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Topic: Salvinorin A

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 Salvia divinorum - Wikipedia, the free encyclopedia
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
The Salvinorin group of compounds (including Salvinorin A, Salvinorin B and Salvinorin C) are called neoclerodane diterpenoids.
Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action. /wiki/Salvia_divinorum   (1793 words)

 Salvinorin A (Salvia): Notes of Caution
Salvinorin A (the major active principal of the plant Salvia divinorum) is an extremely powerful consciousness altering compound.
Salvinorin A has a relatively high boiling point and people often don't get it hot enough to remain a gas all the way down into the lungs.
The neoclerodane diterpene, salvinorin A (also known as divinorin A), has been demonstrated in animals and humans to be its major active ingredient. /drugs/salvia1.htm   (1222 words)

 Salvia divinorum receptors found, salvia receptor, salvinorin receptors, Ask Dr. Shulgin Online January 9, 2002
Salvinorin-A is the active component of the plant Salvia divinorum, also known as Ska Pastora, hojas de la Pastora, or leaves of the shepardess by the Mazatec in northern Oaxaca.
One study has been made with a commercial company screening salvinorin-A within a collection of about a dozen neuroreceptors (including dopamine, serotonin, GABA and muscarinic receptors) and nothing of interest was found.
I was wondering if they had found any neurotransmitter sites for Salvinorin-A, B or C. They are compounds of such high potency that I wonder if they might actually mutate receptor sites into new sites specific for salvia. /shulgin/adsarchive/salviareceptor.htm   (418 words)

 Dosage and Administration
The salvinorin A was placed on the center of a piece of thick aluminum foil, which was heated from below with a butane micro-torch or "jet flame" lighten As the salvinorin A turned to a white vapor, the vapors were inhaled through a 15mm diameter glass tube.
Salvinorin A can be efficiently consumed by inhaling the vaporized crystalline powder, or by smoking, providing the crystalline powder has been placed on a substrate such as dried Salvia divinorum leaf.
Salvinorin A is approximately 10 times the potency of these compounds, and nearly as potent as the semi-synthetic psychedelic, LSD. /donut/dose.html   (1067 words)

 Salvia Divinorum, (Street Names: Maria Pastora, Salvia)
Salvinorin A, also called Divinorin A, is believed to be the ingredient responsible for the psychoactive effects of S. divinorum.
Recent studies using tissue testing (in vitro) assays and functional assays show that Salvinorin A acts as a potent agonist on the Kappa opioid receptor.
This may explain the psychoactive effects of Salvia divinorum and Salvinorin A since other drugs acting at Kappa opioid receptors have been found to cause dysphoria, illusions, and hallucinations. /drugs_concern/salvia_d/salvia_d.htm   (544 words)

 The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys.
Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum.
The opioid antagonist quadazocine (0.32 mg/kg) fully blocked the effects of salvinorin A. The kappa-selective antagonist GNTI (1 mg/kg; 24 h pretreatment) did not cause significant antagonism of the effects of salvinorin A (GNTI, under these conditions, was only effective as an antagonist in two of three monkeys).
The ability of salvinorin A to cause generalization (>/=90% U69,593-appropriate responding) was examined in time course and cumulative dose-effect curve studies. /butelman.htm   (271 words)

Salvinorin A has previously been shown to be active in mice but it has remained uncertain whether this compound is responsible for the psychoactive effects produced in humans.
Salvinorin A has been shown to be active in mice while salvinorin B was inactive.
Salvinorin A is the first entheogenic diterpene reported and is active in humans at extraordinarily low doses. /salvia/salvinorin.htm   (1861 words)

 Salvinorian A
Salvinorin B is desacetyl divinorin A and acetylation is possible to convert Salvinorin B into Salvinorin A. The acetyl group missing in Salvinorin B is on the second carbon of the first ring (White arrow)(Valdes et al 1984).
A 1993 study found that Salvinorin A is not absorbed in the gastrointestinal tract regardless of dose (Seibert 1994).
When the Salvinorin A extract is vaporized and inhaled through a short glass tube, the effects, hallucinations, arise with a 200 microgram dose (Siebert 1994). /chem/bailey/377/PapersF2000/AndrewP   (1324 words)

The trouble is, a lot more than just the salvinorin A gets dissolved out of the leaves, much of the plant lipids get dissolved in the solvent as well and end up in the extract and subsequently in your lungs.
Salvinorin A is a very stable compound and will not lose any potency over time.
The trouble is, a lot more than just the salvinorin-A gets pulled out of the leaves; much of the chlorophyll and plant fats get dissolved as well and end up in the finished extract and subsequently in your lungs. /salviaquality.html   (928 words)

 Neoclerodane Diterpenes as Potential Drug Abuse Therapeutics
Salvinorin A thus represents not only a potential drug of abuse but also a possible route for the creation of novel therapeutics for stimulant and opioid dependence.
The main active component of the hallucinogenic sage is salvinorin A, a neoclerodane diterpene that has been shown to be a selective and potent k-opioid receptor agonist.
Methods: Initially, we set out to optimize the extraction of salvinorin A from Salvia divinorum leaves in order to synthesize and evaluate analogues of salvinorin A. For the isolation of salvinorin A, we have modified existing procedures and increased the bio-yield to approximately 7.5 g from 1.5 kg of dried leaves. /theme_issues/abstracts/view.asp?art=Front-04-00022&pdf=yes   (319 words)

 Salvinorin A, salvinorin A, Ask Dr. Shulgin Online May 22, 2002
Some time ago, in answer to a related question, I drew an analogy between Salvinorin and THC, as neither was an alkaloid and maybe they both worked at the same place.
Salvinorin A, salvinorin A, Ask Dr. Shulgin Online May 22, 2002
All I would need to do (this student told me) is to inject it into an animal, and then watch where it goes, and how it is changed in the body, and in what form it is finally excreted. /shulgin/adsarchive/salvinorinA.htm   (417 words)

