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	SV40 Cancer Articles
		SV40 DNA was identified in samples from 4 of 20 children (1 Wilms' tumor, 3 transplanted kidney samples).
		SV40 large T-antigen sequences were detected at high prevalence, in human biopsies of primary brain (37-44%) and bone (21-37%) tumors, in cell cultures derived from brain (30-54%) and bone (53-80%) tumors.
		SV40 Tag sequences were detected in 29% of buffy coats of blood donors.
	www.sv40foundation.org /Articles.html (1059 words)

	SV40 - Wikipedia, the free encyclopedia
		SV40 is an abbreviation for Simian vacuolating virus 40 or Simian virus 40, a polyomavirus that is found in both monkeys and humans.
		SV40 has not been proven to cause disease in humans, but several studies have suggested a link to cancer based on the presence of relatively large amounts of what may be SV40 DNA fragments in some tumor tissues, particularly mesotheliomas and non-Hodgkin's lymphoma.
		SV40 is a DNA tumor virus thrust upon human populations primarily as a contaminant in various vaccine preparations.
	en.wikipedia.org /wiki/SV40 (1250 words)

	SV40 Cancer Foundation
		SV40 was the 40th virus found in rhesus monkey kidney cells when these cells were used to make the polio vaccine.
		In 1961, SV40 was discovered by Dr. Bernice Eddy of the National Institute of Health, Division of Biologics when she took the material used to grow polio vaccines and injected it into hamsters.
		However, this law did not require that SV40 contaminated vaccines be thrown away or that the contaminated seed material (used to make all polio vaccines for the next four decades) be discarded.
	www.sv40foundation.org (411 words)

	CBER - Simian Virus 40 (SV40:) A Possible Human Polyomavirus Workshop
		The first is to consider the possibility that SV40 is an infectious agent that is endemic in the human population; and second, is to stimulate the effort required to determine if SV40 is a causative agent in human disease.
		SV40 normally infects permissive cells -- that was how it was discovered -- such as this little -- according to this little scheme which is typical of the way that it infects CV1 monkey cells in culture.
		The SV40 prevalence was very high in both HIV negative urines as well as HIV positive urines, and we did not see any much greater increase in prevalence from what was already a very high prevalence in the HIV negative individuals.
	www.fda.gov /cber/minutes/sv40012797-1.htm (21092 words)

	EID V3 N2: News & Notes - Simian Virus 40 (SV40), a Possible Human Polyomavirus (Workshop Held at NIH)
		If SV40 DNA sequences are present in choroid plexus tumors in children born many years after vaccines were SV40 free (8), the possibility that SV40 is present in the population must be considered.
		Researchers reviewed data on SV40 antibodies in sera taken before 1954 (12) and in sera from persons in remote regions (13,14) not exposed to SV40-contaminated polio vaccines; the data suggest that SV40 might have been present in humans before the polio vaccines were introduced in 1954 (11).
		Because of crossreactivity between BK, JC, and SV40 antibodies (15) and the lack of standardized serologic assays to identify SV40 specificity of antibodies present in single samples of human serum, it is difficult to determine whether SV40 was present in humans before the population was exposed to SV40 in the early polio and adenovirus vaccines.
	www.cdc.gov /ncidod/EID/vol3no2/news245.htm (1136 words)

	Some SV40 References the IOM didn't cite
		SV40 Tag is a viral-encoded tumor-specific antigen, and thus a potential target for the induction of anti-tumor immunity and the development of therapeutic vaccines.
		SV40 was discovered as a contaminant of poliovirus vaccines that were inadvertently administered to millions of people in Europe and the United States between 1955 and 1963.
		SV40 DNA sequences have been found in human tumors, such as mesotheliomas, ependymomas, and bone tumors, suggesting that SV40 may be involved in their etiology.
	www.vaccinationnews.com /Scandals/oct_25_02/SV40_refs_not_IOM.htm (5455 words)

	[No title]
		Researchers suggested for years that millions of vials of polio vaccine, contaminated with SV40, infected individuals between 1953 and 1963 and caused human tumors.
		In her paper, Butel isolated a strain of SV40 from three patients that closely matches the strain Carbone sequenced from the polio vaccine vials.
		Indeed, this is one of the recommendations of the Institute of Medicine for studies of SV40 in humans.
	www.mercola.com /2002/apr/27/sv40.htm (1067 words)

