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Topic: SSRIs

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	benzo.org.uk : SSRIs, Drug Withdrawal & Abuse: Problem or Treatment? CH Ashton & AH Young, 1999
		Advantages of SSRIs include: greater tolerability and safety and a wider range of clinical applications, one of which is a potential use in the treatment of drug abuse and some eating disorders (see also: Chapter 4).
		A second factor proposed to account for SSRI withdrawal effects is a decline in serotonergic transmission, although there is no direct evidence for this and the mechanisms for producing particular withdrawal symptoms are obscure.
		SSRIs, including zimelidine, citalopram, viqualine and fluoxetine have been shown in controlled studies to decrease alcohol consumption in non-depressed alcoholics and heavy or problem drinkers.
	www.benzo.org.uk /ssri.htm (6334 words)

	Medinfo: SSRIs
		SSRIs, Selective Serotonin Re-uptake Inhibitors, are a widely used group of antidepressants, which includes such drugs as fluoxetine (Prozac) and paroxetine (Seroxat).
		SSRIs are mostly used for treatment of depression, but individual members of the group have other, specialised uses eg anxiety, panic disorder, obsessive compulsive disorder, eating disorders, and social phobia.
		SSRIs only work after they have built up in your system, and thus need to be taken regularly, and will start to have their effects after two weeks or more.
	www.medinfo.co.uk /drugs/ssris.html (586 words)

	Clinical Pharmacology of SSRI's: How SSRIs as a Group Differ From TCAs
		SSRIs, because of their more focused pharmacology, have a much more limited range of pharmacodynamically mediated drug-drug interactions than do TCAs.
		In contrast, SSRIs as a group have a higher incidence of adverse effects mediated by the indirect potentiation of serotonin via the inhibition of its uptake pump (eg, nausea).
		The difference between TCAs and SSRIs with regard to TDM is that it is a standard of care issue with TCAs, but not with SSRIs, due to the difference in their therapeutic indexes (ie, the difference between a dose that is therapeutic and one that is toxic).
	www.preskorn.com /books/ssri_s4.html (2246 words)

	Gale Encyclopedia of Medicine: Selective serotonin reuptake inhibitors
		The recommended dosage depends on the type of SSRI and the type and severity of depression for which it is being taken.
		Because SSRIs work on the central nervous system, they may add to the effects of alcohol and other drugs that slow down the central nervous system, such as antihistamines, cold medicine, allergy medicine, sleep aids, medicine for seizures, tranquilizers, some pain relievers, and muscle relaxants.
		SSRIs may occasionally cause dry mouth, although this side effect is much more common with an older class of antidepressants known as tricyclics.
	www.findarticles.com /p/articles/mi_g2601/is_0012/ai_2601001233 (1047 words)

	Clinical Pharmacology of SSRI's: How SSRIs as a Group Are Similar
		While the effect on antidepressant response and serotonin uptake inhibition of the SSRIs has on average reached the plateau portion of their dose-response curve, that is not true for their discontinuation rate due to adverse effects (Figure 5.1) nor for the effects of specific SSRIs on specific CYP enzymes (eg, fluoxetine on CYP 2D6).
		The concentration-dependent nature of antidepressant response with the SSRIs is apparent from the flat-dose antidepressant-response relationship and the fact that it parallels the dose- and concentration-dependent effect on serotonin uptake inhibition (Figure 5.3).
		In fact, the manufacturer may actually have a disincentive out of concern that the demonstration of such a relationship might be used to suggest that TDM is necessary with their medication and thus create a perception that may adversely impact the clinical acceptance of the drug.
	www.preskorn.com /books/ssri_s5.html (6315 words)

	SSRIs
		The least expensive SSRI is fluoxetine, which is the least expensive of all anti-depressants at only $3.30 per month at the wholesale rate and standard dose.
		SSRIs Did Better for Young Women: In a small prospective study of venlafaxine, an SSRI, or nefazodone for 115 female patients with major depression for 8 weeks, younger women responded faster and better and were helped more by the SSRI.
		The SSRI increased the brain GABA concentration in the occipital cortex by 35%.
	www.modern-psychiatry.com /new_page_17.htm (1560 words)

