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Topic: SLE


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  Systemic Lupus Erythematosus (SLE) Clinical Overview
SLE is a complex disorder affecting a predominately young population and shares similarities with HIV infection as regards the propensity for multiple organ involvement, potentially life-threatening episodes, and need for sophisticated monitoring.
SLE is notable for unpredictable exacerbations and remissions and a predilection for clinical involvement of the joints, skin, kidney, brain, serosa, lung, heart, and gastrointestinal tract.
SLE is associated with anemia of chronic inflammation, acute hemolytic anemia, leukopenia, lymphopenia, and thrombocytopenia.
www.cerebel.com /lupus/overview.html   (3839 words)

  
 SLE   (Site not responding. Last check: 2007-10-12)
SLE is an autoimmune disease in which the body's own immune system is directed against the body's own tissues.
SLE must be distinguished from discoid lupus erythematosus (DLE) which affects the skin (but only in sun exposed regions) and is unlikely to be associated with systemic illness, such as renal disease.
Renal disease is common with SLE because the immune complexes are often deposited in the renal glomeruli.
www-medlib.med.utah.edu /WebPath/TUTORIAL/SLE/SLE.html   (380 words)

  
 Lupus site (SLE)- information on lupus
SLE is a multi-system disease, and before a multi-system disease can be diagnosed, there have to be symptoms in many parts of the body and lab work (blood tests) that supports the presence of a multi-system disease.
SLE is also difficult to diagnose because it is a disease that does not typically develop rapidly, but develops slowly and evolves over time.
SLE is difficult to diagnose because there is no one diagnostic test for lupus, the doctor has to do a full examination of the patient and do various tests, before looking at all the evidence and coming to a conclusion.
www.uklupus.co.uk /new.html   (2180 words)

  
 SLE
SLE is the most important mosquito-transmitted disease in the United States (Goddard 1996).
The viral organism causing the human disease, and the disease known as St. Louis Encephalitis are not synonymous; during an SLE epidemic, large numbers of people become infected, however, only a very small percentage of the SLE infections are clinically apparent and the majority are never diagnosed.
Disadvantages include the fact that the method is highly dependent upon the location of the sentinel chicken flock; the fact that there is a lag between infection and antibody formation; the possibility of non-specific antibody reactions; and the time, labor, and cost associated with development, maintenance, deployment and bleeding of sentinel chicken flocks.
eis.ifas.ufl.edu /SLE\SLE.htm   (1435 words)

  
 Trends in SLE - CDC Study
SLE is one of the more fatal forms of rheumatic diseases and non-Causcasian race is a risk factor for death from SLE; however, trends in death from SLE have not been analyzed recently.
Although SLE mortality is most frequently caused by active SLE or by associated organ failure, infection, or cardiovascular disease from accelerated atherosclerosis, some studies suggest that renal disease might account for excess SLE deaths among fls.
Differential ascertainment and reporting of SLE deaths by race is possible, but probably does not account for the magnitude of observed differences, especially among different age groups for white and fl women.
www.lupusmn.org /education/Articles/TrendsinSLE-CDCStudy.htm   (1076 words)

  
 Early Diagnosis of SLE in Childhood - Lupus Foundation of America, Inc.
Unfortunately, prompt diagnosis of SLE in childhood is the exception, not the rule.
The most important cause for delay in the diagnosis of childhood SLE is the failure of the initial physician to consider the possibility of a lupus diagnosis.
We have established that the most important key to early diagnosis of SLE is to remember that lupus is one of the possibilities in children who become ill. If physicians remember this, they can be sure that a test for antinuclear antibodies (ANA) is included in the laboratory tests that they order.
www.lupus.org /education/topics/early.html   (1155 words)

  
 MedlinePlus Medical Encyclopedia: Systemic lupus erythematosus
In SLE and other autoimmune diseases, these defenses are turned against the body and rogue immune cells attack tissues.
The diagnosis of SLE is based upon the presence of at least four out of eleven typical characteristics of the disease.
Women with SLE who become pregnant are often able to carry the pregnancy safely to term and deliver normal infants, provided severe kidney or heart disease is not present and the SLE is being managed.
www.nlm.nih.gov /medlineplus/ency/article/000435.htm   (1182 words)

