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	SH3 Domain of Tyrosine Kinase
		SH3 domains are modules of ~60 residues that bind to proline-rich peptides in a sequence-specific manner.
		Interestingly, its placement on the surface of the SH3 domain appears very superficial with the prolines interacting with the aromatic residues on the hydrophobic face of the SH3 domain.
		This superficial contact is in contrast to the deeper binding groove used in the binding of the phospho-tyrosyl peptide on the surface of the SH2 domain.
	biogeometry.duke.edu /research/year1/protein/sh3_tk/index.html (400 words)

	About SH3
		Though their binding to specific proline-rich sequence motifs, SH3 domains are known to play a crucial role in the formation of multiprotein complexes and networks responsible for signal transduction, cytoskeletal organisation and other cellular processes.
		Since many SH3 domains occur in critical intracellular signalling proteins, such as in the oncogene Src and the adaptor proteins Grb2, Nck and Crk, it is essential to understand the rules that underlie SH3-mediated complex formation in the cell.
		The objective of the "Structure" cluster is to describe the diversity of the SH3 domain family ghrough structural analysis.
	www.pdg.cnb.uam.es /jmglez/SH3/about.html (3265 words)

	SH3
		SH3 domains are compact globular structures found in many proteins which have important signalling structures.
		SH3 domains are self-folding entities whose structures have been determined by both NMR and XRD procedures.
		Thus it interacted strongly with the SH3 domains of the tyrosyl kinases fyn, lyn and src as well as those from the cytoskeletal proteins fodrin and cortactin but little, or not at all, with the SH3 domains of the adapter proteins Grb2 and crk.
	www.gla.ac.uk /ibls/BMB/mdh/rpde6_sh3.htm (1960 words)

	SH3 Walk_Through Created with ImageMapper! (Site not responding. Last check: 2007-10-12)
		SH3 domain is a small conserved sequence of about 60 amino acid residues that interacts with proline-rich peptides to form protein aggregates.
		Structurally, the SH3 domain folds as a compact beta-barrel of five anti-parallel beta-strands which bring the amino and the carboxyl termini of the domain close to each other.
		Functionally, the SH3 domain is involved in cell-cell communication and signal transduction from the cell surface to the nucleus.
	www.sdsc.edu /~ffana/html/sh3walk_thru.html (136 words)

	A Potential SH3 Domain-binding Site in the Crk SH2 Domain -- Anafi et al. 271 (35): 21365 -- Journal of Biological ...
		SH3 domains have recently been shown to bind proline-rich peptides that adopt a polyproline type II helix, with three residues per turn (13, 36).
		The N-terminal Crk SH3 domain associates with a proline-rich motif in the C-terminal Abl tail (19, 20): this interaction might facilitate association of the proline-rich motif in the Crk SH2 domain with the Abl SH3 domain.
		The Abl SH3 domain is known to be a negative regulator of Abl kinase and transforming activities, and has been postulated to bind an exogenous inhibitor (44, 45).
	www.jbc.org /cgi/content/full/271/35/21365 (7381 words)

	BioMed Central \| Full text \| A neural strategy for the inference of SH3 domain-peptide interaction specificity
		In the case of class I SH3 domains, NNs' results are controversial: the correlation is higher than the one obtained with PSSMs in three cases (Rvs167, Sho1, Yfr024), and lower in the three remaining cases (Boi1, Myo5, Ysc84).
		Boi2 domain was excluded from the analysis because of the scarcity of positive binding peptides (only six, see Table 3), which makes the use of both a PSSM and a neural network unreliable.
		For each SH3 domain considered, a PSSM was obtained from the alignment of the training set binders, and tested on the peptides of the corresponding test set.
	www.biomedcentral.com /1471-2105/6/S4/S13 (3850 words)

	About SH3 Domain (Site not responding. Last check: 2007-10-12)
		SH3 Domain: This domain is a small, beta-barrel module that presents a non-polar groove complementary to the target proteins short peptides in a polyproline-II conformation.
		The SH2 and SH3 domains mediate protein-protein interactions in cellular signaling cascades, and are found in many proteins outside the Src family.
		SH1 Domain: This is the catalytic domain of the protein which has the kinase activity.
	www.sdsc.edu /~ffana/html/src.html (421 words)

	InterPro: IPR001452 Src homology-3
		SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [ 1, 2 ].
		The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif.
		The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [ 7 ].
	www.ebi.ac.uk /interpro/IEntry?ac=IPR001452 (1551 words)

	The SH3 domain (Site not responding. Last check: 2007-10-12)
		The Src homology 3 domain is a 60 amino acid module identified first in v and c-Src, but also found in many other molecules often in combination with SH2 domains (e.g.
		In 1993 Baltimore’s group shows that the SH3 domain of Abl binds to proline rich sequences in other proteins; the consensus is PxxP, although there is often 6 or more prolines bunched together.
		As with SH2 and PH domains, the N and C termini are close together, possibly allowing the module to be evolutionarily mobile.
	www.mbi.ufl.edu /~shaw/sh3domai.htm (193 words)

	Prediction of Binding Affinities between the Human Amphiphysin-1 SH3 Domain and Its Peptide Ligands Using Homology ...
		The SH3 domain of the human protein amphiphysin-1, which plays important roles in clathrin-mediated endocytosis, actin function and signaling transduction, can recognize peptide motif PXRPXR (X is any amino acid) with high affinity and specificity.
		We have constructed a complex structure of the amphiphysin-1 SH3 domain and a high-affinity peptide ligand PLPRRPPRA using homology modeling and molecular docking, which was optimized by molecular dynamics (MD).
		For each domain, peptides matching the defined patterns were synthesized at high density on cellulose membrances by SPOT synthesis technology, and the membranes were probed with the corresponding SH3 domain fused to glutathione S-transferase (GST).
	pubs.acs.org /cgi-bin/sample.cgi/jprobs/2006/5/i01/html/pr0502267.html (7786 words)

