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Topic: SPECT

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	Why Don't Psychiatrists Look at the Brain?
		Her SPECT study revealed markedly decreased perfusion in the anterior and posterior aspects of her left temporal lobe, a coup-contrecoup injury, and decreased activity in the inferior orbital prefrontal cortex (see Figure 5).
		J's SPECT study was highly abnormal, showing marked hyperperfusion in the anterior cingulate gyrus as well as significant hypoperfusion in the prefrontal cortex and temporal lobes (see Figures 7, 8, and 9).
		SPECT studies may also help to break through the psychological barriers that people with substance abuse problems often erect: When patients are faced with vivid images of the abnormal cerebral perfusion in their own brains, it is harder for them to remain in denial about their problem.
	www.neuropsychiatryreviews.com /feb01/npr_feb01_spect.html (3597 words)

	SPECT scan\| Single Photon Emission Computed Tomography \| Mayfield Clinic (Site not responding. Last check: 2007-08-19)
		Before the SPECT scan, you are injected with a chemical that is radiolabled, meaning it emits gamma rays that can be detected by the scanner.
		SPECT scanning is also useful for pre-surgical evaluation of medically uncontrolled seizures (Figure 1).
		The radioisotopes typically used in SPECT to label tracers are iodine-123, technetium-99m, xenon-133, thallium-201, and fluorine-18.
	www.mayfieldclinic.com /PE-SPECT.htm (773 words)

	SPECT Scan
		A SPECT Scan is capable of providing information about blood flow to tissue.
		As part of the family of nuclear imaging techniques, PET and SPECT scans use small amounts of radionuclides (radioactive isotopes) to measure cellular/tissue change.
		Women who are pregnant are not able to undergo PET or SPECT Scanning because of the radioactive isotopes used.
	www.spineuniverse.com /conditions/spectscan.html (559 words)

	s020923b - SPECT - Lymphoma or Toxoplasmosis?
		CONCLUSIONS: 99mTc-HMPAO labeled leukocyte SPECT is useful for the differential diagnosis of intracerebral ring-enhancing lesions, and the use of steroids or antibiotics does not influence the sensitivity of SPECT.
		The SPECT findings in the seventh patient were classified as false-positive for tumor on the basis of the prospective interpretation of the images; three concurrent infections were found at autopsy.
		This preliminary study indicates that 201Tl SPECT might be a useful, noninvasive method for differentiating intracranial lymphoma from nonneoplastic lesions in patients with AIDS.
	www.emory.edu /WHSCL/grady/amreport/litsrch02/s020923b.html (3727 words)

	SPECT Overview \| New Perspectives SPECT Lab, LLC (Site not responding. Last check: 2007-08-19)
		The use of a brain SPECT scan is based on the principal of blood flow.
		The SPECT Gamma camera system collects these particles and passes them complex system which reconstructs a working image of the brain.
		Using SPECT imaging in the field of neurology and psychiatry allows visualization of the components of the many systems that run our emotional state, our motivation level, our concentration and memory ability and more.
	www.brain-spect.com /spectoverview.html (930 words)

	Brain SPECT Imaging (Site not responding. Last check: 2007-08-19)
		Some of the most common reasons SPECT is ordered include: evaluating suspected seizure activity, analyzing the physiology of underlying mood disorders, evaluating unusual or unresponsive neuropsychiatric conditions, subtyping ADD, evaluating violence and aggression, looking for causes of deteriorating mental functioning.
		SPECT is a powerful tool in combination with clinical history, personal interview, neuropsychological tests, checklists, and collateral information.
		SPECT studies actually show which parts of the brain are activated when we concentrate, laugh, sing, cry, visualize, or perform other functions.
	www.momsanddadsathome.com /spect_imaging.htm (1036 words)

	Brain Spect (Site not responding. Last check: 2007-08-19)
		Brain SPECT is a way for your physician to see how blood is flowing through different areas of your brain.
		A SPECT (single-photon emission computed tomography) brain scan is a diagnostic nuclear medicine imaging procedure that permits physicians to visualize brain function by obtaining three-dimensional images of the brain.
		The SPECT camera, capable of imaging the areas of your brain where the radiopharmaceutical has accumulated, will be moved near your head.
	www.amershamhealth-us.com /patient/diaguide/spect.html (1027 words)

	CT and SPECT Image Registration and Fusion
		The primary role of multimodal image registration and fusion is to increase the specificity of the SPECT study performed and to enhance the sensitivity of CT for the identification in colon and ovarian carcinoma.
		SPECT imagery that have been registered to the CT slices can be compared directly, without fearing that they represent a different area of the body.
		False-positives in the SPECT images have been observed related to activity in the blood pool and in anomalous foci in the liver.
	www.loats.com /docs/3DBS-CTandSPECT/CTandSPECT.htm (3246 words)

