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Topic: SRY

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	SRY Missense Paper
		The existence of the SRY gene was shown by the polymerase chain reaction (PCR) as described elsewhere (5).
		Detection of a mutation in the SRY gene.
		The arrow indicates the nucleotide substitution G to A in the 107th codon from the methionine initiation codon of the SRY gene.
	www.bio.davidson.edu /courses/Molbio/srypaper.html (865 words)

	SRY - Wikipedia, the free encyclopedia
		Individuals with a male phenotype and an XX (female) genotype have been observed; these males have the SRY gene in one or both X chromosomes, moved there by chromosomal translocation.
		Mice with a XX genotype but with an SRY gene on one of their X chromosomes have been engineered; these mice are phenotypically male.
		Athletes with a SRY gene were not permitted to participate as females, although all athletes in whom this was "detected" at the 1996 Summer Olympics were ruled false positives and were not disqualified.
	en.wikipedia.org /wiki/SRY (433 words)

	BioMed Central \| Full text \| A del(X)(p11) carrying SRYsequences in an infant with ambiguous genitalia (Site not responding. Last check: 2007-10-17)
		SRY (sex-determining region, Y) is the gene responsible of gonadal differentiation in the male and it is essential for the regular development of male genitalia.
		The SRY (sex-determining region Y), which is normally located in the distal part of the short arm of the Y chromosome is a genetic 'master switch' of gonadal differentiation [1], the product of which is present in the male genital ridge before testis formation and is required for the regular development of male genitalia [2].
		SRY encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA binding proteins and in mammals triggers the development of undifferentiated gonads towards a testicular phenotype [1,3].
	www.biomedcentral.com /1471-2431/6/11 (1619 words)

	XX Male
		SRY is the candidate gene for the testis determination.
		It is possible that in the present case XX male (SRY negative) may have a recessive mutation in the Z locus, so that it cannot switch off the male determining genes [11] and therefore the present case has normal male phenotypes and testicular development.
		Inspite of the fact that SRY is the testis determining factor (TDF), it is likely that other genes are also involved in pathway of sex determination and differentiation process as both upstream and downstream regulator genes.
	www.priory.com /med/xx.htm (1356 words)

	SRY - Ganfyd
		A trigger – the SRY gene – is responsible for switching on a genetic programme that turns the embryo into a male.
		The SRY gene is found on the p arm of the Y chromosome and encodes for the testis determining factor (TDF).
		If the SRY gene on a Y chromosome is sufficiently mutated that functioning TDF is not produced, the embryo will develop into an XY female.
	ganfyd.org /index.php?title=SRY (179 words)

	Male Determining Factor SRY: Genetic Music (Site not responding. Last check: 2007-10-17)
		The SRY protein is encoded by a gene on the Y chromosome and is a control factor that directs the differentiation of a testis in male embryos.
		SRY binding to the DNA helix bends the DNA and alters its accessibility to other genetic regulators.
		The full SRY sequence is bracketed by an introduction and closing section (chimes) derived from the first part of the sequence, including both DNA and protein informtion.
	www.whozoo.org /mac/Music/SRY.htm (202 words)

	Sry Associates with the Heterochromatin Protein 1 Complex by Interacting with a KRAB Domain Protein -- Oh et al. 72 ...
		A) Schematic of the mouse SRY, DomSRY (Domesticus strain).
		SRY and KAP1, the mouse SRY colocalized with KAP1 in significantly
		The colocalization of the mouse SRY with endogenous HP1
	www.biolreprod.org /cgi/content/full/72/2/407 (6511 words)

	SRY Gene - DNA Analysis (Site not responding. Last check: 2007-10-17)
		The Y chromosome-specific gene SRY is one of the key genes involved in human sex determination.
		The SRY gene encodes a testis-specific transcription factor that plays a central role in sexual differentiation and development in males.
		Testing for the presence or absence of the SRY gene is very useful in the molecular assessment of patients with abnormal sexual differentiation.
	www.bcm.edu /geneticlabs/tests/dna/sry_dna.html (162 words)

	SRY protein explains why men more likely to develop Parkinson's
		SRY, the protein that determines male gender, was discovered by British scientists in 1990.
		SRY is passed from father to son on the Y chromosome and is not present in females.
		Drs Vilain and Harley believe that the variations in genes that control SRY or in the SRY gene itself may be linked to the onset of Parkinson's disease.
	www.news-medical.net /?id=16189 (639 words)

	SRY - FISH Analysis
		FISH for SRY testing may also be appropriate in newborns with ambiguous genitalia.
		It is a rapid, reliable and direct approach for identifying patients with microdeletions or translocations involving the SRY locus.
		Probes for the X centromere and SRY are used simultaneously in order to determine if SRY is deleted or translocated to the X chromosome.
	www.bcm.edu /geneticlabs/tests/cyto/sry_fish.html (205 words)

