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Topic: Sar1

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GTPase superfamily

GTPase

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	liumin-v6ops-silkroad-03.txt
		SAR1 examines the IPv6 destination and checks if there is an entry for this IPv6 address in the list of recent communication peers, and if the entry is still valid.
		SAR1 will check the address binding in its mapping table, in which it will find that the destination IPv6 address is associated with A's mapped IPv4 address and port.
		"SAR1" is the SAR chosen by "A" and "SAR2" is the SAR chosen by "B".
	ietfreport.isoc.org /idref/draft-liumin-v6ops-silkroad (5989 words)

	Rotation Project Description
		COPII associate with cargo and/or cargo receptors upon recruitment to the ER membrane by the activation of Sar1.
		Sar1 initiates cargo concentration and selection by concentrating cargo into morphologically identifiable tubular domains on the ER membrane.
		ER export in these cells and the formation of Sar1 dependent tubular domains that can export cargo is found in both the cell body and dendrites.
	www.medschool.pitt.edu /biomed/rotation/aridor.htm (693 words)

	Anti-SARI, SARI, SARI antibody
		SAR1 protein belongs to the small GTPase superfamily, SAR1 family.
		It is involved in transport from the endoplasmic reticulum to the Golgi apparatus (by similarity).
		Jones, B. et al : Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders.
	www.prosci-inc.com /Antibody-XW-TDS/XW-7549.html (79 words)

	The SAR1 gene of Arabidopsis acts downstream of the AXR1 gene in auxin response -- Cernac et al. 124 (8): 1583 -- ...
		The SAR1 gene of Arabidopsis acts downstream of the AXR1 gene in auxin response -- Cernac et al.
		The SAR1 gene of Arabidopsis acts downstream of the AXR1 gene in auxin response
		AXR1 plants are indistinguishable, indicating that sar1 both suppresses and
	dev.biologists.org /cgi/content/abstract/124/8/1583 (647 words)

	Balch Lab - Research
		Vesicle mediated transport is regulated by a diverse group of small GTPases belonging to the Ras superfamily that function as "molecular sensors" to regulate different steps in the reversible assembly of vesicle coats and targeting-fusion complexes.
		We hope to use knowledge of the function of these cargo selection and trafficking pathways to develop small molecule chemical chaperones to encourage export and stability of misfolded proteins leading to restoration of normal cellular function in disease.
		Sar1 tubules form a scaffold for the initial steps of cargo selection.
	www.scripps.edu /cb/balch/researchrep.html (1226 words)

	Self-assembly of minimal COPII cages
		This coat forms by the sequential recruitment of the small G-protein Sar1 and two cytosolic complexes, Sec23/24 and Sec13/31, to the ER membrane (Barlowe et al., 1994; Matsuoka et al., 1998, 2001).
		The assembly of the COPII coat on lipid membranes is strictly dependent on the presence of Sar1−GTP at the bilayer surface (Barlowe et al., 1994; Matsuoka et al., 1998).
		The fact that Sec23/24 and Sec13/31 can self-assemble in solution suggests that the lateral contacts between these complexes may be strong enough to transiently preserve the structure of the coat, provided that the GTP hydrolysis reaction is properly organized in time and in space (Antonny and Schekman, 2001).
	www.nature.com /embor/journal/v4/n4/full/embor812.html (3829 words)

	Oncogenic Transformation of Cells by a Conditionally Active Form of the Protein Kinase Akt/PKB -- Mirza et al. 11 (6): ...
		SAR1 cells were grown to confluence and rendered quiescent by culture in the absence of serum for 5 days.
		A, confluent monolayers of SAR1 cells were cultured in the absence of serum for 4 h and were subsequently treated with 4-HT for various times from 5 min to 3 h as indicated.
		SAR1 cells were cultured as above and treated with 4-HT (Akt) or PDGF (10 ng/ml) in the absence (DMSO as solvent control) or the presence of the MEK inhibitor PD098059.
	cgd.aacrjournals.org /cgi/content/full/11/6/279 (8405 words)