  
 Arthritis Research Campaign | Systemic Lupus Erythematosus (SLE)   (Site not responding. Last check: 2007-10-12)
The prevalence of SLE is 4-280 cases per 100,000 (based on ARA criteria, Table 1), the highest prevalence being in Afro-Caribbeans, followed by Asians.
The ESR is elevated in virtually all patients with SLE, particularly during active disease and immunoglobulin and lipid abnormalities contribute to this.
Headaches are frequent in SLE, and organic cause is suggested by their sudden development, an association with double vision, minor seizures or a change in personality.
www.arc.org.uk /about_arth/med_reports/series3/pp/6332/6332.htm   (3487 words)

  
 s030205c - Anti-ds-DNA antibodies - SLE Onset
Abstract: In the present study we assessed the frequency and characteristics of the main causes of morbidity and mortality in SLE during a 5-year period and analyzed the prognostic significance for morbidity and mortality of the main immunologic parameters used in clinical practice.
METHODS: Thirty four of a cohort of 72 SLE patients who were positive for IgM class anti-dsDNA at the start of the study or at the time of a relapse were analysed monthly for class specific anti-dsDNA levels during a median observation period of 19.6 months.
In the 21 SLE patients who developed deterioration in renal function a decrease of C4 followed by decreases of C1q and C3 levels was seen first, starting about 25 to 20 weeks before the first signs of renal involvement.
www.emory.edu /WHSCL/grady/amreport/litsrch02/s030205c.html   (4477 words)

  
 Diagnose-Me: Condition: Lupus, SLE (Systemic Lupus Erythromatosis)
SLE is a complex disorder resulting from the production of antibodies that attack the DNA and proteins within healthy cells and the generation of circulating immune complexes.
In the 60% of SLE patients who experience onset between puberty and the fourth decade of life, the female to male ratio is 9:1.
The miscarriage rate in SLE patients is much higher than that of the general population.
www.diagnose-me.com /cond/C161687.html   (4615 words)

  
 CLINICAL AND LABORATORY FEATURES OF SLE:   (Site not responding. Last check: 2007-10-12)
Neonatal SLE is rare and characterized by A-V block and visceral and hematologic involvement with frequency of anti-Ro antibodies in the mothers.
Sixty-eight patients with SLE were investigated in cross-sectional study that included clinical evaluation, cerebral magnetic resonance imaging (MRI), single photon emission tomography (SPET) analysis, electroencephalography (EEG), and serologic tests for antibodies directed against nuclear, cytoplasmic, plasmatic, neuronal and glial cell-related antigens.
Patients with SLE experience premature atherosclerosis that is more extensive than would be anticipated from their predisposing factors, namely, dyslipidemia and use of corticosteroids.
www.rheuma21st.com /archives/featuresle.html   (4358 words)

  
 St. Louis Encephalitis (SLE)
The SLE virus is not known to cause disease in birds and once infected individual birds are immune to further infection.
In areas where SLE occurs, the local health authorities have established a "Sentinel" program, where caged birds, usually chickens, are monitored for the presence of SLE antibodies.
The SLE virus is an arbovirus (a virus transmitted via arthropods) classified in the family Togaviridae and genus Flavivirus.
www.vicioso.com /Health/disease/encephalitis/SLE.html   (604 words)

  
 Systemic Lupus Erythematosus (SLE)
Many studies investigating SLE are hindered by a failure to isolate different patient subgroups, and study each in isolation.
SLE encompasses so many different diseases, that very few features are common among all of them.
One of the difficulties in developing more specific therapies for SLE has been the failure to identify particular cellular and biochemical pathways that are selective to the type of autoimmunity and inflammation resulting in SLE.
www.smbs.buffalo.edu /med/wnysadrc/systemic.htm   (983 words)

  
 Medem: Medical Library: Systemic Lupus Erythematosus
This article is for people who have systemic lupus erythematosus, commonly called SLE or lupus, as well as for their family and friends and others who want to better understand the disease.
Although SLE usually first affects people between the ages of 15 and 45 years, it can occur in childhood or later in life as well.
It is important for women with SLE or other related autoimmune disorders to be under a doctor's care during pregnancy.
www.medem.com /MedLB/article_detaillb.cfm?article_ID=ZZZGMMT4FDC&sub_cat=179   (5231 words)