	SRY - Talk Medical
		SRY: Sex region Y, a region on the Y chromosome that determines the sex of the individual.
		Mutations in SRY give rise to XY females with gonadal dysgenesis who appear to be normal females at birth, but at puberty do not develop secondary sexual characteristics (breasts, etc.), do not menstruate, and have streak (fibrous) gonads without eggs.
		SRY resides in chromosome band Yp11.3 and encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA binding proteins.
	www.talkmedical.com /medical-dictionary/13358/SRY (158 words)

	[No title]
		Sry is a member of the large Sox HMG gene family postulated to have evolved from an ancestor of its paralogue on the Y chromosome, Sox3.
		Sry, previously known as TDF (Testis-Determining Factor), is the single gene that initiates a long cascade toward becoming male in all mammals.
		SRY isn’t a typical transcription factor, though, and all the players in the mammalian sex determination pathway are not understood.
	www.csit.fsu.edu /~ronquist/compgen/SRY.manuscript.doc (5169 words)

	GeneCard for SRY
		Familial mutation in the testis-determining gene SRY shared by an XY female and her normal father.
		Clore G.M. A mutation in the 5' non-high mobility group box region of the SRY gene in patients with Turner syndrome and Y mosaicism.
		Schmidtke J. 41 kilobases of analyzed sequence from the pseudoautosomal and sex- determining regions of the short arm of the human Y chromosome.
	www.genecards.org /cgi-bin/carddisp.pl?gene=SRY (996 words)

	The Rockefeller University - Laboratory of Molecular Biophysics
		The laboratory chose to study the closely related HMG family member SRY because of the role of SRY protein in determining male sex in humans.
		The principle discovery of the study of the HMG-domain of SRY bound to DNA was the presence of a novel mode of protein-induced distortion of DNA structure via protein sidechain intercalation.
		Thus, SRY and Lef-1 act as architectural elements in the enhancer, creating the structural environment in which other proteins may interact with one another; for example, the ETS1 and ATF/CREB proteins bind at sites located 70 basepairs apart, yet interact with one another in the complex in the presence of Lef-1.
	www.rockefeller.edu /labheads/werner/malesex.php (1001 words)

	Rediscovering Biology - Online Textbook: Unit 11 Sex and Gender
		Introduction of the mouse SRY gene into an XX mouse causes the formation of testis and the animal develops as a male anatomically; however, it does not produce sperm.
		Thus, SRY is the testis-determining factor, and is the only gene on the Y chromosome that is essential for development of male genitalia.
		Without SRY to stimulate testis development, the gonad becomes an ovary and the embryo develops into a female; the development pathways of both male and female are complex, however, and are regulated by several gene products (Fig.
	www.learner.org /channel/courses/biology/textbook/gender/gender_7.html (458 words)

	The C-terminal Nuclear Localization Signal of the Sex-determining Region Y (SRY) High Mobility Group Domain Mediates ...
		The sex-determining factor SRY is a DNA-binding protein that diverts primordial gonads from the ovarian pathway toward male
		The SRY oligonucleotide was incubated in the absence (lane 5) and the presence of SRY(HMG)-GFP (lanes 5-10), which was also incubated in the presence of excess (10-fold) unlabeled probe (lane 7) and importins (lanes 8-10) as indicated.
		SRY directly as demonstrated using a range of assays.
	www.jbc.org /cgi/content/full/276/49/46575 (4984 words)

	SRY XY
		SRY and Y fragments will only be amplified from individuals with a Y chromosome.
		Lanes 2 and 5 SRY amplification, lanes 3 and 6 X amplification, lanes 4 and 7 Y amplification.
		Note the absence of amplification of SRY and Y from female DNA (lanes 5 and 7).
	www.genelink.com /technical/sryxy.html (611 words)

	SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity -- Yuan et al. 276 (49): 46647 ...
		SRY repression of AR transcriptional activity on the PSA gene.
		Inhibition of SRY Protein Degradation by the AR-- Expression of the SRY protein in the stably transfected LNCaP-SRY cells was assessed by immunoblotting.
		SRY protein expression is increased by ligated AR and by proteosome inhibitors.
	www.jbc.org /cgi/content/full/276/49/46647 (5887 words)

	SRY: Sex determination
		Analysis of such individuals has revealed some of the molecules involved in sex determination, including one called SRY, which is important for testis formation.
		SRY (which stands for sex-determining region Y gene) is found on the Y chromosome.
		Since human SRY is similar to SRY of mice, a model of SRY function has been developed in mice.
	www.ncbi.nlm.nih.gov /disease/SRY.html (265 words)

