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| | CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to ... (Site not responding. Last check: 2007-10-31) |
 | | Both SCAP and SREBP are shown anchored to the ER membrane through several or two membrane-spanning domains, respectively. |
 | | The role of SCAP in feedback regulation by sterols and insulin was analyzed through a series of feeding studies. |
 | | Matsuda, M., Korn, B.S., Hammer, R.E., Moon, Y.-A., Kumuro, R., Horton, J.D., Goldstein, J.L., Brown, M.S., and Shimomura, I. SERBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. |
| www.genesdev.org /cgi/content/full/15/15/1873 (3881 words) |
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