	InterPro: IPR011511 Variant SH3
		SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation.
		Some domains can be found in more than one type of protein or family of proteins, but is not a SUBTYPE in the family sense.
		The domain is a functional entity, which can be found in proteins with different domain organisations.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR011511 (2969 words)

	TranSignal SH3 Domain Arrays
		Each SH3 domain is a small, conserved sequence of about 60 amino acids that interacts with proline-rich peptides.
		SH3 domains mediate interactions in many key signaling pathways, including epidermal growth factor receptor signaling (2), cellular localization of cytoplasmic proteins (3), up-regulation of GTPase activity of dynamin (4), and activation of phosphatidylinositol 3-kinase in response to IgM crosslinking (5).
		Bacterial extract from the transformed cells was hybridized with the SH3 domain Array I, and the image was acquired using FluorChem™ imager (from Alpha Innotech).
	www.panomics.com /MA3010.cfm (651 words)

	Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition ...
		Amino acids involved in additional contacts between the SH3 domains and ligand residues outside the proline-rich recognition motif are shaded in fl (Lck-SH3–Tip; [Bauer et al.
		SH3 domains from Lyn and Lck (Schweimer et al.
		SH3 domain of PI3 kinase, which was used as a control (Feng et al.
	www.proteinscience.org /cgi/content/full/14/10/2487 (5581 words)

	Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons ...
		SH3 domain-binding peptides and a sterile alpha motif.
		N-terminal region and an SH3 domain at the distal C terminus.
		The SAM domain is underlined, and the ppI motif is indicated by dots.
	mcb.asm.org /cgi/content/full/18/10/5838 (7894 words)

	Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and ... (Site not responding. Last check: 2007-10-12)
		The grey Corey–Pauling–Koltun (CPK) representation shows the atoms of the SH3 domain; however, atoms of the residues involved in direct interaction with the modelled peptide are shown as green sticks (these residues are labelled in yellow).
		Involvement of the SH3 domain RT loop in binding to NS5A.
		The arginine in the RT loop of FynSH3 is residue 96 in the native Fyn polypeptide.
	vir.sgmjournals.org /cgi/content/full/86/4/1035 (5736 words)

	Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte ...
		PX domain and its phosphoinositide-binding activity in activation of the phagocyte NADPH oxidase.
		PX Domain Is Essential for Membrane Translocation of This Protein and Activation of the Phagocyte NADPH Oxidase.
		A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase
	www.pnas.org /cgi/content/full/100/8/4474 (4607 words)

	Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide -- ...
		(SH2) and Src homology 3 (SH3) domains of cytoplasmic tyrosine
		The loop in the Crk SH2 domain important for binding the Abl SH3 domain (DE loop) is labeled.
		Crk SH2 domain and residues pY221–P224 of the Crk phosphopeptide.
	www.pnas.org /cgi/content/full/99/22/14053 (4399 words)

	Interactive Fly, Drosophila
		The Drk SH2 domain interacts with a specific phosphotyrosine residue (Y2546) in the intracellular domain of the activated Sev RTK while both Drk SH3 domains bind to proline-rich sequences of the guanine-nucleotide exchange factor Sos, which activates Ras by promoting the exchange of GDP for GTP (Feller, 2002 and references therein).
		Grb2 interacts with Gab1 primarily via its C-terminal SH3 domain, leaving the Grb2 SH2 domain free to bind to the autophosphorylated RTK (Fixman, 1997; Nguyen, 1997).
		Drk and the vertebrate homolog Grb2 have been shown to bind through their SH3 domains to proline-rich peptide sequences in the C-terminal half of the guanine nucleotide exchange factor Sos; these proline-rich peptide sequences conform to the consensus sequences PxxPxR and adopt a left handed polyproline type II helix conformation.
	www.sdbonline.org /fly/torstoll/dautsev1.htm (2008 words)

	The Pawson Lab - Home
		Modular protein domains that mediate protein-protein interactions are critical elements of this process.
		Since the discovery of SH2 domains, the number of different modules has grown into the dozens, many of which we continue to investigate.
		Work on the molecular dissection and functional significance of protein-protein interactions, in signal transduction, is a primary focus of the lab.
	pawsonlab.mshri.on.ca (175 words)

	Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients -- KARDINAL ...
		Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients -- KARDINAL et al.
		Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients
		with nanomolar affinities to the SH3(1) domains of Crk and CRKL
	www.fasebj.org /cgi/content/full/14/11/1529 (5161 words)

	Role of SH3 Domain-Containing Proteins in Clathrin-Mediated Vesicle Trafficking in Arabidopsis -- Lam et al. 13 (11): ...
		The predicted coiled-coil domain (solid) and SH3 domain (dotted) are underlined.
		AtSH3P1 Binds Actin at a Region Distinct from the SH3 Domain.
		SH3), and the GST-SH3 domain fusion were incubated with (right) or without (left) F-actin and centrifuged at 280,000g.
	www.plantcell.org /cgi/content/full/13/11/2499 (6387 words)

	UniProtKB/Swiss-Prot entry O60239 [3BP5_HUMAN] SH3 domain-binding protein 5
		SH3 domain-binding protein that preferentially associates with BTK
		Molecular function: protein kinase inhibitor activity (inferred from direct assay from MGI).
		Molecular function: SH3 domain binding (inferred from direct assay from MGI).
	www.expasy.org /uniprot/O60239 (479 words)

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