	SPECT Scanning for Parathyroid Glands (Site not responding. Last check: 2007-08-19)
		SPECT scanning can be performed at any time within the first several hours after a patient is injected with the radioactive Sestamibi radiopharmaceutical.
		The most important use for SPECT scanning is when ordinary Sestamibi scans are inconclusive or when a more detailed anatomic localization is necessary such as when patients are being re-operated on.
		Some believe that the SPECT scanning to localize parathyroid glands is a bit over used, and have suggested that it will be less necessary as hospitals become more experienced with the routine sestamibi scan.
	www.endocrineweb.com /spect.html (199 words)

	Does Your Pet Bite? (Site not responding. Last check: 2007-08-19)
		Harper admitted on cross-examination that the SPECT scan was the "basic supporting" evidence of his theory of toxic encephalopathy along with the plaintiff’s history.
		Harper agreed that a SPECT scan is a measure of "blood flow" rather than a test of "function" and admitted that a SPECT could not establish the cause, date or duration of the decrease in perfusion.
		Harper, who was unaware of the second SPECT until the time of his cross-examination, conceded that the remaining area of mildly abnormal perfusion in the left frontal area "would not explain most of the complaints that we had talked about." Id.
	www.morankikerbrown.com /FSL5CS/articles/articles12.asp (4338 words)

	Silicon Valley Brain SPECT Imaging, Inc.
		Brain SPECT (single photon emission computed tomography) imaging is a nuclear medicine study, utilizing minute doses of radioactive Isotopes bound to neurospecific pharmaceuticals to study cerebral perfusion and thus indirectly brain metabolic activity.
		Normal brain SPECT Images reveal homogeneous and uniform tracer accumulation throughout the cerebral cortex, with the cerebellum being the area with the most intense activity.
		Chiron studied the normal progression of cerebral perfusion in children and found that by the age of 2 or 3 there is the same relative perfusion patterns as those seen in adults.
	braininspect.com /spect_research.php (1357 words)

	CBDB SPECT Program
		SPECT IQNB scans demonstrated focal areas of reduced uptake in patients with dementia.
		- SPECT imaging of D2 receptors in Mz twins discordant for severity of Tourette’s syndrome: significant correlation of increased IBZM uptake in caudate with degree of discordance for tic severity.
		SPECT is readily available in many Nuclear Medicine Departments giving the possibility of wide utilization once appropriate single photon tracers and quantification methods have been established.
	cbdb.nimh.nih.gov /spect.htm (1005 words)

	SPECT in the Year 2000: Basic Principles -- -- Journal of Nuclear Medicine Technology
		The total SPECT study acquisition time is T = mt, where m is the number of views acquired (in this case, 60 views over 360°, at 6° intervals).
		Tc-HMPAO brain SPECT study (bottom, left to right) demonstrate the superiority of the Butterworth filter (much better resolution than the 0.5 Nyquist Hamming, yet both better resolution and less noise than the 1.0 Nyquist Hamming).
		Fundamentals of 180 degree acquisition and reconstruction in SPECT imaging.
	tech.snmjournals.org /cgi/content/full/28/4/233 (5704 words)

	NIH Guide: DEVELOPMENT OF PET AND SPECT LIGANDS FOR BRAIN IMAGING (PHASED INNOVATION AWARD)
		This initiative is intended to facilitate the development of: 1) PET and SPECT probes for molecular targets (e.g., receptors, intracellular messengers, disease-related proteins) that are of broad interest to the neuroscience research community, and 2) new technologies for radiotracer development.
		The primary motivation for this initiative is the lack of versatile agonist and antagonist PET and SPECT radiotracers for molecular targets that are implicated in brain disorders.
		Since the goal of the R21 phase of this RFA is the development of novel radioligands for PET and SPECT imaging in preclinical and clinical studies or innovative technologies for radioligand development, hypothesis testing per se may not be the driving force in developing such a proposal, and therefore, may not be applicable.
	grants.nih.gov /grants/guide/rfa-files/RFA-MH-02-003.html (5267 words)

	Recent Developments in the Use of PET and SPECT Scans to Prove Causation and Injury in Toxic Tort Litigation
		Rhilinger had no other identifiable disease process or diagnosis to account for her abnormal SPECT scan results; and, (4) her MRI was normal, thus ruling out other possible origins of her cognitive difficulties.
		Thus, as in the Hose case, the plaintiff got in her SPECT evidence in a round-about way by using it to show a diagnosis “consistent with” toxic exposure.
		While this case did not deal with the admissibility of PET or SPECT evidence, it bears mentioning because the Eighth Circuit noted in its opinion that the plaintiff failed to have one of these tests performed to confirm the existence of a physical injury.
	www.morankikerbrown.com /CM/Articles/Articles67.asp (3746 words)

	Howstuffworks "How Nuclear Medicine Works"
		But the radioactive substances used in SPECT (Xenon-133, Technetium-99, Iodine-123) have longer decay times than those used in PET, and emit single instead of double gamma rays.
		SPECT can provide information about blood flow and the distribution of radioactive substances in the body.
		Also, SPECT centers are more accessible than PET centers because they do not have to be located near a particle accelerator.
	science.howstuffworks.com /nuclear-medicine3.htm (93 words)