	HHMI News: Structure Reveals Details of Cells Cargo-Carriers
		The complex is curved to conform to the spherical shape of a vesicle the gray line indicates the position of the vesicle surface.
		Their studies revealed how each of the components of the complex works: A component called Sar1 launches the budding process by anchoring itself to the ER membrane.
		Sar1 accomplishes this feat by changing its shape through a chemical reaction called GTP binding.
	www.hhmi.org /news/goldbergj2.html (783 words)

	[No title]
		Figure 17-9, Lodish 5e: Role of Sar1 in the assembly and disassembly of COPII coats.
		Both ARF and Sar1 are related to Ras, a protein involved in cell signaling.
		The GDP-bound form of Sar1, Sar1(GDP) interacts with an integral membrane protein of the ER called Sec12, which is a GDP/GTP exchange factor.
	web.uconn.edu /mcb380/lecture09.html (1528 words)

	The Sar1 GTPase Coordinates Biosynthetic Cargo Selection with Endoplasmic Reticulum Export Site Assembly -- Aridor et ...
		Sar1 interacts with the VSV-G cytoplasmic tail and assembles COPII coats in an export signal-dependent manner.
		VSV-G colocalized with Sar1 (a and f) and the cargo SNARE protein Sec22 (b and g), but not with the resident ER membrane protein p63 (c and h), the resident soluble ER protein BIP (d and i), or Man II (e and j).
		Sar1 and GTP to accumulate VSV-G in tubules (stage 1).
	www.jcb.org /cgi/content/full/152/1/213 (8513 words)

	An antibody specific for the C-terminal tail of the gp41 transmembrane protein of human immunodeficiency virus type 1 ...
		Cultures were then washed, and incubated with SAR1 at 20 °C for 30 min.
		Kinetics of the loss of SAR1-mediated PAN at 37 °C. Virus was allowed to attach to cells for 2 h at 20 °C, and unattached virus removed by washing.
		SAR1 inhibited fusion of HIV-1-infected cells with non-infected cells.
	vir.sgmjournals.org /cgi/content/full/86/5/1499 (5852 words)

	A Screen for Genes That Influence Fibroblast Growth Factor Signal Transduction in Drosophila -- Zhu et al. 170 (2): 767 ...
		The breaks in the dorsal trunk also show a large range of variation, and the number of breaks seen in these images is not representative for the whole phenotypic class.
		(I and J) Examples of the fraction of hbr, sar1, and hbr, robo2 double-mutant embryos with defects in germ-band retraction, stained with the 2A12 antibody.
		Sar1 is a small GTPase essential for the formation of COPII
	www.genetics.org /cgi/content/full/170/2/767 (4775 words)

	SAR1 (Site not responding. Last check: 2007-10-25)
		The original SAR1 is shown in table 2, where ``st'' was set on the first cell of a block and ``pf'' indicates that the cell was partly full, which only happened on the last cell of a block.
		The assemble field started at zero when a circuit was opened and was incremented (modulo 64) after each block is transmitted.
		EDL networks use a variant of SAR1 where the part-full bit should never be set.
	www.cl.cam.ac.uk /Research/SRG/bluebook/03/sar/node3.html (184 words)

	From the Cover: Brucella coopts the small GTPase Sar1 for intracellular replication -- Celli et al. 102 (5): 1673 -- ... (Site not responding. Last check: 2007-10-25)
		Sar1 or ARF1 dominant allele constructs cannot be used in conjunction
		Scoring of bacterial replication was performed after 24 h of infection by epifluorescence microscopy analysis of untransfected (control) or transfected, infected cells.
		Calnexin- or LAMP-1-positive BCVs were scored by confocal microscopy on single sections of untransfected cells (control) or cells transfected with either of the Sar1 alleles.
	www.pnas.org /cgi/content/full/102/5/1673 (3720 words)