	Studies:No Evidence That SV40 is Related to Cancer - National Cancer Institute
		In laboratory rodents, SV40 causes lymphoma, a cancer of the lymph nodes.
		Because some laboratory studies report that SV40 DNA can be detected in tumors from humans with this cancer, NCI scientists tested for SV40 antibodies in the blood of 724 non-Hodgkin lymphoma patients and in 622 controls--people without the cancer.
		The mothers may have become infected with SV40 from the vaccines and may have transmitted the virus to their children in the womb or soon after birth.
	www.cancer.gov /newscenter/pressreleases/SV40 (1784 words)

	SV40
		She argued that if SV40 is being transmitted and circulating in the population, then many people in the "unexposed" group would also be carrying the virus and that would undermine the comparison.
		SV40 from the kidney tissue contaminates the vaccine.
		According to the IOM report "SV40 Contamination of Polio Vaccine and Cancer": The committee concludes that the biological evidence is strong that SV40 is a transforming [i.e., cancer-causing] virus,.
	www.vaccinetruth.org /sv40.htm (17949 words)

	Questions and Answers - Polio Vaccine and SV40
		SV40 is a monkey (simian) virus that infects several monkey species without making the animals sick.
		The SV40 virus has also been detected in some patients with three rare cancers in humans; mesothelioma (cancer of the lining of the chest or abdomen, known to be caused by exposure to a certain type of asbestos fibre), osteosarcoma (cancer of the bones) and ependymoma (a childhood brain tumour).
		To date, there is no epidemiological evidence that shows people exposed to the SV40 contaminated polio vaccine are at increased risk of developing the type of cancers that rodents developed after direct exposure to SV40.
	www.phac-aspc.gc.ca /im/polio_e.html (1111 words)

	2003.11.13: SV40 in Polio Vaccine
		This has raised questions about the potential for various modes of SV40 transmission in the human population and the question of whether SV40 was circulating in the human population before the advent of the polio vaccines.
		Following the recognition that SV40 could contaminate cell cultures used to produce polio vaccine and the availability of testing for SV40, FDA required specific tests to assure that poliovirus vaccines are not contaminated with SV40 virus.
		Although scientists have not reached consensus on the potential risks posed by SV40 and whether it may contribute to causing some types of tumors in humans, the one thing we all agree on is that poliovirus vaccine has provided an enormous public health benefit and has practically eradicated this horrible disease.
	www.hhs.gov /asl/testify/t031113.html (2015 words)

	Simian Virus 40 and Human Cancer - National Cancer Institute
		Simian virus 40 (SV40) is a virus that infects several species of monkeys and typically does not cause symptoms or disease in them.
		NCI researchers and collaborators tested for the presence of SV40 in 47 archived samples of choroid plexus tumors and ependymomas, which are rare human brain tumors reportedly linked with SV40 (15, 17), from the All India Institute of Medical Sciences in northern India.
		Because the DNA of the SV40 virus is nearly 70 percent identical to the BK virus, it is difficult to distinguish between antibodies to the two viruses.
	www.cancer.gov /newscenter/sv40 (2730 words)

	SV40.com - Published Papers
		To date, the scientific literature and research examining SV40 and cancer-related diseases has been based upon an assumption that SV40 was not present in any poliovirus vaccine administered in the United States and was removed from the killed polio vaccine by 1963.
		SV40 had already been detected prior to the licensure of the first oral poliovirus vaccine in the United States and had already been discussed at the Pan American Health Conference, PAHO, held in June of 1960.
		Permitting five passages was to enable the manufacturers to remove SV40 from the Sabin original strains of the three types of oral live poliovirus vaccine and would permit the seeds to be free of SV40 and any other adventitious agents.
	www.sv40cancer.com /paper1.asp (3479 words)

	[No title]
		SV40 is known to create tumors in animals, but how it might have gotten into humans was unclear.
		If the monkey virus SV40 is indeed in humans, there are several possible explanations for how it got there, says Janet Butel, a virologist at Baylor College of Medicine and one of America's leading virus researchers.
		If that is true, it suggests another possible reason SV40 has been found in the brain tumors of people born after 1963: transmission from mother to child.
	www.mercola.com /2001/mar/24/monkey_virus.htm (957 words)

	SV40 Lareg and Small T antigen antibodies from Research Diagnostics Inc
		The major SV40 translational products include the 94 kDa large T antigen and the 21 kDa small T antigen, both of which are encoded by the early region of the SV40 viral genome.
		Specificty: Clone PAB419 Mab SV40 T Ag is reactive by immunoprecipitation with the 94,000 dalton SV40 large T antigen and the 20,500 dalton SV40 small T antigen (1) and stains SV40 infected cells.
		Background: SV40 T Ag clone Pab419 is a mouse monoclonal antibody with specificity for antigenic determinants localized to the amino terminal domain of the SV40 large T antigen (1).
	www.researchd.com /miscabs/sv40ab.htm (1385 words)