	Silicon Valley Brain SPECT Imaging Inc.
		Brain SPECT Imaging (BSI) is a nuclear medicine study that allows us to view the blood flow to the different regions of the Brain.
		Currently there is an extensive amount of clinical and research data available to substantiate the use of Brain SPECT Imaging (BSI) in evaluating brain trauma, dementia (including Alzheimer's, Pick's, and Vascular dementias) and cognitive decline, atypical psychiatric disorders, cerebral vascular disorders, and temporal lobe epilepsy.
		William Klindt, M.D. is founder and director of Silicon Valley Brain SPECT Imaging, Inc. He is one of only a handful of Psychiatrists in the country to be licensed to perform Brain SPECT Imaging (BSI).
	www.braininspect.com (415 words)

	[No title]
		Single Photon Emission Computed Tomography (SPECT) is a nuclear medicine technique which we use to image brain function.
		As the tracer is slightly radioactive, we are able to detect it within the brain and produce images representing the way the brain has functioned in taking up and using the tracer.
		The Institute of Neurological Sciences has a dedicated brain SPECT scanner which is used for diagnosis and patient monitoring in both neurology and psychiatry including neurological diseases (dementias), epilepsy, head trauma, neoplasms and cerebrovascular diseases.
	www.gla.ac.uk /departments/clinicalphysics/neuroimaging/SPECT (100 words)

	The Basics of Brain Imaging
		Advances in all these techniques are enabling scientists to produce remarkably detailed computer-screen images of brain structures and to observe neurochemical changes that occur in the brain as it processes information or responds to various stimuli such as drugs of abuse or drug abuse treatment medications.
		SPECT tracers also deteriorate more slowly than many PET tracers, which means that SPECT studies require longer test and retest periods than PET studies do.
		While PET is more versatile than SPECT and produces more detailed images with a higher degree of resolution, particularly of deeper brain structures, SPECT is much less expensive than PET and can address many of the same drug abuse research questions that PET can.
	www.nida.nih.gov /NIDA_Notes/NNVol11N5/Basics.html (1142 words)

	Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome -- O’Brien et al. 55 (11): ...
		Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome -- O’Brien et al.
		Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome
		epilepsy with subtraction ictal SPECT coregistered with MRI
	www.neurology.org /cgi/content/abstract/55/11/1668 (477 words)

	Single Photon Emission Computed Tomography, 330 (Site not responding. Last check: 2007-08-19)
		SPECT is necessary to confirm the infection or inflammation.
		SPECT is not technically capable of detecting hemorrhage prior to consideration of thrombolytics.
		SPECT: One report of Th 201 SPECT (n=17, Lorberboym 1995) noted detection of disease progression in 9/17 patients, compared to only 3/17 noted on CT. Other studies averaged data for a single scan among various patients groups.
	www.bcbsma.com /common/en_US/medical_policies/330.htm (7284 words)

	Prospective Value of Perfusion and X-Ray Attenuation Imaging With Single-Photon Emission and Transmission Computed ...
		Stepwise improvement in the prediction of total MCA territory infarction after rating of the early TCT and SPECT images in addition to clinical evaluation on admission, corresponding to the sequence of event in the clinical setting.
		Brain SPECT imaging with Tc-99m-hexamethylpropyleneamine oxime in the early detection of cerebral infarction: comparison with transmission computed tomography.
		Tc-HMPAO SPECT imaging in early spontaneous reperfusion of cerebral embolism.
	stroke.ahajournals.org /cgi/content/full/32/7/1588 (5260 words)

	Registration of SPECT and CT Brain Images
		The two techniques usually generate a set of transverse slices at approximately the same orientation in three-dimensional space; however, slice thickness, slice position and spatial resolution are different, and direct comparisons between modalities is difficult.
		For CT, slice thickness is much greater than pixel size in a tranverse slice; hence the reconstructed coronal and sagittal sections exhibit poor spatial resolution, despite the high level of detail visible in transverse sections.
		The registration of CT and SPECT images is an example of the wider problem of registering images of high and low resolution with no corresponding internal or external landmarks.
	www.comp.leeds.ac.uk /comir/research/brains/brains.html (810 words)

	Abnormal regional cerebral blood flow on 99mTc ECD brain SPECT in patients with primary Sjogren's syndrome and normal ...
		SPECT to evaluate rCBF in the brains of patients with pSS.
		Technetium-99m d,l-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion.
		SPECT imaging of normal subjects with technetium-99m-HMPAO and technetium-99m-ECD.
	ard.bmjjournals.com /cgi/content/full/61/9/774 (2478 words)

	ECG-Gated 99mTc Single-Photon Emission CT for Assessment of Right Ventricular Structure and Function: Is the ...
		SPECT are both subject to errors, and may be based on different
		ECG-gated SPECT for assessment of the RV is sought.
		Mannting, F, Morgan-Mannting, MG Gated SPECT with technetium-99m-sestamibi for assessment of myocardial perfusion abnormalities.
	www.chestjournal.org /cgi/content/full/124/1/227 (3099 words)

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