  
 SLE   (Site not responding. Last check: 2007-10-12)
Systemic Lupus Erythematosus (SLE) is an auto-immune disease - one of a number of such diseases such as rheumatoid arthritis, pernicious anaemia, etc., in which the body produces antibodies which damage its own tissues, and can affect many body organs as well as the skin.
In SLE, for reasons unknown, the immune system develops a fault; it fails to recognize "self" and produces antibodies against connective tissue - collagen (connective tissue binds the body cells together the way mortar binds the bricks of a building).
SLE is now more common than muscular dystrophy, multiple sclerosis, leukaemia and many other well-known diseases.
www.memorylane.com.au /lupustas/sle.html   (2788 words)

  
 SLE and the kidneys
SLE may do so many different things that it is difficult to list these.
Just as SLE and the kidney diseases it causes are very variable, so the therapies that can be used to treat it are very variable.
As SLE results from some abnormal activity of the body's immune system, it seems logical to use therapy that targets this system; this is called immunosuppressive therapy.
renux.dmed.ed.ac.uk /EdREN/EdRenINFObits/LupusLong.html   (1135 words)

  
 Systemic Lupus Erythematosus   (Site not responding. Last check: 2007-10-12)
Many pediatricians dismiss SLE from their differential diagnosis as 'uncommon in childhood', but positive tests for antinuclear antibodies (ANA) and other findings which warrant inclusion of SLE in the differential diagnosis are in fact quite common.
SLE is an unpredictable disease and may be fatal with or without renal involvement.
When a child or adolescent with SLE becomes noncompliant and difficult, the family and physicians often ascribe the behavior to the psychological problems associated with adolescence and chronic illness or chronic corticosteroid therapy.
www.goldscout.com /page2.html   (2462 words)

  
 5th Tübinger Seminar: SLE and Lupus-Nephritis   (Site not responding. Last check: 2007-10-12)
By measuring antiphospholipid antibodies in patients with SLE a group of persons with increased risk of venous and arterial thrombosis, cerebral complications, recurrent fetal loss and thrombocytopenia can be discerned.
A prophylactic therapy with prednisone in pregnant patients with SLE is not justified.
When SLE is exacerbating, immunosuppressive therapy with prednisone or if needed in combination with azathioprine should be administered.
www.uni-tuebingen.de /CGTS/tusem5_e.htm   (1178 words)

  
 Trends in Deaths from Systemic Lupus Erythematosus --- United States, 1979--1998
Because SLE affects connective tissues and because painful joints and arthritis are among its most common manifestations, this disease is classified with arthritis and other rheumatic diseases (1).
Although SLE mortality is most frequently caused by active SLE or by associated organ failure, infection, or cardiovascular disease from accelerated atherosclerosis (3), some studies suggest that renal disease might account for excess SLE deaths among fls (4).
SLE accounts for 14.5% of all deaths from arthritis (CDC, unpublished data, 1997) and represents one of these conditions that has premature mortality; approximately one third of deaths from SLE occur among persons aged <45 years.
www.cdc.gov /mmwr/preview/mmwrhtml/mm5117a3.htm   (1278 words)

  
 Systemic Lupus Erythematosus, Discoid Lupus Erythematosus (DLE), DLE, Lupus, SLE
Systemic lupus erythematosus (SLE) is an autoimmune illness that causes a characteristic butterfly-shaped rash on the face accompanied by inflammation of connective tissue, particularly joints, throughout the body.
The cause of SLE is unknown, though 90% of cases occur in women of childbearing age.
In addition, people with SLE may have symptoms of mouth sores, joint swelling, hair loss, changes in personality, seizures, and a coin-shaped, red skin rash elsewhere on the body that is aggravated by sunlight.
www.truestarhealth.com /Notes/1233001.html   (3193 words)

  
 Genes in the interferon system important in SLE
Two genes with very strong associations with the disease SLE have been identified by a team of scientists headed by researchers at the Department of Medical Sciences at Uppsala University.
It is therefore possible to imagine the development of methods of treatment for SLE based on blocking the function of the thyrosinkinase enzyme," explains Lars Rönnblom.
FACTS: SLE (systemic lupus erythematosus) is a disease of the rheumatic system that primarily affects fertile women.
www.eurekalert.org /pub_releases/2005-01/src-git011905.php   (565 words)