	SV40 \| Vaccine Education Center - Children's Hospital of Philadelphia
		Recently, investigators found SV40 DNA in biopsy specimens obtained from patients with cancers such as mesothelioma (lung), osteosarcoma (bone) and non-Hodgkins lymphoma (lymph nodes).
		First, SV40 was present in cancers of people who either had or had not received the polio vaccine that was contaminated with SV40.
		Third, people with cancers who were born after SV40 was no longer a contaminant of the polio vaccine were found to have evidence for SV40 in their cancerous cells.
	www.chop.edu /consumer/jsp/division/generic.jsp?id=75822 (292 words)

	SV40 Cancer Foundation Is Launched
		The SV40 Cancer Foundation has just been established by Raphaele and Michael Horwin in memory of their son, Alexander Horwin who passed away in 1999 from an SV40 positive cancer at the age of 2.
		During the hearing, one of the causation experts, a leading SV40 scientist, testified that he had reviewed thousands of pages of internal Lederle documents that demonstrated it was likely that the SV40, which caused Alexander's cancer, came from the oral polio vaccine that he was administered.
		The mission and purpose of the SV40 Cancer Foundation is to raise public awareness, encourage independent research and to facilitate clinical improvements.
	www.medicalnewstoday.com /medicalnews.php?newsid=36928 (434 words)

	SV40 virus issues
		SV40 in human brain cancers and non-Hodgkin's lymphoma.
		Conclusion from report: These results establish that SV40 is associated significantly with brain tumors, bone cancers, malignant mesothelioma, and non-Hodgkins lymphoma.
		And not just any SV40: In several tumors, it was precisely the genome of the SV40 in the vials of the 1955 polio vaccine that Dr. Ratner had held onto, waiting for someone to care.
	www.lymphomation.org /sv40-virus.htm (1754 words)

	SV40 quotes (Site not responding. Last check: 2007-09-10)
		Stanley Kops shows that not only is this not the case, but that the vaccine regulators who are charged with keeping our families safe, have known all along that SV-40 was never removed from vaccines.
		A study of 58,000 women who had received the IPV (killed virus) during the time that SV40 contaminated the vaccine (1959-1965) showed a thirteenfold increased risk of brain tumours in their children.
		"According to one memo, SV40 was found in three of 15 lots of the oral vaccine seven months after the federal directive was issued in March 1961.
	www.whale.to /v/sv40_q.html (383 words)

	The Polio Vaccine and SV40
		In his 1960 paper, "The Vacuolating Virus : SV40" Sweet and co-author M.R. Hilleman write, "This new virus represents the detection for the first time of a hitherto "non-detectable" simian virus of monkey renal cultures and raises the important question of the existence of other such viruses.
		At the time of the discovery of the human exposure to SV40, there was no evidence that the virus was present or active in vaccine recipients.
		In recent years, however, SV40 has been isolated in human tissue, two from the brains of patients with PML (progressive multifocal leukoencephalopathy) and another from a metastatic melanoma patient.
	www.chronicillnet.org /online/bensweet.html (1969 words)

	SV40 Staining Protocol
		SV40 large T antigen (T-ag) is a multifunctional ~85 kD phosphoprotein, which is the sole viral protein required for SV40 replication.
		In addition to its role in SV40 DNA replication, T-ag also causes transformation of susceptible cell lines.
		SV40 T-ag exercises negative regulation on the transcription of SV40 early mRNA by feedback inhibition and exerts positive regulation on transcription from the late promoter.
	www.ihcworld.com /_protocols/antibody_protocols/sv40_pharmingen.htm (502 words)

	A Multicenter Evaluation of Assays for Detection of SV40 DNA and Results in Masked Mesothelioma Specimens -- 10 (5): ...
		SV40 DNA was detected in the positive control but not the negative
		An aliquot from each of 56 specimens (DNA from 25 mesotheliomas, 25 normal lung tissues, and the negative and five positive SV40 controls) was tested by PCR amplification using primers GH20/PC04 and dot blot hybridization with probe PC03.
		Howley P. Molecular biology of SV40 and the human polyomaviruses BK and JC Klein G. eds.
	cebp.aacrjournals.org /cgi/content/full/10/5/523 (7366 words)

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