	Afkicken van een ssri /seroxat dossier (Site not responding. Last check: 2007-11-06)
		SSRIs have been shown to be very effective in the treatment of depressive, anxiety and obsessive-compulsive disorders and have a favorable side effect profile.
		It is possible that the effects SSRI on platelet functioning are causing the bleeding observed in some patients and/or that a separate coagulopathy is present and contributing to bleeding.
		CONCLUSIONS: SSRI use appears to be associated with the development of movement disorders, as either a direct result of the drug or exacerbation of an underlying condition.
	www.dadoo.nl /pfg/ssri-bijwerkingen.htm (5601 words)

	TREATMENTS FOR DEPRESSION - SSRIs
		SSRIs are antidepressants which are used to help to improve mood in people who are feeling low or depressed.
		The SSRIs are classified as "B" or "C" (fluoxetine, paroxetine and sertraline are "B", citalopram and fluvoxamine are "C").
		No major abnormalities have been reported to date with paroxetine, but some "discontinuation" effects (such as increased breathing rate and jitteriness) have been seen in a few infants for a couple of days after birth, so it may be wise to reduce the dose a little before your due date.
	www.nmhct.nhs.uk /pharmacy/depr2.htm (3431 words)

	SSRIs LBand (Site not responding. Last check: 2007-11-06)
		SSRIs cause sexual dysfunction by inhibiting the production of nitric oxide, which is the main mediator of both the male and female sexual arousal response.
		The effect of SSRIs on libido may be the result of multiple factors that impact the central nervous system, especially the mesolimbic system.
		SSRIs have also been associated with increasing prolactin levels, which may have effects on the central nervous system, resulting in decreased libido.
	www.newshe.com /articles/SSRIsLBand.shtml (1507 words)

	Nutrition Articles - The Relationship between Weight Gain and Medications for Depression and Seizures
		SSRIs comprise one of the major classes of antidepressants currently being prescribed by primary care physicians.
		At first, SSRIs were thought to be associated with weight loss and reduced appetite.
		Primary care providers are not likely to be familiar with the difference between the various SSRIs relative to their possible weight gain side effects.
	www.netnutritionist.com /fa12.htm (2106 words)

	Long-Term Side Effects Surface With SSRIs
		When SSRIs first appeared a decade ago, their favorable side effect profile was a key selling point.
		With venlafaxine (Effexor), "the side effects are the same as with SSRIs: insomnia, somnolence, lethargy and fatigue, and weight gain, but they are less intense." The new extended-dose formulation causes lower peak plasma levels, which appears to make the drug more tolerable.
		Physicians should be aware of the fact that patients who are switched directly from SSRIs to nefazodone experience a higher than expected rate of side effects.
	www.antidepressantsfacts.com /LongTermSSRI.htm (1074 words)

	Selective Serotonin Reuptake Inhibitors- The Good, The Bad and The Funny. From People Who Have Taken These Crazy ... (Site not responding. Last check: 2007-11-06)
		In addition to depression, SSRIs are frequently good for panic/anxiety disorders and some are good for OCD as well.
		For most people SSRI poop-out is not an issue, but for some any SSRI will work great for a few months to a couple years or more and then suddenly stop working.
		If you're taking an atypical antipsychotic along with an SSRI, the discontinuation is often not nearly as bad, so if you have some Seroquel (quetiapine) on hand for insomnia, you'll want to take some for your SSRI discontinuation.
	www.crazymeds.org /ssri.html (4738 words)

	Medical Research To Die For - SSRIs
		This "medication," guar-an-teed safe and efficacious by the phantasmagoria of federal science, is prescribed to reduce the symptoms of whatever ails you and to assure healthy and happier lives.
		Kahn has examined the official clinical drug-trial data for all SSRIs approved by the Food and Drug Administration (FDA) between 1985 and 2000, in which 71,604 participants in the clinical trials were treated with antipsychotics, all SSRIs and anticonvulsants.
		But the data show the suicide rate is elevated 68 percent when comparing SSRI participants to those given placebo and to the general population.
	www.rense.com /general31/amed.htm (1199 words)