	[No title] (Site not responding. Last check: 2007-10-25)
		If SAR1 has not yet forwarded any packet towards this IPv6 destination address and has no route information in its local route table, it will connect to its SN to search whether B is one SC serviced by another SAR.
		After determining the address of SAR2, SAR1 will tunnel the IPv6 packet together with the Control Option to the address of SAR2: Expires May,2005 [Page 13] Internet-Draft Silkroad November 2004 4.0.0.4:5188.
		When A receives the Router Response from R1, it compares the IP address and port in Control Option with the local IP address and port it bound to when the request was sent.
	www.faqs.org /ftp/pub/internet-drafts/draft-liumin-v6ops-silkroad-02.txt (5625 words)

	Endoplasmic Reticulum Export of Glycosyltransferases Depends on Interaction of a Cytoplasmic Dibasic Motif with Sar1 -- ...
		The role of Sar1 in ER Golgi transport of the constructs was
		Sar1 binds to cytoplasmic tail sequences containing RR residues.
		Sar1 binds to synthetic peptides with cytoplasmic tail sequences.
	www.molbiolcell.org /cgi/content/full/14/9/3753 (6994 words)

	Cisco - Troubleshooting SAR Crashes on the PA-A3
		Prevents SAR1 crashes by not sending packets to the SAR on an unconfigured VC or sending packets to the SAR with invalid encapsulation.
		Prevents SAR1 crashes caused by receiving a cell on a VPI/VCI pair that does not exist on the transmit SAR.
		This problem can occur when a large number of SVCs are being created or torn down, so the transmit SAR misses a command interrupt from the host CPU on the VIP or NPE.
	www.cisco.com /warp/public/121/sarcrashes.html (1063 words)

	Apolipoprotein B100 Exit from the Endoplasmic Reticulum (ER) Is COPII-dependent, and Its Lipidation to Very Low Density ...
		on rat hepatoma cells transfected with plasmids containing WT or the GDP-restricted mutant (T39N) of the Sar1 protein (5).
		Sar1 activity is regulated by cycling between the GTP-
		in cells transfected with either Sar1 WT or the T39N mutant.
	www.jbc.org /cgi/content/full/278/48/48051 (5695 words)

	A Link between Secretion and Pre-mRNA Processing Defects in Saccharomyces cerevisiae and the Identification of a Novel ...
		Intron-bearing SAR1 pre-mRNA accumulates in rse1-1 and prp2-13 mutants.
		SAR1 is limiting for secretion in prp2-13 and rse1-1.
		As expected, the intronless allele of SAR1 suppressed the ER-to-Golgi transport defects of both mutants.
	mcb.asm.org /cgi/content/full/18/12/7139 (5499 words)

	Endoplasmic Reticulum Export Site Formation and Function in Dendrites -- Aridor et al. 24 (15): 3770 -- Journal of ...
		The neurons in A3 were incubated with Sar1-GDP to determine whether Sar1 activation was required for ER tubule formation.
		Sar1 protein distribution was examined by IF microscopy.
		Sar1 generates tubules that are functional intermediates in ER export in vitro
	www.jneurosci.org /cgi/content/full/24/15/3770 (5434 words)

	Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders - Nature Genetics
		Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
		The Sar1 family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles.
		Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell.
	www.nature.com /doifinder/10.1038/ng1145 (262 words)

	Evidence against an Essential Role of COPII-Mediated Cargo Transport to the Endoplasmic Reticulum-Golgi Intermediate ...
		were transfected and expressed the mutated Sar1 protein.
		Electron microscopy was used to visualize the effects of Sar1
		Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments.
	jvi.asm.org /cgi/content/full/77/21/11754 (5811 words)

	Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export -- Huang et al. 155 ...
		The Sar1 GTPase is an essential component of COPII vesicle coats
		divergence of Sar1 from Arf family GTPases, Sar1 is structurally
		In particular, we show that the Sar1 NH terminus
	www.jcb.org /cgi/content/abstract/155/6/937 (576 words)