  
 Joint And Muscle Pain In Systemic Lupus Erythematosus (SLE) - Lupus Foundation of America, Inc.
The major cause of joint pain in SLE is inflammation of the joints.
Neither a positive lab test for antinuclear antibodies or for rheumatoid factor in the blood are proof of SLE or rheumatoid arthritis.
Proper and early treatment for most forms of arthritis, including SLE and rheumatoid arthritis, is available and can significantly slow down damage to the joints and lessen the pain and stiffness.
www.lupus.org /education/brochures/jointpain.html   (1638 words)

  
 SLE (systemic lupus erythematosus) definition - Arthritis and arthritic conditions, medications, and treatment on ...
SLE (systemic lupus erythematosus): A chronic inflammatory condition caused by an autoimmune disease.
SLE is eight times more common in women than men.
The treatment of SLE is directed toward decreasing inflammation and/or the level of autoimmune activity.
www.medterms.com /script/main/art.asp?articlekey=8066   (439 words)

  
 Medical Dictionary: SLE - CureResearch.com
SLE (condition): Autoimmune disease with numerous effects on various organs and linings.
SLE (condition): Lupus is an autoimmune disease affecting mostly women and causing various effects throughout different parts of the body.
SLE: Lupus (also called systemic lupus erythematosus or SLE) is a disorder of the immune system which normally functions to protect the body against invading infections and cancers.
www.cureresearch.com /medical/sle.htm   (503 words)

  
 AllRefer Health - Systemic Lupus Erythematosus (Disseminated Lupus Erythematosus, Lupus, Lupus Erythematosus, SLE)
In systemic lupus erythematosus (SLE) and other autoimmune diseases, these defenses are turned against the body and rogue immune cells attack tissues.
Some people with SLE have deposits of protein within the cells (glomeruli) of the kidney.
Mild mental dysfunction is the most common symptom, but any area of the brain, spinal cord, or nervous system can be affected.
health.allrefer.com /health/systemic-lupus-erythematosus-info.html   (841 words)

  
 Revolution 1.5 SLE at WindPower Sports Kite Store
The Revolution 1.5 SLE continues to be dominant quad line sport kite on the market.
Weighing 10 oz with a 92" wingspan and a sail of ripstop polyester, the Rev 1.5 SLE is quicker and flies faster than the Revolution EXP with enhanced controllability.
The 1.5 SLE boasts an amazingly crisp dive stop maneuver which will impress the crowds you attract.
www.windpowersports.com /kites/revolution/15sle.html   (314 words)

  
 Laboratory Tests Used to Diagnose and Evaluate SLE
Leukopenia, a decrease in the number of WBCs, is very common in active SLE and is found in 15-20% of patients.
A screening test for ANA is standard in assessing SLE because it is positive in close to 100% of patients with active SLE.
Anti-Ro is found in 30% of SLE patients and 70% of patients with primary Sjögren's syndrome.
webmd.com /content/article/5/1680_51589.htm?...   (1261 words)

  
 Lupus: medical information about the diseases of lupus, its causes, symptoms, diagnosis and treatments
Dozens of medications have been reported to trigger SLE; however, more than 90% of this "drug-induced lupus" occurs as a side effect of one of the following six drugs: hydralazine (used forhigh blood pressure), quinidine and procainamide (used for abnormal heart rhythm), phenytoin (used forepilepsy), isoniazide (used fortuberculosis), d- penicillamine (used for rheumatoid arthritis).
Fortunately, drug-induced SLE is infrequent (accounting for less than 5% of SLE among all patients with SLE) and usually resolves when the medications are discontinued.
It also is known that some women with SLE can experience worsening of their symptoms prior to their menstrual periods.
www.medicinenet.com /systemic_lupus/article.htm   (769 words)

  
 Medical Dictionary: SLE - WrongDiagnosis.com
SLE: Another name for Lupus (or close medical condition association).
SLE: SLE is listed as a type of (or associated with) the following medical conditions in our database: Autoimmune diseases, Rheumatic conditions, Systemic disorders, Connective tissue disorders, Diseases contagious contagious mother-to-fetus SLE (medical condition): Autoimmune disease with numerous effects on various organs and linings.
SLE (medical condition): Lupus is an autoimmune disease affecting mostly women and causing various effects throughout different parts of the body.
www.wrongdiagnosis.com /medical/sle.htm   (380 words)

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