	Selective Serotonin Reuptake Inhibitors / SSRIs
		SSRIs are prescription medications used to inhibit serotonin reuptake and when used result in a potential increase in serotonin levels, which are found lacking, and used for treatment of depression, anxiety, obsessional and impulse control disorders.
		SSRI medications are very effective for certain patients, they may also cause some unwanted reactions if not taken in the right way.
		SSRI's were developed to find presription drugs that were as effective as the tricyclic antidepressants but with fewer safety and tolerability problems than with MAO inhibitors (monoamine oxidase inhibitors).
	www.herbalremedies.com /selserreupin.html (818 words)

	HEALY-REVIEW-SUICIDE 060620
		The effects of the SSRIs are therefore more like those of the H-2 blockers than they are like the effects of antibiotics for ulcers – they appear to have led to increases rather than reductions in the size of the population apparently affected in a manner that is inconsistent with claiming that these drugs work.
		In the case of the SSRIs and suicide, as early as 1992, there was replicated evidence of CDR, and dose response relationships between these drugs and suicide as well as evidence for an ability to intervene on the basis of antidotes to a proposed mechanism of action.
		In the case of SSRI agents and possible suicidality, the only reasonable end point that would justify the use of patient exposure years or a survival analysis is the appearance of agitation.
	www.socialaudit.org.uk /58090-DH.htm (12242 words)

	Blocking Agents (SSRIs) (Site not responding. Last check: 2007-11-06)
		SSRIs can be helpful for depression, panic disorder, social phobia and obsessive compulsive disorder.
		In fact, this may be their principle limitation, occurring in as many as 35 to 40% of patients.
		If these difficulties arise, your choices are to wait several weeks to determine if this side effect diminishes, to lower the dose or to change to a different medication.
	www.anxieties.com /panic_medication_SSRIs.php (655 words)

	Suicidal Behaviour Caused By Antidepressants "Cannot Be Ruled Out"
		Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed class of antidepressant, yet concerns have arisen that these drugs may induce or worsen suicidal feelings in vulnerable patients.
		Increased risks of suicide and self harm caused by SSRIs cannot be ruled out, say the authors, but larger trials with longer monitoring periods are needed to assess the balance of risks and benefits fully.
		The finding that SSRIs and tricyclic antidepressants have a similar risk profile with respect to suicide and self harm is reassuring, say the authors.
	www.medicalnewstoday.com /medicalnews.php?newsid=20154 (731 words)

	eMedicine - Toxicity, Selective Serotonin Reuptake Inhibitor : Article by Mohamed Badawy, MD (Site not responding. Last check: 2007-11-06)
		SSRIs have a high toxic-to-therapeutic ratio, and fatalities are uncommon with pure SSRI overdoses.
		If an SSRI overdose occurs in a patient on medication that relies on that system for its metabolism, toxicity from the concomitant medicine may occur.
		As SSRIs are increasingly prescribed, pediatricians, child psychiatrists, and emergency physicians should be familiar with the manifestations of SS.
	www.emedicine.com /ped/topic2786.htm (3365 words)

	Ssris (Site not responding. Last check: 2007-11-06)
		Selective serotonin re-uptake inhibitors (SSRIs) are a group of drugs used to treat depression, and...
		Selective Serotonin Reuptake Inhibitors (SSRIs): Overview of regulatory status and CSM advice relating to major depressive disorder (MDD) in children and adolescents including a summary of available...
		January 21, 2004 Preliminary Report of the Task Force on SSRIs and Suicidal Behavior in Youth This is the Executive Summary of a Task Force report by the American College of Neuropsychopharmacology...
	wellbutrinandlexapro.safelexapro.com /ssrisnjp (875 words)

	Bupropion ( Wellbutrin , Zyban )
		Many SSRI users insist they are willing to forgo sexual satisfaction to escape from the horrors of depression.
		The Crenshaw Clinic (now closed) was operated by Theresa Crenshaw, M.D. (now retired), one of the nation's most prominent sex and drug researchers and coauthor of the medical text "Sexual Pharmacology." Crenshaw and her colleagues gave 60 men and women suffering from low libido and difficulty with orgasm either a placebo or Wellbutrin.
		According to May, patients on SSRIs who are suffering sex problems because of it can ask their doctors about using a low dose of Wellbutrin (75 milligrams) in addition to their SSRI two hours before sex to mitigate SSRI-induced sexual impairment.
	www.bupropion.com /wonderwell (2473 words)