	Dynamics of COPII Vesicles and the Golgi Apparatus in Cultured Nicotiana tabacum BY-2 Cells Provides Evidence for ...
		When a GDP-fixed Sar1 mutant is expressed, ER export is blocked and the visualization of COPII binding is
		Protein gel blots of total cytosolic proteins, corresponding to the individual panels of the secretion index histogram, are also given to document the gradual increase in expressed effector protein in the protoplast homogenates.
		Note that in marked contrast with LeSec13-GFP, the expression of the Sar1 mutant leads to a drastic reduction in secretory activity.
	www.plantcell.org /cgi/content/full/17/5/1513 (8109 words)

	COPII Coat Assembly and Selective Export from the Endoplasmic Reticulum -- Sato 136 (6): 755 -- Journal of Biochemistry
		by Sar1 leads to disassembly of the coat proteins, which are
		the Sar1 GTPase cycle is thought to regulate COPII coat assembly
		Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues.
	jb.oxfordjournals.org /cgi/content/abstract/136/6/755 (226 words)

	Characterization of Secretory Genes ypt1/yptA and nsf1/nsfA from Two Filamentous Fungi: Induction of Secretory Pathway ...
		Northern hybridization was carried out with total RNA derived from mycelia treated with BFA and from control mycelia.
		pathway and the YPT1 and SAR1 genes are not induced (47; http://www.cell.com/cgi/content/full/101/3/249/DC1).
		Isolation and analysis of functional homologues of the secretion-related SAR1 gene of Saccharomyces cerevisiae from Aspergillus niger and Trichoderma reesei.
	aem.asm.org /cgi/content/full/70/1/459 (5285 words)

	Saiga 7.62 Rifle vs SAR1 - THR
		I've been looking at gettin an SAR1 AK for a loooooooong time now, I just never have.
		I'm wondering how these two guns compare, especially in terms of accuracy and fit/finish.
		The local gun shop has a Saiga 7.62 for $199 and an SAR1 for $369.
	www.thehighroad.org /showthread.php?t=87255 (888 words)

	Review lectures 33-34 (Site not responding. Last check: 2007-10-25)
		Describe how the following proteins contribute to these phases of vesicular transport: Adaptin, Clathrin, Dynamin, COP, Sar1, v-SNARE, t-SNARE.
		34.8) Sar1 and Ran are examples of a monomeric GTPases.
		For Ran, a GEF in the nucleus is responsible for maintaining a high concentration of Ran-GTP in the nucleus.
	www.bmb.psu.edu /courses/bmb251/gilmour_fa04/lecture_33_34_review_F04.html (650 words)

	SAR-1, SAR1, SAR 1
		AKM is the Russian term of: Avtomat Kalashnikova Modernizya, which means modernized AK-47, referring to the stamped AKM of 1968, versus the milled AK-47 of 1947.
		Warsaw-Pact AKM's include: Soviet/Russian mfg.,F.E.G. of Hungary (SA-85's, etc.), and Romanian W.U.M.-1's, W.U.M.-2's, S.A.R.1, S.A.R.2, S.A.R. 3's, as well as Maadi AKM's, RML, RPM, and the MISR.
		SAR1 Romanian AK47 7.62x39 High Capacity Rifle, featuring a Laminated Wood Stock Set
	www.ak-47.us /SAR-1.php (268 words)

	SEN Handbook
		A hyperlink in the letter provides access to more than 40 different telephone numbers for the service.
		With effect from 1 May 2003 all schools must use Form SAR1 when making a request for statutory assessment.
		These notes should be referred to by schools before completing FORM SAR1.
	www.bgfl.org /services/special/handbook.htm (486 words)

	T10M13.9 (Site not responding. Last check: 2007-10-25)
		SAR1 is a 21/22-kDa GTP-binding protein involved in vesicular transport between the endoplasmic reticulum and the Golgi.
		SAR1 can be included in the RAS superfamily of small GTP-binding proteins, but unlike other RAS and RAS-like proteins, SAR1 does not encode cysteine residues at the C-terminus and, thus, is not subject to prenylation.
		mRNA: Based on a comparison of T10M13 and the SAR1 cDNA U56929, the 5'-UTR extends from 47751 to 47818 and the 3'-UTR extends from 48813 to 49041.
	nucleus.cshl.org /protarab/T10M13-9-annotation.html (176 words)

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