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Topic: Salbutamol

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	Salbutamol - Wikipedia, the free encyclopedia
		Salbutamol (INN) or albuterol (USAN) is a short-acting β
		Salbutamol became available in the United Kingdom in 1969 and in the United States in 1980 under the trade name Ventolin.
		While salbutamol is well-tolerated, particularly when compared with previous therapies such as theophylline, like all medications there exists the potential for adverse drug reactions to occur - especially when in high doses, or when taken orally or intravenously.
	en.wikipedia.org /wiki/Salbutamol (443 words)

	Salbutamol
		Salbutamol is used in cases of bronchospasm in patients with reversible airway obstruction: mild and moderate attacks of dyspnea in patients suffering from bronchial asthma; mild and moderate bronchoobstruction in patients with chronic bronchitis and lung emphysema.
		Salbutamol is a selective 2-adrenomimetic agent stimulating mainly the 2-adrenergic receptors and to a lesser extent 1-adrenergic receptors in the myocardium.
		The antiasthmatic action of Salbutamol is related to the decrease of edema and mucus secretion.
	www.bpg.bg /sopharma/salbutamol.phtml (425 words)

	[No title]
		Salbutamol when used as an inhaler is known as a reliever.
		Salbutamol tablets are sometimes prescribed if inhaled salbutamol is being used frequently to relieve shortness of breath.
		Salbutamol can potentially cause a serious decrease in the levels of potassium in the blood (hypokalaemia), which may result in adverse effects.
	www.getpharma.com /printer.asp?productid=73 (872 words)

	Formulation And Evaluation Of Controlled Release Transdermal Patches Of Theophylline - Salbutamol Sulphate
		The in vitro flux of theophylline and salbutamol sulphate from the formulation was 1.22±0.4 mg/hr/sq.cm and 13.36±1.02 mcg/hr/sq.cm respectively.
		Salbutamol sulphate and theophylline are administered in combination by oral route to effect the synergistic activity of drugs.
		Theophylline and salbutamol sulphate flux from the formulation was 1.22±0.4 mg/hr /sq.cm and 13.36± 1.02 mcg/hr/sq.cm.
	www.ispub.com /journals/IJPM/Vol2N1/theosal.html (2092 words)

	National Women's Newborn Drug Protocol - Salbutamol Pharmacology
		Salbutamol stimulates the production of intracellular cyclic AMP, enhancing the binding of intracellular calcium to the cell membrane and endoplasmic reticulum, resulting in bronchodilation.
		Clinical efficacy of nebulised salbutamol in infants under 18 months, especially very young infants with bronchopulmonary dysplasia, is uncertain.
		Transient hypoxaemia may occur during the administration of nebulised salbutamol and therefore it should be administered with oxygen.
	www.adhb.govt.nz /newborn/DrugProtocols/SalbutamolPharmacology.htm (417 words)

	Chemical & Engineering News: Top Pharmaceuticals: Salbutamol
		Within a month, we knew the effective doses of salbutamol, by inhalation and by mouth, the duration of the action, and the probable use-limiting side effects.
		Salbutamol was one of the earliest drugs developed by rational design.
		Salbutamol revolutionized asthma treatment and management within months of appearing on the market, leading to other bronchodilators and an improved quality of life for asthma sufferers.—CORINNE MARASCO
	pubs.acs.org /cen/coverstory/83/8325/8325salbutamol.html (846 words)

	The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of ...
		The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.
		Salbutamol, 200 microgram daily or every other day, had a profound therapeutic effect on the clinical progression of arthritis, as assessed by clinical score and paw thickness.
		In vitro, salbutamol reduced IL-12 and TNF-alpha release by peritoneal macrophages in a dose-dependent manner, as well as TNF release by synovial cells from arthritic mice.
	www.aegis.com /aidsline/1999/aug/A9980320.html (498 words)

	The Effect of AlkylpolyglycosideSurfactants on the Crystallization of Spray-Dried Salbutamol Sulphate: a ... (Site not responding. Last check: 2007-10-13)
		Microparticles of salbutamol sulphate and salbutamol sulphate-APGs were prepared by spray dying from solution in water, using a Büchi 190 mini spray drier fitted with a 7-mm pneumatic nozzle.
		Given that in each case it is salbutamol sulphate that is crystallizing, it might be assumed that the area under the curve (in J/g of salbutamol sulphate) would be the same, even if the shapes of the thermographs were different.
		For salbutamol sulphate spray dried alone it is possible to observe that as soon as the powder is exposed to 75% RH, there is a rapid uptake of water up to 13% wt/wt, which is then desorbed very slowly.
	www.aapspharmsci.org /view.asp?art=ps040316 (3039 words)