	JournalClub Review - Differences in Efficacy Among Currently Available SSRI's (Site not responding. Last check: 2007-11-06)
		SSRIs are more effective than TCAs and have better safety and compliance profiles.
		As a rule, SSRIs do not cause suicidal tendencies.
		Unlike TCAs, SSRIs are not associated with clinically significant anticholinergic side effects, cardiotoxicity, impaired psychomotor or cognitive performance, or suicidal behavior.
	www.pslgroup.com /jclub2.HTM (606 words)

	FDA Antidepressant Suicide Warning
		Issue One: From the time SSRIs were first introduced, a handful of experts have raised safety concerns that, for certain individuals, the new antidepressants may cause mental restlessness and suicidality.
		When the FDA came out with the warning, coincidentally, I was actually in the midst of uncovering the fact that I was misdiagnosed with Unipolar Depression for about a decade and a half, (I am currently 25,) when in fact I have a form of Bipolar.
		My main point is that the extreme reactions I had to the SSRI, (which in hindsight resembled similar actions and states-of-mind back in college and high school,) were due to the fact that I was misdiagnosed years ago, as a teenager, as having Unipolar Major Depression.
	www.mcmanweb.com /FDA_suicide.htm (5181 words)

	SSRIs articles and information
		When a major study reveals that antidepressant drugs quadruple a person's risk of committing suicide, and when that study is backed by an analysis of three million patient records covering four SSRIs like Paxil and Prozac, a reasonable person can only draw one conclusion: these drugs tend to cause people...
		Researchers have discovered that antidepressant drugs such as Prozac not only affect levels of the neurotransmitter serotonin in the brain, but also "hijack" dopamine signaling as well--causing it to launch serotonin signals.
		Use of antidepressants known as serotonin reuptake inhibitors (SSRIs) may be associated with bleeding in the stomach and intestines.
	www.newstarget.com /SSRIs.html (1072 words)

	SSRI Antidepressants - SSRIs
		SSRIs stabilizes the modd and reduces compulsive thought patterns.
		They can also be used in the treatment of praemenstrual dysphoric disorders or stress-related problems.
		SSRI help by enhancing the availability of the neurotransmitter serotonin in the brain.
	www.web4health.info /en/answers/bio-ssri-indication.htm (200 words)

	SSRI (Site not responding. Last check: 2007-11-06)
		A few cases of tardive dyskinesia have been reported in patients taking SSRI chronically.
		SSRI should not be given to patients taking deprenyl for the risk of development of toxic serotonin syndrome.
		Sampson, S. Treating depression with SSRI, a practical approach.
	neuroland.com /psy/ssri.htm (338 words)

	Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo ... (Site not responding. Last check: 2007-11-06)
		Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review -- Gunnell et al.
		inhibitor (SSRI) antidepressants are associated with an increased
		SSRIs cannot be ruled out, but larger trials with longer follow
	bmj.bmjjournals.com /cgi/content/full/330/7488/385 (3300 words)

	Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised ...
		SSRIs and has been consulted on several cases of attempted suicide,
		Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports.
		Use of selective serotonin reuptake inhibitors (SSRIs) in children and adolescents with major depressive disorder (MDD)—only fluoxetine (Prozac) shown to have a favourable balance of risks and benefits for the treatment of MDD in the under 18s.
	bmj.bmjjournals.com /cgi/content/full/330/7488/396 (3695 words)

	Arch Fam Med -- Selective Serotonin Reuptake Inhibitors: Infrequent Medical Adverse Effects, January 1998, Goldberg 7 ...
		to assume that the SSRIs are devoid of potential medical complications.
		SSRIs prior to surgery may be sensible, if appropriate in terms
		in peripheral serotonin caused by SSRI interference with platelet
	archfami.ama-assn.org /cgi/content/full/7/1/78 (3440 words)

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