Last check: 2007-10-14)
		Cells were exposed to rotenone for 48 hr, and cell death was monitored between 24 and 48 hr using Sytox green fluorescence.
		Chronic rotenone infusion increased protein carbonyl levels in soluble protein isolated from the striatum (n = 18), midbrain (n = 18), cortex (n = 11), and olfactory bulb (n = 12) but not the cerebellum (n = 10) or hippocampus (n = 10).
		Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone
	www.jneurosci.org /cgi/content/full/23/34/10756 (5413 words)

	Rotenone-Induced Apoptosis Is Mediated By p38 And JNK MAP Kinases In Human Dopaminergic SH-SY5Y Cells -- Newhouse et ...
		Rotenone (Sigma, 95–98% pure) was dissolved in ethanol.
		Rotenone induces apoptosis in SH-SY5Y cells in a dose-dependent manner.
		SH-SY5Y cells were treated with various concentrations of rotenone as indicated for 24 h (A and B) or 48 h (C and D), and apoptosis was scored (A and C).
	toxsci.oxfordjournals.org /cgi/content/full/79/1/137 (4766 words)

	Wujtewicz Acute Toxicity of 5% Non-Synergized Emulsifiable Rotenone to White River Crayfish Procambarus acutus acutus ...
		In the current study, laboratory and in situ acute toxicity bioassays (96 h) were conducted with 5% non-synergized emulsifiable rotenone to define the maximum non-lethal concentration (LC) for white river crayfish Procumbarus acutus acutus and the minimum lethal concentration (LC) for white perch Morone americana.
		In the final phase of the study a 1.0 mg/L concentration of rotenone was applied to a pond containing both species held in cages.
		It may therefore be possible to use this rotenone formulation to control white perch and other finfish in active crayfish culture ponds.
	sgnis.org /publicat/jwas249.htm (303 words)

	Rotenone Model of Parkinson Disease: MULTIPLE BRAIN MITOCHONDRIA DYSFUNCTIONS AFTER SHORT TERM SYSTEMIC ROTENONE ...
		in mitochondrial yields from the livers of rotenone rats.
		rotenone intoxication the inner mitochondrial membrane was not
		of rotenone infusion, oxidations of the NAD-dependent substrates
	www.jbc.org /cgi/content/full/280/51/42026 (6032 words)

	Active Skim View of: Rotenone
		In vitro studies with microsomal preparations and in vivo studies with mice and houseflies indicated that there are hydroxylation metabolites of rotenone designated as rotenolone I; rotenolone II; dehydrorotenone I; dehydroxyrotenone; 8'-hydroxyrotenolone; 6',7'-dehydro6',7'-dihydrorotenone; and other uncharacterized polar compounds (Fukami et al., 1967; Haley, 19781.
		Short-term administration of rotenone in sunflower oil, injected intraperitoneally in doses of 0.1 mg/kg/day for 5 days into female rats, produced a marked elevation in serum growth hormone concentration and a decrease in serum prolactin (Gosalvez et al., 1979~.
		Rotenone added to Chinese hamster cells in vitro increased the mitotic index, and mitotic cells contained monopolar spindles with chromosomes grouped around centriole pairs near the cell center (Haley, 1978~.
	www.nap.edu /nap-cgi/skimit.cgi?isbn=0309033810&chap=63-70 (454 words)

	Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons -- Gao et al. 23 ...
		NADPH oxidase in mediating the elevated rotenone neurotoxicity.
		rotenone, and the capability of cultures to uptake DA was evaluated.
		Gao HM, Hong JS, Zhang W, Liu B (2003) Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.
	www.jneurosci.org /cgi/content/full/23/15/6181 (3901 words)

	Rotenone Induces Apoptosis via Activation of Bad in Human Dopaminergic SH-SY5Y Cells -- Watabe and Nakaki 311 (3): 948 ...
		DNA fragmentation caused by rotenone was detected (Fig.
		A, SH-SY5Y cells were treated with rotenone at the indicated concentrations for 24 h.
		Heikkila RE, Nicklas WJ, Vyas I, and Duvoisin RC (1985) Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.
	jpet.aspetjournals.org /cgi/content/full/311/3/948 (3074 words)

	Rotenone Symposium
		The symposium will be used to publicize the availability of the Rotenone Use Manual and other elements of the Rotenone Stewardship Program.
		The symposium will cover a wide variety of topics including (a) use trends, (b) controversial issues, (c) administrative and technical procedures, (d) synopses of several treatments highlighting what has been done right and wrong, (e) natural resources agencies policies, and (f) the need for a stewardship program.
		ROTENONE USE FOR THE RESTORATION OF NATIVE TROUT IN THE WESTERN UNITED STATES, 953539205-32, William D.
	www.ecu.edu /org/afs/st_louis/Rotenonesympsium.htm (363 words)

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