	Discrimination of Prohibited Oral Use of Salbutamol from Authorized Inhaled Asthma Treatment -- Bergés et al. 46 ...
		Salbutamol is excreted in urine as a mixture of the unchanged
		on the proportion of inhaled salbutamol to the proportion swallowed,
		Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate.
	www.clinchem.org /cgi/content/full/46/9/1365 (5134 words)

	http://localhost/fhg/revista/vol05/vol05ing/LA ADMINISTRACION DE SALBUTAMOL (Site not responding. Last check: 2007-10-13)
		Indication for salbutamol aerosol is based on clinical data and its delivery to ventilated infants is accomplished by a metered dose inhaler through the endotracheal tube (ETT) with a device (aerochamber) placed on the inspiratory tubing.
		Due to lack of aerochambers direct administration of salbutamol (S) aerosol is frequent in hospitals throughout this country.
		We conclude that salbutamol administered by metered dose inhaler into the ETT is effective in reducing airway resistance.
	www.drwebsa.com.ar /fhg/revista/vol05/vol05ing/salbutamol.htm (229 words)

	Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised ...
		Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial -- Roberts et al.
		salbutamol and 26 (59.1%) to an aminophylline infusion.
		Comparison of IV salbutamol with IV aminophylline in the treatment of severe, acute asthma in childhood.
	thorax.bmj.com /cgi/content/full/58/4/306 (3086 words)

	Salbutamol
		The asthma drug salbutamol is widely used by athletes, not just to prevent exercise-induced asthma but also for its supposed ergogenic properties.
		A study of the effects of two doses of inhaled salbutamol compared with placebo in 12 trained non-asthmatic triathletes failed to demonstrate a significant effect on endurance performance.
		One session was performed after inhalation of 200µg of salbutamol, another after an 800µg dose and a third after inhalation of placebo - the main criterion for an ergogenic effect being an increase in endurance time.
	www.pponline.co.uk /encyc/0669.htm (336 words)

	Effect of budesonide and salbutamol on surfactant properties -- Palmer et al. 89 (3): 884 -- Journal of Applied ...
		The objective of this study was to evaluate the in vitro effect of budesonide and salbutamol on the surfactant biophysical
		Short-time response characteristics of salbutamol in infants with broncho-pulmonary diseases.
		Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction.
	jap.physiology.org /cgi/content/full/89/3/884 (3865 words)

	Salbutamol Turbuhaler (salbutamol) - treats emphysema, bronchial asthma and chronic bronchitis
		Salbutamol sulphate belongs to a group of agents called beta-agonists (or sympathomimetics or adrenergic agonists).
		It is also used to treat chronic bronchitis (inflammation of part of the lungs), emphysema and other lung diseases where bronchospasm (a narrowing of the airways in the lungs making breathing difficult) is a complicating factor.
		Salbutamol binds to specific noradrenaline sites called beta -2-receptors resulting in relaxation, and hence widening, of the bronchial (lung) smooth muscle.
	www.patienthealthinternational.com /product/2386.aspx?nocookies=true (286 words)

	Critical Care \| Full text \| Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in ... (Site not responding. Last check: 2007-10-13)
		Salbutamol was administered through the ventilator circuit by metered dose inhaler (8 to 10 puffs at 100 μg/puff) or by nebulization of 2.5 to 5 mg of salbutamol solution (2.5 to 5 ml).
		We calculated the average daily dose of salbutamol (mg/day) while in the ICU as the sum of total metered dose inhaler and nebulization dose (in mg) divided by the number of days in the ICU.
		In a recent double-blinded placebo controlled trial, intravenous salbutamol was shown to reduce extra vascular lung water in patients with ALI [23].
	ccforum.com /content/10/1/R12 (4474 words)

	Salbutamol for Inhalation - Patient UK
		Salbutamol is available in nebuliser solution, metered dose inhaler and inhalation powder form.
		Salbutamol should be used at regular intervals to get the best effects from your medicine.
		Salbutamol aerosols are sometimes provided with a spacer device to assist young children and those who have problems co-ordinating the actuation of the device with inhalation.
	www.patient.co.uk /showdoc/30002890 (780 words)

	Delivery of Salbutamol Pressurized Metered-Dose Inhaler Administered Via Small-Volume Spacer Devices in Intubated, ... (Site not responding. Last check: 2007-10-13)
		As shown by the intensity of white, more radioactivity was measured in the rabbit’s lungs and in the connector to the ETT using the NES-spacer than in the other two spacer devices (white corresponds to the maximum count rate of radioactivity, fl to the minimum).
		Tal A, Golan H, Grauer N, Aviram M, Albin D, Quastel MR 1996 Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction.
		Conner WT, Dolovich MB, Frame RA, Newhouse MT 1989 Reliable salbutamol administration in 6- to 36-month-old children by means of metered-dose inhaler and aerochamber with mask.
	www.pedresearch.org /cgi/content/full/50/3/384 (3677 words)

	The {beta}2-Adrenergic Agonist Salbutamol Is a Potent Suppressor of Established Collagen-Induced Arthritis: Mechanisms ...
		The {beta}2-Adrenergic Agonist Salbutamol Is a Potent Suppressor of Established Collagen-Induced Arthritis: Mechanisms of Action -- Malfait et al.
		Salbutamol was administered at a dose of 20 or 200 µg
		Synovial cells were isolated from arthritic mice at day 10 of arthritis and cultured for 24 h with salbutamol 1 to 100 µM. Supernatants were assessed for bioactive TNF by the WEHI assay.
	www.jimmunol.org /cgi/content/full/162/10/6278 (4439 words)