	Southern Railway of British Columbia
		Southern Railway of British Columbia (SRY) is a major transporter of freight in British Columbia providing the highest quality service at a competitive cost.
		SRY is based in New Westminster, British Columbia, and services the lower mainland and Fraser Valley providing seamless and competitive freight transportation services to markets throughout North America.
		Southern Railway of Vancouver Island Limited (SVI), is an operating company of SRY based in Nanaimo, British Columbia.
	www.sryraillink.com (78 words)

	Southern Railway of British Columbia
		the SRY Industrial Park consists of for-sale and for-lease properties strategically located along the SRY's 62 miles of mainline, served exclusively by the SRY.
		Along with their central locations, they provide the benefit of having access to a large labor force, linkages to suppliers, are close to local markets in both the Canada/US border cities and have quick and easy access to urban transportation infrastructure.
		Within the SRY Industrial Park, we work very closely with shared partners, realtors and developers to market well-located and rail-served land along the railway.
	www.sryraillink.com /industrial_properties.htm (190 words)

	The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) ...
		The nuclear magnetic resonance structure of the SRY HMG domain, showing the three x-helices and the L-shaped conformation and binding to the minor groove of DNA causing it to bend and severely unwind (35).
		The SRY mutations in the C-terminal NLS, R133W,
		Sry gene (19, 57, 125), indicating that the transgene is subject
	edrv.endojournals.org /cgi/content/full/24/4/466 (10148 words)

	SRY GENE (Site not responding. Last check: 2007-10-17)
		On the other hand, male with XX chromosomal constellation carry a translocation of the SRY gene to one of the X chromosomes or to one of the autosomes developing a male phenotype as a consequence.
		By its structure, the SRY gene is a 1,0 kb one exon gene located just centromeric to the pseudoautosomal region of Yp functioning as the dominant inducer of testis development.
		To determine the frequency of abnormal presence or absence of SRY gene in the whole group of sexual differentiation disorders for the purpose of finding out which of these disorders occur in the early stage of sexual differentiation.
	e20.manu.edu.mk /rcgeb/tempus/SRYGENE.html (2646 words)

	Familial Mutation in the Testis-Determining Gene SRY Shared by an XY Female and Her Normal Father -- Jordan et al. 87 ...
		on fragments of SRY amplified from the DNAs of the proband,
		SRY shared by an XY female and her phenotypically normal father.
		Cameron FJ, Sinclair AH 1997 Mutations in SRY and SOX9: testis-determining genes.
	jcem.endojournals.org /cgi/content/full/87/7/3428 (3143 words)

	Two genes -- Dax 1 and Sry -- required for testis formation
		Dax1 had been widely accepted as an “anti-testis” or ovary-determining gene because patients with a duplication or “double dose” of Dax1 had features of XY sex reversal, a condition in which individuals have the chromosomes of males but the physical attributes of females.
		Because most XY females do not have Sry mutations, Joshua J. Meeks, Jeffrey Weiss, and J. Larry Jameson, M.D., of the Feinberg School of Medicine at Northwestern University, hypothesized that other genes are necessary for testis determination.
		Expression of the Sry gene was similar in Dax1-deleted mice and in those in which Dax1 was normal, indicating that sex reversal is not caused by reduced Sry levels in Dax1-deleted mice.
	www.eurekalert.org /pub_releases/2003-04/nu-tg-040803.php (382 words)

	UNSW Embryo- Molecular Development- Sry
		Sry is the protein involved with male sex determination.
		The gene is located on the chromosome (which has a very low gene density).
		SRY (sex-determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
	embryology.med.unsw.edu.au /MolDev/factor/sry.htm (276 words)

	Porcine SRY Promoter Is a Target for Steroidogenic Factor 1 -- Pilon et al. 68 (4): 1098 -- Biology of Reproduction (Site not responding. Last check: 2007-10-17)
		Sry expression is restricted to the somatic component of the
		of 5' flanking sequences from the porcine SRY gene locus.
		Evidence that the SRY protein is encoded by a single exon on the human Y chromosome.
	www.biolreprod.org /cgi/content/full/68/4/1098 (5846 words)

	Ontogeny and cellular localization of SRY transcripts in the human testes and its detection in spermatozoa -- Modi et ...
		Ontogeny and cellular localization of SRY transcripts in the human testes and its detection in spermatozoa -- Modi et al.
		The sex-determining region on the Y (SRY) gene is unequivocally
		The mRNA for SRY was detected in the spermatogenic
	www.reproduction-online.org /cgi/content/abstract/130/5/603 (313 words)

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