 Salvinorin A isolation
To obtain salvinorin A in its pure form, from blackwax, chromatography is used.
The salvinorin A content in leaves I have tested, ranged from 1.5mg/g for home grown plants, upto a massive 5.4 mg +/- 10% for mexican plants harvested during summer.
The impurities which make up the bulk of the blackwax precipitate out of solution before the salvinorin A. If this doesn't occur another stumbling block must be overcome - the dissolved chlorophylls and other junk keeps the salvinorin in solution stopping any crystallisation. /space/salvia/Isolation/salvinorin.html   (219 words)

Salvinorin A is the primary psychoactive component of Salvia divinorum.a member of the sage family found in the Mexican state of Oaxaca.
The salvinorin A wasplaced on the center of a piece of thick aluminum foil, which was heatedfrom below with a butane micro-torch or "jet flame" lighten As the salvinorinA turned to a white vapor, the vapors were inhaled through a 15mm diameterglass tube.
Salvinorin A can be efficiently consumed by inhaling the vaporizedcrystalline powder, or by smoking, providing the crystalline powder hasbeen placed on a substrate such as dried Salvia divinorum leaf. /info/salviadivinorum/stpe.html   (15554 words)

 Lycaeum > Leda > Salvinorin-A
Salvinorin A - The Breakthrough: Daniel Siebert's discovery of the active chemical in Salvia divinorum, June 6, 1993.
The authoritative Salvia site, maintained by salvinorin pioneer Daniel Siebert.
Explore the strange new world of salvinorin chemistry /?ID=156   (91 words)

 The World of Salvia Divinorum - Leaves, Extract, Fastest Shipping
A more potent version, extracts, take the salvinorin ingredient and multiply it for a more powerful substance, that is still safe.
The active compound, SALVINORIN A, has astonished users and researchers with its dramatic and intense psychoactive effects, which are quite distinct from anything else.
Because of its extreme potency, pure salvinorin A should never be used unless the dosage has been precisely measured with an extremely accurate chemist's scale.   (502 words)

 Erowid Salvia Divinorum Vault : Salvinorin Activity at Kappa Opioid Receptor
By using cloned cells which expressed a variety of neurotransmitter receptor types, bathing them in a solution with salvinorin A in it, and then using radio-labeled chemicals known to bind to the given receptor, they were able to see if the salvinorin kept the other chemical from 'sticking'.
Because the binding 'affinity' for the radio-labeled ligands was known, the amount the salvinorin blocked it produced a numerical value which then could be used to rate how much salvinorin stuck to the receptor.
As Roth writes in his 2002 paper about salvinorin A, "because the KOR has long been recognized as a target for psychotomimetic agents, KOR antagonists may represent a novel class of psychotherapeutic compounds. /plants/salvia/salvia_info5.shtml   (500 words)

 The Discovery of Salvinorin A
Salvinorin A was first isolated in 1982 by Alfredo
Pure salvinorin A is desirable because it permits one to experience intense
Salvinorin A did not affect any of the receptor sites tested, /~nukenet/salvia/disc.html   (590 words)

 Relating to hallucinogenic substances; and prescribing an effective date.
(4) Unlawful importation or possession of salvinorin A or Salvia divinorum is a Class B felony.
(3) A person commits the crime of unlawful importation or possession of salvinorin A or Salvia divinorum if the person knowingly imports into this state or possesses salvinorin A or Salvia divinorum.
(2) Unlawful delivery of salvinorin A or Salvia divinorum is a Class A felony. /03reg/measures/hb3400.dir/hb3485.intro.html   (334 words)

 Salvia Lab
While the isolation of pure Salvinorin A is a complex procedure beyond the scope of these pages, it can be concentrated to various degrees depending on your equipment, materials, and ability.
The theory behind an extraction is fairly simple: separate the components we want from the ones we don't want.
Partitioning w/ a Separatory Funnel : An intermediate extraction /lab/lab.html   (115 words)

Its active principle, salvinorin A, is structurally unique among psychoactive drugs, and receptor binding studies have revealed nothing, which could indicate a previously unknown pathway in the brain.
It is known only in cultivation, and it rarely produces seed, suggesting a chance unstable hybrid, although the genetics have not yet been investigated.
Most users agree Salvia divinorum is quite unique, and some find its effects unsettling.   (2452 words)

 Salvinorin A - The Breakthrough
(Later the material was analyzed and was shown to be approximately 70 - 80% salvinorin A) I had set out to prepare a fairly crude but significantly concentrated extract of Salvia divinorum.
During the extraction procedure I managed to isolate a fairly pure crystalline fraction. /drugs.old/plants/salvia/salvia-experience.html   (927 words)

 Psychedelics - Azarius
An interesting psychoactive plant containing Salvinorin, one of the most potent hallucinogens known to man. Since a couple of years Salvia Divinorum is a very popular smart drug.
The cacti are cultivated in Holland, not taken from nature. /cat_psychedelics.html   (261 words)

 Experimental Salvia Divinorum information
S.Divinorum and salvinorin A is now illegal in Australia and perhaps other countries soon.
I'm taking a break from salvia experiments and I will simply add interesting offsite links for a while until I discover something important.
Try this link for some warnings Caution information /space/salvia   (84 words)

 IconBAZAAR - Molcules - Drugs - Psychedelics - Salvinorin A
IconBAZAAR - Molcules - Drugs - Psychedelics - Salvinorin A
Click on a thumbnail above to view the corresponding 3D animated image. /molecules/drugs/psychedelics/salvinorin-a.html   (22 words)

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