	The Protective Effect of Salbutamol Inhaled Using Different Devices on Methacholine Bronchoconstriction -- Giannini et ...
		Britton, J, Hanley, SP, Garret, HV, et al (1988) Dose related effects of salbutamol and ipratropium bromide on airway calibre and reactivity in subjects with asthma.
		Seppala, OP, Herrala, J, Hedman, J, et al (1998) The bronchoprotective efficacy of salbutamol inhaled from a new metered-dose powder inhaler compared with a conventional pressurized metered-dose inhaler connected to a spacer.
		Barry, PW, O’Callaghan, C (1994) Multiple actuations of salbutamol MDI into spacer devices reduce the amount of drug recovered in the respirable range.
	www.chestjournal.org /cgi/content/full/117/5/1319 (2267 words)

	Effects of salbutamol on intracellular calcium oscillations in porcine airway smooth muscle -- Prakash et al. 82 (6): ...
		Effects of salbutamol on intracellular calcium oscillations in porcine airway smooth muscle -- Prakash et al.
		Effects of salbutamol on intracellular calcium oscillations in porcine airway smooth muscle
		ASM cells were preexposed to 1 µM salbutamol and subsequently to 5 mM caffeine to induce SR Ca release from ryanodine receptor (RyR) channels (28).
	jap.physiology.org /cgi/content/full/82/6/1836 (3435 words)

	Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic ...
		Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease -- Moayyedi et al.
		Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease
		nebulised salbutamol 5 mg and ipratropium bromide 500 micrograms, or
	thorax.bmjjournals.com /cgi/content/abstract/50/8/834 (491 words)

	Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction ...
		Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting {beta}2 agonists -- van der Woude et al.
		Salbutamol was inhaled immediately after reaching a methacholine induced decrease in FEV
		Secondly, in the present study the methacholine provocation test was performed at the peak of the agonist response.
	thorax.bmj.com /cgi/content/full/56/7/529 (3927 words)

	Use of salbutamol in pentamidine induced bronchospasm. A randomized placebo controlled trial.
		The 1.25 mg nebulised salbutamol showed significant increased bronchodilation compared to 200 mg via MDI and was the preferred treatment rated by the patients.
		Although a dose response was noted a full 2.5 mg salbutamol caused significant side effects and was poorly tolerated.
		PEFR dropped over the 4 hours post-AP, but were normalized with salbutamol, the 1.25 mg nebulized regimen was again the most superior, without substantial improvement with 2.5mg.
	www.aegis.com /aidsline/1993/nov/m93b4269.html (475 words)

	Salbutamol - Patient UK
		Salbutamol may also be used to stop premature labour during weeks twenty-four to thirty-three of pregnancy.
		This treatment is usually started by an intravenous infusion of Salbutamol, but may be continued with Salbutamol tablets or liquid.
		Salbutamol is available in tablet, injection and oral liquid form.
	www.patient.co.uk /showdoc/30002946 (737 words)

	Protection against methacholine-induced bronchospasm: salbutamol pMDI versus Clickhaler(R) DPI -- Newhouse et al. 21 ...
		Hindle M, Newton PAG, Chrystyn H. Investigations of an optimal inhaler technique using urinary salbutamol as a measure of relative bioavailability to the lung.
		Dose-response protective effect of salbutamol on methacholine airway responsiveness using pressurized metered dose inhalers and Turbuhalers.
		Chege JK, Chrystyn H. The relative bioavailability of salbutamol to the lung using urinary excretion following inhalation from a novel dry powder inhaler: the effect of inhalation rate and formulation.
	erj.ersjournals.com /cgi/content/full/21/5/816 (2795 words)

	Salbutamol Up-regulates PDE4 Activity and Induces a Heterologous Desensitization of U937 Cells to Prostaglandin E(2) -- ...
		The cells were preincubated with vehicle (distilled water for salbutamol, 0.03% dimethyl sulfoxide for rolipram), or 1 µM salbutamol plus 30 µM rolipram for 4 h.
		Using this protocol cells were exposed to vehicle or a combination of salbutamol and rolipram for a total of 4 h before Ca mobilization was assessed.
		However, after 4 h of treatment with salbutamol and rolipram a band of immunoreactivity was consistently observed.
	www.jbc.org /cgi/content/full/270/40/23598 (7085 words)

	Equivalent Bronchodilation with Salbutamol Given via pMDI or Turbuhaler -- MELLÉN et al. 159 (5): 1663 -- ...
		Data are shown as mean for each dose of salbutamol.
		Blood samples were taken 20 to 25 min after each dose of salbutamol, or at the corresponding time point after placebo.
		Differences in bronchodilating potency of salbutamol in Turbuhaler as compared with a pressurized metered-dose inhaler formulation in patients with reversible airway obstruction.
	ajrccm.atsjournals.org /cgi/content/full/159/5/1663 (2230 words)

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